CN101663326B - 从海藻提取物中纯化岩藻依聚糖的工艺方法 - Google Patents

从海藻提取物中纯化岩藻依聚糖的工艺方法 Download PDF

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CN101663326B
CN101663326B CN2008800079552A CN200880007955A CN101663326B CN 101663326 B CN101663326 B CN 101663326B CN 2008800079552 A CN2008800079552 A CN 2008800079552A CN 200880007955 A CN200880007955 A CN 200880007955A CN 101663326 B CN101663326 B CN 101663326B
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fucoidan
factor
coagulation
mixture
acid
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CN101663326A (zh
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帕特里克·N·嘉康利
詹尼弗·巴哈-戴维森
斯里尼瓦莎·普拉萨德
科克·约翰逊
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Takeda Pharmaceutical Co Ltd
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Baxter Healthcare SA
Baxter International Inc
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0036—Galactans; Derivatives thereof

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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008800079552A 2007-02-23 2008-02-01 从海藻提取物中纯化岩藻依聚糖的工艺方法 Active CN101663326B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89128707P 2007-02-23 2007-02-23
US60/891,287 2007-02-23
PCT/US2008/001425 WO2008103234A1 (en) 2007-02-23 2008-02-01 Process methods for fucoidan purification from seaweed extracts

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CN101663326B true CN101663326B (zh) 2013-03-20

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US (2) US8748595B2 (enExample)
EP (3) EP2121767B1 (enExample)
JP (1) JP5679663B2 (enExample)
KR (1) KR101486931B1 (enExample)
CN (2) CN101663326B (enExample)
ES (2) ES2683948T3 (enExample)
WO (1) WO2008103234A1 (enExample)

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CN101663326B (zh) * 2007-02-23 2013-03-20 巴克斯特国际公司 从海藻提取物中纯化岩藻依聚糖的工艺方法
JP5739816B2 (ja) 2008-12-19 2015-06-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Ｔｆｐｉインヒビターおよび使用法
JO3676B1 (ar) * 2009-07-27 2020-08-27 Arc Medical Devices Inc مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها
CN101659709B (zh) * 2009-09-18 2011-09-07 集美大学 岩藻聚糖的制备方法
US8632991B2 (en) * 2010-01-14 2014-01-21 Baxter International Inc. Methods and compositions for treating bleeding disorders
WO2011115712A2 (en) 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use
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EP2588119A4 (en) * 2010-06-28 2014-01-08 Stemtech Internat Inc METHOD AND COMPOSITIONS FOR IMPROVING STRAIN CELL MOBILIZATION
EP2643356B1 (en) * 2010-11-23 2021-03-31 DuPont Nutrition USA, Inc. Process for isolating fucoidan and laminarin from live, harvested seaweed
CN103338780A (zh) * 2010-12-20 2013-10-02 韩国食品研究院 含有腔昆布提取物和黑昆布提取物的用于正向变构调节gabaa-苯二氮杂*受体的组合物和用于产生镇静催眠效果的组合物
CN102321052B (zh) * 2011-05-26 2013-08-21 天津市尖峰天然产物研究开发有限公司 综合利用海带提取纯化岩藻黄质和岩藻聚糖硫酸酯的方法
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CN104698159B (zh) * 2015-03-10 2017-03-08 中国科学院苏州生物医学工程技术研究所 一种内毒素含量的检测方法
TWI743687B (zh) * 2016-06-27 2021-10-21 日商武田藥品工業股份有限公司 注射器穩定器
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KR101866906B1 (ko) * 2017-04-05 2018-06-12 한남대학교 산학협력단 후코이단의 추출방법
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KR101486931B1 (ko) 2015-01-27
EP2532686A1 (en) 2012-12-12
JP2010519383A (ja) 2010-06-03
US9234051B2 (en) 2016-01-12
CN102911281A (zh) 2013-02-06
EP2121767B1 (en) 2014-04-09
US20140328827A1 (en) 2014-11-06
EP2532686B1 (en) 2018-05-16
EP2121767A1 (en) 2009-11-25
CN102911281B (zh) 2015-04-15
US8748595B2 (en) 2014-06-10
JP5679663B2 (ja) 2015-03-04
US20100144667A1 (en) 2010-06-10
HK1135120A1 (en) 2010-05-28
EP3409694A1 (en) 2018-12-05
ES2683948T3 (es) 2018-09-28
WO2008103234A1 (en) 2008-08-28
ES2476250T3 (es) 2014-07-14
KR20090127142A (ko) 2009-12-09
CN101663326A (zh) 2010-03-03

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Effective date of registration: 20210628

Address after: Osaka

Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd.

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Patentee before: Baishen Co.

Patentee before: BAXALTA GmbH