CN101663326B - 从海藻提取物中纯化岩藻依聚糖的工艺方法 - Google Patents

从海藻提取物中纯化岩藻依聚糖的工艺方法 Download PDF

Info

Publication number
CN101663326B
CN101663326B CN2008800079552A CN200880007955A CN101663326B CN 101663326 B CN101663326 B CN 101663326B CN 2008800079552 A CN2008800079552 A CN 2008800079552A CN 200880007955 A CN200880007955 A CN 200880007955A CN 101663326 B CN101663326 B CN 101663326B
Authority
CN
China
Prior art keywords
fucoidan
factor
coagulation
mixture
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2008800079552A
Other languages
English (en)
Chinese (zh)
Other versions
CN101663326A (zh
Inventor
帕特里克·N·嘉康利
詹尼弗·巴哈-戴维森
斯里尼瓦莎·普拉萨德
科克·约翰逊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Baxter Healthcare SA
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Healthcare SA, Baxter International Inc filed Critical Baxter Healthcare SA
Publication of CN101663326A publication Critical patent/CN101663326A/zh
Application granted granted Critical
Publication of CN101663326B publication Critical patent/CN101663326B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0036—Galactans; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008800079552A 2007-02-23 2008-02-01 从海藻提取物中纯化岩藻依聚糖的工艺方法 Active CN101663326B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89128707P 2007-02-23 2007-02-23
US60/891,287 2007-02-23
PCT/US2008/001425 WO2008103234A1 (en) 2007-02-23 2008-02-01 Process methods for fucoidan purification from seaweed extracts

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201210417761.8A Division CN102911281B (zh) 2007-02-23 2008-02-01 从海藻提取物中纯化岩藻依聚糖的工艺方法

Publications (2)

Publication Number Publication Date
CN101663326A CN101663326A (zh) 2010-03-03
CN101663326B true CN101663326B (zh) 2013-03-20

Family

ID=39545010

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2008800079552A Active CN101663326B (zh) 2007-02-23 2008-02-01 从海藻提取物中纯化岩藻依聚糖的工艺方法
CN201210417761.8A Active CN102911281B (zh) 2007-02-23 2008-02-01 从海藻提取物中纯化岩藻依聚糖的工艺方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201210417761.8A Active CN102911281B (zh) 2007-02-23 2008-02-01 从海藻提取物中纯化岩藻依聚糖的工艺方法

Country Status (7)

