201041586 六、發明說明： . 【發明所屬之技術領域】 尤指一種治療帕金 .. 本發明是揭示一種中藥製劑領域 森氏病的藥物及其製備方法。 【先前技術】201041586 VI. Description of the invention: [Technical field to which the invention pertains] In particular, the invention relates to a treatment of Parkin. The invention discloses a medicament for the treatment of Senis disease in the field of traditional Chinese medicine preparations and a preparation method thereof. [Prior Art]
帕金森氏病又稱為震顫麻缚，是一種影響患者活動能 力的中樞神經系統慢性疾病，多發生於中老年以上的人 群，也是四大常㈣神轉贿疾叙―，本病早期主要 表現包括靜止性震顫、肌強直、行動缓慢、動作起動困難 和姿勢異”。靜止性震_患者料或料受控制地發 抖，在休息時出現或情緒緊張時力1 ;其他早雛狀包括 開始活動時感到困難’其後雙臂和雙腿經常震顫，上肢不 能作精細動作’乃致日常生活不能自理，如穿衣、脫鞋、 洗漱都感咖難。運動遲緩、肌強直、姿勢障礙是病情主 要症狀。因㈣金森氏病常伴有抑#、焦慮、肢體酸痛不 適、便秘、多卜流诞等。帕金森氏病的病情因人而異， 剛開始可^有身體某—邊（左側或右侧）受到影響，不 久後，身體兩側都會出現症狀一般而言，病情會隨著時 間的推移而有所改變，不同時期會有不同的症狀出現，而 且病情會越來越嚴重。普遍認為多_素參於其中，遺傳 口素可使〜紐增加，遺傳时與環境目素及衰老等 因素的=相下’通職體代謝異f、細劇亡加快、 免疫異常等機制導致黑質多巴胺功能神經元病變，而從診 201041586 斷檢測發絲看，除了肢體病症外，帕金森氏患者的腦細 胞中普遍缺乏多巴胺，一些研究證明，是因為患者腦内參 與夕巴胺代謝的—些酶過多，導致多巴胺代謝失衡，濃度 減少。人們發現單胺氧化酶在多巴胺代謝過程中起重要作 用’單胺氧化酶在生物體内普遍存在，但當表達這種酶的 基因由於受到外界有毒物質（比如過氧化紹中毒）的誘導 ^者内部代謝失調的信號指導，這種酶將過量表達，結果 是使細胞内本來正常的多巴胺濃度急劇降低，將多巴胺分 解為高香草酸，同時伴有自由基生成，對神經細胞產生毒 性作用，並能活化i-甲基_4苯基i，2，3，6_四氣。比咬 methy 4-phenyl-1 > 2 » 3 > 6-tetrahydropyridine ； MPTP) ’而MPTP是：種能誘導帕金森的化學物質，因此抑 J蛋白酶單胺氧化酶（副_B)的活性’可以阻斷多巴胺的降 解’減少氧自由基的生成’同時阻斷MPTP轉化為1-甲基 從而抑制多巴胺氧化代謝過程中產 生的過氧化物’延緩黑質細胞死亡的過程，延緩帕金森氏 病的進程。同時由於抑制了多巴胺的降解，增加了腦内多 巴胺的'農度’具有改善帕金錢病症狀的作用。 胺，，於治療帕金森氏病，普遍偏重於對腦細胞補充多巴 妒付:。由於《有清除患者自身存在的身體組織或者細胞機 產生^傷日此必然導致患者對藥物的依賴，以及對藥物 用"I年來的研究所發現的單胺氧化酶抑制劑的作 近了 療帕金森氏病有了更深―層的進步，離病原更 步，並且人們發現紅麴中富含有單胺氧化酶抑制 201041586 劑，因此以紅麴的主要成分的藥物在市場上出現，雖然能 夠緩解症狀，並延緩病情的發展速度，但仍然沒有從根本 上清除患者的病因，中醫認為，本病主要病變臟腑在腎、 脾、肝三臟。因“腎主骨，生髓，上榮於腦，，，腎虛則腦 髓不足，反應遲鈍，動作徐緩；“脾主肌肉，，，為氣血生 化之源，脾虛則氣血虧乏，肌肉失養，加之脾虛運化水濕 停蓄，浸潰肌理，導致肌肉痙攣而失其柔韌。同時，口^ 多、生流延、痰多啥咳等，都是脾胃虛弱、痰濕内盛的表現； 腎精不足’氣血減，不能涵養肝木，致虛風内動，震顏 由是而生。中醫認為腎虧脾虛是發病的關鍵，痰陰、水濕^ 敲停蓄是使病情加重的因素。治療本病，應立足於；;滋 腎補腦 '健脾益氣、燥濕化痰、緩肝熄風，，。痰齋同源'， =血齋徵象者，應佐以活血储。本病難以速癒，病程較 Ο :含=緩治，兼以調理情志。因此目前有藥物雖然利 3、早胺軋化酶抑制劑的紅麴，快速緩解了患者的疒 :並且也與—些具有祛瘀止痛，活血通經，祛風'燥二 / H養血作用財H配合制，但健只是從 ^解帕金森氏病患者的痛苦，難以治癒，究其原因，本 :亂病=雜，尤其是内臟器官代謝方面的 力㈣退、免疫力降低等問題嚴重。目前的藥物藥 八軍―楚且關成分方式上存在利用效率低，提取成 題，因此即使有些藥物本身有效，在不適合的 衣傷方式下也難以發揮作用。 的 對於提高患者免疫力，組織修復能力方面，中藥資源 201041586 豐虽。研究則’越草分泌的多_物質在提高人體免疫 力、抗癌、延緩衰老方面有崎的作用，帕金森氏病的發 展與患者衰麵程及频免疫、清理、修麟力密切相關， 但蛹蟲草資源稀少，使得包含确蟲草的藥物價格一直居高 不下’且由於該藥昂貴，開採利益巨大，造成的過度開採， 嚴重破壞環境和生態失衡，因此如何人X獲制蟲草的有 效藥用多聰是研究者—直關注的問題。 【發明内容】 蓺^發明提供一種治療帕金森氏病的藥物及其製備工 二;=不僅能迅速緩解患者的症狀，並且從改善患者 病變器官的修復能力、提高纽力等方 :=。本發明還提供了本藥物的製備工藝，降低了 讀的原料成本，且藥效突出，副作用小。 該螺3，=森氏_藥物’包㈣蟲草的培養物， 料所採用的培4基中包含下列重量份原 :取液和占原料藥重量h5 U份、蚯着8-12份、白龙削 / 杜仲八、立岔10 知、石斛5-15伤、 份、枸杞粑1〇 12 18知 ' 牛膝5'8份、黃枝子15-25 4己根10-12知、徐長卿12_15 和夏括草8_12份。 朵寄生10-16份 重量份的原料藥為：丹參12份、糾丨幹8份、白 黃枝子：了Λ二、杜仲12份、黃κ 12份、牛膝5份、 、15伤、枸杞根!。份、徐長卿…分、桑寄讀分、 201041586 夏枯草ίο份。 該蛹蟲草為有料活 或蛹蟲草母種。触早亿于蛹触卓囷絲、 該蜎蟲草也可以是 蟲草母種的混合物。 $早亿？虫甬蟲卓囷絲與踊 t:施例中該補蟲草優選為蛹蟲草母種。 包含本發明的藥物製成之藥劑。 Ο Ο 蟲草病的藥物的製備方法：其特徵是蜗 蟲草在上相養基中進行深層發酵。 該發酵步驟為： 原料藥與飲用水以lg:25_40ml體積比 浸泡6小時。 牡吊/皿 在浸泡液中加入原料藥重量的15__紅趨米酒;混 句後裳入發酵罐’常壓下水蒸1小時，冷卻至38 -42。(：， 過渡，棄渣。 再對/文出液滅菌2小時，浸出液冷卻至26。〇。 在發酵罐中注入蛹蟲草母種，深層發酵。 該發酵罐為中國專利號ZL〇327〇56〇. 3，名稱為“食用 菌液體菌種培養罐的罐蓋及培養罐”的實賴型專利中記 載的發酵罐。 該蛹蟲草母種的注入採用中國專利號 ZL200320126960.X，名稱為“食用菌液體注射桿及包含該 注射桿的注射器，，的實用新型專利中記載的注射器。 本發明獲得的藥物，主要以紅麴米酒以及12味原料 201041586 出二的，合液為培養基_蟲 中的早胺氧化酶抑制_物質 快速緩解帕金森患者 卩…巴_分解代謝 有消除病㈣翻，本發_ ^了、是提供_症狀而沒 草發酵後，協同改善患者组;丨2味樂物經過與蛹蟲 及腑臟器官的機能，二# ' 田胞修復能力、免疫力以 病因。本藥物中，在蛹蟲草；；==極應對帕金森氏病 ===麵中含有的化學成分繼森氏症狀的缓解 s ’彻红鮮财的喃物»促進斥料華 二:胞的分解’使藥用成分充分提取出來=樂 起刭田 料’、、工麴米酒中乙醇對原料藥材 起到卒取的作用，使藥用成分快速釋放到液體中來，縮短 I原料藥浸泡_，避免浸泡時間過長帶來的浸泡液徽變 1Ϊ。財種補藥的浸泡液為培養基對蛹蟲草母種發酵 製得本藥物’本祕巾__組成是根射醫對帕金森 氏病的診斷經购人而來，中㈣為，本病主要病變臟腑 在腎脾、肝二臟。腎齡脾虛是發病的關鍵，疫陰、水濕、 齋血停蓄是使病情加㈣因素。本藥物中蛹蟲草的代謝產 物**草I、蟲草素、蟲草多醣和超氧化物歧化酶 (Super0Xide Dismutase;s〇D)具有顯著地降低顱壓，因而 使腦溢血和腦血栓病症得到緩解的作用，還具有促進機體 新陳代謝，延緩機體衰老退化的作用，其自身細胞富含的 硒（Se)元素能全面提高患者身體免疫機能和細胞膜修復功 月b，旎夠使患者在緩解了症狀的情況下，逐漸提高身體組 201041586 ，織的修復免疫能力，主動參與對帕金森氏病的防紫。本藥 ’物針對病原器官的功能衰退，在原料藥中包括具有強健心 - 肌、活血通經功效的丹參、徐長卿、地龍，主治患者氣血 ， _、血管不通，改善患者身體的代謝和迴關能，同時 配以益脾姆的成分··石斛、料、地f、純、桑寄生、 牛膝，從防治腎_虛，有效地抑制病情發展，加強身體 自身修復和代謝能力從而提高免疫力，有效地改善因腎2 〇 ;丨起的職不足、反應遲鈍、動作徐緩症狀，同時益脾: 改善患者氣血齡乏，達到提高身體的健康程度，掌固身體 的抗病能力的作用。本藥射的原㈣同時還包括具有保 濩肝臟、盈血養脈、強筋骨作用的桑寄生、夏枯草兩味藥 從，月肝火’行肝氣、滋養血脈方面提高患者身體對自身代 謝產生的損害物和㈣毒素的代謝能力，使致病因素減· ^ ’同時滋養血管使全身血管通透強勁，大腦必需的物質 旎順暢地到達各組織細胞。本發明中的多味藥同時具備補 0 腎、養肝、益脾的作用，各司其職又捕相成地對帕金森 氏病患者的各種症狀所來源的臟腑發生藥效，從根本上施 化，其中幾味藥同時具有解痙鎮顫作用如：白芷、地龍缓 解患者四肢痙直的症狀。 本藥物的製備需要通過蛹蟲草發酵過程，一方面在發 酵過程中’蛹鱗將原料藥浸出液中無_活性的營養^ 分轉化成自身有機代謝產物，成倍提高蛹蟲草的蟲草酸、 蟲草素等多醣的含量，充分利用了原料藥，同時有研究證 明，通過發酵獲得的蟲草酸、蟲草素的藥用效率高於直接 201041586 =π。究其原因是’發酵過程使有效成分得以 他及料成分被轉化代謝掉。並使餘下的其 有成分更純；另外微生物發酵過程中具有 成分的能力’能分解原料藥中的毒咖 成刀擴大了本樂物的適應症。 蟲草二因此本發明所指的竭蟲草為确 草二===^_物質與曝 二藥物，對帕金森氏病有快速療效的同時 二有的1工_酒中的單胺氧化酶抑制劑類 n制帕盈林氏患者腦内多巴胺過快的分解代謝，同 二3 患者症狀，而是在緩解 狀而>又有消除病根的同時採用多味中藥協同作用，製備時 7通^中藥材中加入紅麴米酒進行浸泡使各味藥的有效成 刀π全提取出來’從而發揮最大的藥效，從根本上改善患 者神經細胞修復能力，恢復正常的代謝，提高患者的肝腎 2、心血管功能，激發患者自身的細胞對單胺氧化酶等 =的免疫能力，從而避免了患者對於速效藥物成分的依 明顯從發病症狀與根源上雙管齊下，因此，治癒效果非常 〜本發明的各原·的用量經發明人進行大量摸索總 結传到’各原料藥在下列重量份範圍内都具有較好的療 201041586 效：丹參12-15份、蚯蚓幹8~12份、白芷10—12份、石斛 5-15份、杜仲10-15份、黃芪12-18份、牛膝5-8份、黃 枝15-25份、枸杞根{地骨皮} 10-12份、徐長卿12-15份、 桑寄生10-16份和夏枯草8-12份，占上述原料藥重量 1· 5%-5%的紅麴米酒。Parkinson's disease, also known as tremor and numbness, is a central nervous system chronic disease that affects the patient's ability to move. It occurs mostly in middle-aged and older people. It is also the four major (four) gods who turn bribes. Including static tremor, muscle rigidity, slow movement, difficulty in starting movement and posture difference. Static _ _ patient material or material trembling controlled, at rest or when the mood is tense; other early gestation including starting activities I feel very difficult. 