JP2008505100A - ガンマ−セクレターゼ阻害剤としての置換ｎ−アリールスルホニル複素環アミン - Google Patents
ガンマ−セクレターゼ阻害剤としての置換ｎ−アリールスルホニル複素環アミン Download PDFInfo
- Publication number
- JP2008505100A JP2008505100A JP2007519415A JP2007519415A JP2008505100A JP 2008505100 A JP2008505100 A JP 2008505100A JP 2007519415 A JP2007519415 A JP 2007519415A JP 2007519415 A JP2007519415 A JP 2007519415A JP 2008505100 A JP2008505100 A JP 2008505100A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- alkylene
- substituted
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C[C@](COC[C@]1C2(CC2)OC(N(CC2)CCN2C(C)(C)CO)=O)N1S(c1ccc(*)cc1)(=O)=O Chemical compound C[C@](COC[C@]1C2(CC2)OC(N(CC2)CCN2C(C)(C)CO)=O)N1S(c1ccc(*)cc1)(=O)=O 0.000 description 10
- UBQKCCHYAOITMY-UHFFFAOYSA-N O=C1NC=CC=C1 Chemical compound O=C1NC=CC=C1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 2
- KPHOKAKFMYXDSZ-ULLVEHKXSA-N CC(CN(C)C)N(C(CC1)C2)C1CN2C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c1ccc(C)cc1)(=O)=O)=O Chemical compound CC(CN(C)C)N(C(CC1)C2)C1CN2C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c1ccc(C)cc1)(=O)=O)=O KPHOKAKFMYXDSZ-ULLVEHKXSA-N 0.000 description 1
- WCEKXYNLDLCTMK-FWVGUBPYSA-N CCC(C1)(CC2(C3CC2)C1N3C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O)O Chemical compound CCC(C1)(CC2(C3CC2)C1N3C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O)O WCEKXYNLDLCTMK-FWVGUBPYSA-N 0.000 description 1
- SDBNRANAKKJELX-ZOAFEQKISA-N CCCC(CC1)(CN1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O)O Chemical compound CCCC(CC1)(CN1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O)O SDBNRANAKKJELX-ZOAFEQKISA-N 0.000 description 1
- LTDWBGCVXKZHDT-IJZHQTRZSA-N CN(CC1CC2)CC2N1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound CN(CC1CC2)CC2N1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O LTDWBGCVXKZHDT-IJZHQTRZSA-N 0.000 description 1
- UEUDSMYWOMGSFV-BULFRSBZSA-N C[C@@H](C1)N(CCO)CCN1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound C[C@@H](C1)N(CCO)CCN1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O UEUDSMYWOMGSFV-BULFRSBZSA-N 0.000 description 1
- VTRKHYUAXBMGKT-QOHKPAHPSA-N C[C@@H](CC1CC(C2)N3CCCCC3)C2N1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound C[C@@H](CC1CC(C2)N3CCCCC3)C2N1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O VTRKHYUAXBMGKT-QOHKPAHPSA-N 0.000 description 1
- BQRJZAIWJJXQAV-UBJVZNKFSA-N O=C(N(CC1)CCC1N1CCCCC1)OC[C@H](COC[C@H]1c2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=C1C=CC1)=O Chemical compound O=C(N(CC1)CCC1N1CCCCC1)OC[C@H](COC[C@H]1c2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=C1C=CC1)=O BQRJZAIWJJXQAV-UBJVZNKFSA-N 0.000 description 1
- LRLDBKFKEAFWHL-GGAORHGYSA-N OCCN(CC1)CCN1C(OC[C@@H](COC[C@H]1c2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound OCCN(CC1)CCN1C(OC[C@@H](COC[C@H]1c2cc(F)cc(F)c2)N1S(c(cc1)ccc1Cl)(=O)=O)=O LRLDBKFKEAFWHL-GGAORHGYSA-N 0.000 description 1
- WVVQUMRBKYSEPM-BDYUSTAISA-N OCCN(CC1)CCN1C(OC[C@H](COC[C@H]1c2cc(F)cc(F)c2)N1S(c1ccc(C2CCC2)cc1)(=O)=O)=O Chemical compound OCCN(CC1)CCN1C(OC[C@H](COC[C@H]1c2cc(F)cc(F)c2)N1S(c1ccc(C2CCC2)cc1)(=O)=O)=O WVVQUMRBKYSEPM-BDYUSTAISA-N 0.000 description 1
- XESVZGUPUFOGTH-NZSAHSFTSA-N O[C@H](CC1)CN1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O Chemical compound O[C@H](CC1)CN1C(OC1(CC1)[C@@H](COC[C@H]1C2CC2)N1S(c(cc1)ccc1Cl)(=O)=O)=O XESVZGUPUFOGTH-NZSAHSFTSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58401004P | 2004-06-30 | 2004-06-30 | |
| PCT/US2005/023187 WO2006004880A2 (en) | 2004-06-30 | 2005-06-28 | Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008505100A true JP2008505100A (ja) | 2008-02-21 |
