KR20200087606A - Compositions for Improving Memory Power and Learning Ability, and Relaxing stress - Google Patents

Compositions for Improving Memory Power and Learning Ability, and Relaxing stress Download PDF

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KR20200087606A
KR20200087606A KR1020190004138A KR20190004138A KR20200087606A KR 20200087606 A KR20200087606 A KR 20200087606A KR 1020190004138 A KR1020190004138 A KR 1020190004138A KR 20190004138 A KR20190004138 A KR 20190004138A KR 20200087606 A KR20200087606 A KR 20200087606A
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/882Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
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    • AHUMAN NECESSITIES
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    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function

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Abstract

The present invention relates to a Chongmyungtang (Korean medicinal drink) composition for improving memory and learning ability, and relieving stress. More specifically, the present invention contains a hot water extract of natural materials including Poria cocos, Polygala tenuifolia, Acorus gramineus, and Nelumbo nucifera. The Chongmyungtang composition according to the present invention has advantages of being safe without side effects, improving anti-fatigue activity and brain activity, especially being helpful for enhancing memory to improve learning ability, and relieving psychological stress.

Description

기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물{Compositions for Improving Memory Power and Learning Ability, and Relaxing stress}Compositions for Improving Memory Power and Learning Ability, and Relaxing stress

본 발명은 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물에 관한 것으로, 더욱 상세하게는 두뇌활동, 특히 기억력 증진에 우수한 활성을 가져 학습능력을 향상시켜주며, 스트레스를 완화시켜주는 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물에 관한 것이다.The present invention relates to a composition of Chongmyeong-tang for improving memory, learning ability, and stress relief. More specifically, it has excellent activity in brain activity, especially memory enhancement, improves learning ability, improves memory, relieves stress, improves learning and stress It relates to a total bath composition for relaxation.

총명탕(聰明湯)은 백복신(白茯神), 석창포(石菖蒲), 원지(遠志)로 이루어진 처방으로 기억력 감퇴와 건망을 치료하는 처방이다. 총명탕은 중국 명나라 때의 의사인 공정현이 창안했다. 대대로 의원을 하던 집안에서 태어난 공정현은 태의원(太醫院) 의관(醫官)을 지낸 아버지 공신에게서 어려서부터 의술을 전수받아 의학에 대한 이해가 몹시 깊었다고 한다.Chongmyeongtang (聰明湯) is a prescription consisting of Baekboksin (白창神), Seokchangpo (石菖蒲), Wonji (遠志), and is a prescription to treat memory loss and forgetfulness. Chong Myung-tang was created by the doctor of the Ming Dynasty of China, Yong-Hyun Lee. Born in a house where he was a member of the hospital, he was said to have had a deep understanding of medicine after receiving medicine from a young father, Gongsin, who served as a medical doctor at Taeuiwon.

그는 『만병회춘(萬病回春)』, 『수세보원(壽世保元)』, 『고금의감(古今醫鑑)』, 『운림신각(雲林神殼)』, 『본초포제약성부정형(本草포製藥性賦定衡)』, 『종행선방(種杏仙方)』, 『노부금방(魯府禁方)』 등과 같은 여러 권의 책을 저술하였다. 총명탕은 1581년에 간행된 『종행선방』에 수록되어 있다. 이 의서에는 대부분 일상에서 쉽게 구할 수 있는 두세 가지의 약재로 만들어진 경험방이 주로 실려 있는데, 총명탕 역시 백복신, 석창포, 원지라는 3가지 약물로 구성된 아주 간결한 처방이다. 우리나라의 의서에서는 허준의 『동의보감(東醫寶鑑)』 내경편(內景編)에서 총명탕은 ‘다망(多忘, 건망증)’을 치료하는 것으로 기록되어 있으며, 기억력 감퇴와 건망 등의 병증을 치료하는 데에 쓰였다. He wrote 『Manbyeong Rejuvenation』, “Susebowon”, “Golden Feeling”, “Woonrim Shingak”, 『Bonchopo Pharmaceuticals Unscheduled” He has authored several books such as Fortune Sexuality, 『Jong Haeng Seonbang』, and 『Nobu Geumbang』. Chongmyeong-tang is included in the 『Jonghaeng Seonbang』, published in 1581. In this book, most of the experience rooms are made of two or three kinds of medicines that are readily available in everyday life. Chongmyeongtang is also a very concise prescription consisting of three drugs: Baekboksin, Seokchangpo, and Wonji. In Korea's protocol, Chong Myung-tang is said to treat'mang-mang-mang' (forgetfulness) in Heo Joon's 『Dongui-Bo-Gam(東醫寶鑑)』 Naekyung-pyeon, and treats diseases such as memory loss and forgetfulness It was used to do.

한편, 사회적인 환경이 다변화되어 감에 따라 사람들은 더 많은 자극을 접하게 되고 이러한 자극을 수용하기 위한 신속한 두뇌활동이 요구된다. 특히, 최근 경제성장과 더불어 산업화, 공업화에 따른 환경 파괴와 수질오염, 그리고 인스턴트 식품의 범람으로 우리의 건강상태가 위협을 받고 있으며, 소득증대에 따른 육식 중심의 식생활에 의한 영양의 과잉섭취와 기계문명의 발달에 의한 운동량의 절대부족 등이 비만을 촉진할 뿐만 아니라 이들 비만이 원인이 되어 동맥경화, 고혈압, 관상심장질환, 심근경색, 협심증, 뇌졸중 등의 만성 퇴행성 성인병이 만연하고 있는 실정이다. 또한, 청소년, 특히 수험생들은 장기간 학습 활동을 함으로써 두뇌와 심신의 피로를 느끼게 될 뿐 아니라 두뇌의 건전한 발달에도 심각한 영향을 받고 있다. On the other hand, as the social environment diversifies, people are exposed to more stimuli and rapid brain activity is required to accommodate these stimuli. In particular, along with the recent economic growth, our health status is threatened by industrialization, environmental destruction and water pollution due to industrialization, and flooding of instant foods, and excessive intake of nutrition and machinery due to meat-driven eating habits due to increased income Absolute lack of momentum due to the development of civilization not only promotes obesity, but also causes obesity, and chronic degenerative adult diseases such as arteriosclerosis, hypertension, coronary heart disease, myocardial infarction, angina pectoris, and stroke are rampant. In addition, adolescents, especially test takers, experience long-term learning activities that not only feel the brain and mind and body fatigue, but are also seriously affected by the healthy development of the brain.

따라서, 사회가 복잡해지고 입시 경쟁이 치열해짐에 따라 피로해진 두뇌를 맑게 하여 기억력을 증진시키고 피로 회복을 촉진할 수 있는 방법의 개발이 절실히 요구되고 있으며, 최근 성장기 학생들의 과중한 학습 부담은 사회적 문제로 대두되고 있는 실정이다.Therefore, as the society becomes complicated and the competition for entrance exams becomes fierce, it is urgently needed to develop a method that can clear the tired brain and improve memory and promote fatigue recovery. It is becoming.

이러한 사회적 요구에 따라 학습능력 향상과 기억력 향상을 위한 제품들이 개발되고 있는데, 특히 종래 개발된 제품들의 경우 뇌신경을 자극하여 학습능력과 기억력을 증진시키기 위해 합성된 화합물들이 사용되곤 하였으나, 다양한 부작용을 초래로 최근에는 천연물을 이용한 제품의 개발이 시도되고 있다.According to these social demands, products for improving learning ability and improving memory have been developed. In particular, in the case of conventionally developed products, compounds synthesized to stimulate the brain's nerves to improve learning ability and memory are used, but cause various side effects. In recent years, development of products using natural products has been attempted.