'There are often tremors in my arms and legs, and my upper limbs can't make fine movements'. I can't take care of myself in daily life. For example, dressing, taking off shoes, and washing are all difficult. Slow exercise, muscle rigidity, and posture disorder are conditions. The main symptoms. Because (4) Jinsen's disease is often accompanied by depression #, anxiety, limb soreness, constipation, Du Buliu birthday, etc. The condition of Parkinson's disease varies from person to person, at the beginning can have a certain body side (left side Or the right side is affected, and soon after, there will be symptoms on both sides of the body. Generally speaking, the condition will change with the passage of time, and different symptoms will appear at different times. Moreover, the condition will become more and more serious. It is generally believed that more _ 素 is involved in it, the genetic mouth can increase ~ 纽, the genetics and environmental factors and aging and other factors = the same as the whole body metabolism, f, drama Mechanisms such as accelerated death and immune abnormalities lead to dopaminergic neuronal disease in the substantia nigra, and in addition to limb disorders, in addition to limb disorders, Parkinson's brain cells are generally deficient in dopamine. Some studies have shown that patients are Intracerebral involvement in glutamine metabolism - excessive enzymes, leading to imbalance of dopamine metabolism, decreased concentration. It has been found that monoamine oxidase plays an important role in the metabolism of dopamine 'monoamine oxidase is ubiquitous in organisms, but when the gene expressing this enzyme is due to It is guided by the signal of the internal metabolic disorder of the toxic substances (such as oxidized poisoning), which is overexpressed. As a result, the normal dopamine concentration in the cells is drastically reduced, and the dopamine is decomposed into high vanillic acid. Simultaneous with free radical formation, toxic to nerve cells, and can activate i-methyl _4 Base i, 2, 3, 6_ four gas. Bite methy 4-phenyl-1 > 2 » 3 >6-tetrahydropyridine; MPTP) 'And MPTP is: a species that can induce Parkinson's chemicals, so J The activity of protease monoamine oxidase (sub-B) can block the degradation of dopamine 'reducing the production of oxygen free radicals' while blocking the conversion of MPTP to 1-methyl group to inhibit the peroxide produced by dopamine oxidative metabolism. The process of cell death delays the progression of Parkinson's disease. At the same time, the inhibition of dopamine degradation increases the 'agronomic degree' of dopamine in the brain and improves the symptoms of P. monetary disease. Amine, in the treatment of Parkinson's disease, It is generally more important to supplement the brain cells with Dopa: because there is a body tissue or cell machine that eliminates the patient's own existence, which will inevitably lead to the patient's dependence on the drug, as well as the drug used in the "I year" research institute. The discovery of monoamine oxidase inhibitors has resulted in a deeper-layered progression of Parkinson's disease, which is more advanced from the pathogen, and it has been found that red peony is rich in monoamine oxidase inhibition 20104158 6 doses, so the main ingredient of the red peony drug appeared on the market, although it can alleviate the symptoms and delay the development of the disease, but still does not fundamentally remove the cause of the patient, Chinese medicine believes that the main disease of the disease is in the kidney The spleen and liver are three dirty. Because of "the kidney main bone, the marrow, the upper glory in the brain,, the kidney deficiency is the brain lack, the reaction is slow, the movement is slow; "the spleen muscle,,, is the source of qi and blood biochemistry, spleen deficiency is qi and blood deficiency, muscle Loss of nurturing, combined with spleen and phlegm, water and wet storage, impregnation of the texture, leading to muscle spasm and loss of flexibility. At the same time, mouth ^ more, birth cast, phlegm and cough, etc., are the manifestations of spleen and stomach weakness, phlegm and dampness; lack of kidney essence 'qi and blood reduction, can not conserve liver wood, causing virtual wind movement, shock face by It is born. Chinese medicine believes that kidney deficiency and spleen deficiency are the key to the onset of the disease. The sputum yin and water wetness are the factors that make the condition worse. Treatment of this disease should be based on;; nourishing kidney and nourishing the brain, spleen and qi, dampness and phlegm, slowing the liver and extinguishing the wind.痰斋同同', = blood zhai murderer, should be accompanied by activating blood storage. The disease is difficult to heal, the course of the disease is more ambiguous: containing = slow treatment, combined with conditioning emotions. Therefore, there are currently drugs, although the 3, the early amine rolling enzyme inhibitor of red mites, quickly relieved the patient's phlegm: and also with some phlegm and pain, blood circulation, hurricane 'dry two / H nourishing effect Financial H system, but Jian is only from the pain of patients with Parkinson's disease, it is difficult to cure, the reason, this: chaotic disease = miscellaneous, especially the metabolism of internal organs (four) retreat, reduced immunity and other issues serious. The current drug-drugs of the Eighth Army-Chuheguan component have low utilization efficiency and are extracted into problems. Therefore, even if some drugs are effective, it is difficult to play a role in unsuitable clothing injuries. For improving patient immunity and tissue repair ability, Chinese medicine resources 201041586 Feng. The research is that the more substances secreted by the grass have a role in improving human immunity, anti-cancer and anti-aging. The development of Parkinson's disease is closely related to the patient's face-down and frequency immunity, cleanup and repairing. However, the scarce resources of Cordyceps sinensis make the price of the drug containing Cordyceps sinensis always high. And because the drug is expensive, the mining interests are huge, the over-exploitation is caused, the environment and ecological imbalance are seriously damaged, so how to get the effective drug of Cordyceps Using Duo Cong is a researcher – a matter of direct concern. SUMMARY OF THE INVENTION The