| JP2008505100A5 JP2008505100A5 (https=) | 2008-08-07 |
Family
ID=35783342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007519415A Pending JP2008505100A (ja) | 2004-06-30 | 2005-06-28 | ガンマ−セクレターゼ阻害剤としての置換ｎ−アリールスルホニル複素環アミン |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US7763613B2 (https=) |
| EP (1) | EP1789404B1 (https=) |
| JP (1) | JP2008505100A (https=) |
| CN (2) | CN101602741A (https=) |
| AR (1) | AR050994A1 (https=) |
| AT (1) | ATE461926T1 (https=) |
| CA (1) | CA2570183A1 (https=) |
| DE (1) | DE602005020156D1 (https=) |
| ES (1) | ES2341560T3 (https=) |
| MX (1) | MX2007000040A (https=) |
| PE (1) | PE20060481A1 (https=) |
| TW (1) | TWI297270B (https=) |
| WO (1) | WO2006004880A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080095885A (ko) * | 2006-01-20 | 2008-10-29 | 쉐링 코포레이션 | 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제 |
| WO2007092435A2 (en) | 2006-02-07 | 2007-08-16 | Wyeth | 11-beta hsd1 inhibitors |
| WO2007125364A1 (en) * | 2006-04-26 | 2007-11-08 | Merck Sharp & Dohme Limited | Piperidines and related compounds for treatment of alzheimer’s disease |
| ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| AU2008220785B2 (en) | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
| JP5667440B2 (ja) | 2007-04-18 | 2015-02-12 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体 |
| ES2378594T3 (es) * | 2007-10-19 | 2012-04-16 | Janssen Pharmaceutica, N.V. | Moduladores de piperidinilo y piperazinilo de la y-secretasa |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| WO2011107530A2 (en) | 2010-03-03 | 2011-09-09 | Probiodrug Ag | Novel inhibitors |
| JP5688745B2 (ja) | 2010-03-10 | 2015-03-25 | プロビオドルグ エージー | グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤 |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| AR091279A1 (es) | 2012-06-08 | 2015-01-21 | Gilead Sciences Inc | Inhibidores macrociclicos de virus flaviviridae |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN109705052B (zh) * | 2019-01-25 | 2020-12-08 | 苏州大学 | 一种制备1,4-二氢噁嗪的方法 |
| CN119060034B (zh) * | 2024-09-02 | 2026-03-24 | 上海信诺维生物医药有限公司 | 一种含吡喃取代的吗啉类化合物的制备方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997028130A1 (en) * | 1996-02-02 | 1997-08-07 | Nippon Shinyaku Co., Ltd. | Isoquinoline derivatives and drugs |
| JP2001261657A (ja) * | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| JP2003518126A (ja) * | 1999-12-22 | 2003-06-03 | アストラゼネカ・アクチエボラーグ | 新規ピペリジンおよびピペラジン誘導体 |
| WO2003066592A1 (en) * | 2002-02-06 | 2003-08-14 | Schering Corporation | Gamma secretase inhibitors |
| US20030216380A1 (en) * | 2001-08-03 | 2003-11-20 | Schering Corporation | Novel gamma secretase inhibitors |
| JP2007538106A (ja) * | 2004-05-20 | 2007-12-27 | イーラン ファーマスーティカルズ、インコーポレイテッド | γセクレターゼのＮ−環式スルホンアミド阻害剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04247081A (ja) | 1991-02-01 | 1992-09-03 | Takeda Chem Ind Ltd | ５員複素環酸アミド類 |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| CA2333964A1 (en) * | 1998-06-03 | 1999-12-09 | Gpi Nil Holdings, Inc. | Aza-heterocyclic compounds used to treat neurological disorders and hair loss |
| WO2000050391A1 (en) | 1999-02-26 | 2000-08-31 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
| FR2802206B1 (fr) | 1999-12-14 | 2005-04-22 | Sod Conseils Rech Applic | Derives de 4-aminopiperidine et leur utilisation en tant que medicament |
| AU2001254546A1 (en) | 2000-04-20 | 2001-11-07 | Nps Allelix Corp. | Aminopiperidines |
| US6589978B2 (en) | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| IL154363A0 (en) | 2000-09-25 | 2003-09-17 | Actelion Pharmaceuticals Ltd | Substituted amino-aza-cycloalkanes useful against malaria |
