CN101558062A - 作为激酶抑制剂的吲哚基马来酰亚胺衍生物 - Google Patents

作为激酶抑制剂的吲哚基马来酰亚胺衍生物 Download PDF

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Publication number
CN101558062A
CN101558062A CNA2007800465026A CN200780046502A CN101558062A CN 101558062 A CN101558062 A CN 101558062A CN A2007800465026 A CNA2007800465026 A CN A2007800465026A CN 200780046502 A CN200780046502 A CN 200780046502A CN 101558062 A CN101558062 A CN 101558062A
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China
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alkyl
hydrogen
compound
methyl
alkoxy
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CNA2007800465026A
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Chinese (zh)
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M·范艾斯
P·冯马特
J·瓦格纳
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Novartis AG
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Novartis AG
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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CNA2007800465026A 2006-12-19 2007-12-14 作为激酶抑制剂的吲哚基马来酰亚胺衍生物 Pending CN101558062A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126534.4 2006-12-19
EP06126534 2006-12-19

Publications (1)

Publication Number Publication Date
CN101558062A true CN101558062A (zh) 2009-10-14

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Country Status (11)

Country Link
US (2) US8193236B2 (https=)
EP (1) EP2094689B1 (https=)
JP (1) JP2010513386A (https=)
KR (1) KR20090100363A (https=)
CN (1) CN101558062A (https=)
AU (1) AU2007336338A1 (https=)
BR (1) BRPI0720388A2 (https=)
CA (1) CA2671525A1 (https=)
ES (1) ES2410955T3 (https=)
MX (1) MX2009006533A (https=)
WO (1) WO2008074752A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101973993A (zh) * 2010-11-05 2011-02-16 天津药物研究院 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN103130790A (zh) * 2013-03-15 2013-06-05 浙江工业大学 一种3-苯并异噁唑-4-吲哚马来酰亚胺衍生物及其用途
CN103965093A (zh) * 2014-04-04 2014-08-06 华南理工大学 2-全氟烷基吲哚类化合物及其制备方法和应用
CN104693198A (zh) * 2014-12-13 2015-06-10 浙江工业大学 3-(1,2,4-三氮唑并[4,3-a]吡啶-3-基)-4-(1H-吲哚-3-基)马来酰亚胺类衍生物及其制备方法和应用

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ES2410955T3 (es) 2006-12-19 2013-07-04 Novartis Ag Derivados de indolilmaleimida como inhibidores de la quinasa
WO2010144780A1 (en) * 2009-06-12 2010-12-16 University Of Kansas Compositions and methods for establishing and maintaining stem cells in an undifferentiated state
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
PT3137456T (pt) 2014-04-29 2021-08-06 Fmc Corp Herbicidas de piridazinona
BR112018008597B1 (pt) 2015-10-28 2022-03-03 Fmc Corporation Composto, composições herbicidas, mistura herbicida e método para o controle do crescimento de vegetação indesejada
EP3920885A1 (en) 2019-02-08 2021-12-15 Frequency Therapeutics, Inc. Valproic acid compounds and wnt agonists for treating ear disorders
TW202126617A (zh) 2019-09-20 2021-07-16 美商富曼西公司 間二醯胺類殺蟲劑

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US5491242A (en) 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5821072A (en) 1996-02-20 1998-10-13 Sloan-Kettering Institute For Cancer Research Combinations of PKC inhibitors and therapaeutic agents for treating cancers
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
AU2548699A (en) * 1998-02-23 1999-09-06 Rei Asakai Cell death inhibitors
WO2001044247A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
AU2002221810B2 (en) * 2000-11-07 2005-06-23 Novartis Ag Indolylmaleimide derivatives as protein kinase C inhibitors
JP2004526676A (ja) * 2000-12-08 2004-09-02 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド キナーゼ阻害剤として有用な大員複素環式化合物
MXPA04008671A (es) * 2002-03-08 2004-12-06 Lilly Co Eli Derivados de pirrol-2,5-diona y su uso como inhibidores de gsk-3.
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
DE60323749D1 (de) 2002-06-05 2008-11-06 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
GB0303319D0 (en) 2003-02-13 2003-03-19 Novartis Ag Organic compounds
CA2529353A1 (en) * 2003-06-13 2005-01-06 Janssen Pharmaceutica N.V. Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors
ATE486872T1 (de) * 2005-02-09 2010-11-15 Arqule Inc Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs
AU2006268908A1 (en) * 2005-07-11 2007-01-18 Novartis Ag Indolylmaleimide derivatives
ES2410955T3 (es) 2006-12-19 2013-07-04 Novartis Ag Derivados de indolilmaleimida como inhibidores de la quinasa

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101973993A (zh) * 2010-11-05 2011-02-16 天津药物研究院 一种制备2-[咪唑并(1,2-a)吡啶-3-基]乙酸的方法
CN103130790A (zh) * 2013-03-15 2013-06-05 浙江工业大学 一种3-苯并异噁唑-4-吲哚马来酰亚胺衍生物及其用途
CN103130790B (zh) * 2013-03-15 2015-10-28 浙江工业大学 一种3-苯并异噁唑-4-吲哚马来酰亚胺衍生物及其用途
CN103965093A (zh) * 2014-04-04 2014-08-06 华南理工大学 2-全氟烷基吲哚类化合物及其制备方法和应用
CN104693198A (zh) * 2014-12-13 2015-06-10 浙江工业大学 3-(1,2,4-三氮唑并[4,3-a]吡啶-3-基)-4-(1H-吲哚-3-基)马来酰亚胺类衍生物及其制备方法和应用

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AU2007336338A1 (en) 2008-06-26
JP2010513386A (ja) 2010-04-30
MX2009006533A (es) 2009-06-26
EP2094689B1 (en) 2013-04-03
US20100041693A1 (en) 2010-02-18
BRPI0720388A2 (pt) 2014-01-14
WO2008074752A3 (en) 2008-10-30
KR20090100363A (ko) 2009-09-23
US8742132B2 (en) 2014-06-03
CA2671525A1 (en) 2008-06-26
EP2094689A2 (en) 2009-09-02
US8193236B2 (en) 2012-06-05
ES2410955T3 (es) 2013-07-04
US20120219593A1 (en) 2012-08-30
WO2008074752A2 (en) 2008-06-26

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