invention provides a medicine for treating Parkinson's disease and a preparation thereof; 2; not only can quickly relieve the symptoms of the patient, but also improve the repairing ability of the patient's diseased organs, and improve the force and the like: The invention also provides a preparation process of the medicine, reduces the raw material cost of reading, and has outstanding medicine effect and small side effects. The snail 3, = Sens _ drug 'package (four) Cordyceps culture, the material used in the culture of the base contains the following parts by weight: take the liquid and account for the weight of the drug substance h5 U, squat 8-12, white龙削/杜仲八,立岔10 知,石斛5-15伤,份,枸杞粑1〇12 18知' Achyranthes 5'8 parts, Huangzhizi 15-25 4Hanggen 10-12 Zhi, Xu Changqing 12_15 and Summer grass 8_12 copies. The parasitic 10-16 parts by weight of the raw materials are: 12 parts of Salvia miltiorrhiza, 8 parts of sorghum, and white yellow branches: Λ2, eucommia 12, yellow κ 12, achyranthes 5, 15 wounds, 枸杞root!. Share, Xu Changqing... points, mulberry sent reading points, 201041586 Prunella ίο. The Cordyceps militaris is a live or Cordyceps species. It is also possible to use a mixture of Cordyceps sinensis. $早亿? Insect mites and cockroaches t: In the example, the Cordyceps militaris is preferably a genus of Cordyceps militaris. An agent made of the drug of the present invention is contained. Ο 制备 Preparation method of Cordyceps drug: It is characterized by deep fermentation of Coprinus comatus in the upper phase. The fermentation step is: the raw material medicine and the drinking water are soaked for 6 hours in a volume ratio of lg:25_40 ml. The squid/dish is added to the soaking liquid by adding 15__ red rice wine with the weight of the raw material; after mixing, it is poured into the fermenter and steamed under normal pressure for 1 hour, and cooled to 38-42. (:, transition, discard the slag. Then sterilize / literate for 2 hours, and leaching the solution to 26. 〇. Inject the cordyceps mother seed in the fermenter and deep-ferment. The fermenter is Chinese patent number ZL〇327〇56 〇. 3, the fermenter described in the patent entitled "Canned lid and culture tank of edible fungus liquid culture culture tank". The injection of the Cordyceps militaris parent species is based on the Chinese patent number ZL200320126960.X, entitled " The syringe of the utility model patent of the edible mushroom liquid injection rod and the syringe containing the injection rod. The medicine obtained by the invention mainly uses the red glutinous rice wine and the 12-flavored raw material 201041586, and the liquid mixture is the medium _ worm Early amine oxidase inhibition _ substance rapid relief of Parkinson's patients 卩 ... bar _ catabolism has elimination disease (four) turn, the hair _ ^, is to provide _ symptoms and no grass fermentation, synergistic improvement of the patient group; 丨 2 taste music The function of the object and the mites and sputum organs, the second # ' field cell repair ability, immunity to cause. In this drug, in Cordyceps sinensis;; == extremely response to Parkinson's disease === chemistry contained in the face Inheritance The mitigation of 'the red and fresh foods» promotes the smear of Hua 2: the decomposition of the cells 'to make the medicinal ingredients fully extracted = Leqi 刭田料', and the glutinous rice wine in the ethanol to the raw materials to fight The role of the rapid release of medicinal ingredients into the liquid, shortening the I raw material soaking _, avoiding the soaking liquid emblem caused by too long soaking time change. The soaking liquid of the financial supplement is used as the medium to ferment the Cordyceps militaris. The drug 'this secret towel __ composition is the root of the doctor for the diagnosis of Parkinson's disease, the middle (four), the main pathological disease of the disease in the kidney spleen, liver two organs. Kidney age spleen is the disease The key, vaccination, water and dampness, and blood stasis are the factors that make the disease add (4). Metabolites of Cordyceps militaris in this drug ** grass I, cordycepin, cordyceps polysaccharide and superoxide dismutase (Super0Xide Dismutase; s〇D It has the effect of significantly reducing the intracranial pressure, thus alleviating the cerebral hemorrhage and cerebral thrombosis, and also promoting the metabolism of the body and delaying the aging of the body. The selenium (Se) element rich in its own cells can improve the body immunity of the patient. Function and fine The repair of the membrane repair function b, enough to make the patient relieve the symptoms, gradually improve the body group 201041586, the ability to repair immunity, and actively participate in the anti-purple against Parkinson's disease. The drug is directed against the pathogen organ The function declines, including Danshen, Xu Changqing, and Dilong, which have strong heart-muscle and blood circulation effects in the raw materials, and treat patients with qi and blood, _, blood vessels, improve the metabolism and recovery of the patient's body, and benefit at the same time. Ingredients of spleen m.