CN101602741A - 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 - Google Patents

作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 Download PDF

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Publication number
CN101602741A
CN101602741A CNA200910152119XA CN200910152119A CN101602741A CN 101602741 A CN101602741 A CN 101602741A CN A200910152119X A CNA200910152119X A CN A200910152119XA CN 200910152119 A CN200910152119 A CN 200910152119A CN 101602741 A CN101602741 A CN 101602741A
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CN
China
Prior art keywords
alkyl
aryl
alkylene
substituted
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200910152119XA
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English (en)
Chinese (zh)
Inventor
H·B·乔西恩
J·W·克拉德
T·A·贝拉
R·徐
李虹美
D·比萨尼斯基
赵志强
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN101602741A publication Critical patent/CN101602741A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CNA200910152119XA 2004-06-30 2005-06-28 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺 Pending CN101602741A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58401004P 2004-06-30 2004-06-30
US60/584010 2004-06-30

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800284229A Division CN101048393A (zh) 2004-06-30 2005-06-28 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺

Publications (1)

Publication Number Publication Date
CN101602741A true CN101602741A (zh) 2009-12-16

Family

ID=35783342

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA200910152119XA Pending CN101602741A (zh) 2004-06-30 2005-06-28 作为γ-分泌酶抑制剂的取代的N-芳基磺酰基杂环胺
CNA2005800284229A Pending CN101048393A (zh) 2004-06-30 2005-06-28 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2005800284229A Pending CN101048393A (zh) 2004-06-30 2005-06-28 作为γ－分泌酶抑制剂的取代的N－芳基磺酰基杂环胺

Country Status (13)

Country Link
US (3) US7763613B2 (https=)
EP (1) EP1789404B1 (https=)
JP (1) JP2008505100A (https=)
CN (2) CN101602741A (https=)
AR (1) AR050994A1 (https=)
AT (1) ATE461926T1 (https=)
CA (1) CA2570183A1 (https=)
DE (1) DE602005020156D1 (https=)
ES (1) ES2341560T3 (https=)
MX (1) MX2007000040A (https=)
PE (1) PE20060481A1 (https=)
TW (1) TWI297270B (https=)
WO (1) WO2006004880A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109705052A (zh) * 2019-01-25 2019-05-03 苏州大学 一种制备1,4-二氢噁嗪的方法
CN119060034A (zh) * 2024-09-02 2024-12-03 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法

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KR20080095885A (ko) * 2006-01-20 2008-10-29 쉐링 코포레이션 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제
WO2007092435A2 (en) 2006-02-07 2007-08-16 Wyeth 11-beta hsd1 inhibitors
WO2007125364A1 (en) * 2006-04-26 2007-11-08 Merck Sharp & Dohme Limited Piperidines and related compounds for treatment of alzheimer’s disease
ATE509956T1 (de) * 2006-06-08 2011-06-15 Helmholtz Zentrum Muenchen Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
AU2008220785B2 (en) 2007-03-01 2013-02-21 Vivoryon Therapeutics N.V. New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
ES2378594T3 (es) * 2007-10-19 2012-04-16 Janssen Pharmaceutica, N.V. Moduladores de piperidinilo y piperazinilo de la y-secretasa
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

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JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
US5646167A (en) 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
ATE247090T1 (de) * 1996-02-02 2003-08-15 Hidaka Hiroyoshi Dr Isochinolinderivate und arzneimittel
CA2333964A1 (en) * 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Aza-heterocyclic compounds used to treat neurological disorders and hair loss
WO2000050391A1 (en) 1999-02-26 2000-08-31 Merck & Co., Inc. Novel sulfonamide compounds and uses thereof
FR2802206B1 (fr) 1999-12-14 2005-04-22 Sod Conseils Rech Applic Derives de 4-aminopiperidine et leur utilisation en tant que medicament
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JP2001261657A (ja) * 2000-03-17 2001-09-26 Yamanouchi Pharmaceut Co Ltd シアノフェニル誘導体
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JP4247081B2 (ja) 2003-09-24 2009-04-02 三菱電機株式会社 レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置
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CA2567343A1 (en) * 2004-05-20 2005-12-01 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
KR20080095885A (ko) 2006-01-20 2008-10-29 쉐링 코포레이션 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109705052A (zh) * 2019-01-25 2019-05-03 苏州大学 一种制备1,4-二氢噁嗪的方法
CN119060034A (zh) * 2024-09-02 2024-12-03 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法
CN119060034B (zh) * 2024-09-02 2026-03-24 上海信诺维生物医药有限公司 一种含吡喃取代的吗啉类化合物的制备方法

Also Published As

Publication number Publication date
ATE461926T1 (de) 2010-04-15
PE20060481A1 (es) 2006-06-19
TW200612928A (en) 2006-05-01
MX2007000040A (es) 2007-03-07
ES2341560T3 (es) 2010-06-22
US20100087425A1 (en) 2010-04-08
DE602005020156D1 (de) 2010-05-06
CN101048393A (zh) 2007-10-03
US7763613B2 (en) 2010-07-27
EP1789404A2 (en) 2007-05-30
WO2006004880A3 (en) 2007-03-08
HK1099300A1 (en) 2007-08-10
JP2008505100A (ja) 2008-02-21
US20100093695A1 (en) 2010-04-15
TWI297270B (en) 2008-06-01
AR050994A1 (es) 2006-12-13
US7998958B2 (en) 2011-08-16
CA2570183A1 (en) 2006-01-12
EP1789404B1 (en) 2010-03-24
WO2006004880A2 (en) 2006-01-12
US20060040936A1 (en) 2006-02-23

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
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Open date: 20091216