Country Link
US (2) US8748595B2 (enExample)
EP (3) EP3409694A1 (enExample)
JP (1) JP5679663B2 (enExample)
KR (1) KR101486931B1 (enExample)
CN (2) CN101663326B (enExample)
ES (2) ES2683948T3 (enExample)
WO (1) WO2008103234A1 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5679663B2 (ja) * 2007-02-23 2015-03-04 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 海藻抽出物からのフコイダン精製のためのプロセスの方法
EP2379096B1 (en) 2008-12-19 2019-10-30 Baxalta GmbH Tfpi inhibitors and methods of use
JO3676B1 (ar) * 2009-07-27 2020-08-27 Arc Medical Devices Inc مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها
CN101659709B (zh) * 2009-09-18 2011-09-07 集美大学 岩藻聚糖的制备方法
WO2011088267A1 (en) * 2010-01-14 2011-07-21 Baxter International Inc. Methods and compositions for treating bleeding disorders
ES2983470T3 (es) 2010-03-19 2024-10-23 Takeda Pharmaceuticals Co Inhibidores del TFPI y métodos de uso
CN102933192A (zh) * 2010-05-27 2013-02-13 勒蒂实验室有限公司 用于治疗通过编码角质化包膜成熟缺陷发生的疾病或病症的局部用药物或化妆品组合物
BR112012033548A2 (pt) 2010-06-28 2017-06-20 Stemtech Int Inc métodos e composições para melhorar a mobilização de células-tronco
BR112013012712A2 (pt) * 2010-11-23 2016-09-06 Fmc Corp processo para isolar fucoidano e laminarina a partir de alga marinha colhida, viva
WO2012086853A1 (en) * 2010-12-20 2012-06-28 Korea Food Research Institute Composition for positively allosterically modulating gabaa-benzodiazepine receptor and composition for producing sedative-hypnotic effects containing ecklonia cava extract and ecklonia kurome extract
CN102321052B (zh) * 2011-05-26 2013-08-21 天津市尖峰天然产物研究开发有限公司 综合利用海带提取纯化岩藻黄质和岩藻聚糖硫酸酯的方法
EP2734213B1 (en) * 2011-07-19 2018-06-06 Baxalta GmbH Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides
US20140186456A1 (en) * 2011-08-25 2014-07-03 Lillian M. Day Tripartite Bioactive Composition Providing Anti-Oxidant and Anti-Inflammatory Effects with Immune System and Stem Cell Production Enhancement
CN102417549B (zh) * 2011-11-07 2013-07-24 沈阳科思高科技有限公司 一种基于微波化学的褐藻活性多糖的提取方法
WO2013074801A1 (en) 2011-11-18 2013-05-23 Stemtech International, Inc. Use of foti to enhance stem cell mobilization and proliferation
BR112014022435B1 (pt) 2012-03-21 2023-02-14 Takeda Pharmaceutical Company Limited Inibidores de tfpi e métodos de uso
CA2881785A1 (en) * 2012-08-14 2014-02-20 Baxter International Inc. Methods and systems for screening compositions comprising non-anticoagulant sulfated polysaccharides
RU2686088C2 (ru) * 2013-01-25 2019-04-24 Маринова Пти Лтд Способ обработки экстракта из морских водорослей, экстракт, фармацевтическая композиция, биоматериал, способ лечения, применение экстракта и композиции
CN104698159B (zh) * 2015-03-10 2017-03-08 中国科学院苏州生物医学工程技术研究所 一种内毒素含量的检测方法
CN113082349B (zh) 2016-06-27 2023-07-28 武田药品工业株式会社 注射器稳定装置
KR101721998B1 (ko) * 2016-08-16 2017-03-31 (주)한국바이오엔지니어링 이미, 이취, 및 염분 제거를 위한 반용매 정제기술이 적용된 후코이단 제조 방법
KR101866906B1 (ko) * 2017-04-05 2018-06-12 한남대학교 산학협력단 후코이단의 추출방법
CN108641008B (zh) * 2018-05-11 2020-07-24 大连工业大学 裙带菜孢子叶提取岩藻聚糖硫酸酯及脱除重金属的方法
US12186334B2 (en) 2018-07-27 2025-01-07 ARC Medical Inc. High-molecular-weight fucans for treating fibrous adhesions and other diseases and conditions
MX2021000864A (es) * 2018-07-27 2021-03-26 Arc Medical Devices Inc Fucanos altos en sulfato para el tratamiento de adhesiones fibrosas.
CN109134680B (zh) * 2018-09-10 2021-03-09 深圳华创生物医药科技有限公司 一种褐藻糖胶的提取和纯化方法及其应用
GB2579600B (en) 2018-12-05 2023-07-05 Byotrol Plc Anti-viral composition
AU2020230466B2 (en) 2019-03-05 2021-05-13 Arc Medical Devices Inc. Systems and methods for tangential flow filtration of viscous compositions
RU2717672C1 (ru) * 2019-04-05 2020-03-25 Гордейчук Владимир Евгеньевич Способ стимуляции клеток иммунной системы человека
SE1950885A1 (en) 2019-07-11 2021-01-12 Faelker Knut Treatment of patients under antiplatelet medication experiencing acute bleeding complications during/after surgery
KR102309085B1 (ko) 2019-12-13 2021-10-08 한국프라임제약주식회사 비소가 저감된 해조류 추출물 및 이의 제조방법
EP3932411A1 (en) * 2020-06-30 2022-01-05 GSK Consumer Healthcare SARL Antiviral pharmaceutical composition
CN112062871B (zh) * 2020-10-14 2022-06-28 福州海王福药制药有限公司 一种红藻多糖的制备方法
JP7770121B2 (ja) * 2021-06-30 2025-11-14 ポーラ化成工業株式会社 ヒアルロン酸受容体発現促進剤、これを含む皮膚外用剤並びに高分子ヒアルロン酸の保持効率向上方法
EP4490042A4 (en) 2022-03-08 2026-03-04 Equashield Medical Ltd FLUID TRANSFER STATION IN A ROBOTIC PHARMACEUTICAL PREPARATION SYSTEM
CN115386013B (zh) * 2022-04-19 2023-05-12 广西中医药大学 一种具有强效抗凝活性的海带多糖及其制备方法和应用
EP4590285A1 (en) 2022-09-21 2025-07-30 Bioatlantis Limited Phlorotannins and alpha-fucans to treat type 2 diabetes mellitus
EP4389251A1 (en) 2022-12-23 2024-06-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Means and methods to purify and/or quantify fucoidan
CN118221839A (zh) * 2023-07-10 2024-06-21 陈泽昊 一种绿藻多糖衍生物的制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1328062A (zh) * 2001-04-28 2001-12-26 武汉大学 高纯度魔芋葡甘聚糖的提取工艺
CN1344565A (zh) * 2001-10-19 2002-04-17 汤洁 岩藻多糖酯作为抗病毒及免疫调节剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2097279B (en) * 1981-04-27 1984-08-01 Health Lab Service Board Affinity chromatography in presence of metal ions
JPS6157520A (ja) * 1984-08-29 1986-03-24 Kibun Food Chemiphar:Kk フコイダン純度の高い溶液又は、フコイダンの製造方法
JP3714426B2 (ja) 1994-02-01 2005-11-09 株式会社糖鎖工学研究所 フコイダンオリゴ糖組成物含有癌転移抑制剤
AU720004B2 (en) 1996-01-26 2000-05-18 Research Institute For Glycotechnology Apoptosis inducers
JP3371124B2 (ja) * 1996-12-24 2003-01-27 正邦 田幸 養殖オキナワモズクを原料とするアセチルフコイダンおよ びそれの製造法
JPH10195106A (ja) * 1997-01-13 1998-07-28 Masakuni Tako 養殖イトモズクからの純度の高いフコイダンの製造法
JP4347950B2 (ja) * 1999-06-14 2009-10-21 株式会社ヤクルト本社 高純度フコイダンおよびその製造方法
US20030039670A1 (en) * 1999-11-30 2003-02-27 Shigetoshi Mizutani Cosmetics
JPWO2002022140A1 (ja) * 2000-09-13 2004-03-04 タカラバイオ株式会社 恒常性維持剤
JP3676682B2 (ja) * 2001-01-26 2005-07-27 株式会社スペース商事 フコイダン含有抽出物の簡易な製造方法
JP4768142B2 (ja) 2001-03-08 2011-09-07 協同乳業株式会社 フコイダンの簡易製造方法
JP2003155244A (ja) * 2002-09-13 2003-05-27 Kyodo Milk Industry Co Ltd モズク由来のフコイダンを含む食品
CN1229393C (zh) * 2003-01-02 2005-11-30 合肥学院 酶法制备低分子量岩藻多糖工艺
EP2165711B1 (en) * 2004-05-27 2014-05-21 Baxter International Inc. Methods for treating bleeding disorders using sulfated polysaccharides
WO2006019804A2 (en) * 2004-07-14 2006-02-23 Wyeth Compositions and methods of purifying myelin-associated glycoprotein (mag)
JP5679663B2 (ja) * 2007-02-23 2015-03-04 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 海藻抽出物からのフコイダン精製のためのプロセスの方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1328062A (zh) * 2001-04-28 2001-12-26 武汉大学 高纯度魔芋葡甘聚糖的提取工艺
CN1344565A (zh) * 2001-10-19 2002-04-17 汤洁 岩藻多糖酯作为抗病毒及免疫调节剂及其制备方法

