CN101687058B - 制备用于伤口处理的聚氨酯泡沫的方法和由其所得伤口敷料以及该泡沫的用途和相关组合物的用途 - Google Patents
制备用于伤口处理的聚氨酯泡沫的方法和由其所得伤口敷料以及该泡沫的用途和相关组合物的用途 Download PDFInfo
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- CN101687058B CN101687058B CN200880023844.0A CN200880023844A CN101687058B CN 101687058 B CN101687058 B CN 101687058B CN 200880023844 A CN200880023844 A CN 200880023844A CN 101687058 B CN101687058 B CN 101687058B
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Abstract
本发明涉及通过使硅烷封端的聚氨酯发泡并且固化得到的新的基于聚氨酯的伤口敷料。
Description
本发明提供通过使硅烷封端的聚氨酯发泡并且固化得到的新的基于聚氨酯的伤口敷料(Wundauflage)。
由泡沫制成的伤口敷料用于处理渗漏伤口(Wund)的用途是现有技术。由于它们高的吸收性和它们好的机械性能，因此通常使用通过在某些催化剂以及(发泡)添加剂的存在下使二异氰酸酯和多元醇或者NCO官能(funktionell)聚氨酯预聚物的混合物与水反应制备的聚氨酯泡沫。在此，通常使用芳族二异氰酸酯，因为它们发泡最好。这些方法的许多形式是已知的，例如描述于US3,978,266、US3,975,567和EP-A0059048中。然而，上述方法具有它们必须使用包含二异氰酸酯或者合适的NCO官能预聚物的反应性混合物的缺点，该混合物的处理在技术上昂贵，因为例如需要有合适的保护措施。由于存在的异氰酸酯基团的高反应活性，因此这些混合物直接施加在(人的)皮肤上是不可能的。
除了使用包含游离异氰酸酯基团的组合物之外，也可以使用可通过使用发泡剂发泡的硅烷封端的聚氨酯预聚物制备聚氨酯泡沫。已知用于制备密封和绝缘泡沫的许多实施方案，例如描述于EP-A1098920中。该组合物用于制备伤口敷料的用途迄今为止是未知的。迄今也没有描述用作伤口敷料的关键要求的适用性，例如好的水蒸气渗透性和高的液体吸收能力。
本发明的目的是提供避免了上述使用含异氰酸酯基团的反应性混合物的缺点的聚氨酯伤口敷料。
现已惊奇地发现，硅烷封端的聚氨酯预聚物(STP)在发泡和通过硅烷基团交联而固化之后可同样优异地用作医学应用的伤口敷料。
本发明因此提供可由硅烷封端的聚氨酯预聚物得到的泡沫作为伤口敷料的用途。
本发明进一步提供一种用于制备伤口敷料的方法，其中使包含以下组分的组合物发泡，在发泡之前、期间或之后将其施加到基材上并且最后在存在水的条件下固化：
a)硅烷封端的聚氨酯预聚物(I)
b)(发泡)添加剂(II)
c)任选的催化剂(III)
d)任选的发泡剂(IV)，以及
e)任选的另外的辅助和添加物质(V)。
本发明进一步提供可通过本发明方法得到的伤口敷料。
本发明进一步提供包含以下组分的组合物用于制备伤口处理用的敷料(Auflage)的用途：
a)包含多于一个烷氧基硅烷基团的硅烷封端的聚氨酯预聚物(I)
b)(发泡)添加剂(II)
c)任选的催化剂(III)
d)任选的发泡剂(IV)，以及
e)任选的另外的辅助和添加物质(V)。
本发明意义上的聚氨酯泡沫伤口敷料是多孔材料，优选具有至少部分开孔度(Offenzelligkeit)，其基本由通过硅氧烷键Si-O-Si交联的聚氨酯组成并且通过在阻隔细菌或环境影响来保护伤口，提供快速和高的生理盐水或伤口渗出液(Wundflüssigkeit)的吸收性，并且通过对水分合适的渗透性而确保最佳的伤口环境(Wundklima)。
在本发明意义上的硅烷封端的聚氨酯预聚物(I)是具有多于一个氨基甲酸酯基团和多于一个烷氧基硅烷基团的所有(预)聚合物，其能够在存在水和任选的催化剂(III)的条件下反应通过硅氧烷键Si-O-Si形成交联的聚氨酯。
该硅烷封端的预聚物可通过以下方式得到，其中：
