CN102911281B - 从海藻提取物中纯化岩藻依聚糖的工艺方法 - Google Patents
从海藻提取物中纯化岩藻依聚糖的工艺方法 Download PDFInfo
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- CN102911281B CN102911281B CN201210417761.8A CN201210417761A CN102911281B CN 102911281 B CN102911281 B CN 102911281B CN 201210417761 A CN201210417761 A CN 201210417761A CN 102911281 B CN102911281 B CN 102911281B
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
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- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0036—Galactans; Derivatives thereof
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- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
亲本样品批次(NP-051316) | 实验批次1 | 实验批次2 | |
岩藻糖 | 60.7 | 60.3 | 61.1 |
木糖 | 22.8 | 27.4 | 24.9 |
葡萄糖 | 5.5 | 1.6 | 0.8 |
半乳糖 | 3.9 | 0.6 | ND |
甘露糖 | 3.3 | ND | 4.0 |
半乳糖醛酸 | 2.4 | 2.2 | 3.1 |
葡萄糖醛酸 | 1.4 | ND | ND |
鼠李糖 | ND | 4.3 | 6.1 |
内毒素(EU/mg) | |
亲本批次(NP-051316) | 88.6 |
实验批次1 | 38 |
实验批次2 | 40 |
Claims (14)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89128707P | 2007-02-23 | 2007-02-23 | |
US60/891,287 | 2007-02-23 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008800079552A Division CN101663326B (zh) | 2007-02-23 | 2008-02-01 | 从海藻提取物中纯化岩藻依聚糖的工艺方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102911281A CN102911281A (zh) | 2013-02-06 |
CN102911281B true CN102911281B (zh) | 2015-04-15 |
Family
ID=39545010
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN2008800079552A Active CN101663326B (zh) | 2007-02-23 | 2008-02-01 | 从海藻提取物中纯化岩藻依聚糖的工艺方法 |
CN201210417761.8A Active CN102911281B (zh) | 2007-02-23 | 2008-02-01 | 从海藻提取物中纯化岩藻依聚糖的工艺方法 |
Family Applications Before (1)
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---|---|---|---|
CN2008800079552A Active CN101663326B (zh) | 2007-02-23 | 2008-02-01 | 从海藻提取物中纯化岩藻依聚糖的工艺方法 |
Country Status (8)
Country | Link |
---|---|
US (2) | US8748595B2 (zh) |
EP (3) | EP2121767B1 (zh) |
JP (1) | JP5679663B2 (zh) |
KR (1) | KR101486931B1 (zh) |
CN (2) | CN101663326B (zh) |
ES (2) | ES2476250T3 (zh) |
HK (1) | HK1135120A1 (zh) |
WO (1) | WO2008103234A1 (zh) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2121767B1 (en) * | 2007-02-23 | 2014-04-09 | Baxter International Inc. | Process methods for fucoidan purification from seaweed extracts |
SI2379096T1 (sl) | 2008-12-19 | 2020-03-31 | Baxalta GmbH | Zaviralci TFPI in postopki uporabe |
JO3676B1 (ar) * | 2009-07-27 | 2020-08-27 | Arc Medical Devices Inc | مركبات صيدلانية تضم فوكانات معدلة وطرق تتعلق بها |
CN101659709B (zh) * | 2009-09-18 | 2011-09-07 | 集美大学 | 岩藻聚糖的制备方法 |
JP6393453B2 (ja) * | 2010-01-14 | 2018-09-19 | バクスアルタ ゲーエムベーハー | 出血性障害を治療するための方法及び組成物 |
WO2011115712A2 (en) | 2010-03-19 | 2011-09-22 | Baxter International Inc | Tfpi inhibitors and methods of use |
CA2798811A1 (en) * | 2010-05-27 | 2011-12-01 | Laboratorios Leti, S.L. | Topical pharmaceutical or cosmetic composition useful for the treatment of diseases or conditions that transcur through a deficit of maturation of the cornified envelope |
MY170013A (en) * | 2010-06-28 | 2019-06-20 | Stemtech Int Inc | Methods and compositions for enhancing stem cell mobilization |