| WO2003014075A2 (en) | 2001-08-03 | 2003-02-20 | Schering Corporation | Novel gamma secretase inhibitors |
| US20040171614A1 (en) | 2002-02-06 | 2004-09-02 | Schering-Plough Corporation | Novel gamma secretase inhibitors |
| US7256186B2 (en) | 2002-02-06 | 2007-08-14 | Schering Corporation | Gamma secretase inhibitors |
| DE602004015110D1 (de) | 2003-05-13 | 2008-08-28 | Schering Corp | Verbrückte n-arylsulfonylpiperidine als gamma-sekretaseinhibitoren |
| JP4247081B2 (ja) | 2003-09-24 | 2009-04-02 | 三菱電機株式会社 | レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置 |
| TWI300410B (en) | 2004-04-05 | 2008-09-01 | Schering Corp | Novel gamma secretase inhibitors |
| KR20080095885A (ko) | 2006-01-20 | 2008-10-29 | 쉐링 코포레이션 | 벤젠설포닐-크로만, 티오크로만, 테트라하이드로나프탈렌 및 관련된 감마 세크라타제 억제제 |
-
2005
- 2005-06-28 PE PE2005000751A patent/PE20060481A1/es not_active Application Discontinuation
- 2005-06-28 WO PCT/US2005/023187 patent/WO2006004880A2/en not_active Ceased
- 2005-06-28 AR ARP050102662A patent/AR050994A1/es not_active Application Discontinuation
- 2005-06-28 CA CA002570183A patent/CA2570183A1/en not_active Abandoned
- 2005-06-28 CN CNA200910152119XA patent/CN101602741A/zh active Pending
- 2005-06-28 ES ES05790194T patent/ES2341560T3/es not_active Expired - Lifetime
- 2005-06-28 MX MX2007000040A patent/MX2007000040A/es active IP Right Grant
- 2005-06-28 DE DE602005020156T patent/DE602005020156D1/de not_active Expired - Lifetime
- 2005-06-28 JP JP2007519415A patent/JP2008505100A/ja active Pending
- 2005-06-28 AT AT05790194T patent/ATE461926T1/de not_active IP Right Cessation
- 2005-06-28 CN CNA2005800284229A patent/CN101048393A/zh active Pending
- 2005-06-28 US US11/168,797 patent/US7763613B2/en not_active Expired - Fee Related
- 2005-06-28 EP EP05790194A patent/EP1789404B1/en not_active Expired - Lifetime
- 2005-06-29 TW TW094121770A patent/TWI297270B/zh not_active IP Right Cessation
-
2009
- 2009-12-08 US US12/633,311 patent/US7998958B2/en not_active Expired - Fee Related
- 2009-12-08 US US12/633,286 patent/US20100087425A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997028130A1 (en) * | 1996-02-02 | 1997-08-07 | Nippon Shinyaku Co., Ltd. | Isoquinoline derivatives and drugs |
| JP2003518126A (ja) * | 1999-12-22 | 2003-06-03 | アストラゼネカ・アクチエボラーグ | 新規ピペリジンおよびピペラジン誘導体 |
| JP2001261657A (ja) * | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| US20030216380A1 (en) * | 2001-08-03 | 2003-11-20 | Schering Corporation | Novel gamma secretase inhibitors |
| WO2003066592A1 (en) * | 2002-02-06 | 2003-08-14 | Schering Corporation | Gamma secretase inhibitors |
| JP2007538106A (ja) * | 2004-05-20 | 2007-12-27 | イーラン ファーマスーティカルズ、インコーポレイテッド | γセクレターゼのＮ−環式スルホンアミド阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE461926T1 (de) | 2010-04-15 |
| PE20060481A1 (es) | 2006-06-19 |
| TW200612928A (en) | 2006-05-01 |
| CN101602741A (zh) | 2009-12-16 |
| MX2007000040A (es) | 2007-03-07 |
| ES2341560T3 (es) | 2010-06-22 |
| US20100087425A1 (en) | 2010-04-08 |
| DE602005020156D1 (de) | 2010-05-06 |
| CN101048393A (zh) | 2007-10-03 |
| US7763613B2 (en) | 2010-07-27 |
| EP1789404A2 (en) | 2007-05-30 |
| WO2006004880A3 (en) | 2007-03-08 |
| HK1099300A1 (en) | 2007-08-10 |
| US20100093695A1 (en) | 2010-04-15 |
| TWI297270B (en) | 2008-06-01 |
| AR050994A1 (es) | 2006-12-13 |
| US7998958B2 (en) | 2011-08-16 |
| CA2570183A1 (en) | 2006-01-12 |
| EP1789404B1 (en) | 2010-03-24 |
| WO2006004880A2 (en) | 2006-01-12 |
| US20060040936A1 (en) | 2006-02-23 |
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