CN101903014B - 固体内核中包含生长激素的固体脂质微囊 - Google Patents

固体内核中包含生长激素的固体脂质微囊 Download PDF

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Publication number
CN101903014B
CN101903014B CN200880121661.2A CN200880121661A CN101903014B CN 101903014 B CN101903014 B CN 101903014B CN 200880121661 A CN200880121661 A CN 200880121661A CN 101903014 B CN101903014 B CN 101903014B
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CN
China
Prior art keywords
microcapsules
hgh
microcapsules according
growth hormone
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200880121661.2A
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English (en)
Chinese (zh)
Other versions
CN101903014A (zh
Inventor
J·理查德
H·G·巴尔达斯尼
R·阿格斯蒂尼托
L·德安格里斯
F·德恰姆普斯
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Merck Patent GmbH
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Merck Patent GmbH
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Publication date
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Publication of CN101903014A publication Critical patent/CN101903014A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880121661.2A 2007-12-21 2008-11-21 固体内核中包含生长激素的固体脂质微囊 Expired - Fee Related CN101903014B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07024906.5 2007-12-21
EP07024906 2007-12-21
PCT/EP2008/009849 WO2009080164A1 (en) 2007-12-21 2008-11-21 Solid lipid microcapsules containing growth hormone in the inner solid core

Publications (2)

Publication Number Publication Date
CN101903014A CN101903014A (zh) 2010-12-01
CN101903014B true CN101903014B (zh) 2014-04-16

Family

ID=40566364

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880121661.2A Expired - Fee Related CN101903014B (zh) 2007-12-21 2008-11-21 固体内核中包含生长激素的固体脂质微囊

Country Status (15)

Country Link
US (1) US8729015B2 (enExample)
EP (1) EP2231120B1 (enExample)
JP (1) JP5773651B2 (enExample)
KR (1) KR20100103846A (enExample)
CN (1) CN101903014B (enExample)
AR (1) AR069844A1 (enExample)
AT (1) ATE514417T1 (enExample)
AU (1) AU2008340785B8 (enExample)
BR (1) BRPI0821359A2 (enExample)
CA (1) CA2710062C (enExample)
EA (1) EA201001002A1 (enExample)
ES (1) ES2367093T3 (enExample)
IL (1) IL206393A (enExample)
WO (1) WO2009080164A1 (enExample)
ZA (1) ZA201005167B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0821359A2 (pt) 2007-12-21 2015-06-16 Merck Patent Ges Mit Beschränkter Haftung Microcápsulas de lipídeos sólidas contendo hormônio de crescimento no núcleo sólido interno
WO2010017965A2 (en) * 2008-08-11 2010-02-18 Merck Serono S.A. SOLID LIPID MICROCAPSULES CONTAINING hGH
CN102370630B (zh) * 2010-08-11 2014-04-02 中国科学院过程工程研究所 重组人生长激素rhGH长效缓释微囊及其制备方法
ES2810003T3 (es) 2011-11-18 2021-03-08 Regeneron Pharma Micropartícula que contiene proteína terapéutica recubierta con polímero biodegradable para uso médico
JP6554493B2 (ja) 2014-06-24 2019-07-31 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 可溶性生物製剤、治療薬およびイメージング剤をカプセル化するためのプロセス
KR101602138B1 (ko) 2014-11-21 2016-03-10 강원대학교산학협력단 염화칼슘 미세입자가 봉입된 온도 의존성 고체지질입자 및 그 제조방법
US11103461B2 (en) 2015-12-22 2021-08-31 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
KR20170079409A (ko) * 2015-12-30 2017-07-10 한미약품 주식회사 지속형 인간 성장 호르몬 결합체의 신규 액상 제제
CN109380730B (zh) * 2017-08-09 2023-02-03 内蒙古伊利实业集团股份有限公司 微胶囊油脂及其制备方法
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME
JP2021501753A (ja) 2017-11-03 2021-01-21 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿
US12186436B2 (en) 2018-07-19 2025-01-07 The Trustees Of Princeton University Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
CN114240934B (zh) * 2022-02-21 2022-05-10 深圳大学 一种基于肢端肥大症的图像数据分析方法及系统
CN116571178A (zh) * 2023-05-11 2023-08-11 仲恺农业工程学院 一种蓝莓花色苷微胶囊的制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US6544646B2 (en) * 2000-04-27 2003-04-08 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6068044A (ja) * 1983-09-24 1985-04-18 Tetsuo Kato 二重膜構造のマイクロカプセル
ATE90203T1 (de) * 1989-03-17 1993-06-15 Pitman Moore Inc Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
FR2820319B3 (fr) * 2001-02-08 2003-12-05 Ellipse Pharmaceuticals Procede de fabrication d'un comprime flottant incluant de l'alfuzosine et comprime obtenu
EP1595549A4 (en) * 2003-02-19 2010-09-22 Takeda Pharmaceutical DISPERSE FOR PREPARATIONS WITH DELAYED RELEASE
PL2040682T3 (pl) * 2006-06-05 2018-01-31 Dsm Nutritional Products Ag Mikrokapsułki o ulepszonych otoczkach
BRPI0821359A2 (pt) 2007-12-21 2015-06-16 Merck Patent Ges Mit Beschränkter Haftung Microcápsulas de lipídeos sólidas contendo hormônio de crescimento no núcleo sólido interno

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
US6544646B2 (en) * 2000-04-27 2003-04-08 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof

Also Published As

Publication number Publication date
AU2008340785A1 (en) 2009-07-02
EA201001002A1 (ru) 2011-06-30
EP2231120A1 (en) 2010-09-29
EP2231120B1 (en) 2011-06-29
CA2710062C (en) 2016-05-31
WO2009080164A1 (en) 2009-07-02
ES2367093T3 (es) 2011-10-28
CN101903014A (zh) 2010-12-01
CA2710062A1 (en) 2009-07-02
ZA201005167B (en) 2011-03-30
JP2011506499A (ja) 2011-03-03
IL206393A (en) 2015-06-30
BRPI0821359A2 (pt) 2015-06-16
AR069844A1 (es) 2010-02-24
ATE514417T1 (de) 2011-07-15
US20100310649A1 (en) 2010-12-09
AU2008340785B2 (en) 2014-05-08
US8729015B2 (en) 2014-05-20
IL206393A0 (en) 2010-12-30
AU2008340785B8 (en) 2014-09-18
JP5773651B2 (ja) 2015-09-02
KR20100103846A (ko) 2010-09-28

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