HRP20160485T1 - Anti-mezotelinska protutijela i njihova uporaba - Google Patents
Anti-mezotelinska protutijela i njihova uporaba Download PDFInfo
- Publication number
- HRP20160485T1 HRP20160485T1 HRP20160485TT HRP20160485T HRP20160485T1 HR P20160485 T1 HRP20160485 T1 HR P20160485T1 HR P20160485T T HRP20160485T T HR P20160485TT HR P20160485 T HRP20160485 T HR P20160485T HR P20160485 T1 HRP20160485 T1 HR P20160485T1
- Authority
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- Croatia
- Prior art keywords
- antibody
- seq
- isolated
- fragment
- acid sequence
- Prior art date
Links
- 239000012634 fragment Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 102000003735 Mesothelin Human genes 0.000 claims 3
- 108090000015 Mesothelin Proteins 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
1. Izolirano ljudsko protutijelo ili njegov funkcionalni fragment koje sadrži regiju koja veže antigen koji je specifičan za Mezotelin iz SEQ ID NO: 370, naznačeno time da navedeno protutijelo ili njegov funkcionalni fragment prepoznaje epitop za mezotelin koji nije maskiran s karcinom antigenom 125 (CA125), te pri čemu navedeno protutijelo ili njegov funkcionalni fragment internalizira u stanice koje eksprimiraju mezotelin i ima regiju koja veže antigen, pri čemu regija koja veže protutijelo sadrži HCDR 1, HCDR 2, HCDR 3, LCDR 1, LCDR 2 i LCDR 3 pri čemu:
a) HCDR1 je SEQ ID NO: 5,
b) HCDR2 je SEQ ID NO: 39,
c) HCDR3 je SEQ ID NO: 71,
d) LCDR1 je SEQ ID NO: 103,
e) LCDR2 je SEQ ID NO: 133 i
f) LCDR3 je SEQ ID NO: 169.
2. Protutijelo prema zahtjevu 1, naznačeno time da sadrži varijabilnu sekvencu amino kiseline teškog lanca od SEQ ID NO 212
3. Protutijelo prema zahtjevu 1, naznačeno time da sadrži varijabilnu sekvencu amino kiseline lakog lanca od MF-T VL iz Tablice 4.
4. Protutijelo prema bilo kojem od zahtjeva 1 do 3, naznačeno time da je IgG.
5. Izolirani funkcionalni fragment protutijela prema bilo kojem od zahtjeva 1 do 3, naznačeno time da je Fab ili fragment protutijela scFv.
6. Izolirana sekvenca nukleinske kiseline naznačena time da kodira regiju koja veže antigen ljudskog protutijela ili njegov funkcionalni fragment prema bilo kojem od zahtjeva 1 - 5.
7. Vektor naznačen time da sadrži sekvencu nukleinske kiseline prema zahtjevu 6.
8. Izolirana stanica naznačena time da sadrži vektor prema zahtjevu 7.
9. Izolirana stanica prema zahtjevu 9, naznačena time da navedena stanica je bakterijska stanica ili stanica sisavca.
10. Farmaceutski pripravak naznačen time da sadrži protutijelo ili funkcionalni fragment prema bilo kojem od zahtjeva 1-5, te farmaceutski prihvatljiv nosač ili pomoćno sredstvo.