·Dendrobium, material, ground f, pure, mulberry parasitic, achyranthes, from the prevention and treatment of kidney _ deficiency, effectively inhibit the development of the disease, strengthen the body's own repair and metabolism ability to improve immunity, effectively improve the kidney 2 〇; 丨 的 职 、 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨 丨The original (4) of this medicine also includes the mulberry parasitic and the Prunella vulgaris with the functions of protecting the liver, enriching the blood and nourishing the veins, strengthening the bones and muscles, and improving the body's metabolism to the body by the liver and the nourishing blood. The metabolic capacity of the damage and (4) toxins reduces the pathogenic factors. At the same time, the blood vessels are nourished to make the whole blood vessels transparent, and the essential substances of the brain smoothly reach the tissues of the tissues. The multi-flavor medicine of the invention has the functions of supplementing kidney, nourishing the liver and benefiting the spleen, and each of its functions has the effect of taking the viscera of various symptoms of Parkinson's disease patients, and fundamentally Shihua, in which several flavors have both antispasmodic and tremor effects such as: white peony and earthworm relieve symptoms of limb straightness in patients. The preparation of the drug requires the fermentation process of Cordyceps militaris. On the one hand, in the fermentation process, the sputum scale converts the _-free nutrient component of the raw material leaching solution into its own organic metabolite, and doubles the cordycepic acid and cordycepin of Cordyceps militaris. The content of polysaccharides makes full use of the raw materials, and studies have shown that the medicinal efficiency of cordycepic acid and cordycepin obtained by fermentation is higher than that of direct 201041586 = π. The reason is that the fermentation process allows the active ingredient to be metabolized and metabolized. And the remaining ingredients are more pure; in addition, the ability to have ingredients in the microbial fermentation process can decompose the poisonous coffee in the drug substance and expand the indications of the music. Cordyceps II Therefore, the Cordyceps militaris referred to in the present invention is a medicinal herb====^_ substance and an exposure drug, and has a rapid therapeutic effect on Parkinson's disease, while the other has a work_monoamine oxidase inhibitor in wine In the brain of patients with Pa Yinglin, the catabolism of dopamine in the brain is too fast, and the symptoms of patients in the same 2 and 3 patients are in the form of remission and > and the root of the disease is eliminated. The synergistic effect of multi-flavored traditional Chinese medicine is adopted. The red glutinous rice wine is soaked so that the effective knives of all the medicinal herbs are fully extracted, thereby maximizing the pharmacological effect, fundamentally improving the nerve cell repair ability of the patient, restoring normal metabolism, and improving the liver and kidney 2, cardiovascular function of the patient. Stimulate the patient's own cells' immunity to monoamine oxidase, etc., thereby avoiding the patient's dependence on the fast-acting drug components from the onset of symptoms and root causes. Therefore, the healing effect is very large~ the amount of each original of the present invention is performed by the inventor A large number of groping summaries have been passed to 'all raw materials in the following parts of the weight range have better treatment 201041586 effect: Danshen 12-15, dried 8-12, white 芷 10 - 12 parts, 5-15 parts of Dendrobium, 10-15 parts of Eucommia, 12-18 parts of Astragalus, 5-8 parts of Achyranthes, 15-25 parts of yellow branches, 10 roots of 枸杞根{地骨皮}, Xu Changqing 12 -15 parts, 10-16 parts of mulberry parasitic and 8-12 parts of Prunella vulgaris, accounting for 1.5% to 5% of the above-mentioned bulk drug weight of red rice wine.
優選為：丹參12份、蚯蚓幹8份、白芷1〇份、石斛 1〇份、杜仲12份、黃芪12份、牛膝5份、黃枝子15份、 枸杞根10份、徐長卿15份、桑寄生Η份、夏枯草1〇份。 優選紅麴米酒的酒精度10度，占原料藥重量的。 對於酒精度較高的紅麴米酒，加入量少一點，酒精度低的 加入量多一點，以保證有適量的乙醇參與原料藥的提取。 各味原料藥經大量中西醫臨床試驗研究，證實： 紅麴米酒：紅麴米酒冲的紅麴味甘性溫，入肝、脾、 ，腸經；具有活血化淤、健脾暖胃消食等功效。現代醫學 二明，紅麴中的單胺氧化酶抑制劑類物質是多巴胺異常代 謝的抑制劑，因此對帕金森氏患者有速效緩解作用。 虫蛹蟲草：蛹蟲草為子囊菌亞門，麥角菌目，麥角菌科、 虫草屬的模式種。學名為C〇rdyCepsmilitaris，又名北冬 *夏草北蜗蟲草、蟲草等。其菌絲液含有大量多耱，蟲 草素。中醫認為，蟲草素入肺腎二經，既能補肺陰，又能 ^腎陽，主治腎虛’陽痿遺精，腰膝酸痛，病後虛弱，久 ^虛弱二勞咳痰血，自汗盜汗等，是唯一的一種能同時斗 :、調節陰陽的中藥。其化學成份人工蛹&草 Ν6-Γ R- c ^ β 〔乙醯胺甲醯）氧乙基]，腺苷；蟲草環肽人；杉 201041586 苦；麥角留醇過氧化物。其中尤以蠢草酸、蟲草素、&草 多醋和超氧化物歧化轉綠生物时㈣賴則賈值最 為顯著。蟲草酸（甘露醇）可以顯著地降低顧壓，促進機 體新陳代謝。蟲草素是-種具有抗菌活性的核_物質， 對核多聚腺《聚合酶有很強的抑制作用，在基因體 (deoxyribonucleic acid ; DNA)轉錄稱為信使基因（mRN A )過程 中使mRNA成_礙，抑制異常細胞的生長，並有降血糖的 作用。蟲草多較-種高度分制半乳甘露聚糖，它能促 進淋巴細胞轉化，提高血清抗體（IgG)的含量和機體的免疫 功能，增強機體自身抗癌抑癌的能力。超氧化物歧化酶可 以消除機體内超氧自由基，具有抗衰老、抗癌抑癌的作用。 '此外，蜗蟲草還含有豐富的砸，砸是穀胱甘肽過氧化物酶 的組成成分，能防止不飽和脂肪酸的氧化，抑制對機體有 損害作用的過氧化物和自由基的產生，保護細胞免受損害 並刺激免疫球蛋白和抗體的產生，增強機體免疫和抗氧化 能力。竭蟲草母種經發酵培養的代謝產物的藥用活性與補 蟲草全草相當，甚至更好。 丹茶.本品為唇形科植物丹參（Salvia miltiorrhiza BUNGE)的乾燥根及根莖。性味歸經：苦，微寒。歸心、肝 '、里。功此主治：祛瘀止痛、活血通經、清心除煩；（1)對 〜血官系統的作用①強心··加強心肌收縮力、改善心臟功 能，不增加心肌耗氧量。②對血管作用：擴張冠脈，增加 :肌血流量；擴張外周血管’血流增加；腦血流量下降:③ 抗血栓形成提高纖溶酶活性；延長出、凝血時間；抑制血 201041586 Ο ο 小板聚集；改善血液流變學特性（血粘度降低、紅細胞在 瓊脂糖凝膠中電泳時閭縮短）。@改善微循環；（2)促進組 織的修復與再生作用①促進組織的修復與再生：丹參製劑 治療：壞死心肌清除快；纖維母細胞分化、膠原纖維形成 較明顯，肉芽形成比較成熟。局部游血減輕、血液迴圈改 善，癒合時_短。©抑制過度增生制度增生的纖維母 t胞有抑制作用。⑺保肝：改善肝微循環。丹參在心金 管系統方面對抗血栓形成、擴張冠脈的作用，益氣行血， 有效治療患者由於血凝阻滞引起的大腦局部細胞傳導方面 7障礙，其對於組織的修復和再生侧，能有效清除腦細 月匕局部病變和衰退，快速恢復組織的機能延緩甚 情的發展。 m ㈣幹·異名：地龍’虫丘蝴曬乾或者烘乾而得，功能 主…病驚狂、小兒驚風、咳喘、 Λ而碩痛目赤、咽喉腫痛、小 更不通、風濕關節疼痛，半身 主治壯熱驚癇，動風抽搐切2不二二1、清熱息風： 氣喘，對肺熱型支氣管哮喘療效車=疋二：可治肺熱疫咳 用於濕熱下注，熱淋溫痛4 、利尿通淋··適 腫赤痛’與丹參等益氣行血 4即 利，偏癱失語者… 、用於軋虛血瘀’經絡不 散寒===’溫。歸肺、W 形科植==:!:燥濕亡帶。來源中國％ 風的根。化學成分.含担川白止、抗白止或雲南牛防 成刀·3揮發油，香豆素及其衍生物，如當 201041586 歸素、白當歸、 用。 歐前胡乙素、白芷毒素等。具有解 痙作 石斛：補益藥，歸胃、腎經，緩益胃生津，滋卜敎 用於陰傷津齡，口幹須渴，厭如區吐，病後虛熱ΓΓ暗不。 明。從健脾盈氣上著手緩解帕金森氏患者脾胃^ 血虛的症狀。 風弱 杜仲，為杜件科植物杜件的樹皮。具有①降 樹皮的提取物及煎劑對動物有持久的降㈣用。作 用.。式驗》且明杜仲的各種製劑對麻醉犬均有利 無:_ ”現象。臨床使用杜仲浸劑，能使高心 血藶有所降低，並改善頭t、失眠等症狀。 •黃民，性味與歸經：甘，溫，歸肺、脾經。功. =氣固表’利尿托毒，排膿，傲瘡生肌。用於二 氣下陷，久_，便血崩漏，表虛二 :虛水腫，癌疽難潰，久潰不敛，金虛痿黃，内熱消渴； 又性腎炎蛋白尿’糖尿病。中醫認為腎虐亏脾虛是發病的關 =痰陰、水濕、瘀血停蓄是使病情加重的因素，杜㈣ =加_效’有效改善這些症狀，使病情得以延緩。 、'肖腫1用性平’味苦、酸，歸肝、腎經。生用散瘀血、 祕’热用補肝腎、強筋骨，牛膝“性善下行” 廣泛用於臨床。在本方法的原料藥中起藥引的作用：引藥下 二隨弓it下行、弓丨熱下行。經使脈通暢以便於其他藥物成 刀次行至患者四肢，使藥效得以發揮。 枸把根（地骨皮）：為祐種植物枸4己等的根皮，據劉若 201041586 金的《本草述》記載：主治虛勞發熱，往來寒熱，諸見血 證、流鼻血、咳嗽血，咳嗽、喘，消痰，中風，眩暈，痙 攣，腰痛’行癖’腳氣，水腫，虛煩，悖，健忘，小便不 通，赤白濁。在本方法的藥方中主治患者脾為虛弱，痰濕 内盛引起的流涎、痰多咳嗷、健忘等症狀。 畀枝子.