CN101801198A - 稳定化的吡铂剂型 - Google Patents

稳定化的吡铂剂型 Download PDF

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Publication number
CN101801198A
CN101801198A CN200880022248A CN200880022248A CN101801198A CN 101801198 A CN101801198 A CN 101801198A CN 200880022248 A CN200880022248 A CN 200880022248A CN 200880022248 A CN200880022248 A CN 200880022248A CN 101801198 A CN101801198 A CN 101801198A
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CN
China
Prior art keywords
cancer
formulation
pyrrole platinum
platinum
pyrrole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880022248A
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English (en)
Chinese (zh)
Inventor
A·J·利
C·A·普罗西星
罗纳德·A·马特尔
大卫·A·卡尔林
C·郭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poniard Pharmaceuticals Inc
Original Assignee
Poniard Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poniard Pharmaceuticals Inc filed Critical Poniard Pharmaceuticals Inc
Publication of CN101801198A publication Critical patent/CN101801198A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN200880022248A 2007-06-27 2008-06-27 稳定化的吡铂剂型 Pending CN101801198A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US94663907P 2007-06-27 2007-06-27
US60/946,639 2007-06-27
US2738808P 2008-02-08 2008-02-08
US61/027,388 2008-02-08
US5507108P 2008-05-21 2008-05-21
US61/055,071 2008-05-21
PCT/US2008/008076 WO2009032034A2 (en) 2007-06-27 2008-06-27 Stabilized picoplatin dosage form

Publications (1)

Publication Number Publication Date
CN101801198A true CN101801198A (zh) 2010-08-11

Family

ID=40429589

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880022248A Pending CN101801198A (zh) 2007-06-27 2008-06-27 稳定化的吡铂剂型

Country Status (12)

Country Link
US (2) US20100178328A1 (enExample)
EP (1) EP2157864A4 (enExample)
JP (1) JP2010531877A (enExample)
KR (1) KR20100051797A (enExample)
CN (1) CN101801198A (enExample)
AU (1) AU2008295576A1 (enExample)
BR (1) BRPI0811816A2 (enExample)
CA (1) CA2691115A1 (enExample)
IL (2) IL202743A0 (enExample)
MX (1) MX2009013835A (enExample)
TW (1) TW200916094A (enExample)
WO (1) WO2009032034A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102590385A (zh) * 2012-02-14 2012-07-18 昆明贵研药业有限公司 一种甲啶铂及其杂质的检测方法
CN106943343A (zh) * 2016-01-06 2017-07-14 山东新时代药业有限公司 一种甲啶铂注射液及其制备方法
CN107773538A (zh) * 2016-08-27 2018-03-09 鲁南制药集团股份有限公司 稳定的甲啶铂无菌冻干粉末及其制备工艺

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US8178564B2 (en) 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
WO2010132596A1 (en) * 2009-05-12 2010-11-18 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
AU2008214199A1 (en) * 2007-02-09 2008-08-14 Poniard Pharmaceuticals, Inc. Encapsulated picoplatin
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
TW200920347A (en) * 2007-07-16 2009-05-16 Poniard Pharmaceuticals Inc Oral formulations for picoplatin
JP2011511072A (ja) * 2008-02-08 2011-04-07 ポニアード ファーマシューティカルズ， インコーポレイテッド 結腸直腸癌を治療するためのピコプラチンおよびベバシツマブの使用
EP2418955A4 (en) * 2009-04-15 2012-11-21 Poniard Pharmaceuticals Inc ORBIOTIC ANTICANCER THERAPY BASED ON HIGH BIODISIBILITY PICOPLATIN
CN101804025B (zh) * 2010-03-31 2011-09-21 昆明贵研药业有限公司 甲啶铂的一种水溶液注射剂
EP3294292A1 (en) * 2015-05-13 2018-03-21 Monopar Therapeutics Inc. Clonidine and/or clonidine derivatives for use in the prevention of skin injury resulting from radiotherapy
PL3393478T3 (pl) * 2015-12-23 2020-07-13 NuCana plc Terapia skojarzona
CN117940164A (zh) * 2022-04-26 2024-04-26 石药集团中奇制药技术（石家庄）有限公司 米托蒽醌脂质体联合抗血管生成靶向药治疗卵巢癌的用途

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102590385A (zh) * 2012-02-14 2012-07-18 昆明贵研药业有限公司 一种甲啶铂及其杂质的检测方法
CN102590385B (zh) * 2012-02-14 2013-09-11 昆明贵研药业有限公司 一种甲啶铂及其杂质的检测方法
CN106943343A (zh) * 2016-01-06 2017-07-14 山东新时代药业有限公司 一种甲啶铂注射液及其制备方法
CN106943343B (zh) * 2016-01-06 2020-05-12 山东新时代药业有限公司 一种甲啶铂注射液及其制备方法
CN107773538A (zh) * 2016-08-27 2018-03-09 鲁南制药集团股份有限公司 稳定的甲啶铂无菌冻干粉末及其制备工艺
CN107773538B (zh) * 2016-08-27 2022-09-13 鲁南制药集团股份有限公司 稳定的甲啶铂无菌冻干粉末及其制备工艺

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WO2009032034A2 (en) 2009-03-12
KR20100051797A (ko) 2010-05-18
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EP2157864A2 (en) 2010-03-03
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