ES2367093T3 - Microcápsulas lípidas sólidas que contienen hormona del crecimiento en el núcleo sólido interno. - Google Patents
Microcápsulas lípidas sólidas que contienen hormona del crecimiento en el núcleo sólido interno. Download PDFInfo
- Publication number
- ES2367093T3 ES2367093T3 ES08864968T ES08864968T ES2367093T3 ES 2367093 T3 ES2367093 T3 ES 2367093T3 ES 08864968 T ES08864968 T ES 08864968T ES 08864968 T ES08864968 T ES 08864968T ES 2367093 T3 ES2367093 T3 ES 2367093T3
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- lipid
- hgh
- microcapsules according
- microcapsules
- growth hormone
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- 238000013379 physicochemical characterization Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229940044476 poloxamer 407 Drugs 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 230000021014 regulation of cell growth Effects 0.000 description 1
- 230000009086 regulation of organ growth Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 230000007781 signaling event Effects 0.000 description 1
- 238000012868 site-directed mutagenesis technique Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000008362 succinate buffer Substances 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 229940098780 tribehenin Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07024906 | 2007-12-21 | ||
| EP07024906 | 2007-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2367093T3 true ES2367093T3 (es) | 2011-10-28 |
Family
ID=40566364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08864968T Active ES2367093T3 (es) | 2007-12-21 | 2008-11-21 | Microcápsulas lípidas sólidas que contienen hormona del crecimiento en el núcleo sólido interno. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8729015B2 (enExample) |
| EP (1) | EP2231120B1 (enExample) |
| JP (1) | JP5773651B2 (enExample) |
| KR (1) | KR20100103846A (enExample) |
| CN (1) | CN101903014B (enExample) |
| AR (1) | AR069844A1 (enExample) |
| AT (1) | ATE514417T1 (enExample) |
| AU (1) | AU2008340785B8 (enExample) |
| BR (1) | BRPI0821359A2 (enExample) |
| CA (1) | CA2710062C (enExample) |
| EA (1) | EA201001002A1 (enExample) |
| ES (1) | ES2367093T3 (enExample) |
| IL (1) | IL206393A (enExample) |
| WO (1) | WO2009080164A1 (enExample) |
| ZA (1) | ZA201005167B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8729015B2 (en) | 2007-12-21 | 2014-05-20 | Merck Patent Gmbh | Solid lipid microcapsules containing growth hormone inner core microparticles |
| WO2010017965A2 (en) * | 2008-08-11 | 2010-02-18 | Merck Serono S.A. | SOLID LIPID MICROCAPSULES CONTAINING hGH |
| CN102370630B (zh) * | 2010-08-11 | 2014-04-02 | 中国科学院过程工程研究所 | 重组人生长激素rhGH长效缓释微囊及其制备方法 |
| AU2012340107B2 (en) | 2011-11-18 | 2017-06-15 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
| WO2015200054A2 (en) | 2014-06-24 | 2015-12-30 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| KR101602138B1 (ko) | 2014-11-21 | 2016-03-10 | 강원대학교산학협력단 | 염화칼슘 미세입자가 봉입된 온도 의존성 고체지질입자 및 그 제조방법 |
| WO2017112828A1 (en) * | 2015-12-22 | 2017-06-29 | The Trustees Of Princeton University | Process for encapsulating soluble biologics, therapeutics, and imaging agents |
| KR20170079409A (ko) * | 2015-12-30 | 2017-07-10 | 한미약품 주식회사 | 지속형 인간 성장 호르몬 결합체의 신규 액상 제제 |
| CN109380730B (zh) * | 2017-08-09 | 2023-02-03 | 内蒙古伊利实业集团股份有限公司 | 微胶囊油脂及其制备方法 |
| WO2019055539A1 (en) | 2017-09-12 | 2019-03-21 | Prudhomme Robert K | CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME |
| JP2021501753A (ja) | 2017-11-03 | 2021-01-21 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿 |
| WO2020018890A1 (en) | 2018-07-19 | 2020-01-23 | Prudhomme Robert K | Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents |
| US11731099B2 (en) | 2018-07-20 | 2023-08-22 | The Trustees Of Princeton University | Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation |
| US20200147032A1 (en) | 2018-11-14 | 2020-05-14 | Robert K. Prud'homme | Dihydromyricetin hot melt extrusion formulations and methods for forming them |
| MX2021015457A (es) | 2019-06-14 | 2022-04-06 | Univ Princeton | Formulaciones de dihidromiricetina y un permeabilizante. |
| CN114240934B (zh) * | 2022-02-21 | 2022-05-10 | 深圳大学 | 一种基于肢端肥大症的图像数据分析方法及系统 |
| CN116571178B (zh) * | 2023-05-11 | 2026-01-20 | 仲恺农业工程学院 | 一种蓝莓花色苷微胶囊的制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6068044A (ja) * | 1983-09-24 | 1985-04-18 | Tetsuo Kato | 二重膜構造のマイクロカプセル |
| ATE90203T1 (de) * | 1989-03-17 | 1993-06-15 | Pitman Moore Inc | Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen. |
| US5219572A (en) * | 1989-03-17 | 1993-06-15 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
| ATE364442T1 (de) * | 2000-04-27 | 2007-07-15 | Verion Inc | Nullte-ordnung-freisetzung und temperatur- kontrollierte mikrokapseln sowie herstellungsverfahren |
| US6967028B2 (en) * | 2000-07-31 | 2005-11-22 | Mainelab | Prolonged release microspheres for injectable administration |
| FR2820319B3 (fr) * | 2001-02-08 | 2003-12-05 | Ellipse Pharmaceuticals | Procede de fabrication d'un comprime flottant incluant de l'alfuzosine et comprime obtenu |
| EP1595549A4 (en) * | 2003-02-19 | 2010-09-22 | Takeda Pharmaceutical | DISPERSE FOR PREPARATIONS WITH DELAYED RELEASE |
| KR20090046773A (ko) * | 2006-06-05 | 2009-05-11 | 오션 뉴트리션 캐나다 리미티드 | 개선된 쉘을 가지는 마이크로캡슐 |
| US8729015B2 (en) | 2007-12-21 | 2014-05-20 | Merck Patent Gmbh | Solid lipid microcapsules containing growth hormone inner core microparticles |
-
2008
- 2008-11-21 US US12/809,397 patent/US8729015B2/en not_active Expired - Fee Related
- 2008-11-21 WO PCT/EP2008/009849 patent/WO2009080164A1/en not_active Ceased
- 2008-11-21 CN CN200880121661.2A patent/CN101903014B/zh not_active Expired - Fee Related
- 2008-11-21 JP JP2010538383A patent/JP5773651B2/ja not_active Expired - Fee Related
- 2008-11-21 AT AT08864968T patent/ATE514417T1/de not_active IP Right Cessation
- 2008-11-21 ES ES08864968T patent/ES2367093T3/es active Active
- 2008-11-21 CA CA2710062A patent/CA2710062C/en not_active Expired - Fee Related
- 2008-11-21 EA EA201001002A patent/EA201001002A1/ru unknown
- 2008-11-21 BR BRPI0821359-3A patent/BRPI0821359A2/pt not_active IP Right Cessation
- 2008-11-21 AU AU2008340785A patent/AU2008340785B8/en not_active Ceased
- 2008-11-21 EP EP08864968A patent/EP2231120B1/en not_active Not-in-force
- 2008-11-21 KR KR1020107016389A patent/KR20100103846A/ko not_active Withdrawn
- 2008-12-19 AR ARP080105563A patent/AR069844A1/es unknown
-
2010
- 2010-06-15 IL IL206393A patent/IL206393A/en not_active IP Right Cessation
- 2010-07-20 ZA ZA2010/05167A patent/ZA201005167B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201001002A1 (ru) | 2011-06-30 |
| CN101903014B (zh) | 2014-04-16 |
| EP2231120A1 (en) | 2010-09-29 |
| KR20100103846A (ko) | 2010-09-28 |
| IL206393A0 (en) | 2010-12-30 |
| CA2710062C (en) | 2016-05-31 |
| BRPI0821359A2 (pt) | 2015-06-16 |
| IL206393A (en) | 2015-06-30 |
| JP2011506499A (ja) | 2011-03-03 |
| US20100310649A1 (en) | 2010-12-09 |
| EP2231120B1 (en) | 2011-06-29 |
| AU2008340785A1 (en) | 2009-07-02 |
| CA2710062A1 (en) | 2009-07-02 |
| AU2008340785B8 (en) | 2014-09-18 |
| AU2008340785B2 (en) | 2014-05-08 |
| CN101903014A (zh) | 2010-12-01 |
| US8729015B2 (en) | 2014-05-20 |
| ATE514417T1 (de) | 2011-07-15 |
| ZA201005167B (en) | 2011-03-30 |
| AR069844A1 (es) | 2010-02-24 |
| WO2009080164A1 (en) | 2009-07-02 |
| JP5773651B2 (ja) | 2015-09-02 |
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