BR112012033548A2 - métodos e composições para melhorar a mobilização de células-tronco - Google Patents

métodos e composições para melhorar a mobilização de células-tronco

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Publication number
BR112012033548A2
BR112012033548A2 BR112012033548A BR112012033548A BR112012033548A2 BR 112012033548 A2 BR112012033548 A2 BR 112012033548A2 BR 112012033548 A BR112012033548 A BR 112012033548A BR 112012033548 A BR112012033548 A BR 112012033548A BR 112012033548 A2 BR112012033548 A2 BR 112012033548A2
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BR
Brazil
Prior art keywords
stem cell
hscs
circulation
compositions
methods
Prior art date
Application number
BR112012033548A
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English (en)
Inventor
Christian Drapeau
Gitte S Jensen
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Stemtech Int Inc
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Publication date
Application filed by Stemtech Int Inc filed Critical Stemtech Int Inc
Publication of BR112012033548A2 publication Critical patent/BR112012033548A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

métodos e composições para melhorar a mobilização de células-tronco. a presente invenção provê um método de usar fucoidano para melhorar a mobilização de células-tronco em um indivíduo, incluindo células-tronco hematopoiéticas (hscs) e células de medula óssea (bmscs). em uma forma de realização, uma composição misturada de frutas, cogumelos, microorganismos, fluidos maternais, e extratos dos mesmos são usados para promover a movimentação de células-tronco, resultando em migração de células-tronco para sítios específicos de manutenção e reparo dentro dos tecidos e/ou órgãos. em outras formas de realização, o método envolve o uso de fucoidano obtido a partir de espécies de algas particulares para ajudar a liberação e circulação de hscs, como demonstrado por um aumento significante da circulação de hscs no sangue periférico. circulação aumentada de hscs e/ou bmscs e migração para sítios de manutenção e mecanismos de regeneração natural no corpo. ainda provê-se um regime de dosagem para a administração de fuciodano e um método de melhorar a liberação e circulação de células-tronco.
BR112012033548A 2010-06-28 2011-06-28 métodos e composições para melhorar a mobilização de células-tronco BR112012033548A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35928810P 2010-06-28 2010-06-28
US201061427023P 2010-12-23 2010-12-23
PCT/US2011/042211 WO2012006100A2 (en) 2010-06-28 2011-06-28 Methods and compositions for enhancing stem cell mobilization

Publications (1)

Publication Number Publication Date
BR112012033548A2 true BR112012033548A2 (pt) 2017-06-20

Family

ID=45441732

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012033548A BR112012033548A2 (pt) 2010-06-28 2011-06-28 métodos e composições para melhorar a mobilização de células-tronco

Country Status (10)