천연물을 이용하여 개발된 제품관련 기술을 살펴보면, 대한민국 등록특허 제10-524385호에는 용안육, 산조인, 원지 및 백복신의 복합생약 추출물을 함유한 기억력 증진 및 청소년기 학습능력 개선용 조성물에 대한 내용이 개시되어 있고, 대한민국 등록특허 제10-530211호에는 결명자, 숙지황, 복령, 우슬, 산약, 육종용, 파극천, 육계, 음양곽, 보골지, 황기, 당귀, 두충, 저실자, 원지, 석창포, 산수유, 생강, 대추 등 19종의 식물 생약을 함유한 학습능력을 향상시키는 건강기능식품 조성물이 개시되어 있으며, 대한민국 등록특허 제10-484416호에는 구기자 (Lycii fructus) 추출물을 유효성분으로 함유하는 학습 및 기억력 향상 생약조성물에 대한 내용이 개시되어 있다.Looking at the product-related technology developed using natural products, Korean Patent Registration No. 10-524385 discloses a composition for improving memory and adolescent learning ability containing composite herbal extracts of Yonganyuk, Sanjoin, Wonji and Baekboksin In Korean Patent Registration No. 10-530211, nominee, Sukjihwang, Bokryeong, Woosul, Wild Medicine, Yukjongyong, Pagukcheon, Broiler, Eumyanggwak, Bogolji, Hwanggi, Angelica, Duchung, Jeosilja, Wonji, Seokchangpo, Cornus officinalis, Ginger, Jujube A health functional food composition is disclosed that improves the learning ability containing 19 kinds of plant herbal medicines, etc., and in Korean Patent No. 10-484416, a learning and memory-enhancing herbal composition containing wolfberry (Lycii fructus) extract as an active ingredient The content is disclosed.

그러나 선행문헌들의 어디에서도 총명탕의 원료인 백복신, 석창포 및 원지에 연자육, 구상나무를 더한 복합추출물을 통해 기억력과 학습력을 향상시키고, 스트레스 완화한 예는 없었다.However, none of the prior literature has improved memory and learning ability through the complex extracts of Baekboksin, Seokchangpo and Wonji, which are raw materials for Chongmyeongtang, and spheroidal wood, and stress relief.

KR 10-524385 B1KR 10-524385 B1 KR 10-484416 B1KR 10-484416 B1

따라서, 본 발명의 목적은 항피로 활성 및 두뇌활동, 특히 기억력 증진에 우수한 활성을 가져 학습 능력을 향상시키고, 스트레스를 완화하는 총명탕 조성물을 제공하는 것이다. Accordingly, an object of the present invention is to provide an anti-fatigue activity and brain activity, in particular, excellent activity for enhancing memory, to improve learning ability, and to provide a composition for reducing stress.

상기한 목적을 달성하기 위한 본 발명의 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물은, 백복신, 원지, 석창포 및 연자육을 포함하는 천연재의 열수추출물을 포함하는 것을 특징으로 한다.To achieve the above object, the memory, learning power improvement and stress relief composition of the present invention is characterized in that it comprises a hot water extract of natural materials including Baekboksin, Wonji, Seokchangpo and Yeonjayuk.

상기 천연재는, 상기 백복신 100중량부에 대하여, 원지 50~100중량부, 석창포 50~100중량부 및 연자육 50~100중량부를 포함하고, 녹용 1~50중량부, 지골피 1~50중량부, 선령비 1~50중량부, 백출 1~50중량부, 백지 1~50중량부, 원육 1~50중량부, 백자인 1~50중량부, 합환피 1~50중량부, 자하거 1~50중량부, 복령 1~50중량부, 단삼 1~50중량부, 용골 1~50중량부, 모려 1~50중량부, 구기자 1~50중량부, 결명자 1~50중량부, 감국 1~50중량부, 산조인 1~50중량부, 백작약 1~50중량부, 인삼 1~50중량부, 황기 1~50중량부 및 영신초 1~50중량부 중 1종 이상을 더 포함하는 것을 특징으로 한다.The natural material includes 50 to 100 parts by weight of base paper, 50 to 100 parts by weight of Seokchangpo, and 50 to 100 parts by weight of soft meat, and 1 to 50 parts by weight of antler, 1 to 50 parts by weight of phalanx, Rain 1-50 parts by weight, Baekchul 1-50 parts by weight, white paper 1-50 parts by weight, raw meat 1-50 parts by weight, white porcelain 1-50 parts by weight, combined skin 1-50 parts by weight, self-harvesting 1-50 parts by weight, 1-50 parts by weight of Bokryeong, 1-50 parts by weight of ginseng, 1-50 parts by weight of keel, 1-50 parts by weight of wool, 1-50 parts by weight of wolfberry, 1-50 parts by weight of ginseng, 1-50 parts by weight of chrysanthemum, Sanjoin It is characterized in that it further comprises 1 to 50 parts by weight, 1 to 50 parts by weight of the count, 1 to 50 parts by weight of ginseng, 1 to 50 parts by weight of astragalus and 1 to 50 parts by weight of Youngsincho.

상기 천연재는, 구상나무 50~100중량부를 더 포함하는 것을 특징으로 한다.The natural material is characterized in that it further comprises 50 to 100 parts by weight of a globular tree.

아레카야자 1~10중량부, 무화과나무 1~10중량부 및 토란 1~10중량부를 더 포함하는 것을 특징으로 한다.Areca palm 1 to 10 parts by weight, the fig tree 1 to 10 parts by weight and taro 1 to 10 parts by weight, characterized in that it further comprises.

본 발명에 의한 총명탕 조성물은, 부작용이 없이 안전하며, 항피로 활성 및 두뇌활동, 특히 기억력 증진에 도움이 되어 학습능력을 향상시키며, 심리적인 스트레스를 해소시킨다는 장점이 있다.The composition of Chongmyeong-tang according to the present invention is safe without side effects, has anti-fatigue activity and brain activity, and particularly helps to improve memory, improves learning ability, and relieves psychological stress.

이하, 본 발명을 상세히 설명한다. Hereinafter, the present invention will be described in detail.

본 발명의 가장 큰 특징은 천연재의 추출물만으로 기억력과 학습력을 향상시키고, 스트레스를 완화한다는 데 있다. 즉, 본 발명에 의한 총명탕 조성물이란, 기억력과 학습력을 향상시키고, 스트레스 완화하는 탕, 즉 액상의 조성물을 의미하는 것으로, 이러한 액상의 조성물은 식품 조성물 또는 약학 조성물일 수 있다. 구체적으로, 본 발명의 총명탕 조성물은 음료, 액상차 등의 식품 형태로 제공될 수 있으며, 약학 조성물로서 경구투여를 위한 액상, 캡슐제 등으로 제공될 수도 있다.The biggest feature of the present invention is that it improves memory and learning ability and relieves stress with only natural extracts. That is, the total myeongtang composition according to the present invention refers to a bath that improves memory and learning ability and relieves stress, that is, a liquid composition. The liquid composition may be a food composition or a pharmaceutical composition. Specifically, the Chongmyeongtang composition of the present invention may be provided in the form of a food such as a beverage or liquid tea, or may be provided as a liquid or capsule for oral administration as a pharmaceutical composition.

아울러, 본 발명에 의한 조성물은 약재의 추출물만으로 구성될 수도 있고, 제형화를 위해 공지된 다양한 종류의 첨가제가 첨가될 수도 있다.In addition, the composition according to the present invention may be composed of only the extract of the medicinal material, or various kinds of additives known for formulation may be added.

이를 위한 본 발명의 총명탕 조성물은, 백복신, 원지, 석창포 및 연자육을 포함하는 천연재의 열수추출물을 포함하는 것을 특징으로 한다. The composition of the present invention for this purpose is characterized in that it comprises a hot water extract of natural materials including Baekboksin, Wonji, Seokchangpo and Yeonjayuk.

즉, 상기 백복신, 원지 및 석창포는 종래 총명탕의 원료로서 사용되는 것으로, 건망증에 좋으며, 기억력을 향상시키는 효과가 있다. 다만, 이러한 백복신, 원지 및 석창포만을 사용할 경우, 그 효과가 미미하였는바, 본 발명에서는 연자육을 천연재로서 더 사용함으로써, 기억력 향상 및 심리적 스트레스 완화를 통해 학습능력을 현저히 개선하는 것이다. That is, the baekbokshin, original paper and Seokchangpo are conventionally used as raw materials for Chongmyeongtang, which are good for forgetfulness and have an effect of improving memory. However, when only these baekbokshin, original paper and Seokchangpo are used, the effect is negligible. In the present invention, by further using soft meat as a natural material, the learning ability is significantly improved through improved memory and psychological stress.

또한, 본 발명은 천연재로서 녹용, 지골피, 선령비, 백출, 백지, 원육, 백자인, 합환피, 자하거, 복령, 단삼, 용골, 모려, 구기자, 결명자, 감국, 산조인, 백작약, 인삼, 황기 및 영신초 중 1종 이상을 더 사용함으로써, 기억력 향상 및 심리적 스트레스 완화의 효과를 더욱 높일 수 있다.In addition, the present invention, as a natural material, antler, phalanx, seonryeongbi, Baekchul, Baekji, raw meat, Baekjain, Haphwanpi, Zahager, Bokryeong, Dansam, Keel, Mori, Gojija, ginseng, Gamguk, Sanjoin, Countess, Ginseng, Hwanggi and By using one or more of Youngsincho, the effect of improving memory and alleviating psychological stress can be further enhanced.

더욱 구체적으로, 상기 녹용, 지골피 및 선령비는 도파민의 작용을 도와 집중력과 학습력을 더욱 개선해주고, 백출, 백지, 원육, 백자인 및 합환피는 시험불안, 두통, 과민성대장증후군 등을 예방하며, 영신초는 언어능력 향상에 도움을 주고, 자하거, 복령, 단삼, 용골 및 모려는 세로토닌을 조절하여 안정적인 학습태도와 정서안정을 도와주는 역할을 한다. 또한, 구기자, 결명자 및 감국은 학습시 안구건조증, 눈의 피로감을 덜어주는 역할을 하며, 산조인, 백작약, 인삼 및 황기는 학생들의 수면장애와 만성피로를 돕는 역할을 하는바, 이를 선택적으로 사용할 수 있다.More specifically, the deer antler, phalanx and senior ratio improve the concentration and learning ability by helping dopamine work, Baekchul, Baekji, raw meat, Baekjain and Happi avoid test anxiety, headache, irritable bowel syndrome, and Yeongsincho It helps to improve language ability, and helps to stabilize learning attitude and emotional stability by controlling serotonin by controlling Jahager, Bokryeong, Dansam, Keel and Mori. In addition, wolfberry, terminator, and chrysanthemum play a role in relieving dry eye syndrome and eye fatigue during learning. Sanjoin, Countess, Ginseng, and Hwanggi help students with sleep disorders and chronic fatigue. have.

따라서, 가장 바람직하게는 녹용, 지골피 및 선령비 중 1종 이상; 백출, 백지, 원육, 백자인 및 합환피 중 1종 이상; 영신초; 자하거, 복령, 단삼, 용골 및 모려 중 1종 이상; 구기자, 결명자 및 감국 중 1종 이상; 산조인, 백작약, 인삼 및 황기 중 1종 이상;을 선택하여 천연재에 더 포함하는 것이다. Therefore, most preferably, at least one of deer antler, phalanx and age ratio; One or more of Baekchul, Baekji, raw meat, Baekjain, and Hwanhappi; Youngsincho; One or more of Jahager, Bokryeong, Dansam, Keel and Moryeo; One or more of wolfberry, terminator, and chrysanthemum; One or more of Sanjoin, Count, Ginseng, and Astragalus; selected to be further included in natural materials.

본 발명에서 사용되는 천연재에 대해 간략히 살펴보면 다음과 같다.A brief look at the natural materials used in the present invention are as follows.

먼저, 상기 백복신은 복령(구명장이버섯과 Polyporaceae)의 균핵으로 속에 소나무뿌리가 박힌 것을 의미하는바, 이를 건조한 약재이다. 상기 백복신은 이뇨, 억균작용, 장관이완작용, 궤양예방효과, 혈당강하작용, 심장수축력 증가, 면역증강작용, 항종양작용 등이 있어 건망증, 가슴두근거림 등에 사용된다. 상기 백복신은 천연재 내 100중량부로 사용된다.(이하, '중량부'는 상기 백복신 100중량부를 기준으로 한다.)First, the baekboksin means that pine roots are embedded in the bacterial nuclei of Bokryeong (lifejack and Polyporaceae), which is a dry herb. The baekboksin is used for forgetfulness, throbbing, etc., such as diuretic, anti-bacteria, intestinal relaxation, ulcer prevention effect, hypoglycemic effect, increased heart contractility, immune enhancement, anti-tumor effect, etc. The baekxin is used as 100 parts by weight in the natural material. (hereinafter,'part by weight' is based on 100 parts by weight of the baekxin).

상기 원지는 원지의 뿌리를 건조한 약재로, 거담제, 강장제, 강정제로 쓰인다. 상기 원지는 천연재 내 50~100중량부로 사용됨이 바람직하다.The base paper is used as a dry medicinal material, expectorant, tonic, and gangjeongje root of the base. The base paper is preferably used as 50 to 100 parts by weight in natural materials.

상기 석창포는 석창포의 뿌리줄기를 건조한 약재로, 정신을 맑게 하고 혈액 순환을 촉진하며 풍습사(風濕邪)와 담(痰)을 없앤다. 상기 석창포는 천연재 내 50~100중량부로 사용됨이 바람직하다.The Seokchangpo is a dry medicinal root of Seokchangpo, which clears the mind, promotes blood circulation, and eliminates wind and death. The Seokchangpo is preferably used in 50 to 100 parts by weight in the natural material.

상기 연자육은 연꽃(Nelumbo nucifera Gaertner)의 씨로서 종피를 벗겨 말린 약재로, 비위를 돕고 정신과 기운 돋운다. 상기 연자육은 천연재 내 50~100중량부로 사용됨이 바람직하다.The lotus seed is a seed of a lotus flower (Nelumbo nucifera Gaertner) and is a dried medicinal material that peels off the seed coat to help the stomach and awaken the spirit and energy. The soft meat is preferably used as 50 to 100 parts by weight in the natural material.

상기 녹용은 자라기 시작한 지 2개월 이내의 아직 각질화가 되지 않아 만져보면 약간 물렁할 정도로 조직이 연하고 털이 골고루 덮여 있는 수컷의 뿔을 사용하는바, 강장작용, 보혈작용, 강정작용, 진통작용, 조혈작용, 생장발육촉진작용, 심부전증 치료작용 및 기능항진작용 등의 치료학적 효과뿐만 아니라, 피로회복, 신체활력증강 및 신장의 이뇨기능강화효과 등 많은 효능을 갖고 있다. 상기 녹용은 천연재 내 1~50중량부로 혼합될 수 있다. The antler has not been keratinized within 2 months of starting to grow, so it uses a male horn that is soft and evenly covered with tissue that is slightly soft when touched. Tonic, tonic, blood, action, analgesic, hematopoietic In addition to the therapeutic effects such as action, growth and growth promotion, heart failure treatment, and hyperactivity, it has many effects such as fatigue recovery, enhancement of physical vitality, and enhancement of diuretic function of the kidneys. The antler may be mixed in 1 to 50 parts by weight in natural materials.

상기 지골피는 구기자나무의 뿌리껍질을 건조한 약재로, 혈압강하작용, 혈당강하작용 등이 있다. 상기 지골피는 천연재 내 1~50중량부로 혼합될 수 있다. The phalanx is a dry medicinal material that peels the root of a goji tree, and has a hypotensive action, hypoglycemic action, and the like. The phalanx can be mixed in 1 to 50 parts by weight in natural materials.

상기 선령비는 삼지구엽초의 지상부를 건조한 약재로, 정액분비촉진, 혈압강하, 관상동맥 혈류량 증가, 혈당강하, 콜레스테롤강하, 면역기능증진, 진해, 거담, 평천, 진정작용, 억균, 소염작등 등의 작용을 한다. 상기 선령비는 천연재 내 1~50중량부로 혼합될 수 있다. The above age ratio is a dry herb in the upper part of trilobite, promoting semen secretion, lowering blood pressure, increasing coronary blood flow, lowering blood sugar, lowering cholesterol, enhancing immune function, Jinhae, Geodam, Pyeongcheon, sedative, anti-bacterial, anti-inflammatory, etc. It works. The age ratio may be mixed in 1 to 50 parts by weight in natural materials.

상기 백출은 백출의 뿌리줄기 또는 주피를 제거하여 말린 약재로서, 체중 증가와 지구력 증가, 탐식 능력을 증가, 세포 면역 기능 촉진 등의 작용을 한다. 상기 백출은 천연재 내 1~50중량부로 혼합될 수 있다. The Baekchul is a dried herb by removing the rhizome or skin of the Baekchul, which increases weight, increases endurance, increases gluttony, and promotes cellular immune function. The baekchul can be mixed in 1 to 50 parts by weight in natural materials.

상기 백지는 산형과의 구릿대(Angelica dahurica Bentham et Hooker) 또는 그 변종의 뿌리를 말려 만든 약재로서, 유행성 감기로 인한 두통, 코막힘, 콧물을 다스리는 진통약이며, 위장장애, 산전 산후두통, 어지럼증, 치통, 안면신경통, 마비 등에 유효하다. 또한 월경 뒤 하혈이나, 대하, 대변에 피가 섞여 나올 때, 축농증으로 인한 두통, 창양, 종독, 피부궤양 등에도 효과가 있다. 상기 백지는 천연재 내 1~50중량부로 혼합될 수 있다. The white paper is a medicine made by drying the roots of the mountain type (Angelica dahurica Bentham et Hooker) or its variants, as a pain reliever for headaches, stuffy nose, and runny nose caused by a pandemic cold, gastrointestinal disorders, prenatal postpartum headache, dizziness, It is effective for toothache, facial neuralgia, and paralysis. It is also effective for headaches, swelling, poisoning, and skin ulcers caused by sinusitis when blood is mixed with lower blood, stool, and feces after menstruation. The white paper may be mixed in 1 to 50 parts by weight in natural materials.

상기 원육은 용안(Dimocarpus longan Lour.:龍眼)의 가종피를 건조한 것으로, 옴균억제, 강장작용, 항산화작용, 면역 기능활성화작용 등이 있다. 상기 원육은 천연재 내 1~50중량부로 혼합될 수 있다. The raw meat is a dried dry skin of Longan (Dimocarpus longan Lour.: 龍眼), and has anti-ombacteria, tonic, antioxidant, and immune function activation. The raw meat may be mixed in 1 to 50 parts by weight in natural materials.

상기 백자인은 측백나무의 여문 씨를 말린 것으로, 심혈부족으로 잘 놀라면서 가슴이 두근거리는 데 쓰인다. 상기 백자인은 천연재 내 1~50중량부로 혼합될 수 있다. The white porcelain is a dried pear seed of the cypress tree, and is used to beat the chest while being surprised by the lack of cardiovascular system. The white porcelain may be mixed in 1 to 50 parts by weight in natural materials.

상기 합환피는 자귀나무의 껍질을 말린 약재로, 건망증, 불면증, 폐농양, 부스럼, 골절 등에 사용된다. 상기 합환피는 천연재 내 1~50중량부로 혼합될 수 있다. The haphwanpi is a medicinal material that has dried the bark of a tree, and is used for forgetfulness, insomnia, lung abscess, swelling, and fractures. The combined skin may be mixed in 1 to 50 parts by weight in natural materials.

상기 자하거는 태반을 건조한 약재로, 정혈을 돕는다. 상기 자하거는 천연재 내 1~50중량부로 혼합될 수 있다. The Zahager is a dry medicinal placenta that helps with blood clotting. The Zahager may be mixed in 1 to 50 parts by weight in natural materials.

상기 복령은 복령(Poria cocas Wolf.)의 균핵을 건조한 약재로, 예전부터 강장제로 사용되었으며, 질병을 앓고 난 후 허약한 사람이나 만성 위장병 환자 등의 치료를 위한 약재로 이용되고 있다. 상기 복령은 천연재 내 1~50중량부로 혼합될 수 있다. The bok-ryeong is a dry medicinal material for the nucleus of Poria (Poria cocas Wolf.), and has been used as a tonic for a long time. It has been used as a medicine for the treatment of people with weakness or chronic gastrointestinal disease after suffering from the disease. The bokryeong may be mixed in 1 to 50 parts by weight in natural materials.

상기 단삼은 단삼의 뿌리를 건조한 약재로서, 혈액순환을 돕고, 어혈을 제거하며 사지관절 동통을 완화시킨다. 부인의 생리불순, 생리통, 산후복통, 어혈성심복부통, 타박상 등을 치료한다. 고열로 인한 정신혼몽, 헛소리, 번조, 불면증, 피부발진, 심계항진 등을 치료한다. 상기 단삼은 천연재 내 1~50중량부로 혼합될 수 있다. The ginseng is a dry medicinal root of the ginseng, helps blood circulation, removes blood and relieves limb pain. It treats women's menstrual irregularities, menstrual cramps, postpartum abdominal pain, hemophilic abdominal pain, and bruises. It treats mental disorders, bullshit, insomnia, insomnia, skin rash, and hyperactivity caused by high fever. The ginseng may be mixed in 1 to 50 parts by weight in natural materials.

상기 용골은 큰 포유동물의 뼈를 의미하는 것으로, 정신을 안정시키고 수렴(收斂) 작용을 한다. 상기 용골은 천연재 내 1~50중량부로 혼합될 수 있다. The keel refers to the bone of a large mammal, and stabilizes the mind and converges. The keel may be mixed in 1 to 50 parts by weight in natural materials.

상기 모려는 굴조개류의 조가비를 씻어 말린 것으로, 신경(腎經) · 간경(肝經)에 작용한다. 상기 모려는 천연재 내 1~50중량부로 혼합될 수 있다. The morye is washed and dried conch of oyster shellfish, and acts on nerves and liver cirrhosis. The wool may be mixed in 1 to 50 parts by weight in natural materials.

상기 구기자는 구기자나무의 열매를 건조한 것으로, 비특이성 면역증강 작용, 조혈작용, 콜레스테롤강하작용, 항지방간작용, 혈압강하, 혈당강하, 생장촉진, 항암작용 등을 한다. 상기 구기자는 천연재 내 1~50중량부로 혼합될 수 있다. The goji berry is dried fruit of the goji berry, and has non-specific immune enhancing action, hematopoietic action, cholesterol lowering action, anti-fatty liver action, lowering blood pressure, lowering blood sugar, promoting growth, and anti-cancer action. The goji berry may be mixed in 1 to 50 parts by weight in natural materials.

상기 결명자는 결명의 씨를 의미하는 것으로, 간화(肝火)를 내려 눈이 충혈되고 붓고 아프며 눈물이 흐르는 증상을 치료한다. 상기 결명자는 천연재 내 1~50중량부로 혼합될 수 있다. The gyeolmyeongja means the seed of the gyeolmyeong, ganhwa (肝火) down the eyes are congested, swelling, pain, and the symptoms of tears are treated. The terminator may be mixed in 1 to 50 parts by weight in natural materials.

상기 감국은 감국 또는 국화의 말린 꽃을 의미하는 것으로, 눈과 머리를 시원하게 하고 눈물이 나는 것을 멎게 하며 열을 내린다. 가슴속에 열이 있어 답답한 증상, 폐렴, 기관지염, 두통, 어깨결림, 고혈압에 효과가 있다. 간기능과 충혈, 생리불순과 여드름 등 피부트러블에 사용한다. 상기 감국은 천연재 내 1~50중량부로 혼합될 수 있다. The gamguk refers to dried flowers of chrysanthemum or chrysanthemum, cools eyes and hair, stops tears, and lowers heat. It has fever in the chest and is effective for frustrating symptoms, pneumonia, bronchitis, headache, stiff shoulder, and high blood pressure. It is used for skin problems such as liver function and hyperemia, menstrual impurity and acne. The chrysanthemum can be mixed in 1 to 50 parts by weight in natural materials.

상기 산조인은 묏대추(Zizyphus jujuba Miller)의 씨로 만든 약재로, 신경과민, 불면증, 건망증, 식은땀 등에 사용한다. 또한, 비위를 튼튼하게 하고 빈혈에 효과가 있다. 상기 산조인은 천연재내 1~50중량부로 혼합될 수 있다. The sanjoin is a medicine made from seeds of Zizyphus jujuba Miller, and is used for nervousness, insomnia, forgetfulness, and cold sweat. In addition, it strengthens the spleen and is effective for anemia. The sanjoin may be mixed in 1 to 50 parts by weight in natural materials.

상기 백작약은 집함박꽃 Paeonia albiflora Pallas var. trichocarpa Bunge · 산함박꽃 Paeonia obovata Maxim.의 뿌리를 말린 약재로, 간경(肝經)·비경(脾經)·폐경(肺經)에 작용한다. 혈액을 풍부하게 하고 통증과 땀을 멎게 하며 지혈하고 간화(肝火)를 없애며 소변이 잘 나오게 한다. 상기 백작약은 천연재 내 1~50중량부로 혼합될 수 있다. The Count is Paeonia albiflora Pallas var. trichocarpa Bunge · This is a dried herb of Paeonia obovata Maxim., which acts on liver cirrhosis, menopause and menopause. It enriches the blood, stops the pain and sweat, stops hemostasis, eliminates liver and helps urine to come out well. The Count can be mixed in 1 to 50 parts by weight in natural materials.

상기 인삼은 사포닌 등 유효성분이 다량 함유되어 있어, 체력보강에 유용하다. 상기 인삼은 천연재 내 1~50중량부로 혼합될 수 있다. The ginseng contains a large amount of active ingredients such as saponins, and is useful for stamina. The ginseng may be mixed in 1 to 50 parts by weight in natural materials.

상기 황기는 황기의 뿌리를 건조한 것으로, 강장(强壯) 작용, 면역 기능 조절 작용, 소염 작용 등이 있다. 상기 황기는 천연재 내 1~50중량부로 혼합될 수 있다. The astragalus is a dry root of the astragalus, and has tonic (强壯) action, immune function regulation action, anti-inflammatory action, and the like. The astragalus may be mixed in 1 to 50 parts by weight in natural materials.

상기 영신초는 애기풀의 뿌리를 포함한 모든 부분을 건조한 것으로, 기침, 천식, 백일해, 기관지염, 편도선염, 소아 간질병, 토혈, 골수염 등에 사용된다. 그밖에 종기와 뱀에 물린 상처의 치료에도 쓰인다. 상기 영신초는 천연재 내 1~50중량부로 혼합될 수 있다. The Yeongsincho is dried on all parts including the roots of celandine, and is used for cough, asthma, whooping cough, bronchitis, tonsillitis, childhood epilepsy, hemolysis, and osteomyelitis. It is also used to treat boils and snake bites. The Yeongsincho may be mixed in 1 to 50 parts by weight in natural materials.

즉, 상기 백복신 100중량부에 대하여, 원지 50~100중량부, 석창포 50~100중량부 및 연자육 50~100중량부를 포함하고, 상기 녹용 1~50중량부, 지골피 1~50중량부, 선령비 1~50중량부, 백출 1~50중량부, 백지 1~50중량부, 원육 1~50중량부, 백자인 1~50중량부, 합환피 1~50중량부, 자하거 1~50중량부, 복령 1~50중량부, 단삼 1~50중량부, 용골 1~50중량부, 모려 1~50중량부, 구기자 1~50중량부, 결명자 1~50중량부, 감국 1~50중량부, 산조인 1~50중량부, 백작약 1~50중량부, 인삼 1~50중량부, 황기 1~50중량부 및 영신초 1~50중량부 중 1종 이상을 더 포함하는 것으로 이는 각 천연재의 성분, 약리작용 등을 고려한 혼합비이다.That is, with respect to 100 parts by weight of the baekboksin, including 50 to 100 parts by weight of base paper, 50 to 100 parts by weight of Seokchangpo and 50 to 100 parts by weight of soft meat, 1 to 50 parts by weight of antler, 1 to 50 parts by weight of phalanx, 1-50 parts by weight, Baekchul 1-50 parts by weight, white paper 1-50 parts by weight, raw meat 1-50 parts by weight, white porcelain 1-50 parts by weight, haptic skin 1-50 parts by weight, self-harvesting 1-50 parts by weight, Bokryeong 1-50 parts by weight, 1-50 parts by weight of ginseng, 1-50 parts by weight of keel, 1-50 parts by weight of wool, 1-50 parts by weight of wolfberry, 1-50 parts by weight of ginseng, 1-50 parts by weight of chrysanthemum, 1 part of Sanjoin ~50 parts by weight, 1-50 parts by weight of the count, 1-50 parts by weight of ginseng, 1-50 parts by weight of astragalus, and 1-50 parts by weight of Yeongsincho, which further include one or more components of each natural material, pharmacological action, etc. It is a mixing ratio considering.

본 발명에서 상기 열수추출물은 종래 게시된 통상의 방법에 따라 제조될 수 있으며, 예시적으로 천연재에 5~20중량배의 물을 가하고, 이를 50~100℃로 1~24시간 가열하고, 여과함으로써, 제조될 수 있다. 또한, 이러한 추출물은 필요에 따라 여과하거나 농축 또는 건조과정을 수행하여 용매인 물을 제거할 수 있음은 당연하다.In the present invention, the hot water extract may be prepared according to a conventionally published conventional method, for example, adding 5 to 20 weight times water to natural materials, heating it to 50 to 100°C for 1 to 24 hours, and filtering By doing so, it can be produced. In addition, it is natural that these extracts can remove water, which is a solvent, by filtering or performing a concentration or drying process as necessary.

상기와 같이 구성되는 총명탕 조성물은 앞서 설명된 바와 같이, 항피로 활성 및 두뇌활동, 특히 기억력 증진에 우수한 활성을 가져 학습 능력을 향상시키고, 스트레스를 완화한다는 장점이 있다.As described above, the composition of Chongmyeong-tang composed as described above has an advantage of anti-fatigue activity and brain activity, in particular, excellent activity in enhancing memory, thereby improving learning ability and alleviating stress.

한편, 본 발명의 총명탕 조성물은, 상기 천연재로서 구상나무 50~100중량부를 더 포함함으로써, 상기한 백복신, 석창포, 원지 및 연자육과의 상호작용을 통해 피로를 회복시키고, 체력을 증진시키며, 두뇌 활성을 증가시키고, 심리적인 스트레스를 해소시켜 학습능력을 더욱 향상시키는 것이다.On the other hand, the total myeongtang composition of the present invention, by further comprising 50 to 100 parts by weight of the globular tree as the natural material, restores fatigue through interaction with the above-mentioned Baekbokshin, Seokchangpo, Wonji and Yeonjayuk, improves physical strength, and improves the brain It increases activity and relieves psychological stress to further improve learning ability.

상기 구상나무는 소나무과의 여러해살이 상록 침엽 교목으로, 그 잎, 수피 및 구과 중 하나 이상을 건조한 것을 의미한다. 상기 구상나무는 우수한 항염 및 항균 효과를 갖는다. The globular tree is a perennial coniferous tree of the pine family, and means that one or more of its leaves, bark, and conifers are dried. The bulbous tree has excellent anti-inflammatory and antibacterial effects.

또한, 본 발명에서 상기 천연재는 아레카야자 1~10중량부, 무화과나무 1~10중량부 및 토란 1~10중량부를 더 포함할 수 있다.In addition, in the present invention, the natural material may further include 1 to 10 parts by weight of areca palm, 1 to 10 parts by weight of fig tree, and 1 to 10 parts by weight of taro.

상기 아레카야자(Chrysalidorcarpus lutescens)는 가시가 없는 야자의 일종인 공기정화식물로서, 그 잎을 건조한 것을 사용하며, 이를 통해 스트레스를 완화에 도움을 주어 더욱 우수한 학습력을 발휘할 수 있다. The Areca palm (Chrysalidorcarpus lutescens) is an air-purifying plant that is a kind of thorn-free palm, and uses the dried leaves of the leaves, thereby helping to alleviate stress, thereby exerting superior learning ability.

또한, 상기 무화과나무는 무화과나무의 잎을 건조한 것이고, 토란은 토란의 알뿌리를 건조한 것으로, 상기 무화과나무와 토란은 상기 백복신, 원지 및 석창포와 함께 사용시 인지력 및 학습력을 현저히 증진시키는 효과가 있다. In addition, the fig tree is a dry leaf of the fig tree, the taro is the dried root of the taro, and the fig tree and the taro have the effect of significantly improving cognition and learning ability when used together with the baekboksin, raw paper, and changchangpo.

상기 본 발명에 의한 총명탕 조성물의 섭취량 또는 복용량(경구 투여)은 당업자의 수준 내의 범위에서 한정될 수 있으며, 본 발명에 따른 조성물의 1일 투여 용량은 투여하고자 하는 대상의 체질, 체중, 나이, 건강상태, 합병증 등의 다양한 요인에 따라 달리할 수 있으며, 예시적으로 청소년 45kg 기준으로, 상기 총명탕 조성물 5~400ml를 1일 1 내지 2회 분할하여 복용할 수 있다. The intake amount or dosage (oral administration) of the cheongmyeongtang composition according to the present invention may be limited within a range of those skilled in the art, and the daily dosage of the composition according to the present invention is the constitution, weight, age, and health of the subject to be administered. It can be varied according to various factors such as condition and complications, and for example, based on adolescents 45 kg, 5 to 400 ml of the total myeongtang bath composition can be divided into 1 to 2 times a day.

이하, 구체적인 실시예를 통해 본 발명을 더욱 상세히 설명한다.Hereinafter, the present invention will be described in more detail through specific examples.

(실시예 1)(Example 1)

백복신 100g, 원지 100g, 석창포 100g 및 건조 연자육 100g을 혼합한 천연재에 10중량배의 물을 가한 후 90℃에서 4시간 환류추출하였다. 100 g of bokboksin, 100 g of base paper, 100 g of Seokchangpo and 100 g of dried lotus meat were added with 10 weight times of water and refluxed at 90°C for 4 hours.

그리고 이를 40℃로 냉각한 다음, 여과포 여과와 원심분리를 통해 잔사와 여액을 분리하였다. 그리고 이를 다시 90℃에서 20분간 살균하였다. 이때, 상기 천연재는 100mesh 정도로 분말화하여 사용하였다. Then, after cooling to 40° C., the residue and the filtrate were separated through filtration and filtration and centrifugation. And it was sterilized again at 90°C for 20 minutes. At this time, the natural material was used by pulverizing to about 100 mesh.

(실시예 2)(Example 2)

실시예 1과 동일하게 실시하되, 녹용 5g, 백출 5g, 단삼 5g, 결명자 5g, 인삼 5g, 영신초 5g 및 구상나무 건잎 50g을 천연재로서 더 사용하였다. It was carried out in the same manner as in Example 1, 5g antler, 5g baekchul, 5g ginseng, 5g ginseng, 5g ginseng, 5g Yeongsincho and 50g globose dried leaves were used as natural materials.

(실시예 3)(Example 3)

실시예 2와 동일하게 실시하되, 무화과나무의 건잎 10g, 토란의 알뿌리 건조물 10g을 천연재로서 더 사용하였다. The same procedure as in Example 2 was performed, but 10 g of dried leaves of the fig tree and 10 g of dried dried roots of taro were further used as natural materials.

(비교예 1)(Comparative Example 1)

백복신 100g, 원지 100g, 석창포 100g를 혼합한 천연재에 10중량배의 물을 가한 후 90℃에서 4시간 환류 추출하였다. 그리고 이를 40℃로 냉각한 다음, 여과포 여과와 원심분리를 통해 잔사와 여액을 분리하였다. 그리고 이를 다시 90℃에서 20분간 살균하였다. 이때, 상기 천연재는 100mesh 정도로 분말화하여 사용하였다. 100 g of baekboksin, 100 g of base paper, and 100 g of Seokchangpo were added with 10 times the weight of water, followed by reflux extraction at 90°C for 4 hours. Then, after cooling to 40° C., the residue and the filtrate were separated through filtration and filtration and centrifugation. And it was sterilized again at 90°C for 20 minutes. At this time, the natural material was used by pulverizing to about 100 mesh.