學名為 Gardenia Jasminoides Ellis，酋草Preferably, it is: 12 parts of Salvia miltiorrhiza, 8 parts of medlar, 1 part of Radix, 1 part of Shiqi, 12 parts of Eucommia, 12 parts of Astragalus, 5 parts of Achyranthes, 5 parts of Astragalus, 10 parts of Astragalus, 10 parts of Radix, 15 parts of Xu Changqing, Mulberry Parasitic sputum, Prunella vulgaris 1 。. Preferably, the red glutinous rice wine has an alcohol content of 10 degrees, which accounts for the weight of the raw material drug. For red glutinous rice wine with higher alcohol content, the amount added is less, and the amount of alcohol is lower, so as to ensure that there is an appropriate amount of ethanol to participate in the extraction of the drug substance. A large number of traditional Chinese medicine and western medicine clinical trials have confirmed that: red glutinous rice wine: red glutinous rice wine rushed red glutinous sweet and warm, into the liver, spleen, intestines; with blood circulation, spleen warm stomach digestion and other effects. Modern Medicine Erming, the monoamine oxidase inhibitor substance in red peony is an inhibitor of dopamine abnormal metabolism, and therefore has a quick-acting effect on Parkinson's patients. Cordyceps militaris: Cordyceps militaris is a subspecies of Ascomycetes, ergots, ergotaceae, and Cordyceps. The scientific name is C〇rdyCepsmilitaris, also known as North Winter * Xia Cao North Worm Cordyceps, Cordyceps and so on. Its mycelial liquid contains a lot of polysaccharides, cordycepin. Chinese medicine believes that Cordyceps into the lung and kidney two, can not only fill the lung yin, but also ^ kidney yang, attending kidney deficiency 'yang dying nocturnal emission, waist and knee pain, weak after illness, long ^ weak two labor cough blood, spontaneous sweating, etc. It is the only Chinese medicine that can fight at the same time: regulate yin and yang. Its chemical composition artificial 蛹 & grass Ν 6-Γ R- c ^ β [acetamide methyl hydrazine) oxyethyl], adenosine; Cordyceps cyclin; cedar 201041586 bitter; ergoline alcohol peroxide. Among them, stupid oxalic acid, cordycepin, & grass vinegar and superoxide disproportionate to green organisms (4) Lai is the most significant. Cordycepic acid (mannitol) can significantly reduce the pressure and promote the body's metabolism. Cordycepin is a kind of nuclear substance with antibacterial activity, which has a strong inhibitory effect on the nuclear polyglycoprotein "polymerase, and makes mRNA in the process of transcription of the gene (deoxyribonucleic acid; DNA) called messenger gene (mRN A ). It inhibits the growth of abnormal cells and has the effect of lowering blood sugar. Cordyceps has a higher degree of galactomannan, which promotes lymphocyte transformation, increases serum antibody (IgG) content and immune function, and enhances the body's ability to fight cancer and inhibit cancer. Superoxide dismutase can eliminate superoxide free radicals in the body and has anti-aging, anti-cancer and anti-cancer effects. 'In addition, Coleoptera is also rich in strontium, which is a component of glutathione peroxidase, which prevents oxidation of unsaturated fatty acids, inhibits the production of peroxides and free radicals that damage the body, and protects The cells are protected from damage and stimulate the production of immunoglobulins and antibodies, enhancing the body's immunity and antioxidant capacity. The medicinal activity of the metabolites fermented by the Cordyceps militaris is comparable to or better than that of the turfgrass whole grass. Dancha. This product is the dried root and rhizome of Salvia miltiorrhiza BUNGE. Sexual tastes return: bitter, slightly cold. Heart, liver, and inside. Indications: 祛瘀 祛瘀 pain, blood circulation, clear heart and trouble; (1) the role of ~ blood system 1. Strong heart · strengthen myocardial contractility, improve heart function, do not increase myocardial oxygen consumption. 2 effect on blood vessels: dilatation of coronary artery, increase: muscle blood flow; expansion of peripheral blood vessels 'blood flow increased; cerebral blood flow decreased: 3 antithrombotic increase plasmin activity; prolonged clotting time; inhibited blood 201041586 Ο ο small Plate aggregation; improved hemorheological properties (decreased blood viscosity, shortened erythrocytes when electrophoresed in an agarose gel). @ Improve microcirculation; (2) Promote tissue repair and regeneration 1 Promote tissue repair and regeneration: Danshen preparation Treatment: Necrotic myocardium clearance is fast; fibroblast differentiation, collagen fiber formation is more obvious, granulation formation is more mature. Local blood loss is reduced, blood circulation is improved, and healing is short. © Inhibition of hyperproliferative system hyperplasia of fibroblasts t cells have inhibitory effects. (7) Liver protection: improve liver microcirculation. Salvia miltiorrhiza in the prevention of thrombosis and dilation of coronary artery in the cardiac tube system, benefiting qi and blood, effectively treating the 7 obstacles in the local cell conduction of the brain caused by blood clot block, which can effectively remove the repair and regeneration side of the tissue. Local lesions and decline of the cerebral palsy, rapid recovery of the function of the tissue delays the development of affection. m (4) Dry · Synonym: Dilong's insects are dried or dried, the main function... madness, convulsions, cough, phlegm and phlegm, sore throat, sore throat, small and imperceptible, rheumatism Joint pain, hemiplegia, strong heat, epilepsy, convulsions, convulsions, sputum, sputum, sputum, sputum, sputum, sputum, sputum, sputum, sputum, sputum, sputum, sputum Hot shower and warm pain 4, diuretic Tonglin · · swollen red pain 'and Danshen and other benefits of qi and blood 4 profit, hemiplegia aphasia ..., used to rolling blood stasis 'mechanical not cold cold === 'warm. Return to the lungs, W-shaped branch plant ==:!: dry and wet belt. Source China% The root of the wind. Chemical composition. Contains chuanchuan Baizhi, anti-baizhi or Yunnan cattle defense Chengdao·3 volatile oil, coumarin and its derivatives, such as when 201041586 is vegetarian, white