NZ610788A (en) * | 2010-11-23 | 2014-07-25 | Fmc Corp | Process for isolating fucoidan and laminarin from live, harvested seaweed |
CN103338780A (zh) * | 2010-12-20 | 2013-10-02 | 韩国食品研究院 | 含有腔昆布提取物和黑昆布提取物的用于正向变构调节gabaa-苯二氮杂*受体的组合物和用于产生镇静催眠效果的组合物 |
CN102321052B (zh) * | 2011-05-26 | 2013-08-21 | 天津市尖峰天然产物研究开发有限公司 | 综合利用海带提取纯化岩藻黄质和岩藻聚糖硫酸酯的方法 |
DK2734213T3 (en) * | 2011-07-19 | 2018-08-13 | Baxalta GmbH | RESORPTION PROMOTERS ADDITIVES TO IMPROVE ORAL FORMULATION OF NON-ANTI-COATING SULPHATE POLYSACCHARIDS |
US20140186456A1 (en) * | 2011-08-25 | 2014-07-03 | Lillian M. Day | Tripartite Bioactive Composition Providing Anti-Oxidant and Anti-Inflammatory Effects with Immune System and Stem Cell Production Enhancement |
CN102417549B (zh) * | 2011-11-07 | 2013-07-24 | 沈阳科思高科技有限公司 | 一种基于微波化学的褐藻活性多糖的提取方法 |
EA201490995A1 (ru) | 2011-11-18 | 2014-08-29 | Стемтек Интернэшнл, Инк. | Использование фо-ти для усиления мобилизации и пролиферации стволовых клеток |
DK2827883T3 (da) | 2012-03-21 | 2019-07-29 | Baxalta GmbH | Tfpi-inhibitorer og fremgangsmåder til anvendelse |
DK2885642T3 (da) | 2012-08-14 | 2019-07-29 | Baxalta GmbH | Fremgangsmåder og systemer til screening af sammensætninger omfattende ikke-antikoagulerende sulfaterede polysaccharider |
CA2898515C (en) * | 2013-01-25 | 2022-01-04 | Marinova Pty Ltd | Methods for depyrogentating a seaweed extract |
CN104698159B (zh) * | 2015-03-10 | 2017-03-08 | 中国科学院苏州生物医学工程技术研究所 | 一种内毒素含量的检测方法 |
EP3925642A1 (en) | 2016-06-27 | 2021-12-22 | Takeda Pharmaceutical Company Limited | Syringe stabilizer |
KR101721998B1 (ko) * | 2016-08-16 | 2017-03-31 | (주)한국바이오엔지니어링 | 이미, 이취, 및 염분 제거를 위한 반용매 정제기술이 적용된 후코이단 제조 방법 |
KR101866906B1 (ko) * | 2017-04-05 | 2018-06-12 | 한남대학교 산학협력단 | 후코이단의 추출방법 |
CN108641008B (zh) * | 2018-05-11 | 2020-07-24 | 大连工业大学 | 裙带菜孢子叶提取岩藻聚糖硫酸酯及脱除重金属的方法 |
US11642368B2 (en) | 2018-07-27 | 2023-05-09 | ARC Medical Inc. | Highly purified and/or modified fucan compositions for the treatment of fibrous adhesions |
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CN112062871B (zh) * | 2020-10-14 | 2022-06-28 | 福州海王福药制药有限公司 | 一种红藻多糖的制备方法 |
WO2023170680A1 (en) | 2022-03-08 | 2023-09-14 | Equashield Medical Ltd | Fluid transfer station in a robotic pharmaceutical preparation system |
CN115386013B (zh) * | 2022-04-19 | 2023-05-12 | 广西中医药大学 | 一种具有强效抗凝活性的海带多糖及其制备方法和应用 |
WO2024062077A1 (en) | 2022-09-21 | 2024-03-28 | Bioatlantis Limited | Phlorotannins and alpha-fucans to treat type 2 diabetes mellitus |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1328062A (zh) * | 2001-04-28 | 2001-12-26 | 武汉大学 | 高纯度魔芋葡甘聚糖的提取工艺 |
CN1344565A (zh) * | 2001-10-19 | 2002-04-17 | 汤洁 | 岩藻多糖酯作为抗病毒及免疫调节剂及其制备方法 |
US6593311B2 (en) * | 1996-01-26 | 2003-07-15 | Takara Shuzo Co., Ltd. | Apoptosis inducers |
CN1515592A (zh) * | 2003-01-02 | 2004-07-28 | 合肥学院 | 微生物酶法制备低分子量岩藻多糖工艺 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2097279B (en) * | 1981-04-27 | 1984-08-01 | Health Lab Service Board | Affinity chromatography in presence of metal ions |
JPS6157520A (ja) * | 1984-08-29 | 1986-03-24 | Kibun Food Chemiphar:Kk | フコイダン純度の高い溶液又は、フコイダンの製造方法 |
JP3714426B2 (ja) | 1994-02-01 | 2005-11-09 | 株式会社糖鎖工学研究所 | フコイダンオリゴ糖組成物含有癌転移抑制剤 |
JP3371124B2 (ja) * | 1996-12-24 | 2003-01-27 | 正邦 田幸 | 養殖オキナワモズクを原料とするアセチルフコイダンおよ びそれの製造法 |
JPH10195106A (ja) * | 1997-01-13 | 1998-07-28 | Masakuni Tako | 養殖イトモズクからの純度の高いフコイダンの製造法 |
JP4347950B2 (ja) * | 1999-06-14 | 2009-10-21 | 株式会社ヤクルト本社 | 高純度フコイダンおよびその製造方法 |
US20030039670A1 (en) * | 1999-11-30 | 2003-02-27 | Shigetoshi Mizutani | Cosmetics |
CN1592626A (zh) * | 2000-09-13 | 2005-03-09 | 宝生物工程株式会社 | 内环境稳定维持剂 |
JP3676682B2 (ja) * | 2001-01-26 | 2005-07-27 | 株式会社スペース商事 | フコイダン含有抽出物の簡易な製造方法 |
JP4768142B2 (ja) | 2001-03-08 | 2011-09-07 | 協同乳業株式会社 | フコイダンの簡易製造方法 |
JP2003155244A (ja) * | 2002-09-13 | 2003-05-27 | Kyodo Milk Industry Co Ltd | モズク由来のフコイダンを含む食品 |
JP5232470B2 (ja) | 2004-05-27 | 2013-07-10 | バクスター・インターナショナル・インコーポレイテッド | 硫酸化多糖を用いて出血性疾患を処置するための方法 |
AU2005275249A1 (en) * | 2004-07-14 | 2006-02-23 | Wyeth | Compositions and methods of purifying myelin-associated glycoprotein (MAG) |
EP2121767B1 (en) * | 2007-02-23 | 2014-04-09 | Baxter International Inc. | Process methods for fucoidan purification from seaweed extracts |
-
2008
- 2008-02-01 EP EP08725114.6A patent/EP2121767B1/en active Active
- 2008-02-01 ES ES08725114.6T patent/ES2476250T3/es active Active
- 2008-02-01 ES ES12175889.0T patent/ES2683948T3/es active Active
- 2008-02-01 CN CN2008800079552A patent/CN101663326B/zh active Active
- 2008-02-01 CN CN201210417761.8A patent/CN102911281B/zh active Active
- 2008-02-01 KR KR1020097019831A patent/KR101486931B1/ko active IP Right Grant
- 2008-02-01 US US12/449,712 patent/US8748595B2/en active Active
- 2008-02-01 JP JP2009550877A patent/JP5679663B2/ja active Active
- 2008-02-01 WO PCT/US2008/001425 patent/WO2008103234A1/en active Application Filing
- 2008-02-01 EP EP12175889.0A patent/EP2532686B1/en active Active
- 2008-02-01 EP EP18172045.9A patent/EP3409694A1/en active Pending
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6593311B2 (en) * | 1996-01-26 | 2003-07-15 | Takara Shuzo Co., Ltd. | Apoptosis inducers |
CN1328062A (zh) * | 2001-04-28 | 2001-12-26 | 武汉大学 | 高纯度魔芋葡甘聚糖的提取工艺 |
CN1344565A (zh) * | 2001-10-19 | 2002-04-17 | 汤洁 | 岩藻多糖酯作为抗病毒及免疫调节剂及其制备方法 |
CN1515592A (zh) * | 2003-01-02 | 2004-07-28 | 合肥学院 | 微生物酶法制备低分子量岩藻多糖工艺 |
Also Published As
Publication number | Publication date |
---|---|
ES2476250T3 (es) | 2014-07-14 |
KR101486931B1 (ko) | 2015-01-27 |
US20100144667A1 (en) | 2010-06-10 |
EP2121767B1 (en) | 2014-04-09 |
CN101663326A (zh) | 2010-03-03 |
HK1135120A1 (en) | 2010-05-28 |
KR20090127142A (ko) | 2009-12-09 |
EP2121767A1 (en) | 2009-11-25 |
CN101663326B (zh) | 2013-03-20 |
CN102911281A (zh) | 2013-02-06 |
WO2008103234A1 (en) | 2008-08-28 |
EP2532686B1 (en) | 2018-05-16 |
EP3409694A1 (en) | 2018-12-05 |
US9234051B2 (en) | 2016-01-12 |
JP5679663B2 (ja) | 2015-03-04 |
EP2532686A1 (en) | 2012-12-12 |
JP2010519383A (ja) | 2010-06-03 |
ES2683948T3 (es) | 2018-09-28 |
US20140328827A1 (en) | 2014-11-06 |
US8748595B2 (en) | 2014-06-10 |
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