使i)具有游离异氰酸酯基团的平均NCO官能度为至少1.5的聚氨酯预聚物(A)与
ii)具有通过亚烷基与硅原子键合的氨基、羟基和/或硫醇基团的二和/或三烷氧基硅烷(B)反应，
或者
使iii)具有至少1.5的平均OH官能度的多羟基化合物(C)与
iv)具有通过亚烷基与硅原子键合的异氰酸酯和/或异硫代氰酸酯基团的二和/或三烷氧基硅烷(D)反应。
含有游离异氰酸酯基团的聚氨酯预聚物(A)可以以已知的方式通过使用过量的有机多异氰酸酯(摩尔比NCO/OH＞1)，让有机多异氰酸酯与具有1.5-6官能度的多羟基化合物反应来获得。
合适的多异氰酸酯包括本领域技术人员公知的具有≥2的平均NCO官能度的芳族、芳脂族、脂族或脂环族多异氰酸酯。
这些合适的多异氰酸酯的例子是1，4-亚丁基二异氰酸酯、1，6-六亚甲基二异氰酸酯(HDI)、异佛尔酮二异氰酸酯(IPDI)、2，2，4和/或2，4，4-三甲基六亚甲基二异氰酸酯、异构的双(4，4’-异氰酸根合环己基)甲烷或者它们的具有任何所希望的异构体含量的混合物、1，4-亚环己基二异氰酸酯、1，4-亚苯基二异氰酸酯、2，4-和/或2，6-亚甲苯基二异氰酸酯、1，5-亚萘基二异氰酸酯、2，2’-和/或2，4’-和/或4，4’-二苯基甲烷二异氰酸酯、1，3-和/或1，4-双(2-异氰酸根合丙-2-基)苯(TMXDI)、1，3-双(异氰酸根合甲基)苯(XDI)，具有C1-C8烷基的烷基-2，6-二异氰酸根合己酸酯(赖氨酸二异氰酸酯)，和4-异氰酸根合甲基-1，8-辛烷二异氰酸酯(壬烷三异氰酸酯)和三苯基甲烷-4，4’，4”-三异氰酸酯。
除了上述多异氰酸酯之外，也可以按比例(anteilig)使用具有异氰酸酯二聚体(Uretdion)、异氰脲酸酯、氨基甲酸酯、脲基甲酸酯、缩二脲、亚氨基二嗪二酮和/或二嗪三酮结构的改性的二异氰酸酯或三异氰酸酯。
优选地，上述类型的多异氰酸酯或者多异氰酸酯混合物只具有脂族和/或脂环族键合的异氰酸酯基团，和2-4，优选2-2.6并且更优选2-2.4的平均NCO官能度。特别优选使用1，6-六亚甲基二异氰酸酯、异佛尔酮二异氰酸酯、异构的双(4，4’-异氰酸根合环己基)甲烷，以及它们的混合物。
可用作组分(C)的多羟基化合物的是所有公知的聚氨酯漆料技术中的具有至少1.5的平均OH官能度的聚酯多元醇、聚丙烯酸酯多元醇、聚氨酯多元醇、聚碳酸酯多元醇、聚醚多元醇、聚酯聚丙烯酸酯多元醇、聚氨酯聚丙烯酸酯多元醇、聚氨酯聚酯多元醇、聚氨酯聚醚多元醇、聚氨酯聚碳酸酯多元醇和聚酯聚碳酸酯多元醇。这些可以单独或者以彼此任何所希望的混合物使用。然而，优选使用聚醚多元醇。
组分(C)的聚酯多元醇是公知的由二元醇以及任选的三元醇和四元醇与二元羧酸以及任选的三元羧酸和四元羧酸或者羟基羧酸或内酯形成的缩聚物。代替游离多元羧酸，还可以使用相应的多元羧酸酐或者相应的低级醇多元羧酸酯用于制备聚酯。
用于制备聚酯多元醇的合适二元醇的例子是乙二醇、丁二醇、二甘醇、三甘醇、聚亚烷基二醇例如聚乙二醇，以及1，2-丙二醇、1，3-丙二醇、丁二醇(1，3)、丁二醇(1，4)、己二醇(1，6)和异构体、新戊二醇或羟基新戊酸新戊二醇酯，其中优选己二醇(1，6)和异构体、新戊二醇和羟基新戊酸新戊二醇酯。三羟甲基丙烷、甘油、赤藻糖醇、季戊四醇、三羟甲基苯或三羟乙基异氰脲酸酯适合例如作为上述类型的三元醇和二元醇。
作为二元羧酸可以使用邻苯二甲酸、间苯二甲酸、对苯二甲酸、四氢邻苯二甲酸、六氢邻苯二甲酸、环己烷二羧酸、己二酸、壬二酸、癸二酸、戊二酸、四氯邻苯二甲酸、马来酸、富马酸、衣康酸、丙二酸、辛二酸、2-甲基琥珀酸、3，3-二乙基戊二酸和/或2，2-二甲基琥珀酸。作为酸源也可以使用相应的酸酐。优选的酸是上述类型的脂族或芳族酸。特别优选的是己二酸、间苯二甲酸和视需要的偏苯三酸。
在制备具有末端羟基的聚酯多元醇时可以一并使用作为反应参与物的羟基羧酸例如是羟基己酸、羟基丁酸、羟基癸酸、羟基硬脂酸等。合适的内酯是己内酯、丁内酯和同系物。优选的是己内酯。
作为组分(C)的多羟基化合物还可以使用数均分子量Mn为400-8000g/mol，优选600-3000g/mol的聚碳酸酯，优选聚碳酸酯二元醇。这些可以以本身已知的方式由碳酸衍生物例如碳酸二苯酯、碳酸二甲酯或光气与多元醇优选二元醇的反应获得。