Also Published As

Publication number Publication date
EP2121767A1 (en) 2009-11-25
KR101486931B1 (ko) 2015-01-27
EP2532686B1 (en) 2018-05-16
HK1135120A1 (en) 2010-05-28
EP2532686A1 (en) 2012-12-12
CN102911281B (zh) 2015-04-15
US8748595B2 (en) 2014-06-10
WO2008103234A1 (en) 2008-08-28
US9234051B2 (en) 2016-01-12
EP3409694A1 (en) 2018-12-05
ES2683948T3 (es) 2018-09-28
KR20090127142A (ko) 2009-12-09
ES2476250T3 (es) 2014-07-14
US20140328827A1 (en) 2014-11-06
CN102911281A (zh) 2013-02-06
US20100144667A1 (en) 2010-06-10
JP5679663B2 (ja) 2015-03-04
EP2121767B1 (en) 2014-04-09
JP2010519383A (ja) 2010-06-03
CN101663326A (zh) 2010-03-03

Similar Documents

Publication Publication Date Title
CN102911281B (zh) 从海藻提取物中纯化岩藻依聚糖的工艺方法
CA2567495C (en) Methods for treating bleeding disorders using sulfated polysaccharides
US20090098185A1 (en) Method for treating thrombotic disorders using sulfated polysaccharides
EP2734213B1 (en) Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides
HK1135120B (en) Process methods for fucoidan purification from seaweed extracts
HK40002622A (en) Resorption enhancers as additives to improve the oral formulation of non-anticoagulant sulfated polysaccharides
HK1142276B (en) Methods for treating bleeding disorders using sulfated polysaccharides
Söderström et al. Effect of active site‐inactivated factor viia on ischaemia/reperfusion injury in a porcine flap model

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1135120

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1135120

Country of ref document: HK

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20180211

Address after: Illinois

Co-patentee after: Hundred deep limited liability company

Patentee after: Hundred deep company

Address before: Illinois State

Co-patentee before: Baxter Healthcare SA

Patentee before: Baxter International Inc.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210628

Address after: Osaka

Patentee after: TAKEDA PHARMACEUTICAL Co.,Ltd.

Address before: Illinois

Patentee before: Baishen Co.

Patentee before: BAXALTA GmbH