(시험예 1) 기억력 증진효과 실험(Test Example 1) Experiment for improving memory

실시예 1 내지 3, 비교예 1에서 제조한 시험물질을 20~40대의 사람들에게 4주간 경구 투여한 후, 기억력 개선 효과 및 기억력 감퇴의 보호 효과가 있는지 ADAS-cog 검사법(Mohs et al ., Psychopharmacol. Bull. , 19(3):448-450, 1983)을 이용하여 검증하였다. 상기 검사법은 단어회상, 단어 지연회상, 단어재인, 검사지침 기억하기, 낱말 찾기 어려움, 알아듣기 총 6개 영역으로 구성되어 있고, 각 영역의 점수를 합산하여 평가하였다.(점수가 낮을수록 수행이 좋다는 것(인식능력 및 기억능력이 높다는 것)을 의미한다.) 100명의 피험자를 대조군(20명)과 처치1군(20명), 처치2군(20명), 처치3군(20)명, 처치4군(20명)에 무작위로 할당하였다. 처치1군에는 상기 실시예 1에서 제조한 시험물질을 1일 2회(150ml) 12주간 복용하게 하였으며, 처치2군에는 상기 실시예 2, 처치3군에는 상기 실시예 3, 처치4군에는 상기 비교예 1의 시험물질을 동일한 용량으로 동일기간 동안 복용하게 하였으며, 대조군에는 증류수를 복용하게 하였다. 효과 검증을 위한 평가는 투여 전과 투여 4주 후에 각각 측정하였고, 그 결과를 하기 표 1에 기재하였다.ADAS-cog test (Mohs et al., Psychopharmacol) whether or not the test substances prepared in Examples 1 to 3 and Comparative Example 1 were orally administered to people in their 20s and 40s for 4 weeks, and there was an effect of improving memory and protecting memory. Bull., 19(3):448-450, 1983). The test method consists of a total of six areas: word recall, word delay recall, word recognition, test instruction memorization, word search difficulties, and listening, and the scores of each area are summed and evaluated. It means good (high recognition ability and memory ability). 100 subjects in control group (20), treatment group 1 (20), treatment group 2 (20), treatment group 3 (20) , Treatment group 4 (20) was randomly assigned. In the treatment group 1, the test substance prepared in Example 1 was taken twice a day (150 ml) for 12 weeks, in the treatment group 2, in Example 2, in the treatment group 3, in Example 3, in treatment group 4, The test substance of Comparative Example 1 was taken at the same dose for the same period, and distilled water was taken as the control. Evaluation for effect verification was measured before and 4 weeks after administration, respectively, and the results are shown in Table 1 below.

시험예 2 결과Test Example 2 results 구분division 대조군Control 처치1군
(실시예 1)
Group 1
(Example 1)
처치2군
(실시예 2)
Group 2
(Example 2)
처치3군
(실시예 3)
District 3
(Example 3)
처치4군
(비교예 1)
District 4
(Comparative Example 1)
투여 전Before administration 투여 후After administration 투여
administration
I'm
투여
administration
after
투여
administration
I'm
투여
administration
after
투여
administration
I'm
투여
administration
after
투여
administration
I'm
투여
administration
after
단어 회상Word recall 5.305.30 5.285.28 5.325.32 4.224.22 5.295.29 4.014.01 5.305.30 3.893.89 5.295.29 5.015.01 단어지연회상Word Delay Award 6.376.37 6.306.30 6.356.35 4.454.45 6.436.43 4.134.13 6.426.42 4.014.01 6.436.43 4.824.82 단어 재인Word jane 4.504.50 4.484.48 4.514.51 3.733.73 4.354.35 3.313.31 4.354.35 3.203.20 4.364.36 4.014.01 검사지침 기억하기Remember test instructions 0.380.38 0.400.40 0.390.39 0.170.17 0.310.31 0.140.14 0.320.32 0.120.12 0.330.33 0.210.21 낱말찾기 어려움Difficulty finding words 0.210.21 0.150.15 0.250.25 0.000.00 0.250.25 0.000.00 0.260.26 0.000.00 0.250.25 0.120.12 알아듣기Understand 0.150.15 0.130.13 0.170.17 0.020.02 0.150.15 0.000.00 0.160.16 0.000.00 0.170.17 0.090.09 총점Total score 16.9116.91 16.7416.74 16.9916.99 12.5912.59 16.7916.79 11.5911.59 16.8116.81 11.2211.22 16.8316.83 14.2614.26

상기 표 1에서 확인할 수 있는 바와 같이, 상기 각 처치군에서는 모두 ADAS-cog 지수가 현저히 감소한 반면, 대조군에서는 지수의 변동이 거의 없음을 확인하였다. 아울러, 처치1군 내지 처치3군이 처치4군에 비하여 지수가 현저히 감소하였음을 확인하였다.As can be seen from Table 1, in each of the treatment groups, the ADAS-cog index was significantly reduced, while the control group confirmed that there was little change in the index. In addition, it was confirmed that the treatment groups 1 to 3 were significantly decreased in index compared to the treatment 4 group.

따라서, 본 발명에 따른 총명탕 조성물은 인식능력이나 기억력을 증진시킬 수 있어 학습능력을 현저히 향상시킬 수 있음을 확인할 수 있었다.Therefore, it was confirmed that the composition of Chongmyeong-tang according to the present invention can enhance cognitive ability or memory, thereby significantly improving learning ability.

(시험예 2) 항스트레스 활성 시험(Test Example 2) anti-stress activity test

실험동물은 생후 6주령된 Wister계 Rat 수컷(Shizuoka Laboratory Animal Center, JP)을 구입하여 사용하였으며, 실험 시작 전 1주일 동안 순화시킨 후 건강한 동물만을 이용하여 실험을 시작하였다. 사육환경은 온도: 22±1℃, 습도:50±10%, 조명:12hr/day로 조절하였다.Experimental animals were purchased and used for 6-week-old Wister rat males (Shizuoka Laboratory Animal Center, JP), and purified for 1 week prior to the start of the experiment to start the experiment using only healthy animals. The breeding environment was adjusted to temperature: 22±1℃, humidity: 50±10%, and lighting: 12hr/day.

시험물질(실시예 1 내지 3, 비교예 1)은 식이에 혼합하여 100mg/kg씩 1일 1회씩 4주간 경구투여 하였으며, 식이는 자유급여하였다. Test substances (Examples 1 to 3 and Comparative Example 1) were mixed in the diet and administered orally for 4 weeks once a day for 100 mg/kg, and the diet was freely fed.

스트레스는 구속 스트레스를 가하였으며, 구체적으로 4주간의 시료 투여 후, 5시간 동안 구속 케이지에서 이루어졌다.The stress was applied to restraint stress, and specifically, after 4 weeks of sample administration, it was performed in a restraint cage for 5 hours.