适合于制备聚碳酸酯的二元醇是例如乙二醇、1，2-丙二醇和1，3-丙二醇、1，3-丁二醇和1，4-丁二醇、1，6-己二醇、1，8-辛二醇、新戊二醇、1，4-双羟基甲基环己烷、2-甲基-1，3-丙二醇、2，2，4-三羟甲基戊二醇-1，3、二丙二醇、多丙二醇、二丁二醇、多丁二醇、双酚A和内酯改性的上述类型的二元醇。
基于作为基础的二元醇，聚碳酸酯二元醇优选含有40-100重量％的己二醇，优选1，6-己二醇和/或己二醇衍生物。这些己二醇衍生物基于己二醇并且除了末端OH基之外还具有酯基或醚基。这些衍生物可通过己二醇与过量的己内酯反应或者通过己二醇与自身醚化形成二或三己二醇获得。
作为组分(C)的多羟基化合物可以额外使用聚醚多元醇。合适的例如为在聚氨酯化学中本身已知的聚四亚甲基二醇聚醚，正如可借助于阳离子开环通过四氢呋喃聚合获得。
组分(C)的优选的聚醚多元醇是公知的氧化苯乙烯、环氧乙烷、环氧丙烷、环氧丁烷和/或表氯醇在二或更多官能起始物分子上的加成产物，其中特别优选来自环氧乙烷或环氧丙烷的加成产物，以及提及的那些的混合物。非常特别优选地，环氧乙烷的重量份额为至少5至80重量％，优选10-65重量％，特别优选10-30重量％的来自环氧乙烷和环氧丙烷的加成产物，其中该重量份额基于加成产物中存在的环氧乙烷和环氧丙烷加上使用的起始物分子的总量。
用环氧乙烷或环氧丙烷的烷氧基化可以在碱催化下或者通过使用双金属氰化物化合物(DMC-化合物)进行。
适合作为用于制备组分(C)的聚醚多元醇的起始物分子可以使用所有现有技术的已知低分子量多元醇、有机多胺和/或水，例如丁基二甘醇、甘油、二甘醇、三羟甲基丙烷、丙二醇、山梨醇、亚乙基二胺、三乙醇胺、1，4-丁二醇。优选的起始物分子是水、乙二醇、丙二醇、1，4-丁二醇、二甘醇、丁基二甘醇或上述物质的任意混合物。
聚醚多元醇的数均分子量Mn优选为300-20000g/mol，更优选1000-12000g/mol，最特别优选2000-6000g/mol。
有机二或多异氰酸酯与具有1.5-6官能度的多羟基化合物以＜1的NCO/OH摩尔比反应得到具有氨基甲酸酯基团的多羟基化合物，其同样可用作组分(C)。
组分(B)的具有氨基、羟基和/或硫醇基团的合适二和/或三烷氧基硅烷是本领域技术人员公知的，例子是氨基丙基三甲氧基硅烷、巯基丙基三甲氧基硅烷、氨基丙基甲基二甲氧基硅烷、巯基丙基甲基二甲氧基硅烷、氨基丙基三乙氧基硅烷、巯基丙基三乙氧基硅烷、氨基丙基甲基二乙氧基硅烷、巯基丙基甲基二乙氧基硅烷、氨基甲基三甲氧基硅烷、氨基甲基三乙氧基硅烷、(氨基甲基)甲基二甲氧基硅烷、(氨基甲基)甲基二乙氧基硅烷、N-丁基氨基丙基三甲氧基硅烷、N-乙基氨基丙基三甲氧基硅烷、N-苯基氨基丙基三甲氧基硅烷、N-(3-三乙氧基甲硅烷基丙基)天门冬氨酸二乙基酯、N-(3-三甲氧基甲硅烷基丙基)天门冬氨酸二乙基酯和N-(3-二甲氧基甲基甲硅烷基丙基)天门冬氨酸二乙基酯。优选使用N-(3-三甲氧基甲硅烷基丙基)天门冬氨酸二乙基酯和氨基丙基三甲氧基硅烷。
组分(D)的具有异氰酸酯和/或异硫代氰酸酯基团的合适二和/或三烷氧基硅烷原则上同样是已知的。
例子是异氰酸根合甲基三甲氧基硅烷、异氰酸根合甲基三乙氧基硅烷、(异氰酸根合甲基)甲基二甲氧基硅烷、(异氰酸根合甲基)甲基二乙氧基硅烷、3-异氰酸根合丙基三甲氧基硅烷、3-异氰酸根合丙基甲基二甲氧基硅烷、3-异氰酸根合丙基三乙氧基硅烷和3-异氰酸根合丙基甲基二乙氧基硅烷。这里优选使用3-异氰酸根合丙基三甲氧基硅烷和3-异氰酸根合丙基三乙氧基硅烷。
添加剂(II)是非离子、阴离子、阳离子或两性离子表面活性剂或上述表面活性剂的混合物，其在本发明的组合物中用于改进泡沫形成、泡沫稳定性或者所得的聚氨酯泡沫的性能。优选的添加剂(II)是非离子表面活性剂，更优选基于聚醚硅氧烷的非离子表面活性剂。
优选的添加剂(II)不仅具有稳定化效果，而且具有就泡沫亲水化而言特别有利的影响，这本身在水分吸收的量和速率中表现出来。
作为催化剂(III)原则上可以向本发明组合物中添加从硅化学本身已知的催化烷氧基硅烷和硅醇基团的水解和缩合的所有物质。例子是金属盐、金属配合物、有机金属化合物以及酸和碱。优选使用有机和无机酸或碱，并且特别优选使用有机或无机酸例如盐酸或对甲苯磺酸。当催化剂(III)用于组合物中时，优选将它们溶于水中，泡沫的实际交联也需要水。