11. Protutijelo ili fragment prema bilo kojem od zahtjeva 1-5 naznačeno time da je za uporabu kao farmaceutski proizvod.
12. Ljudsko protutijelo prema bilo kojem od zahtjeva 1-5, naznačeno time da ljudsko protutijelo je sintetsko ljudsko protutijelo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US437807P | 2007-11-26 | 2007-11-26 | |
| EP08855189.0A EP2215121B1 (en) | 2007-11-26 | 2008-11-19 | Anti-mesothelin antibodies and uses therefor |
| PCT/EP2008/009756 WO2009068204A1 (en) | 2007-11-26 | 2008-11-19 | Anti-mesothelin antibodies and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160485T1 true HRP20160485T1 (hr) | 2016-06-03 |
Family
ID=40351874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160485TT HRP20160485T1 (hr) | 2007-11-26 | 2016-05-06 | Anti-mezotelinska protutijela i njihova uporaba |
Country Status (31)
| Country | Link |
|---|---|
| US (3) | US9023351B2 (hr) |
| EP (3) | EP3103814A1 (hr) |
| JP (3) | JP5608091B2 (hr) |
| KR (1) | KR101559599B1 (hr) |
| CN (2) | CN101952319B (hr) |
| AU (1) | AU2008329221B2 (hr) |
| BR (1) | BRPI0819909B8 (hr) |
| CA (1) | CA2706529C (hr) |
| CO (1) | CO6280409A2 (hr) |
| CR (1) | CR11456A (hr) |
| CU (1) | CU23833A3 (hr) |
| CY (1) | CY1117437T1 (hr) |
| DK (1) | DK2215121T3 (hr) |
| DO (1) | DOP2010000150A (hr) |
| EC (1) | ECSP10010191A (hr) |
| ES (1) | ES2569513T3 (hr) |
| GT (1) | GT201000148A (hr) |
| HK (2) | HK1148541A1 (hr) |
| HN (1) | HN2010001062A (hr) |
| HR (1) | HRP20160485T1 (hr) |
| HU (1) | HUE027358T2 (hr) |
| IL (1) | IL205681A0 (hr) |
| MA (1) | MA31862B1 (hr) |
| MX (1) | MX2010005603A (hr) |
| MY (1) | MY157164A (hr) |
| NZ (1) | NZ585551A (hr) |
| PL (1) | PL2215121T3 (hr) |
| SI (1) | SI2215121T1 (hr) |
| TN (1) | TN2010000234A1 (hr) |
| UA (1) | UA106036C2 (hr) |
| WO (1) | WO2009068204A1 (hr) |
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| UY32560A (es) * | 2009-04-29 | 2010-11-30 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| US8911732B2 (en) * | 2010-12-20 | 2014-12-16 | Genentech, Inc. | Anti-mesothelin antibodies and immunoconjugates |
| CN110038135B (zh) | 2011-03-17 | 2021-03-05 | 伯明翰大学 | 重新定向的免疫治疗 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
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| US20140004121A1 (en) | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
| EP2900695B1 (en) * | 2012-09-27 | 2018-01-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin antibodies and methods for eliciting potent antitumor activity |
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| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
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| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| DE69621940T2 (de) | 1995-08-18 | 2003-01-16 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| US6083502A (en) | 1996-01-05 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Mesothelium antigen and methods and kits for targeting it |
| CA2318576C (en) * | 1997-12-01 | 2009-04-14 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Antibodies, including fv molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| US6809184B1 (en) * | 1997-12-01 | 2004-10-26 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
| WO2000050900A2 (en) * | 1999-02-26 | 2000-08-31 | Pacific Northwest Research Institute | Methods and compositions for diagnosing carcinomas |
| ES2327382T3 (es) | 1999-07-20 | 2009-10-29 | Morphosys Ag | Metodos para presentar (poli)peptidos/proteinas en particulas de bacteriofagos a traves de enlaces disulfuro. |
| JP4949373B2 (ja) | 2005-03-10 | 2012-06-06 | モルフォテック、インク． | 抗メソテリン抗体 |
| WO2006124641A2 (en) * | 2005-05-12 | 2006-11-23 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Anti-mesothelin antibodies useful for immunological assays |
| DK3620171T3 (da) | 2005-05-18 | 2022-06-07 | Morphosys Ag | Anti-GM-CSF-antistoffer og anvendelser af disse |
| JP2008541758A (ja) * | 2005-06-02 | 2008-11-27 | アストラゼネカ エービー | Ｃｄ２０に対する抗体およびその使用 |
| WO2009045957A1 (en) * | 2007-10-01 | 2009-04-09 | Medarex, Inc. | Human antibodies that bind mesothelin, and uses thereof |
| WO2009068204A1 (en) * | 2007-11-26 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Anti-mesothelin antibodies and uses therefor |
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