JP5773651B2 - 内部固形コア中に成長ホルモンを含有する固形脂質マイクロカプセル - Google Patents

内部固形コア中に成長ホルモンを含有する固形脂質マイクロカプセル Download PDF

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Publication number
JP5773651B2
JP5773651B2 JP2010538383A JP2010538383A JP5773651B2 JP 5773651 B2 JP5773651 B2 JP 5773651B2 JP 2010538383 A JP2010538383 A JP 2010538383A JP 2010538383 A JP2010538383 A JP 2010538383A JP 5773651 B2 JP5773651 B2 JP 5773651B2
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Japan
Prior art keywords
lipid
microcapsule
growth hormone
hgh
surfactant
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JP2010538383A
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English (en)
Japanese (ja)
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JP2011506499A (ja
JP2011506499A5 (enExample
Inventor
ジョエル リチャード
ジョエル リチャード
ヘレン ガブリエラ バルダスチーニ
ヘレン ガブリエラ バルダスチーニ
リタ アゴスティネット
リタ アゴスティネット
アンジェリス ルイーザ デ
アンジェリス ルイーザ デ
フランツ デシャン
フランツ デシャン
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Merck Patent GmbH
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Merck Patent GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010538383A 2007-12-21 2008-11-21 内部固形コア中に成長ホルモンを含有する固形脂質マイクロカプセル Expired - Fee Related JP5773651B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07024906.5 2007-12-21
EP07024906 2007-12-21
PCT/EP2008/009849 WO2009080164A1 (en) 2007-12-21 2008-11-21 Solid lipid microcapsules containing growth hormone in the inner solid core

Publications (3)

Publication Number Publication Date
JP2011506499A JP2011506499A (ja) 2011-03-03
JP2011506499A5 JP2011506499A5 (enExample) 2012-01-19
JP5773651B2 true JP5773651B2 (ja) 2015-09-02

Family

ID=40566364

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010538383A Expired - Fee Related JP5773651B2 (ja) 2007-12-21 2008-11-21 内部固形コア中に成長ホルモンを含有する固形脂質マイクロカプセル

Country Status (15)

Country Link
US (1) US8729015B2 (enExample)
EP (1) EP2231120B1 (enExample)
JP (1) JP5773651B2 (enExample)
KR (1) KR20100103846A (enExample)
CN (1) CN101903014B (enExample)
AR (1) AR069844A1 (enExample)
AT (1) ATE514417T1 (enExample)
AU (1) AU2008340785B8 (enExample)
BR (1) BRPI0821359A2 (enExample)
CA (1) CA2710062C (enExample)
EA (1) EA201001002A1 (enExample)
ES (1) ES2367093T3 (enExample)
IL (1) IL206393A (enExample)
WO (1) WO2009080164A1 (enExample)
ZA (1) ZA201005167B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0821359A2 (pt) 2007-12-21 2015-06-16 Merck Patent Ges Mit Beschränkter Haftung Microcápsulas de lipídeos sólidas contendo hormônio de crescimento no núcleo sólido interno
WO2010017965A2 (en) * 2008-08-11 2010-02-18 Merck Serono S.A. SOLID LIPID MICROCAPSULES CONTAINING hGH
CN102370630B (zh) * 2010-08-11 2014-04-02 中国科学院过程工程研究所 重组人生长激素rhGH长效缓释微囊及其制备方法
ES2810003T3 (es) 2011-11-18 2021-03-08 Regeneron Pharma Micropartícula que contiene proteína terapéutica recubierta con polímero biodegradable para uso médico
JP6554493B2 (ja) 2014-06-24 2019-07-31 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 可溶性生物製剤、治療薬およびイメージング剤をカプセル化するためのプロセス
KR101602138B1 (ko) 2014-11-21 2016-03-10 강원대학교산학협력단 염화칼슘 미세입자가 봉입된 온도 의존성 고체지질입자 및 그 제조방법
US11103461B2 (en) 2015-12-22 2021-08-31 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
KR20170079409A (ko) * 2015-12-30 2017-07-10 한미약품 주식회사 지속형 인간 성장 호르몬 결합체의 신규 액상 제제
CN109380730B (zh) * 2017-08-09 2023-02-03 内蒙古伊利实业集团股份有限公司 微胶囊油脂及其制备方法
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME
JP2021501753A (ja) 2017-11-03 2021-01-21 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿
US12186436B2 (en) 2018-07-19 2025-01-07 The Trustees Of Princeton University Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
CN114240934B (zh) * 2022-02-21 2022-05-10 深圳大学 一种基于肢端肥大症的图像数据分析方法及系统
CN116571178A (zh) * 2023-05-11 2023-08-11 仲恺农业工程学院 一种蓝莓花色苷微胶囊的制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6068044A (ja) * 1983-09-24 1985-04-18 Tetsuo Kato 二重膜構造のマイクロカプセル
ATE90203T1 (de) * 1989-03-17 1993-06-15 Pitman Moore Inc Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
AU2001257359A1 (en) * 2000-04-27 2001-11-07 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
FR2820319B3 (fr) * 2001-02-08 2003-12-05 Ellipse Pharmaceuticals Procede de fabrication d'un comprime flottant incluant de l'alfuzosine et comprime obtenu
EP1595549A4 (en) * 2003-02-19 2010-09-22 Takeda Pharmaceutical DISPERSE FOR PREPARATIONS WITH DELAYED RELEASE
PL2040682T3 (pl) * 2006-06-05 2018-01-31 Dsm Nutritional Products Ag Mikrokapsułki o ulepszonych otoczkach
BRPI0821359A2 (pt) 2007-12-21 2015-06-16 Merck Patent Ges Mit Beschränkter Haftung Microcápsulas de lipídeos sólidas contendo hormônio de crescimento no núcleo sólido interno

Also Published As

Publication number Publication date
AU2008340785A1 (en) 2009-07-02
EA201001002A1 (ru) 2011-06-30
EP2231120A1 (en) 2010-09-29
EP2231120B1 (en) 2011-06-29
CA2710062C (en) 2016-05-31
WO2009080164A1 (en) 2009-07-02
ES2367093T3 (es) 2011-10-28
CN101903014A (zh) 2010-12-01
CA2710062A1 (en) 2009-07-02
ZA201005167B (en) 2011-03-30
JP2011506499A (ja) 2011-03-03
IL206393A (en) 2015-06-30
BRPI0821359A2 (pt) 2015-06-16
AR069844A1 (es) 2010-02-24
CN101903014B (zh) 2014-04-16
ATE514417T1 (de) 2011-07-15
US20100310649A1 (en) 2010-12-09
AU2008340785B2 (en) 2014-05-08
US8729015B2 (en) 2014-05-20
IL206393A0 (en) 2010-12-30
AU2008340785B8 (en) 2014-09-18
KR20100103846A (ko) 2010-09-28

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