在最简单的情况下，发泡剂(IV)可以是空气或氮气，但是当然也可以使用从聚氨酯化学中本身已知的任何其它发泡剂用于使本发明的组合物发泡。例子是正丁烷、异丁烷、丙烷和二甲醚，以及上述物质的混合物。
作为辅助和添加物质(V)可以使用例如填料、增稠剂或触变剂、抗氧化剂、光稳定剂、增塑剂、颜料和/或流动助剂(Verlaufshilfmittel)。
优选的辅助和添加物质是填料，优选能够有助于改进本发明的聚氨酯泡沫的机械性能的无机填料。合适的是例如白垩和高分散的硅石特别是火焰热解(flammpyrolytisch)制备的硅石。
作为增塑剂可以使用与聚氨酯泡沫充分相容的所有天然或合成物质。合适的增塑剂的例子是樟脑，(脂族)二羧酸例如己二酸的酯，特别地基于与1，3-丁二醇、1，4-丁二醇或1，6-己二醇缩合的己二酸、癸二酸、壬二酸和邻苯二甲酸的聚酯，以及磷酸酯、脂肪酸酯和羟基羧酸酯(例如基于柠檬酸、酒石酸或乳酸)。
通过使烷氧基硅烷基团交联固化形成硅氧烷桥在存在水的条件下进行，水可以以液体形式例如作为用于催化剂的溶剂直接加入，或者可以以大气湿气的形式来自空气。
基于干物质，本发明必要的组合物通常包含80-99.9重量份硅烷封端的聚氨酯预聚物(I)和0.1-20重量份(发泡)添加剂(II)。优选地，基于干物质，该组合物包含85-99.9重量份硅烷封端的聚氨酯预聚物(I)和0.1-15重量份(发泡)添加剂(II)，更优选95-99.9重量份(I)和0.1-5重量份(II)。
辅助和添加物质(V)通常以0-50重量份，优选10-40重量份的量加入。
如果为了交联除了环境水分之外加入水，那么水通常以使得烷氧基与加入的水的摩尔比为小于或等于1的量加入(过量的水)。该摩尔比优选小于或等于0.75，并且更优选小于或等于0.55。
发泡剂或发泡剂混合物(IV)通常以1-50重量％，优选5-40重量％并且更优选5-20重量％的量使用，使用的组分(I)、(II)和任选的(III)、(IV)、(V)的总和为100重量％。
组分(I)和(II)的混合可以任何顺序进行，具有任选的组分(III)-(V)的混合物也一样。
优选地，组分(I)和(II)以及任选的(III)-(V)各自分开提供；即，也即反应性组分(I)在不存在水和任选使用的催化剂(III)的情况下提供。这得到在23℃下储存稳定至少6个月的组合物(储存稳定将被理解为是指基于组合物的起始水平，混合物的粘度增加少于50％，优选少于25％并且更优选少于15％)。
在本发明的方法中，通过振荡组合物、在高旋转速度下机械搅拌或者通过使发泡气体膨胀(entspannung)来完成发泡。在发泡之后或期间，组合物进行固化得到所希望的聚氨酯泡沫。在完全凝固或固化之前，即只要组合物仍然可流动，则可以通过常用的施加技术例如倾倒或刀涂将其涂覆在合适的基材上。另外，可以将组合物直接涂覆在人或动物的皮肤上，在该情况下则通常同时进行发泡和固化。
可以使用任何所希望的机械搅拌、混合和分散技术进行机械发泡。通常将空气引入工艺中，但氮气和其它气体也可用于该目的。
在发泡过程中或者之后即刻，将由此得到的泡沫涂覆在基材上或者引入模具并且固化。
可以例如通过流延或者刀涂来施加到基材上，但其它常规技术也是可能的。具有任选插入的固化步骤的多层施加原则上也是可能的。
在低至20℃的温度下就已观察到令人满意的泡沫固化速率。然而为了更迅速的泡沫固化和定形，也可以例如借助于常规的加热和干燥装置，例如(循环空气)干燥箱、热空气或IR辐射器而使用优选超过30℃的更高温度。
可以在发泡之后或者在发泡时，将组合物直接施加到皮肤上，或者在伤口敷料的工业生产过程中施加到隔离纸(Trennpapier)上或者膜上，所述隔离纸(Trennpapier)上或者膜使得能够在其用于覆盖受伤位置之前简单地剥离所述伤口敷料。
施加和固化可以各自间歇或连续进行，但对于伤口敷料的工业生产而言优选完全连续的方法。
当通过例如喷雾将组合物直接施加到人或动物皮肤上时，固化同样分别在环境条件或通过体温非常迅速地进行。外部热源辅助在这里同样是可能的，尽管不优选。
在本发明的一个实施方案中，将硅烷封端的聚氨酯预聚物(I)与添加剂(II)以及任选另外的辅助和添加物质(V)混合。在例如由于空气或其它气体的机械引入而可发生混合物发泡之后，加入催化剂(III)，将(发泡的)混合物施加到合适的基材上并且最后在空气湿度的存在下固化。为了加速发泡混合物的固化，可以额外加入水，这优选与(溶解的)催化剂(III)一起进行。