angelica, used. Eucommia, alkaloids and so on. It has the solution of 斛 痉 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛 斛Bright. Starting from the spleen and qi, it relieves the symptoms of spleen and stomach and blood deficiency in Parkinson's patients. The wind is weak, Eucommia ulmoides, is the bark of the Dusitaceae plant. Extracts and decoctions with 1 bark have a long-lasting drop in animals (4). Function. The formula and the various preparations of eucommia ulmoides are beneficial to anesthetized dogs: _ ” phenomenon. Clinical use of Eucommia ulmoides can reduce high blood stasis and improve symptoms such as head t, insomnia, etc. • Huang Min, sexual taste And return to the classics: Gan, warm, return to the lungs, spleen. Gong. = gas-solid table 'diuretic toxin, pus, auspicious muscles. For the second gas sag, a long time _, blood in the stool, two: Virtual edema, cancer sputum is difficult to collapse, long-term ulceration is not congested, gold deficiency and yellow, internal heat and thirst; and nephritis proteinuria 'diabetes. Chinese medicine believes that kidney damage and spleen deficiency is the onset of the disease = phlegm, dampness, phlegm Blood storage is a factor that aggravates the condition. Du (4) = plus _ effect 'effectively improve these symptoms, so that the condition can be delayed. 'Sha Xiao swollen with a sexual flat' bitter taste, acid, liver, kidney. Blood stasis, secret 'hot use of liver and kidney, strong bones and bones, Achyranthes "sexual good down" widely used in clinical. In the method of the bulk of the drug to play the role of the drug: the second drug with the bow down, bow and heat down After the pulse is smooth, so that other drugs can be used to reach the limbs of the patient, so that the effect can be exerted. According to Liu Ruo 201041586 Jin's "The Herbal Description" records: Indications of fever, fever, heat, blood, nosebleeds, cough, blood, cough, asthma, phlegm, stroke, dizziness , 痉挛, low back pain 'walking' athlete's foot, edema, vain, sputum, forgetfulness, urinary dysfunction, red and turbid. In the prescription of this method, the patient's spleen is weak, and the phlegm caused by phlegm and dampness is coughing. Forgetfulness and other symptoms. Litchi. The scientific name is Gardenia Jasminoides Ellis, Emirates
科，別名.振子、山枝子、黃果樹、紅枝子，藥用部分. 成热的果貫，稱山梔子。性能：性寒，味苦；清熱 血止血。具有消炎去腐生機的功效。· 、 “ 桑寄生.本叩為桑寄生科植物桑寄生的乾燥帶葉贫 枝。性味歸經：苦、甘，平。歸肝、腎經。功能主治：補 轉/筋骨’祛職，安胎元。用於風濕翻，腰膝酸 軟’筋骨無力’高血壓。在本方法的藥方中與牛膝等配伍 應用’用於風濕#痛，腰膝酸軟等。與本藥方巾的杜仲配 伍’用於肝腎不足、腰膝酸痛、腳膝疼弱無力等。 τ用部分為全草及根。性能：性溫，味辛 疏風解熱，行氣活血。來源：牛皮消屬植物徐長Branch, alias. Vibrator, mountain branch, yellow fruit tree, red branch, medicinal part. The fruit of heat, called hawthorn. Performance: Sexual cold, bitter taste; heat and blood to stop bleeding. It has the effect of reducing inflammation and eliminating vitality. · "Mulberry parasitic. This is a dry branch of the mulberry parasitic plant of the mulberry family. The taste of the scent is: bitter, sweet, flat. Go to the liver, kidney. Function Indications: make up / bones and bones, dereliction of duty, An fetal element. It is used for rheumatism, and the waist and knees are sore and 'strength bones' high blood pressure. In the prescription of this method, it is used in combination with achyranthes, etc. 'For rheumatism# pain, waist and knees, etc.. Compatible with Eucommia ulmoides 'Used for liver and kidney deficiency, waist and knee soreness, weak knees and weakness, etc. The part of τ is whole grass and root. Performance: temperature, taste, spleen and wind, antipyretic, qi and blood circulation. Source: cow hides plant Xu Chang
Cy腦麵paniculatum (Bge.)出吨.的乾燥根及 莖，具有1.鎮靜作用；2.鎮痛作用。3.對心血管系 的作用。4·對血脂的影響：對於喂飼膽固醇食物弓|起的 兔實驗性高血脂症和實驗性動脈舰硬化翻，徐長 有降低A清總膽固醇和^脂蛋白的作用，並可減^ 脈粥樣硬化及小動脈脂類沉積，從而表明徐 樣硬化有防治作用.在太心1賴脈 在本樂方中與丹麥的藥效相互促進 15 201041586 相輔相成’從促進心血管擴張、抗血栓形成兩方面共同作 用，本病中西醫皆認為與腦細胞之間的傳導功能阻礙有 關，本藥與丹參一起從改善心肌代謝、減輕血管硬化著手 提咼患者腦供血供氧的能力，逐步緩解腦細胞之間的傳導 功能障礙，達到治療的作用。 夏枯草：學名Prunella vulgaris Linn.科名唇形科 abiatae來源.本品為唇形科植物夏枯草（pruneua vuUarisLirm.)的乾燥果穗。性味功用：苦、辛寒。夏 括草的功用是清肝明目、用齋消瘤、清熱散結、還有利尿 f壓的作用。①《本經》：主寒熱、皮下腫塊、生於頸、腋 軟、.且，、我破/貝難叙者、頭瘡，破症，散癭結氣，腳腫濕 2。②《本草衍義補遺》：補養血脈。③《滇南本草》··接 風，行經絡，治σ眼歪斜。行肝氣，開㈣，止筋骨疼 :二眼睛痛’周身結核。④《生草藥性備要》:去痰消膿， 清上補下，去眼膜，止痛。⑤《本草從新》： 狀腺腫塊或』於㈣之軟組織破潰難傲者、頸部甲 代實用^ 紐_、_。⑥《現 丁呆並此治咼血壓，能使血壓下降。 發二二二:種治療帕金森氏病的藥物’為了使本 慮_蟲草=賴用成分更好地發揮藥效，並考 用藥:轉取液作為培養基_蟲草二“方:原料 用原料藥的浸—基，：聊方:出： 16 201041586 中沒有藥效作用_分營養㈣。發㈣程不僅成倍地提 尚了蜗蟲草自身有效__的含量，且微生物發酵過程 中通具有強大的分解轉化物質的能力，使原料藥毒副作用 稱微’並_了其他原料藥中的無活性的營養物質，使餘 下的有效藥成分更純，並擴大了本藥物的適應症。培養基 中加入紅麴米酿使各味原料藥中多種成分充分萃取到液 體中來，各味祕_齡成分才能真正發揮藥效，為竭 蟲草提供了豐富的發酵底物，避免了藥材的浪費。另一方 面，以發酵方法來製備本藥物，可以有效.降低制藥成本以 降低患者的費用，使更多人受益，而又不影響藥效，而且 減少了大量開採野生冬蟲夏草帶來的環境破壞。 本叙明中，以25—40倍體積水浸泡原料藥，可以使原 料藥有效成份充分浸泡出來，水太少.會導致浸泡不充分， 水太多會導致浸出液中有效藥物成分濃度太低，最後需要 濃縮以到達一定濃度，而這比例的用水量可以省略濃縮步 驟。常溫浸泡時間以5—8小時為宜，大多數藥材為幹製， 常溫下浸泡使藥材組織細胞壁充分軟化，細胞吸脹水，以 使細胞内部分物質透過分離並滲透到浸泡液中，本發明優 先6個小時，能最有效地達到這個效果，為了能更成分地 提取出各種藥用成分，在浸泡液中加入原料藥重量的 1.5-5%的紅麴米酒，在loo^常壓環境下蒸1小時，紅麵 中的乙醇促使原料藥被充分萃取到液體中來，待充分提取 後，隨著時間的推移，乙醇漸漸揮發，而紅麴米酒中的紅 麴被保留下來，在製得的藥物中發揮藥效。 201041586 去潰後再常壓100°c滅菌2小時，目的是使藥物浸出 液作為發酵培養基時是單菌發酵，同時使乙醇成分徹底揮 發’使本藥物適合的患者類型更叙。本發明優選使用本 發明人之中國專利號為ZL03270560. 3，名稱為“食用菌液 體菌種培養罐的罐蓋及培養罐”的實用新型專利中記載的 發酵罐，使用起來方便，發酵效果好。在原料藥浸出液中 注入-定量_蟲草母種培養液，蛹蟲草_浸^液中的 糖分等營♦物質進行細胞分裂、繁殖，只需要加入少量母 種，通過發酵作用提高其藥物成分的含量從而達到起較言 的濃f。發酵時間優選為72小時至96小時，有效固體: 含量高’多_含量高，其獲得的製品治療功效最好，發 終止以多醣含量達9〇g/L為准。 X 【實施方式】 有關本發明所採用之技術、手段及其功效，兹舉 佳實施例並配合_詳述如後，此僅供綱之用，在專^ 申請上並不受此種結構之限制。第一實施例:各原料 伤.丹蒼（根）12份 '虫丘虫引幹（全蟲）8份、白足 10伤、石斛（災）1〇份、杜仲（勒皮）12份、黃笑（根） 12份、牛膝（根）5份、至社/里趣、1C八 知用枝（果貫）15份、枸才己根{地 月皮U0份、徐長卿（全草及根）15份、桑寄生（帶葉莖 ，）14份、夏枯草（花期果穗）1G份，共9_，各原料 藥均指幹製品。紅麴米酒（酒精度1G度），27Qg，占原料藥 3%。 y、 201041586 步驟1..原料藥浸提：Cyal paniculatum (Bge.) dried roots and stems with a sedative effect; 2. analgesic effect. 3. The role of the cardiovascular system. 4. The effect on blood lipids: For experimental hyperlipidemia and experimental arteriosclerosis in rabbits fed with cholesterol food bow, Xu Chang has the effect of lowering total cholesterol and lipoprotein of A, and can reduce the pulse Atherosclerosis and small arterial lipid deposition, which indicates that Xu-like sclerosis has a preventive effect. In Taixin 1 Laimai in the music side and Danish drug synergy 15 201041586 complement each other 'from promoting cardiovascular expansion, anti-thrombosis The two sides work together, the disease is considered to be related to the conduction function between brain cells. This medicine and Danshen together improve the myocardial metabolism, reduce the ability of blood vessels to provide blood supply and oxygen supply to the brain, and gradually relieve brain cells. The conduction dysfunction between the two reaches the role of treatment. Prunella vulgaris: scientific name Prunella vulgaris Linn. Family name Lamiaceae abiatae source. This product is the dry ear of Prunus vulgaris (pruneua vuUarisLirm.). Sexual taste function: bitter, bitter cold. The function of Xia Kucao is to clear the liver and improve eyesight, use radish to eliminate tumor, clear heat and dissipate, and also have the effect of diuretic f pressure. 1 "The Classic": The main cold and heat, subcutaneous mass, born in the neck, soft, and, and I broke / shell difficult to tell, head sores, broken disease, dilated phlegm, feet swollen. 2 "Materia Medica's Supplementary Supplement": nourishing blood. 3 "Minnan Materia Medica" · · Take the wind, go through the meridians, cure σ eye slant. Liver gas, open (four), stop the bones and pains: two eyes pain 'body tuberculosis. 4 "Herbal Herbs": go to sputum to eliminate pus, clear up, go to the eye mask, pain. 5 "Materia Medica from the New": The glandular mass or the soft tissue of the (4) rupture is not proud, the neck is a practical ^ _, _. 6 "The current Ding stays and cures blood pressure, which can lower blood pressure. Hair 22: a drug for the treatment of Parkinson's disease 'In order to make this consideration _ Cordyceps = the ingredients used to better play the drug, and the drug: the transfer liquid as the medium _ Cordyceps two" side: raw materials for raw materials The dip-based,: Liaofang: out: 16 201041586 There is no pharmacodynamic effect _ sub-nutrition (four). The hair (four) process not only doubles the content of the effective __, but also has a strong microbial fermentation process. The ability to decompose and convert substances, so that the toxic side effects of the raw materials are called 'micro' and the inactive nutrients in other raw materials make the remaining effective ingredients more pure, and expand the indications of the drug. The red glutinous rice is brewed to fully extract various components of the various raw materials into the liquid, and each of the secret ingredients can truly exert its effects, providing a rich fermentation substrate for the Cordyceps, and avoiding waste of the medicinal materials. In terms of fermentation, the preparation of the drug can effectively reduce the cost of the drug to reduce the cost of the patient, benefit more people without affecting the efficacy, and reduce the number of rings brought by the exploitation of wild Cordyceps sinensis. In this description, soaking the drug substance in 25-40 volumes of water can fully soak the active ingredients of the drug substance, too little water, which will result in insufficient soaking. Too much water will result in the concentration of effective drug components in the leachate. Too low, and finally need to be concentrated to reach a certain concentration, and the water consumption of this ratio can omit the concentration step. The room temperature soaking time is preferably 5-8 hours, most of the herbs are dry, soaking at room temperature makes the cell wall of the medicinal material fully soften. The cells swell the water so that some of the cells in the cells are separated and permeate into the soaking solution. The present invention gives priority to this effect for 6 hours, in order to extract various medicinal ingredients more in a soaking solution. 1.5-5% of the red glutinous rice wine with the weight of the raw material is added, and steamed for 1 hour under the normal pressure environment, the ethanol in the red surface promotes the extraction of the raw material into the liquid, and after sufficient extraction, with time On the other hand, the ethanol gradually evaporates, and the red peony in the red glutinous rice wine is preserved, and the drug is exerted in the obtained drug. 201041586 After the ulceration, the normal pressure is 100 °c sterilization 2 When the drug leachate is used as the fermentation medium, it is a single-fermentation fermentation, and at the same time, the ethanol component is completely volatilized, which makes the type of the patient suitable for the drug more detailed. The present invention preferably uses the inventor's Chinese patent number ZL03270560. 3, the name The fermenter described in the utility model patent of the "can lid and culture tank of the edible fungus liquid culture culture tank" is convenient to use and has a good fermentation effect. Injecting - quantification - Cordyceps mother seed culture solution in the raw material drug leachate, 蛹Cordyceps _ immersion liquid in the sugar and other camp ♦ substances for cell division and reproduction, only need to add a small amount of parent species, through the fermentation to increase the content of its pharmaceutical ingredients to achieve a more concentrated f. Fermentation time is preferably 72 hours to 96 hours, effective solids: high content 'more _ high content, the best therapeutic effect of the obtained product, the termination of the polysaccharide content of 9 〇g / L. X [Embodiment] Regarding the technology, means and effects of the present invention, the preferred embodiment and the detailed description are as follows, and this is only for the purpose of the application, and is not subject to such a structure in the application. limit. The first embodiment: each raw material injury. Danococ (root) 12 parts of 'worm worms dry (the whole insect) 8 parts, white foot 10 wounds, stone scorpion (disaster) 1 〇, eucommia (lepi) 12, Huang Xiao (root) 12 copies, Achyranthes (root) 5 copies, to the community / interest, 1C eight knowledge branches (fruit) 15 copies, 枸才己根 {地月皮U0份, 徐长卿 (全草和Root) 15 parts, mulberry parasitic (with leaf stems), 14 parts, Prunella vulgaris (flowering ear) 1G, a total of 9_, each raw material medicine refers to dry products. Red glutinous rice wine (alcohol degree 1G degree), 27Qg, accounting for 3% of raw materials. y, 201041586 Step 1: Raw material leaching:
