ATE514417T1 - Feststofflipid-mikrokapseln mit einem wachstumshormon im inneren festkern - Google Patents

Feststofflipid-mikrokapseln mit einem wachstumshormon im inneren festkern

Info

Publication number
ATE514417T1
ATE514417T1 AT08864968T AT08864968T ATE514417T1 AT E514417 T1 ATE514417 T1 AT E514417T1 AT 08864968 T AT08864968 T AT 08864968T AT 08864968 T AT08864968 T AT 08864968T AT E514417 T1 ATE514417 T1 AT E514417T1
Authority
AT
Austria
Prior art keywords
solid
microcapsulations
growth hormone
lipid
core
Prior art date
Application number
AT08864968T
Other languages
German (de)
English (en)
Inventor
Joel Richard
Helen Baldascini
Rita Agostinetto
Angelis Luisa De
Frantz Deschamps
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE514417T1 publication Critical patent/ATE514417T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT08864968T 2007-12-21 2008-11-21 Feststofflipid-mikrokapseln mit einem wachstumshormon im inneren festkern ATE514417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07024906 2007-12-21
PCT/EP2008/009849 WO2009080164A1 (en) 2007-12-21 2008-11-21 Solid lipid microcapsules containing growth hormone in the inner solid core

Publications (1)

Publication Number Publication Date
ATE514417T1 true ATE514417T1 (de) 2011-07-15

Family

ID=40566364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08864968T ATE514417T1 (de) 2007-12-21 2008-11-21 Feststofflipid-mikrokapseln mit einem wachstumshormon im inneren festkern

Country Status (15)

Country Link
US (1) US8729015B2 (enExample)
EP (1) EP2231120B1 (enExample)
JP (1) JP5773651B2 (enExample)
KR (1) KR20100103846A (enExample)
CN (1) CN101903014B (enExample)
AR (1) AR069844A1 (enExample)
AT (1) ATE514417T1 (enExample)
AU (1) AU2008340785B8 (enExample)
BR (1) BRPI0821359A2 (enExample)
CA (1) CA2710062C (enExample)
EA (1) EA201001002A1 (enExample)
ES (1) ES2367093T3 (enExample)
IL (1) IL206393A (enExample)
WO (1) WO2009080164A1 (enExample)
ZA (1) ZA201005167B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729015B2 (en) 2007-12-21 2014-05-20 Merck Patent Gmbh Solid lipid microcapsules containing growth hormone inner core microparticles
WO2010017965A2 (en) * 2008-08-11 2010-02-18 Merck Serono S.A. SOLID LIPID MICROCAPSULES CONTAINING hGH
CN102370630B (zh) * 2010-08-11 2014-04-02 中国科学院过程工程研究所 重组人生长激素rhGH长效缓释微囊及其制备方法
AU2012340107B2 (en) 2011-11-18 2017-06-15 Regeneron Pharmaceuticals, Inc. Polymer protein microparticles
WO2015200054A2 (en) 2014-06-24 2015-12-30 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
KR101602138B1 (ko) 2014-11-21 2016-03-10 강원대학교산학협력단 염화칼슘 미세입자가 봉입된 온도 의존성 고체지질입자 및 그 제조방법
WO2017112828A1 (en) * 2015-12-22 2017-06-29 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
KR20170079409A (ko) * 2015-12-30 2017-07-10 한미약품 주식회사 지속형 인간 성장 호르몬 결합체의 신규 액상 제제
CN109380730B (zh) * 2017-08-09 2023-02-03 内蒙古伊利实业集团股份有限公司 微胶囊油脂及其制备方法
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME
JP2021501753A (ja) 2017-11-03 2021-01-21 ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 徐放性ナノキャリア製剤を形成するための疎水性イオン対化およびフラッシュナノ沈殿
WO2020018890A1 (en) 2018-07-19 2020-01-23 Prudhomme Robert K Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
MX2021015457A (es) 2019-06-14 2022-04-06 Univ Princeton Formulaciones de dihidromiricetina y un permeabilizante.
CN114240934B (zh) * 2022-02-21 2022-05-10 深圳大学 一种基于肢端肥大症的图像数据分析方法及系统
CN116571178B (zh) * 2023-05-11 2026-01-20 仲恺农业工程学院 一种蓝莓花色苷微胶囊的制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6068044A (ja) * 1983-09-24 1985-04-18 Tetsuo Kato 二重膜構造のマイクロカプセル
ATE90203T1 (de) * 1989-03-17 1993-06-15 Pitman Moore Inc Kontrollierte, verzoegerte wirkstofffreisetzung von makromolekularen proteinen.
US5219572A (en) * 1989-03-17 1993-06-15 Pitman-Moore, Inc. Controlled release delivery device for macromolecular proteins
ATE364442T1 (de) * 2000-04-27 2007-07-15 Verion Inc Nullte-ordnung-freisetzung und temperatur- kontrollierte mikrokapseln sowie herstellungsverfahren
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
FR2820319B3 (fr) * 2001-02-08 2003-12-05 Ellipse Pharmaceuticals Procede de fabrication d'un comprime flottant incluant de l'alfuzosine et comprime obtenu
EP1595549A4 (en) * 2003-02-19 2010-09-22 Takeda Pharmaceutical DISPERSE FOR PREPARATIONS WITH DELAYED RELEASE
KR20090046773A (ko) * 2006-06-05 2009-05-11 오션 뉴트리션 캐나다 리미티드 개선된 쉘을 가지는 마이크로캡슐
US8729015B2 (en) 2007-12-21 2014-05-20 Merck Patent Gmbh Solid lipid microcapsules containing growth hormone inner core microparticles