Country Link
US (1) US10159705B2 (pt)
EP (2) EP2588119A4 (pt)
JP (2) JP2013531012A (pt)
KR (1) KR20140011295A (pt)
AU (1) AU2011276479B2 (pt)
BR (1) BR112012033548A2 (pt)
MX (1) MX344304B (pt)
MY (1) MY170013A (pt)
WO (1) WO2012006100A2 (pt)
ZA (1) ZA201300101B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX344304B (es) 2010-06-28 2016-12-13 Stemtech Int Inc Metodos y composiciones para mejorar la movilizacion de celulas madre.
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
EP2779834A4 (en) 2011-11-18 2015-07-08 Stemtech International Inc USE OF FO-TI TO IMPROVE MOBILIZATION AND PROLIFERATION OF STEM CELLS
WO2013169355A1 (en) 2012-05-09 2013-11-14 Paringenix, Inc. Treatment of myelosuppression
JP6050033B2 (ja) * 2012-06-05 2016-12-21 日本メナード化粧品株式会社 幹細胞から外胚葉系細胞への分化誘導剤
EP2872623A4 (en) * 2012-07-11 2016-08-10 Stemtech International Inc COMPOSITIONS AND METHODS FOR INCREASING THE MOBILIZATION AND PROLIFERATION OF BLASTOMIC STEM CELLS
EP2929013B1 (en) 2012-12-06 2020-02-05 Stembios Technologies, Inc. Lgr5+ somatic stem cells
EP2746770A1 (en) * 2012-12-21 2014-06-25 Stembios Technologies, Inc. Method for evaluating effect of action on subject based on stem celldynamics
WO2014205250A1 (en) * 2013-06-19 2014-12-24 Stemtech International, Inc. Methods and compositions for enhancing stem cell mobilization
TWI640884B (zh) * 2013-06-24 2018-11-11 幹細胞生物科技公司 獲得幹細胞及其資料的方法
US20150141901A1 (en) * 2013-11-08 2015-05-21 Alan S. Lichtbroun Low-level laser irradiation of stimulated human stem cells
US20160243168A1 (en) * 2015-02-17 2016-08-25 Cantex Pharmaceuticals, Inc. Adoptive cell transfer methods
US10052346B2 (en) 2015-02-17 2018-08-21 Cantex Pharmaceuticals, Inc. Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids
CN109432028A (zh) * 2018-11-30 2019-03-08 广东乾禾药用植物发展有限公司 一种猴头菌胃漂浮片的制备方法
JP7205880B2 (ja) * 2018-12-13 2023-01-17 日本メナード化粧品株式会社 メラノサイト分化誘導促進剤及びその使用方法
CN112806569A (zh) * 2021-01-20 2021-05-18 中科优术(黑龙江)科技产业有限公司 一种具有保护胃黏膜和抗幽门螺杆菌功能的组合物的制备方法与应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2878597B2 (ja) 1994-04-15 1999-04-05 惇 額田 養毛剤
US6814961B1 (en) 2001-05-14 2004-11-09 Gitte S. Jensen Method for enhancing stem cell trafficking
CN1827766B (zh) 2001-06-28 2010-08-25 徐荣祥 体外细胞的培养方法
JP2003135028A (ja) 2001-07-27 2003-05-13 Social Excellent Community Kk 健康機能食品
JP3721432B2 (ja) 2002-03-12 2005-11-30 株式会社コムス 海藻を原料とする飲料用食品の製造方法
US20050042314A1 (en) 2003-08-22 2005-02-24 National Yang-Ming University Extracts of Polygonum multiflorum Thunb., and preparation process and uses of the same
US20070122492A1 (en) 2004-11-18 2007-05-31 Stephen Behr Plant extracts and dermatological uses thereof
US20060068022A1 (en) 2004-09-29 2006-03-30 Playford Raymond J Bioactive agent compositions for repair of cell injuries
US20070020358A1 (en) * 2005-03-18 2007-01-25 Mower Thomas E Sports drink concentrate
CN101163415B (zh) * 2005-04-21 2013-03-13 N.V.努特里奇亚 用于hiv患者的营养补充剂
US20080085330A1 (en) * 2005-05-02 2008-04-10 Cyndy Davis Sanberg Compounds for stimulating stem cell proliferation including spirulina
US20070003669A1 (en) * 2005-06-02 2007-01-04 Troy Kearl Fucoidan delivery system
JP4839021B2 (ja) * 2005-06-10 2011-12-14 国立大学法人 岡山大学 白血球及び／又は造血幹・前駆細胞動員剤
BRPI0612672B8 (pt) 2005-06-24 2021-05-25 Cerule Llc composição de extrato aquoso de alga verde-azulada
CA2640087A1 (en) 2006-01-25 2007-08-02 Mount Sinai School Of Medicine Methods and compositions for modulating the mobilization of stem cells
US20080089941A1 (en) * 2006-06-01 2008-04-17 Mower Thomas E Fucoidan compositions and methods
KR20080007698A (ko) 2006-07-18 2008-01-23 전홍일 푸코이단을 포함하는 산후 조리용 식품 조성물
US20080247989A1 (en) 2006-09-21 2008-10-09 Daniel Tzu-Bi Shih Reishi - Mediated Enhancement of Human Tissue Progenitor Cell Adhesion and Differentiation
EP2121767B1 (en) * 2007-02-23 2014-04-09 Baxter International Inc. Process methods for fucoidan purification from seaweed extracts
HUP0700594A2 (en) * 2007-09-13 2009-04-28 Laszlo Szabo Composition and process for the protection and increasing the number of stem cells in the blood circulation and for enhancing p53 gene expression
CN101433313B (zh) * 2007-11-13 2012-05-30 蒋爱芳 一种具有抗辐射功能的保健食品
JP5186253B2 (ja) 2008-03-14 2013-04-17 第一薬品工業株式会社 抗ウイルス活性強化組成物
KR20090099374A (ko) * 2008-03-17 2009-09-22 김명숙 후코이단을 보강한 미역추출물 및 그 제조방법
US8871492B2 (en) * 2008-05-02 2014-10-28 Masaki Shirota Anti-dementia substance from Hericium erinaceum and method of extraction
US20100173024A1 (en) 2008-12-01 2010-07-08 LifeSpan Extension, LLC Methods and compositions for altering health, wellbeing, and lifespan
TW201041586A (en) * 2009-05-22 2010-12-01 Du Peng Medicine and its preparation method for treating Parkinson's disease
US20110287061A1 (en) 2010-05-20 2011-11-24 Cathy Beggan Dietary composition and method for promoting healthy hair growth and melanogenesis
MX344304B (es) 2010-06-28 2016-12-13 Stemtech Int Inc Metodos y composiciones para mejorar la movilizacion de celulas madre.
CN103561754A (zh) 2011-03-28 2014-02-05 玫琳凯有限公司 包含植物提取物的局部护肤制剂
MY171285A (en) 2011-08-05 2019-10-07 Stemtech Int Inc Skin care compositions containing combinations of natural ingredients
EP2779834A4 (en) 2011-11-18 2015-07-08 Stemtech International Inc USE OF FO-TI TO IMPROVE MOBILIZATION AND PROLIFERATION OF STEM CELLS
US20140363379A1 (en) 2011-12-29 2014-12-11 Entia Biosciences, Inc. Nutritional approach to the use of ergothioneine and vitamin d2 for hair, nail and skin growth
EP2872623A4 (en) 2012-07-11 2016-08-10 Stemtech International Inc COMPOSITIONS AND METHODS FOR INCREASING THE MOBILIZATION AND PROLIFERATION OF BLASTOMIC STEM CELLS
WO2014205250A1 (en) 2013-06-19 2014-12-24 Stemtech International, Inc. Methods and compositions for enhancing stem cell mobilization

Also Published As

Publication number Publication date
WO2012006100A3 (en) 2012-03-15
MX344304B (es) 2016-12-13
US10159705B2 (en) 2018-12-25
MX2012015063A (es) 2013-04-03
MY170013A (en) 2019-06-20
EP2588119A2 (en) 2013-05-08
EP2588119A4 (en) 2014-01-08
WO2012006100A2 (en) 2012-01-12
ZA201300101B (en) 2014-03-26
EP3153173A1 (en) 2017-04-12
US20130108587A1 (en) 2013-05-02
AU2011276479B2 (en) 2015-06-25
JP2013531012A (ja) 2013-08-01
KR20140011295A (ko) 2014-01-28
AU2011276479A1 (en) 2013-01-17
JP2016153430A (ja) 2016-08-25

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