(1)將原料藥混合均勻’放入浸泡罐中，按藥液比1 g : 4〇ml加入飲用水36L，22_28攝氏度浸泡6小時。 (2) 在原料藥浸泡液中加入12度的紅麴米酒135g， 即原料藥重量的丨.5%，混合均勻後，裝入發酵罐，發酵罐 優選採用中國專利號為03270560.3,名稱為“食用菌液體 菌種培養罐的罐蓋及培養罐，，的實用新型專利中記載的發 ，罐，罐内必需留下10%的空間，鎖緊法蘭蓋，用“飽和 瘵汽無壓鍋爐，，（專利號200320126611.8)發生的墓裔者 1小時，冷卻至4(TC時，用60目篩網過濾、，棄渣。'—' (3) 對上一步得到的原料藥浸出液進行常壓滅菌2 小時，浸出液冷卻至26。〇。 步驟2.蛹蟲草深層發酵： ' 將蛹蟲草母種注入步驟丨中獲得的浸出液中混勻，裝 入务酵罐内深層發酵，檢測糖含量達9Gg/L時，放罐。 口步驟3.將發酵液在〇. 15mpa滅菌20分鐘，在符合藥 口口生產°°質管制規範（G〇〇d Manufacture Practice，GMP) 的條件下灌裝。 服用万法 母天一次在睡前，用20毫升1〇〇攝氏度 飲用水，兌入l〇〜2〇ml。 聲辦本么聽㈣藥劑，猶微涼後趁熱服下，服用5天見 改4 ’並解除對其他藥物的依賴，對本藥隨服用 時間推移症狀得到改善後顧量可停止服藥。 弟二實施例： 19 201041586 原料藥為：丹參15份、蚯蚓幹d w份、白芷12份、 石解5份、杜仲丨0、黃Kl8份、牛膝8份、黃枝子烈份、 枸杞根12伤、徐長卿12份、桑寄生1()份和夏枯草 共9_g，各藥材取材部位同實施例！，__酒= 12度）135g ’占原料藥1. 5%。 _又 步驟同第一實施例。 服用方法同第一實施例。 第三實施例： 原料藥為：丹參14份、虫丘蚓幹】n彳八 · T iU份、白芷1〇份、 石斛15份、杜仲15、黃式15份、牛膝6份、黃枝 份、枸杞根10份' 徐長卿14份、桑寄生16份和夏(1) Mix the raw materials uniformly into the soaking tank, add 36L of drinking water to the solution of 1 g: 4〇ml, and soak for 6 hours at 22_28 °C. (2) Add 135g of 12-degree red glutinous rice wine to the raw material medicine soaking solution, that is, 丨.5% of the weight of the raw material medicine, mix it evenly, and then put it into the fermenter. The fermenter is preferably Chinese Patent No. 03270650.3, the name is “ For the cans and culture tanks of the edible fungus liquid culture culture tanks, the hair, cans and tanks described in the utility model patent must leave 10% of space, lock the flange cover, and use the "saturated steam-free pressure-free boiler." , (Patent No. 200320126611.8) The tomb of the tomb occurred for 1 hour, cooled to 4 (TC, filtered with a 60 mesh screen, and slag was discarded. '-' (3) The raw material leaching solution obtained in the previous step was subjected to atmospheric pressure. Sterilize for 2 hours, and dip the solution to 26. 〇 Step 2. Deep-fermentation of Cordyceps militaris: 'Inject the Cordyceps militaris seed into the leaching solution obtained in the step 混 and mix it into the fermentation tank for deep fermentation to detect the sugar content up to 9Gg. At the time of /L, put the can. Step 3. Sterilize the fermentation broth at 15 mp. for 20 minutes, and fill it under the conditions of G 〇〇 Manufacture Practice (GMP). Once every day at bedtime, use 10 ml of 1 〇〇 Celsius Use water, and mix into l〇~2〇ml. Listen to the book (4) Pharmacy, after the cool, take the heat, take 5 days to see 4' and relieve the dependence on other drugs, the symptoms of taking this drug with time After the improvement, the dosage can be stopped. Brother II Example: 19 201041586 The drug substance is: 15 parts of Salvia miltiorrhiza, Dw part of sputum, 12 parts of Radix, 5 parts of Shijie, 8 parts of Eucommia ulmoides, 8 parts of yellow Kl, 8 parts of Achyranthes, Huangzhizi Lie, 枸杞根12伤, Xu Changqing 12 parts, mulberry parasitic 1 () and Prunella vulgaris 9_g, the same parts of the herbs are the same as the examples!, __ wine = 12 degrees) 135g 'accounting for raw materials 1. 5 %. The steps are the same as the first embodiment. The administration method is the same as that of the first embodiment. Third embodiment: The raw material medicines are: 14 parts of Salvia miltiorrhiza, dried worms, n彳8·T iU parts, 1 part of white peony, 15 parts of sarcophagus, eucommia ulmoides, 15 parts of yellow type, 6 parts of achyranthes, yellow branches 10 parts of radix and roots '14 pieces of Xu Changqing, 16 parts of mulberry parasitic and summer
份。共9000g，各藥材取材部位同實施例j，紅麵米酒， 精度7度450g，占原料藥5%。 '“ /S 步驟同第一實施例。 服用方法同第一實施例。 試驗例1:本發明獲得的藥物治療帕金森氏广 床觀察。 $人的臨 一般資料： 收治患者共14例，其中男性1〇例，+柯 艾生4例；年私 都在50歲以上，治癒率1〇〇%，治癒後不再依賴藥物7 顫消失，四肢靈活性良好，自身身體免疫力提言，二，震 阿，§己性好， 睡眠好，代謝正常，身體進入良性迴圈狀態。 部分治癒患者如下： 病例1·吳友明，男67歲，治癒，廣西扶綏藜塘農妒 20 201041586 電話：13535470321。 病例2,朱婆，女81歲，治癒，廣東從化。 病例3.陳校長，男70歲，治癒，廣州太和大原學校。 病例4.沈莉，女62歲，治癒，香港，電話： 13410170725 [深圳：吳馨]。 病例5.王多賢，男50歲，治癒，香港，電話： 15017628405 。 病例6.陳建文，男59歲，治癒，香港，電話： 15920001331。 · 【圖式簡單說明】 【主要元件符號說明】Share. A total of 9000g, each medicinal material is the same as the example j, red noodles rice wine, the accuracy of 7 degrees 450g, accounting for 5% of the raw materials. 'The /S step is the same as the first embodiment. The administration method is the same as that of the first embodiment. Test Example 1: The drug obtained by the present invention is used to treat Parkinson's wide bed observation. The general information of the person: 14 cases of patients admitted to the patient, wherein 1 case of male, 4 cases of Ke Aisheng; annual private are over 50 years old, the cure rate is 1〇〇%, no longer depends on the drug after the cure, 7 tremor disappears, the flexibility of the limbs is good, his body immunity is said, second, Zhena § Having good self, good sleep, normal metabolism, and the body enters a benign lap state. Some patients are cured as follows: Case 1·Wu Youming, male 67 years old, cured, Guangxi Fushuntang Farm Reclamation 20 201041586 Tel: 13535570321. Case 2 , Zhu Po, female 81 years old, cured, Guangdong Conghua. Case 3. President Chen, male 70 years old, cured, Guangzhou Taihe Taiyuan School. Case 4. Shen Li, female 62 years old, cured, Hong Kong, Tel: 13410170725 [ Shenzhen: Wu Xin]. Case 5. Wang Duoxian, male 50 years old, cured, Hong Kong, Tel: 15017628405. Case 6. Chen Jianwen, male 59 years old, cured, Hong Kong, Tel: 15920001331. · [Simple diagram] Main component No. Description