CN101918549B - 改良的人源化的抗-人α9-整联蛋白抗体 - Google Patents
改良的人源化的抗-人α9-整联蛋白抗体 Download PDFInfo
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- CN101918549B CN101918549B CN2009801019731A CN200980101973A CN101918549B CN 101918549 B CN101918549 B CN 101918549B CN 2009801019731 A CN2009801019731 A CN 2009801019731A CN 200980101973 A CN200980101973 A CN 200980101973A CN 101918549 B CN101918549 B CN 101918549B
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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Abstract
Description
小鼠Y9A2抗体 | 嵌合Y9A2抗体 | |
IC50(μg/mL) | 0.039 | 0.038 |
抗体 | 比活 |
Y9A2 | 1.0 |
RY9A2v501 | 0.77 |
RY9A2v801 | 0.82 |
抗体 | 比活 |
Y9A2 | 1.0 |
RY9A2v5(IAW)01 | 0.29 |
RY9A2v11(M34L)012 | 0.23 |
RY9A2v12(M34L)012 | 0.23 |
抗体 | 人VCAM-1比活 | 人结合腕蛋白C-RAA比活 |
Y9A2 | 1.0 | 1.0 |
RY9A2v5(IAW)01 | 1.0 | 0.44 |
RY9A2v11(M34L)012 | 0.44 | 0.35 |
RY9A2v12(M34L)012 | 0.95 | 0.26 |
抗体 | 抗体浓度(μg/mL) | 抑制率(%) |
Y9A2 | 5 20 50 | 28 24 99* |
RY9A2v5(IAW)01 | 5 | 109** |
RY9A2v11(M34L)012 | 5 | 84* |
RY9A2v12(M34L)012 | 5 | 86* |
抗体 | 2小时的活性残余率 (%) | 10小时的活性残余率 (%) |
Y9A2 | 27 | 33 |
RY9A2v5(IAW)01 | 89 | 86 |
RY9A2v11(M34L)012 | 92 | 87 |
RY9A2v12(M34L)012 | 91 | 89 |
Claims (12)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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JP2008004975 | 2008-01-11 | ||
JP2008-004975 | 2008-01-11 | ||
JP2008-282496 | 2008-10-31 | ||
JP2008282496 | 2008-10-31 | ||
PCT/JP2009/050187 WO2009088064A1 (ja) | 2008-01-11 | 2009-01-09 | 改良型ヒト化抗ヒトα9インテグリン抗体 |
Publications (2)
Publication Number | Publication Date |
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CN101918549A CN101918549A (zh) | 2010-12-15 |
CN101918549B true CN101918549B (zh) | 2012-11-28 |
Family
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CN2009801019731A Expired - Fee Related CN101918549B (zh) | 2008-01-11 | 2009-01-09 | 改良的人源化的抗-人α9-整联蛋白抗体 |
Country Status (21)
Country | Link |
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US (2) | US8603476B2 (zh) |
EP (2) | EP2239323A4 (zh) |
JP (2) | JP5440179B2 (zh) |
KR (1) | KR101634636B1 (zh) |
CN (1) | CN101918549B (zh) |
AU (1) | AU2009203369B2 (zh) |
BR (1) | BRPI0905656B8 (zh) |
CA (1) | CA2711882C (zh) |
CY (1) | CY1115897T1 (zh) |
DK (1) | DK2243829T3 (zh) |
ES (1) | ES2519047T3 (zh) |
HR (1) | HRP20141110T1 (zh) |
IL (1) | IL206898A (zh) |
MX (1) | MX2010007515A (zh) |
PL (1) | PL2243829T3 (zh) |
PT (1) | PT2243829E (zh) |
RU (1) | RU2503720C2 (zh) |
SI (1) | SI2243829T1 (zh) |
TW (1) | TWI432453B (zh) |
WO (2) | WO2009088064A1 (zh) |
ZA (1) | ZA201004770B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2010104208A1 (en) * | 2009-03-10 | 2010-09-16 | Gene Techno Science Co., Ltd. | Generation, expression and characterization of the humanized k33n monoclonal antibody |
WO2011004847A1 (ja) * | 2009-07-07 | 2011-01-13 | 一般財団法人化学及血清療法研究所 | 新規ヒト化抗ヒトα9インテグリン抗体 |
GB2504887B (en) * | 2011-05-06 | 2016-02-03 | Nvip Pty Ltd | Anti-Nerve growth factor antibodies and methods of preparing and using the same |
US20140294819A1 (en) * | 2011-10-13 | 2014-10-02 | Nvip Pty Ltd | Canine/feline cd20 binding epitope and compositions for binding thereto |
JP2021008406A (ja) * | 2017-09-29 | 2021-01-28 | アステラス製薬株式会社 | 改良型ヒト化抗ヒトα9インテグリン抗体含有医薬組成物 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1227607A (zh) * | 1996-08-15 | 1999-09-01 | 罗克塞特有限公司 | 与α4β7整合蛋白相作用的人化免疫球蛋白 |
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IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
ATE256751T1 (de) | 1993-03-11 | 2004-01-15 | Chemo Sero Therapeut Res Inst | Monoklonaler anti-hiv antikörper |
US6939855B2 (en) * | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
US20040234524A1 (en) | 2001-04-05 | 2004-11-25 | Toshimitsu Uede | Anti-osteopontin antibody and use thereof |
EP1431310A4 (en) * | 2001-09-25 | 2005-03-23 | Immuno Biological Lab Co Ltd | ANTI-OSTEOPONTIN RECOMBINANT ANTIBODY AND USE THEREOF |
AU2003256307A1 (en) * | 2002-06-25 | 2004-01-06 | The Regents Of The University Of California | Methods for inhibiting angiogenesis, cell migration, cell adhesion, and cell survival |
ES2377979T3 (es) | 2004-09-03 | 2012-04-03 | Genentech, Inc. | Antagonistas anti-beta7 humanizados y utilizaciones para los mismos |
CA2593777C (en) | 2005-01-13 | 2014-12-02 | Gene Techno Science Co., Ltd. | Anti-.alpha.9 integrin antibody and the use thereof |
BRPI0711229A2 (pt) | 2006-05-31 | 2013-01-08 | Astellas Pharma Inc | anticorpo humanizado da osteopontina anti-humana, polinucleotÍdeo, vetor de expressço, cÉlula hospedeita, mÉtodo para produzir um anticorpo humanizado de osteopontina anti-humana, fÁrmaco terapÊutico, mÉtodo para prevenir ou tratar doenÇa autoimune e uso do anticorpo humanizado de oesteopontina anti-humana |
JP4841326B2 (ja) | 2006-06-20 | 2011-12-21 | 三菱電機株式会社 | ホームネットワークシステム |
EP2048163A4 (en) * | 2006-07-12 | 2010-07-21 | Gene Techno Science Co Ltd | ALPHA-9 HUMAN ANTI-INEGRIN ANTIBODY AND USE THEREOF |
JP2008282496A (ja) | 2007-05-11 | 2008-11-20 | Konica Minolta Opto Inc | 光ピックアップ装置 |
JP2007302676A (ja) * | 2007-05-29 | 2007-11-22 | Genentech Inc | ヒト化抗β7アンタゴニストおよびその使用 |
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CN1227607A (zh) * | 1996-08-15 | 1999-09-01 | 罗克塞特有限公司 | 与α4β7整合蛋白相作用的人化免疫球蛋白 |
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王臣等.构建预设CDR3基因噬菌体抗体库筛选抗人整合素αvβ3 mAb的人源化Fab.《细胞与分子免疫学杂志》.2006,第22卷(第1期),第64-67页. * |
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