Also Published As

Publication number Publication date
EA201001002A1 (ru) 2011-06-30
CN101903014B (zh) 2014-04-16
EP2231120A1 (en) 2010-09-29
KR20100103846A (ko) 2010-09-28
IL206393A0 (en) 2010-12-30
CA2710062C (en) 2016-05-31
BRPI0821359A2 (pt) 2015-06-16
IL206393A (en) 2015-06-30
JP2011506499A (ja) 2011-03-03
US20100310649A1 (en) 2010-12-09
EP2231120B1 (en) 2011-06-29
AU2008340785A1 (en) 2009-07-02
CA2710062A1 (en) 2009-07-02
AU2008340785B8 (en) 2014-09-18
AU2008340785B2 (en) 2014-05-08
CN101903014A (zh) 2010-12-01
US8729015B2 (en) 2014-05-20
ZA201005167B (en) 2011-03-30
AR069844A1 (es) 2010-02-24
WO2009080164A1 (en) 2009-07-02
JP5773651B2 (ja) 2015-09-02
ES2367093T3 (es) 2011-10-28

Similar Documents

Publication Publication Date Title
ZA201005167B (en) Solid lipid microcapsules containing growth hormone in the inner solid core
GB0723875D0 (en) Wound management
IT1393761B1 (it) Cursore per chiusura lampo con arresto automatico.
ZA201001069B (en) Reinforced green slope structure
EP2289014A4 (en) ENCRYPTION OF CONTENT USING AT LEAST ONE PRE-KEY CONTENT
PL2123197T3 (pl) Rdzeń sprężynowy ze wzmocnionym obrzeżem
EP2087314A4 (en) QUANTUM nanodot CAMERA
PL2643254T3 (pl) Rdzeń z etykietą
DE602008001958D1 (de) Rollerartiges Fahrzeug mit einer Aufbewahrungsbehälterstruktur
FR2959738B1 (fr) Composes a la note boisee.
DE112008003929A5 (de) Mehrfachgetriebe mit magnetischer Ansteuerung
FR2922192B1 (fr) Aeronef a double fuselage.
FI20080124A0 (fi) Läheis-Josephson-ilmaisin
EP2114655A4 (en) PLATE FOR MOLDING SYSTEM HAVING ANTI-TILT STRUCTURE
EP2663284A1 (en) Implant comprising a core and a tube encasing the core
GB0722112D0 (en) Fishing reel
GB0718490D0 (en) Biodiesel
ATE513768T1 (de) Lagersystem mit einem greifsystem
GB201001089D0 (en) The cybernetic speaking fishing float
GB2453650B (en) Fishing reel
TWI366246B (en) A conductive film structure and the forming method thereof
DE112007003751A5 (de) Stabantenne mit einem verschwenkbaren Antennenstab
DE502007001029D1 (de) Treppe mit einem Mittelholm
FI20085666A0 (fi) Kiinnirullain
GB0714425D0 (en) offshore structure

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties