CN101723949B - 用于治疗呼吸道合胞体病毒感染的多环试剂 - Google Patents
用于治疗呼吸道合胞体病毒感染的多环试剂 Download PDFInfo
- Publication number
- CN101723949B CN101723949B CN2009102585362A CN200910258536A CN101723949B CN 101723949 B CN101723949 B CN 101723949B CN 2009102585362 A CN2009102585362 A CN 2009102585362A CN 200910258536 A CN200910258536 A CN 200910258536A CN 101723949 B CN101723949 B CN 101723949B
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- compound
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- 0 [*+]c1ccc(C(c2c3cccc2)(N(CC2)C(c(cc4)ccc4F)=O)N2C3=O)cc1 Chemical compound [*+]c1ccc(C(c2c3cccc2)(N(CC2)C(c(cc4)ccc4F)=O)N2C3=O)cc1 0.000 description 5
- IBXJBAJDUUWERR-UHFFFAOYSA-N C=C(c1ccccc11)N(CC2)C1(c(cc1)ccc1Cl)N2C(c1ccccc1)=O Chemical compound C=C(c1ccccc11)N(CC2)C1(c(cc1)ccc1Cl)N2C(c1ccccc1)=O IBXJBAJDUUWERR-UHFFFAOYSA-N 0.000 description 1
- DICDWJCDJDUHPK-UHFFFAOYSA-N CC(C1=CCCC=C11)(c2ccc(C)cc2)N(CCCC(NCc2ccccc2)=O)C1=O Chemical compound CC(C1=CCCC=C11)(c2ccc(C)cc2)N(CCCC(NCc2ccccc2)=O)C1=O DICDWJCDJDUHPK-UHFFFAOYSA-N 0.000 description 1
- WJHHHKBTJZSEMT-UHFFFAOYSA-N Cc1ccc(C(c2c3cccc2)(N(Cc2ccccc2)CC2)N2C3=O)cc1 Chemical compound Cc1ccc(C(c2c3cccc2)(N(Cc2ccccc2)CC2)N2C3=O)cc1 WJHHHKBTJZSEMT-UHFFFAOYSA-N 0.000 description 1
- OSGJVMCEWRZPES-MPSNESSQSA-N Cc1ccc([C@](C(CCC2)C(Cc(cc3)ccc3OC)=O)(c3ccccc33)N2C3=O)cc1 Chemical compound Cc1ccc([C@](C(CCC2)C(Cc(cc3)ccc3OC)=O)(c3ccccc33)N2C3=O)cc1 OSGJVMCEWRZPES-MPSNESSQSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003907196A AU2003907196A0 (en) | 2003-12-24 | Polycyclic agents for the treatment of respiratory syncytial virus infections | |
| AU2003907196 | 2003-12-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200480039049A Division CN100582109C (zh) | 2003-12-24 | 2004-12-24 | 用于治疗呼吸道合胞体病毒感染的多环试剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101723949A CN101723949A (zh) | 2010-06-09 |
| CN101723949B true CN101723949B (zh) | 2013-10-23 |
Family
ID=34705575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102585362A Expired - Fee Related CN101723949B (zh) | 2003-12-24 | 2004-12-24 | 用于治疗呼吸道合胞体病毒感染的多环试剂 |
| CN200480039049A Expired - Fee Related CN100582109C (zh) | 2003-12-24 | 2004-12-24 | 用于治疗呼吸道合胞体病毒感染的多环试剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200480039049A Expired - Fee Related CN100582109C (zh) | 2003-12-24 | 2004-12-24 | 用于治疗呼吸道合胞体病毒感染的多环试剂 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8598193B2 (https=) |
| EP (2) | EP1697377B1 (https=) |
| JP (2) | JP5384793B2 (https=) |
| KR (1) | KR20060127909A (https=) |
| CN (2) | CN101723949B (https=) |
| AT (1) | ATE496920T1 (https=) |
| BR (1) | BRPI0418127A (https=) |
| CA (1) | CA2551178C (https=) |
| DE (1) | DE602004031258D1 (https=) |
| ES (1) | ES2360222T3 (https=) |
| IL (1) | IL176155A0 (https=) |
| NO (1) | NO20062758L (https=) |
| NZ (1) | NZ551468A (https=) |
| RU (1) | RU2422444C2 (https=) |
| WO (1) | WO2005061513A1 (https=) |
| ZA (1) | ZA200604528B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0418127A (pt) | 2003-12-24 | 2007-04-27 | Biota Scient Management | uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto |
| AU2006329007A1 (en) * | 2005-12-20 | 2007-06-28 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutamate receptors |
| JP2010501567A (ja) | 2006-08-24 | 2010-01-21 | ノバルティス アクチエンゲゼルシャフト | 代謝系、心血管系および他の障害の処置のためのステアロイル−ＣｏＡ不飽和化酵素（ＳＣＤ）阻害剤としての２−（ピラジン−２−イル）−チアゾールおよび２−（１Ｈ−ピラゾール−３−イル）チアゾール誘導体ならびに関連化合物 |
| KR20090053923A (ko) | 2006-09-22 | 2009-05-28 | 노파르티스 아게 | 헤테로시클릭 유기 화합물 |
| TWI423972B (zh) * | 2006-09-28 | 2014-01-21 | Biota Scient Management | 治療呼吸系融合細胞病毒感染之多環劑 |
| CN101595105B (zh) | 2006-12-20 | 2013-01-23 | 诺瓦提斯公司 | 作为scd抑制剂的2-取代的5元杂环化合物 |
| TWI508968B (zh) | 2010-02-08 | 2015-11-21 | Biota Scient Management | 用於治療呼吸道融合性病毒感染的化合物 |
| AU2015200638B2 (en) * | 2010-06-24 | 2016-11-10 | Gilead Sciences, Inc. | Pyrazolo [1, 5 -a] pyrimidines as antiviral agents |
| MA34392B1 (fr) * | 2010-06-24 | 2013-07-03 | Gilead Sciences Inc | Pyrimidines en tant qu'agents antiviraux |
| US8796303B2 (en) * | 2010-11-26 | 2014-08-05 | Biota Scientific Management Pty Ltd. | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections |
| US8871756B2 (en) | 2011-08-11 | 2014-10-28 | Hoffmann-La Roche Inc. | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease |
| EP2766370B1 (en) * | 2011-10-11 | 2016-08-03 | F.Hoffmann-La Roche Ag | Compounds for the treatment and prophylaxis of respiratory syncytial virus disease |
| CN103748098B (zh) * | 2011-10-11 | 2016-06-29 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗或预防呼吸道合胞病毒疾病的化合物 |
| GB201119538D0 (en) * | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| CA2858096C (en) | 2011-12-22 | 2020-06-23 | Gilead Sciences, Inc. | Pyrazolo[1,5-a]pyrimidines as antiviral agents |
| CN106986869A (zh) | 2012-04-17 | 2017-07-28 | 吉利德科学公司 | 用于抗病毒治疗的化合物和方法 |
| CN104311559A (zh) * | 2014-09-12 | 2015-01-28 | 中山大学 | 一类光学纯手性环状n,n-缩醛的合成方法 |
| US10118890B2 (en) | 2014-10-10 | 2018-11-06 | The Research Foundation For The State University Of New York | Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration |
| WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
| JO3637B1 (ar) | 2015-04-28 | 2020-08-27 | Janssen Sciences Ireland Uc | مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv |
| CN107635999B (zh) | 2015-05-20 | 2020-09-25 | 豪夫迈·罗氏有限公司 | 用于治疗脊髓性肌萎缩的化合物 |
| CN108290882B (zh) | 2015-07-16 | 2021-07-06 | 豪夫迈·罗氏有限公司 | 用于治疗呼吸道合胞病毒感染的4-喹唑啉胺衍生物的晶形 |
| EA036399B1 (ru) | 2015-11-12 | 2020-11-06 | Ф. Хоффманн-Ля Рош Аг | Композиции для лечения спинальной мышечной атрофии |
| WO2017097728A1 (en) | 2015-12-10 | 2017-06-15 | F. Hoffmann-La Roche Ag | Bridged piperidine derivatives |
| EA201800367A1 (ru) | 2015-12-10 | 2019-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения болезни хантингтона |
| CN109641042B (zh) * | 2016-05-10 | 2023-06-09 | 乔治亚州立大学研究基金会股份有限公司 | 用于治疗rsv的杂环衍生物 |
| EP3634953B1 (en) | 2017-06-05 | 2024-01-03 | PTC Therapeutics, Inc. | Compounds for treating huntington's disease |
| BR112019026434A2 (pt) | 2017-06-14 | 2020-07-14 | Virometix Ag | peptídeos cíclicos para proteção contra vírus sincicial respiratório |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| MX2019015580A (es) | 2017-06-28 | 2020-07-28 | Ptc Therapeutics Inc | Metodos para tratar la enfermedad de huntington. |
| TW201932470A (zh) | 2017-11-29 | 2019-08-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 具有抗ｒｓｖ活性之吡唑并嘧啶 |
| CN111670189A (zh) | 2018-01-31 | 2020-09-15 | 爱尔兰詹森科学公司 | 对rsv具有活性的环烷基取代的吡唑并嘧啶 |
| WO2019168874A1 (en) | 2018-02-27 | 2019-09-06 | The Research Foundation For The State University Of New York | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
| EA202092001A1 (ru) | 2018-03-27 | 2021-01-29 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения болезни гентингтона |
| MA52348A (fr) | 2018-04-23 | 2021-03-03 | Janssen Sciences Ireland Unlimited Co | Composés hétéroaromatiques ayant une activité contre vrs |
| EP3802539B1 (en) | 2018-06-05 | 2023-09-20 | F. Hoffmann-La Roche AG | Tetrahydro-1h-pyrazino[2,1-a]isoindolylquinoline compounds for the treatment of autoimmune disease |
| EP3814360B8 (en) | 2018-06-27 | 2024-11-06 | PTC Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| HRP20240935T1 (hr) | 2018-06-27 | 2024-11-22 | Ptc Therapeutics, Inc. | Heterociklični i heteroaril spojevi za liječenje huntingtonove bolesti |
| WO2020005877A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| CN108997354B (zh) * | 2018-08-08 | 2021-12-31 | 青岛大学附属医院 | 二氢嘧啶并异吲哚酮类化合物及其乳膏剂和在治疗高尿酸血症中的用途 |
| JP7649257B2 (ja) | 2019-05-13 | 2025-03-19 | ピーティーシー セラピューティクス， インコーポレイテッド | ハンチントン病を処置するための化合物 |
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| US6489338B2 (en) | 2000-06-13 | 2002-12-03 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrimidine antiviral agents |
| US6506738B1 (en) * | 2000-09-27 | 2003-01-14 | Bristol-Myers Squibb Company | Benzimidazolone antiviral agents |
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| JP2002310962A (ja) * | 2001-04-19 | 2002-10-23 | Hitachi Ltd | 画像分類方法並びに観察方法及びその装置 |
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| BRPI0418127A (pt) | 2003-12-24 | 2007-04-27 | Biota Scient Management | uso de um composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, método para o tratamento de infecções envolvendo vìrus da sub-famìlia pneumovirinae, formulação farmacêutica, métodos para tratar mamìferos infectados e para prevenir a infecção de mamìferos com vìrus da sub-famìlia pneumovirinae, composto, seus sais, e derivados farmaceuticamente aceitáveis dos mesmos, composto e a forma n-óxido e sal piridìnio do mesmo, e, método de separação de enantiÈmeros de um composto |
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-
2004
- 2004-12-24 BR BRPI0418127-1A patent/BRPI0418127A/pt not_active IP Right Cessation
- 2004-12-24 CA CA2551178A patent/CA2551178C/en not_active Expired - Fee Related
- 2004-12-24 RU RU2006126663/04A patent/RU2422444C2/ru not_active IP Right Cessation
- 2004-12-24 EP EP04802131A patent/EP1697377B1/en not_active Expired - Lifetime
- 2004-12-24 KR KR1020067014876A patent/KR20060127909A/ko not_active Ceased
- 2004-12-24 JP JP2006545846A patent/JP5384793B2/ja not_active Expired - Fee Related
- 2004-12-24 DE DE602004031258T patent/DE602004031258D1/de not_active Expired - Lifetime
- 2004-12-24 EP EP10177705A patent/EP2287167A1/en not_active Withdrawn
- 2004-12-24 WO PCT/AU2004/001830 patent/WO2005061513A1/en not_active Ceased
- 2004-12-24 CN CN2009102585362A patent/CN101723949B/zh not_active Expired - Fee Related
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- 2004-12-24 AT AT04802131T patent/ATE496920T1/de not_active IP Right Cessation
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- 2004-12-24 NZ NZ551468A patent/NZ551468A/en not_active IP Right Cessation
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2006
- 2006-06-02 ZA ZA200604528A patent/ZA200604528B/en unknown
- 2006-06-06 IL IL176155A patent/IL176155A0/en unknown
- 2006-06-13 NO NO20062758A patent/NO20062758L/no not_active Application Discontinuation
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2012
- 2012-09-18 JP JP2012204388A patent/JP5536842B2/ja not_active Expired - Fee Related
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2013
- 2013-10-24 US US14/062,780 patent/US20140051689A1/en not_active Abandoned
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| US3657221A (en) * | 1969-02-19 | 1972-04-18 | American Home Prod | Process for preparing 9b-substituted-1 - sulfonyl - 1 2 3 9b - tetrahydro-5h-imidazo(2 1-a)isoindol-5-ones |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ551468A (en) | 2010-05-28 |
| WO2005061513A1 (en) | 2005-07-07 |
| JP2012246318A (ja) | 2012-12-13 |
| CA2551178C (en) | 2012-11-06 |
| JP2007516983A (ja) | 2007-06-28 |
| KR20060127909A (ko) | 2006-12-13 |
| EP1697377A4 (en) | 2008-03-19 |
| CA2551178A1 (en) | 2005-07-07 |
| US20070287700A1 (en) | 2007-12-13 |
| US20140051689A1 (en) | 2014-02-20 |
| RU2006126663A (ru) | 2008-01-27 |
| JP5384793B2 (ja) | 2014-01-08 |
| CN1898247A (zh) | 2007-01-17 |
| US8598193B2 (en) | 2013-12-03 |
| EP1697377A1 (en) | 2006-09-06 |
| JP5536842B2 (ja) | 2014-07-02 |
| HK1088607A1 (en) | 2006-11-10 |
| ES2360222T3 (es) | 2011-06-02 |
| RU2422444C2 (ru) | 2011-06-27 |
| BRPI0418127A (pt) | 2007-04-27 |
| NO20062758L (no) | 2006-07-17 |
| ATE496920T1 (de) | 2011-02-15 |
| ZA200604528B (en) | 2007-06-27 |
| DE602004031258D1 (de) | 2011-03-10 |
| EP1697377B1 (en) | 2011-01-26 |
| CN100582109C (zh) | 2010-01-20 |
| EP2287167A1 (en) | 2011-02-23 |
| CN101723949A (zh) | 2010-06-09 |
| IL176155A0 (en) | 2006-10-05 |
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