CN101616925B - 三环化合物及其作为糖皮质激素受体调节剂的用途 - Google Patents

三环化合物及其作为糖皮质激素受体调节剂的用途 Download PDF

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CN101616925B
CN101616925B CN2008800052954A CN200880005295A CN101616925B CN 101616925 B CN101616925 B CN 101616925B CN 2008800052954 A CN2008800052954 A CN 2008800052954A CN 200880005295 A CN200880005295 A CN 200880005295A CN 101616925 B CN101616925 B CN 101616925B
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salt
present
asthma
patient
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CN101616925A (zh
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R·V·德弗拉耶
G·A·德克雷森佐
X·胡
K·D·杰罗米
M·G·奥巴考维克兹
L·奥尔森
P·V·拉克尔
R·K·韦伯
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Pfizer Products Inc
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CN2008800052954A 2007-02-02 2008-01-25 三环化合物及其作为糖皮质激素受体调节剂的用途 Expired - Fee Related CN101616925B (zh)

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US88798107P 2007-02-02 2007-02-02
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PCT/IB2008/000229 WO2008093227A1 (en) 2007-02-02 2008-01-25 Tricyclic compounds and their use as glucocorticoid receptor modulators

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CN2008800056527A Expired - Fee Related CN101616896B (zh) 2007-02-02 2008-01-28 三环类化合物及其作为糖皮质激素受体调节剂的用途

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU714980B2 (en) 1996-07-24 2000-01-13 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
CN101616925B (zh) 2007-02-02 2012-05-23 辉瑞产品公司 三环化合物及其作为糖皮质激素受体调节剂的用途
KR101377860B1 (ko) * 2008-07-28 2014-03-25 화이자 인코포레이티드 페난트렌온 화합물, 조성물 및 방법
US8765787B2 (en) * 2008-11-21 2014-07-01 Bridge Pharma, Inc. Methods of treatment of xerophthalmia with self-preserving ocular formulations of norketotifen
US20100137843A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
CA2798697A1 (en) 2010-05-10 2011-11-17 Radikal Therapeutics Inc. Lipoic acid and nitroxide derivatives and uses thereof
US8598154B2 (en) * 2010-08-27 2013-12-03 Corcept Therapeutics, Inc. Pyridyl-amine fused azadecalin modulators
KR20140015472A (ko) * 2011-03-15 2014-02-06 애브비 인코포레이티드 핵 호르몬 수용체 조절제
US8545904B1 (en) 2012-06-05 2013-10-01 Liquid Innovators, LLC Topical composition containing Carapa (andiroba) oil for psoriasis and other related dermatological disorders
US9227901B2 (en) 2012-07-05 2016-01-05 Abbvie Inc. Process for preparing bicyclic amine derivatives
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
EP2935284A4 (en) 2012-12-21 2016-04-27 Abbvie Inc HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS
WO2015175986A2 (en) 2014-05-16 2015-11-19 Liqwd, Inc. Keratin treatment formulations and methods
SG10202011669PA (en) * 2014-10-20 2020-12-30 Oyster Point Pharma Inc Methods of treating ocular conditions
CN104591988A (zh) * 2014-12-29 2015-05-06 甘肃省化工研究院 6-溴-2-萘满酮的合成方法
US10722513B2 (en) * 2015-03-23 2020-07-28 The University Of Melbourne Treatment of respiratory diseases
PT3439661T (pt) 2016-04-07 2021-09-30 Oyster Point Pharma Inc Métodos de tratamento de condições oculares
WO2020093097A1 (en) 2018-11-07 2020-05-14 The University Of Melbourne Compounds and compositions for the treatment of respiratory diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201649A1 (en) * 2000-10-28 2002-05-02 Pfizer Products Inc. Glucocorticoid receptor modulators
CN1356319A (zh) * 2000-10-27 2002-07-03 辉瑞产品公司 非甾族糖皮质激素受体调节剂的制备方法
CN1781890A (zh) * 1999-04-30 2006-06-07 辉瑞产品公司 糖皮质激素受体调制剂

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576025B1 (fr) 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
FR2600450B1 (fr) * 1986-06-19 1988-08-26 Pechiney Aluminium Procede de marquage individuel des anodes precuites pour la production electrolytique d'aluminium
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
WO2001005229A1 (en) 1999-07-15 2001-01-25 The General Hospital Corporation Non-defective epstein-barr viral vector
EP1201660B1 (en) 2000-10-30 2005-08-31 Pfizer Products Inc. Glucocorticoid receptor modulators
WO2002042995A1 (en) * 2000-11-20 2002-05-30 Seagate Technology Llc Rf id tag attachment to a disc drive
AU2002309172A1 (en) 2001-06-22 2003-01-08 Pfizer Products Inc. Pharmaceutical compositions containing polymer and drug assemblies
DE60229411D1 (de) 2001-08-31 2008-11-27 Corcept Therapeutics Inc Verfahren zur hemmung der verschlechterung der kognitiven leistungsfähigkeit bei erwachsenen mit down-syndrom
WO2003029217A2 (en) 2001-09-27 2003-04-10 Universite De Liege Pyridinic sulfonamide derivatives, method of production and use thereof
DE10164366C1 (de) * 2001-12-28 2003-06-05 Rehau Ag & Co Permanentkathode
EP1469832B2 (en) 2002-02-01 2016-10-26 Bend Research, Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
WO2004004653A2 (en) 2002-07-02 2004-01-15 Corcept Therapeutics, Inc. Methods for treating psychosis associated with interferon-alpha therapy
SI1521733T1 (sl) 2002-07-08 2014-10-30 Pfizer Products Inc. Modulatorji glukokortikoidnega receptorja
CA2504751C (en) 2002-11-05 2013-02-05 Corcept Therapeutics, Inc. Methods for treating gastroesophageal reflux disease
AU2004208842B2 (en) 2003-02-04 2009-05-28 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of postpartum psychosis
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
US20050080061A1 (en) 2003-07-23 2005-04-14 Corcept Therapeutics, Inc. Antiglucocorticoid therapy for the prevention of neurological damage in premature infants
TW200512181A (en) 2003-09-26 2005-04-01 Tanabe Seiyaku Co Amide-type carboxamide derivatives
US7592177B2 (en) * 2003-11-10 2009-09-22 The Scripps Research Institute Compositions and methods for inducing cell dedifferentiation
WO2005047254A1 (en) * 2003-11-13 2005-05-26 Pfizer Products Inc. Octahydrophenanthrene hydrazinde derivatives useful as glucocorticoid receptor modulators
TWI370129B (en) 2005-02-14 2012-08-11 Msd Oss Bv Non steroidal glucocorticoid receptor modulators
JP2009535430A (ja) 2006-05-02 2009-10-01 コーセプト セラピューティクス， インコーポレイテッド Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用
CN101616925B (zh) * 2007-02-02 2012-05-23 辉瑞产品公司 三环化合物及其作为糖皮质激素受体调节剂的用途
CA2676907C (en) * 2007-02-02 2012-03-20 Pfizer Products Inc. Tricyclic compounds and their use as glucocorticoid receptor modulators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1781890A (zh) * 1999-04-30 2006-06-07 辉瑞产品公司 糖皮质激素受体调制剂
CN1356319A (zh) * 2000-10-27 2002-07-03 辉瑞产品公司 非甾族糖皮质激素受体调节剂的制备方法
EP1201649A1 (en) * 2000-10-28 2002-05-02 Pfizer Products Inc. Glucocorticoid receptor modulators

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