CN101600725B - 制备呋喃核糖基嘧啶核苷 - Google Patents

制备呋喃核糖基嘧啶核苷 Download PDF

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Publication number
CN101600725B
CN101600725B CN200780037855.XA CN200780037855A CN101600725B CN 101600725 B CN101600725 B CN 101600725B CN 200780037855 A CN200780037855 A CN 200780037855A CN 101600725 B CN101600725 B CN 101600725B
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China
Prior art keywords
aryl
formula
methyl
fluoro
furan
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Chinese (zh)
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CN101600725A (zh
Inventor
S·D·阿克斯特
K·萨尔曼
J·瓦伊塔尔
J·朱
B·罗斯
S·拉卡康达
金庆武
牛炳权
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Pharmasset Ltd
F Hoffmann La Roche AG
Gilead Pharmasset LLC
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Pharmasset Ltd
F Hoffmann La Roche AG
Gilead Pharmasset LLC
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Publication of CN101600725A publication Critical patent/CN101600725A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN200780037855.XA 2006-10-10 2007-10-05 制备呋喃核糖基嘧啶核苷 Active CN101600725B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85096206P 2006-10-10 2006-10-10
US60/850,962 2006-10-10
PCT/US2007/021548 WO2008045419A1 (en) 2006-10-10 2007-10-05 Preparation of nucleosides ribofuranosyl pyrimidines

Publications (2)

Publication Number Publication Date
CN101600725A CN101600725A (zh) 2009-12-09
CN101600725B true CN101600725B (zh) 2014-11-26

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CN200780037855.XA Active CN101600725B (zh) 2006-10-10 2007-10-05 制备呋喃核糖基嘧啶核苷

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US (2) US8912321B2 (https=)
EP (1) EP2084174B1 (https=)
JP (1) JP5252459B2 (https=)
KR (1) KR101057239B1 (https=)
CN (1) CN101600725B (https=)
AU (1) AU2007307057B2 (https=)
BR (1) BRPI0719174A2 (https=)
CA (1) CA2666098C (https=)
DK (1) DK2084174T3 (https=)
ES (1) ES2429290T3 (https=)
GT (1) GT200900080A (https=)
IL (1) IL198086A (https=)
MX (1) MX2009003795A (https=)
PL (1) PL2084174T3 (https=)
PT (1) PT2084174E (https=)
RU (1) RU2421461C2 (https=)
SI (1) SI2084174T1 (https=)
WO (1) WO2008045419A1 (https=)

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Also Published As

Publication number Publication date
BRPI0719174A2 (pt) 2017-06-13
AU2007307057A1 (en) 2008-04-17
KR20090060460A (ko) 2009-06-12
RU2009117396A (ru) 2010-11-20
CA2666098A1 (en) 2008-04-17
US20080139802A1 (en) 2008-06-12
JP2010505954A (ja) 2010-02-25
SI2084174T1 (sl) 2013-10-30
KR101057239B1 (ko) 2011-08-16
RU2421461C2 (ru) 2011-06-20
DK2084174T3 (da) 2013-11-04
EP2084174A1 (en) 2009-08-05
AU2007307057B2 (en) 2011-09-15
WO2008045419A1 (en) 2008-04-17
IL198086A0 (en) 2009-12-24
US8912321B2 (en) 2014-12-16
PT2084174E (pt) 2013-10-08
GT200900080A (es) 2012-04-10
CN101600725A (zh) 2009-12-09
EP2084174B1 (en) 2013-07-31
US20100056770A1 (en) 2010-03-04
IL198086A (en) 2012-03-29
ES2429290T3 (es) 2013-11-14
MX2009003795A (es) 2009-06-18
HK1133889A1 (en) 2010-04-09
PL2084174T3 (pl) 2013-12-31
CA2666098C (en) 2012-09-25
JP5252459B2 (ja) 2013-07-31

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