在本发明的另一个实施方案中，将硅烷封端的聚氨酯预聚物(I)与添加剂(II)以及任选另外的辅助和添加物质(V)混合，并且转移到合适的压力容器例如喷雾罐中。此后加入发泡剂(IV)；当混合物施加到合适的基材上时，其发泡并且通过大气湿度固化。
在本发明的另一个实施方案中，将硅烷封端的聚氨酯预聚物(I)与添加剂(II)以及任选另外的辅助和添加物质(V)混合，并且转移到合适的压力容器的第一腔室例如喷雾罐中，所述压力容器具有至少两个分开的腔室。将催化剂(III)引入压力容器的第二腔室中，催化剂优选与合适数量的水混合。也可以将辅助和添加物质(V)混合入第二腔室中，但这是次优选的。然后将发泡剂(IV)加入腔室之一或两者中，并且最终将双组分混合物施加到合适的基材上，其中同时进行发泡和固化。
在其固化前，聚氨酯泡沫的泡沫密度通常为50-800g/l，优选100-500g/l，并且更优选100-250g/l(基于1升泡沫体积的所有进料质量[以g计])。
干燥后，聚氨酯泡沫具有微孔、至少部分开孔的包括相互连接的单元的结构。固化的泡沫的密度通常低于0.4g/cm3，优选小于0.35g/cm3并且更优选0.01-0.2g/cm3。
对于聚氨酯泡沫而言，生理盐水吸收率通常为100-1500％，并且优选300-800％(吸收的液体质量，基于干燥泡沫的质量；根据DINEN13726-1部分3.2测定)。水蒸气渗透率通常为500-8000g/24h*m2，优选1000-6000g/24h*m2，并且更优选2000-5000g/24h*m2(根据DINEN13726-2，部分3.2测定)。
该聚氨酯泡沫展现出好的机械强度和高弹性。一般而言，最大应力为大于0.1N/mm2，并且最大伸长率为大于100％。优选地，伸长率大于200％(根据DIN53504测量)。
固化后，聚氨酯泡沫的厚度通常为0.1mm-50mm，优选0.5mm-20mm，更优选1-10mm并且非常特别优选1-5mm。
此外，可以将聚氨酯泡沫与另外的材料例如基于水凝胶、(半)渗透膜、涂层、水胶体或者其它泡沫相粘结、层压或涂覆。
同样可以加入、引入或者涂覆抗菌或生物的活性成分，这些活性成分例如具有就伤口愈合和避免细菌负荷而言的积极效果。
实施例：
除非另外说明，所有百分比数据以重量计。
除非另外明确地提及，根据DIN-ENISO11909用体积法测量NCO含量。
使用的物质和缩写：
PO环氧丙烷
EO环氧乙烷
DBTL二月桂酸二丁基锡
B1048聚醚硅氧烷(得自Degussa公司，Düsseldorf，德国)
R9200高分散的火焰热解硅石(得自Degussa公司，Düsseldorf，德国)
基于烷基磺酸酯的增塑剂(得自Lanxess公司，Leverkusen，德国)
硅烷封端的预聚物1(STP1)的制备：
伴随着搅拌将2003.6g双官能含环氧乙烷的聚醚(OH值28，分子量4000g/mol，PO/EO比例＝6.5)、214.3g3-异氰酸根合三甲氧基硅烷和133μlDBTL的混合物在60℃加热，直到NCO含量为0。
实施例1：在碱催化条件下制备泡沫
在塑料烧杯中使用手动搅拌器将117.5gSTP1和3.8gB1048混合，并且在10分钟内发泡至约300ml的体积。然后加入2.5g氢氧化钾水溶液(1.25mol/L)，由此在20s内进行固化。得到白色泡沫。
实施例2：通过酸催化制备泡沫
a)在塑料烧杯中使用手动搅拌器将117.5gSTP1和3.8gB1048混合，并且在10分钟内发泡至约300ml的体积。然后加入2.5g5％的对甲苯磺酸水溶液，由此在100s内进行固化。得到白色泡沫。
b)用2g20％的对甲苯磺酸水溶液重复实验a)。在50s后已经固化成白色泡沫。
实施例3：具有填料和增塑剂的泡沫
最初使用溶解器将50gR9200分散在117.5gSTP1中(几乎透明的分散体)。然后加入25g和3.8gB1048，最后在塑料烧杯中使用手动搅拌器在10分钟内将混合物发泡至约300ml的体积。在加入2.5g5％的对甲苯磺酸水溶液之后，在20s内固化成白色泡沫。
Claims (11)
1.由硅烷封端的聚氨酯预聚物得到的泡沫用作伤口敷料的用途。
2.用于制备伤口敷料的方法，其中使包含以下组分的组合物发泡，在发泡之前、期间或之后将其施加到基材上并且最后在存在水的条件下固化：
a)通过以下方式得到的包含多于一个烷氧基硅烷基团的硅烷封端的聚氨酯预聚物(I)，其中：
使i)具有游离异氰酸酯基团的平均NCO官能度为至少1.5的聚氨酯预聚物(A)与
ii)具有通过亚烷基与硅原子键合的氨基、羟基和/或硫醇基团的二和/或三烷氧基硅烷(B)反应，
或者
使iii)具有至少1.5的平均OH官能度的多羟基化合物(C)与
iv)具有通过亚烷基与硅原子键合的异氰酸酯和/或异硫代氰酸酯基团的二和/或三烷氧基硅烷(D)反应，
b)添加剂(II)，其是非离子、阴离子、阳离子或两性离子表面活性剂或上述表面活性剂的混合物，
c)任选的催化剂(III)，
d)任选的发泡剂(IV)，以及
e)任选的另外的辅助和添加物质(V)。
3.根据权利要求2的方法，特征在于所述添加剂(II)是发泡添加剂。
4.根据权利要求2或3的方法，特征在于所述硅烷封端的预聚物(I)基于只具有脂族和/或脂环族键合的异氰酸酯基团并且具有2-4的平均NCO官能度的多异氰酸酯或多异氰酸酯混合物。
5.根据权利要求2或3的方法，特征在于作为添加剂(II)使用基于聚醚硅氧烷的非离子表面活性剂。
6.根据权利要求2或3的方法，特征在于基于干物质，待发泡的组合物包含85-99.9重量份硅烷封端的聚氨酯预聚物(I)和0.1-15重量份添加剂(II)以及0-50重量份辅助和添加物质(V)。
7.根据权利要求6的方法，特征在于所述添加剂(II)是发泡添加剂。
8.根据权利要求2或3的方法，特征在于加入水用于固化，数量为使得硅烷封端的预聚物中烷氧基硅烷基团与加入的水的摩尔比为小于或等于1。
9.通过根据权利要求2-8任一项的方法得到的伤口敷料。
10.包含以下组分的组合物用于制备伤口处理用的接触材料的用途：
a)包含至少一个烷氧基硅烷基团的硅烷封端的聚氨酯预聚物(I)
b)添加剂(II)，其是非离子、阴离子、阳离子或两性离子表面活性剂或上述表面活性剂的混合物，
c)任选的催化剂(III)
d)任选的发泡剂(IV)，以及
e)任选的另外的辅助和添加物质(V)。
11.根据权利要求10的用途，特征在于所述添加剂(II)是发泡添加剂。
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| EP07013425.9 | 2007-07-10 | ||
| EP07013425A EP2014314A1 (de) | 2007-07-10 | 2007-07-10 | Verfahren zur Herstellung von Polyurethan-Schäumen für die Wundbehandlung |
| PCT/EP2008/005259 WO2009007018A1 (de) | 2007-07-10 | 2008-06-27 | Verfahren zur herstellung von polyurethan-schäumen für die wundbehandlung |
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| CN101687058B true CN101687058B (zh) | 2016-06-22 |
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| CN (1) | CN101687058B (zh) |
| CA (1) | CA2692799A1 (zh) |
| TW (1) | TW200918108A (zh) |
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| DE102009028640A1 (de) * | 2009-08-19 | 2011-02-24 | Evonik Goldschmidt Gmbh | Härtbare Masse enthaltend Urethangruppen aufweisende silylierte Polymere und deren Verwendung in Dicht- und Klebstoffen, Binde- und/oder Oberflächenmodifizierungsmitteln |
| DE102009028636A1 (de) * | 2009-08-19 | 2011-02-24 | Evonik Goldschmidt Gmbh | Neuartige Urethangruppen enthaltende silylierte Präpolymere und Verfahren zu deren Herstellung |
| US8772567B2 (en) | 2010-08-19 | 2014-07-08 | Paul Hartmann Ag | Use of a polyurethane foam as a wound dressing in negative pressure therapy |
| EP2420214B1 (de) * | 2010-08-19 | 2014-02-26 | Paul Hartmann AG | Wundauflage, enthaltend Schaumstoff und Salbengrundlage zur Unterdrucktherapie |
| EP2734243A1 (en) * | 2011-07-20 | 2014-05-28 | 3M Innovative Properties Company | Dressing with ion-carrying composition |
| JP6141852B2 (ja) * | 2011-09-29 | 2017-06-07 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 速硬化性アルコキシシランスプレーフォーム |
| EP2760488B1 (de) * | 2011-09-29 | 2015-06-03 | Bayer Intellectual Property GmbH | Schnellhärtende alkoxysilan-sprühschäume |
| US9440996B2 (en) | 2011-09-29 | 2016-09-13 | Covestro Deutschland Ag | Alpha-alkoxysilane-terminated prepolymer for fast-curing spray foams with improved propellant gas solubility |
| EP2725044B1 (de) | 2012-10-24 | 2017-06-21 | Covestro Deutschland AG | Alkoxysilanterminiertes Präpolymer auf Basis von Polyethercarbonatpolyolen für Sprühschäume |
| WO2014064039A1 (de) | 2012-10-24 | 2014-05-01 | Bayer Materialscience Ag | Mehrkomponentensystem zur herstellung von alkoxysilanbasierten sprühschäumen |
| DE102013107464A1 (de) | 2013-07-15 | 2015-01-15 | Wilhelm Fleischmann | Wundauflage |
| JP2016214296A (ja) * | 2015-05-14 | 2016-12-22 | 株式会社カネカ | 粘着層を持つ軟質発泡体を用いた褥瘡予防パッド |
| DE102015007622A1 (de) * | 2015-06-16 | 2016-12-22 | Paul Hartmann Ag | Vorrichtung zur Unterdrucktherapie von Wunden enthaltend siliconhaltigen Polyurethanschaumstoff |
| WO2017050840A1 (en) * | 2015-09-21 | 2017-03-30 | Poly Terra Innovation Gmbh | Synthetic foam material comprising silane-terminated polymers |
| CN106038065B (zh) * | 2016-05-26 | 2019-06-18 | 华南理工大学 | 一种基于聚硅氧烷超分子弹性体具有双层结构的皮肤创伤敷料及其制备方法 |
| GB201610184D0 (en) | 2016-06-10 | 2016-07-27 | Eumar Tech Ltd | Product |
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| EP3756850A1 (en) * | 2019-06-24 | 2020-12-30 | Mölnlycke Health Care AB | High throughput manufacture of polyurethane foam layers |
| TWI733144B (zh) * | 2019-07-22 | 2021-07-11 | 中鎮醫療產品科技股份有限公司 | 疤痕膠片用水膠及其製法 |
| JP7277346B2 (ja) * | 2019-12-02 | 2023-05-18 | 株式会社イノアックコーポレーション | シリコーン系樹脂発泡体の製造方法 |
| PL3842075T3 (pl) * | 2019-12-23 | 2023-10-16 | Paul Hartmann Ag | Opatrunek na ranę zawierający siloksan |
| TWI744865B (zh) * | 2020-02-07 | 2021-11-01 | 中鎮醫療產品科技股份有限公司 | 預防壓瘡用的減壓墊 |
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- 2008-06-27 KR KR1020107000438A patent/KR20100035703A/ko not_active Application Discontinuation
- 2008-06-27 CN CN200880023844.0A patent/CN101687058B/zh not_active Expired - Fee Related
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- 2008-06-27 CA CA 2692799 patent/CA2692799A1/en not_active Abandoned
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- 2008-07-09 US US12/169,842 patent/US9168324B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2175896B1 (de) | 2015-08-19 |
| TW200918108A (en) | 2009-05-01 |
| JP2010532691A (ja) | 2010-10-14 |
| KR20100035703A (ko) | 2010-04-06 |
| WO2009007018A1 (de) | 2009-01-15 |
| US20090018480A1 (en) | 2009-01-15 |
| JP5192040B2 (ja) | 2013-05-08 |
| EP2175896A1 (de) | 2010-04-21 |
| EP2014314A1 (de) | 2009-01-14 |
| CN101687058A (zh) | 2010-03-31 |
| WO2009007018A8 (de) | 2010-01-07 |
| CA2692799A1 (en) | 2009-01-15 |
| US9168324B2 (en) | 2015-10-27 |
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