실험군은 비스트레스 유발군(정상군, n=6), 스트레스 유발1군(실시예 1 투여군, n=6), 스트레스 유발2군(실시예 2 투여군, n=6), 스트레스 유발3군(실시예 3 투여군, n=6), 스트레스 유발4군(비교예 1 투여군, n=6), 스트레스 유발5군(시험물질 비투여군, n=6))으로 구성되었다.The experimental group was the non-stress-induced group (normal group, n=6), stress-induced group 1 (Example 1 administration group, n=6), stress-induced group 2 (Example 2 administration group, n=6), stress-induced group 3 ( Example 3 was composed of the administration group, n=6), the stress-induced group 4 (comparative example 1 administration group, n=6), and the stress-induced group 5 (non-administration group, n=6).

항스트레스 활성을 평가하기 위하여, 비스트레스 유발군을 제외하고 구속 스트레스를 가한 직후, 코티졸(cortisol), 글루코오스(glucouse) 및 젖산(lactic acid)의 혈중 농도를 측정하고, 그 결과를 하기 표 2에 나타내었다.In order to evaluate the anti-stress activity, immediately after applying restraint stress excluding the non-stress-induced group, blood concentrations of cortisol, glucose, and lactic acid were measured, and the results are shown in Table 2 below. Shown.

시험예 2 결과Test Example 2 results 구분division 코티졸의 혈중 농도(㎍/㎗)Cortisol blood concentration (㎍/㎗) 글루코오스의 혈중 농도(㎍/㎗)Glucose concentration in blood (㎍/㎗) 젖산의 혈중 농도(㎍/㎗)Blood concentration of lactic acid (㎍/㎗) 비스트레스 유발군Non-stressed group 6.86±3.436.86±3.43 105.29±5.82105.29±5.82 8.26±2.488.26±2.48 스트레스 유발5군
(시험물질 -비투여군)
Stress-induced group 5
(Test substance-non-administered group)
38.43±4.2738.43±4.27 143.70±4.59143.70±4.59 34.82±2.6334.82±2.63
스트레스 유발1군
(실시예 1 투여군)
Stress induction group 1
(Example 1 administration group)
24.15±3.2424.15±3.24 127.12±5.01127.12±5.01 23.51±3.2523.51±3.25
스트레스 유발2군
(실시예 2 투여군)
Stress-induced group 2
(Example 2 administration group)
20.02±4.1220.02±4.12 115.25±3.98115.25±3.98 20.12±3.0120.12±3.01
스트레스 유발3군
(실시예 3 투여군)
Stress-induced group 3
(Example 3 administration group)
15.28±3.9715.28±3.97 112.81±4.25112.81±4.25 15.28±2.9515.28±2.95
스트레스 유발4군
(비교예 1 투여군)
Stress-induced group 4
(Comparative Example 1 administration group)
35.40±4.8535.40±4.85 137.34±4.67137.34±4.67 30.25±2.6830.25±2.68

상기 표 2에서 확인할 수 있는 바와 같이, 본 발명의 조성물은 스트레스 유발시 스트레스 유발5군(시험물질 비투여군)에 비해 스트레스 관련 혈중 표지 인자의 농도가 뚜렷하게 감소하였음을 확인할 수 있었다. 아울러, 스트레스 유발4군(비교예 1 투여군)은 스트레스의 감소 효과가 미미함을 확인할 수 있었다. As can be seen from Table 2, it was confirmed that the composition of the present invention significantly reduced the concentration of stress-related blood markers compared to the stress-induced group 5 (non-administration group) when stress was induced. In addition, the stress-induced group 4 (Comparative Example 1 administration group) was confirmed that the effect of reducing the stress is negligible.

이상, 본 발명을 바람직한 실시예를 사용하여 상세히 설명하였으나, 본 발명의 범위는 특정 실시 예에 한정되는 것은 아니며, 첨부된 특허청구범위에 의하여 해석되어야 할 것이다. 또한, 이 기술분야에서 통상의 지식을 습득한 자라면, 본 발명의 범위에서 벗어나지 않으면서도 많은 수정과 변형이 가능함을 이해하여야 할 것이다.As described above, the present invention has been described in detail using preferred embodiments, but the scope of the present invention is not limited to specific embodiments, and should be interpreted by the appended claims. In addition, those skilled in the art should understand that many modifications and variations are possible without departing from the scope of the present invention.

Claims (4)

백복신, 원지, 석창포 및 연자육을 포함하는 천연재의 열수추출물을 포함하는 것을 특징으로 하는 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물.
Baekboksin, Wonji, Seokchangpo and hot water extracts of natural materials, including soft meat, memory, learning power improvement and stress relief myeongmyeongtang composition.
제1항에 있어서,
상기 천연재는,
상기 백복신 100중량부에 대하여, 원지 50~100중량부, 석창포 50~100중량부 및 연자육 50~100중량부를 포함하고,
녹용 1~50중량부, 지골피 1~50중량부, 선령비 1~50중량부, 백출 1~50중량부, 백지 1~50중량부, 원육 1~50중량부, 백자인 1~50중량부, 합환피 1~50중량부, 자하거 1~50중량부, 복령 1~50중량부, 단삼 1~50중량부, 용골 1~50중량부, 모려 1~50중량부, 구기자 1~50중량부, 결명자 1~50중량부, 감국 1~50중량부, 산조인 1~50중량부, 백작약 1~50중량부, 인삼 1~50중량부, 황기 1~50중량부 및 영신초 1~50중량부 중 1종 이상을 더 포함하는 것을 특징으로 하는 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물.
According to claim 1,
The natural material,
With respect to 100 parts by weight of the baekboksin, including 50 to 100 parts by weight of base paper, 50 to 100 parts by weight of Seokchangpo and 50 to 100 parts by weight of soft meat,
Deer Antler 1-50 parts by weight, phalanx 1-50 parts by weight, age ratio 1-50 parts by weight, Baekchul 1-50 parts by weight, white paper 1-50 parts by weight, raw meat 1-50 parts by weight, white porcelain 1-50 parts by weight, 1 to 50 parts by weight of combined skin, 1 to 50 parts by weight of Jahager, 1 to 50 parts by weight of Bokryeong, 1 to 50 parts by weight of ginseng, 1 to 50 parts by weight of keel, 1 to 50 parts by weight of wool, 1 to 50 parts by weight of wolfberry, 1 to 50 parts by weight of ginseng, 1 to 50 parts by weight of chrysanthemum, 1 to 50 parts by weight of Sanjoin, 1 to 50 parts by weight of ginseng, 1 to 50 parts by weight of ginseng, 1 to 50 parts by weight of astragalus and 1 to 50 parts by weight of Yeongsincho Chongmyeongtang composition for improving memory, learning ability, and stress relief, further comprising more than one species.
제2항에 있어서,
상기 천연재는,
구상나무 50~100중량부를 더 포함하는 것을 특징으로 하는 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물.
According to claim 2,
The natural material,
A composition of gongmyeongtang for improving memory, learning ability, and stress relief, further comprising 50 to 100 parts by weight of a spherical tree.
제1항 내지 제3항 중 어느 한 항에 있어서,
아레카야자 1~10중량부, 무화과나무 1~10중량부 및 토란 1~10중량부를 더 포함하는 것을 특징으로 하는 기억력, 학습력 향상 및 스트레스 완화용 총명탕 조성물.
The method according to any one of claims 1 to 3,
Areca palm 1 to 10 parts by weight, fig tree 1 to 10 parts by weight, and taro 1 to 10 parts by weight further comprising memory, learning power improvement and stress relief total myeongtang bath composition.
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