CN101525328A - 从山竹果皮中提取α-倒捻子素的方法 - Google Patents
从山竹果皮中提取α-倒捻子素的方法 Download PDFInfo
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- CN101525328A CN101525328A CN200810017640A CN200810017640A CN101525328A CN 101525328 A CN101525328 A CN 101525328A CN 200810017640 A CN200810017640 A CN 200810017640A CN 200810017640 A CN200810017640 A CN 200810017640A CN 101525328 A CN101525328 A CN 101525328A
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- Prior art keywords
- mangostin
- extracting
- peel
- iii
- silica gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- QTDMGAWIBXJNRR-UHFFFAOYSA-N Mangostin Natural products CC(=CCc1c(O)cc2Oc3cc(C)c(O)c(CC=C(C)C)c3C(=O)c2c1O)C QTDMGAWIBXJNRR-UHFFFAOYSA-N 0.000 title claims abstract description 29
- GNRIZKKCNOBBMO-UHFFFAOYSA-N alpha-mangostin Chemical compound OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3OC2=C1 GNRIZKKCNOBBMO-UHFFFAOYSA-N 0.000 title claims abstract description 29
- ZVFQDLCERPGZMO-UHFFFAOYSA-N alpha-mangostin Natural products OC1=C(CC=C(C)C)C(O)=C2C(=O)C3=C(CC=C(C)C)C(OC)=C(O)C=C3CC2=C1 ZVFQDLCERPGZMO-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 27
- 240000006053 Garcinia mangostana Species 0.000 title claims abstract description 13
- 235000017048 Garcinia mangostana Nutrition 0.000 title claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 7
- 238000002425 crystallisation Methods 0.000 claims abstract description 25
- 230000008025 crystallization Effects 0.000 claims abstract description 25
- 239000007788 liquid Substances 0.000 claims abstract description 18
- 238000001953 recrystallisation Methods 0.000 claims abstract description 13
- 239000003960 organic solvent Substances 0.000 claims abstract description 11
- 238000010898 silica gel chromatography Methods 0.000 claims abstract description 6
- 239000013078 crystal Substances 0.000 claims abstract description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 45
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- 238000000605 extraction Methods 0.000 claims description 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 27
- 239000003153 chemical reaction reagent Substances 0.000 claims description 22
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 20
- 239000000284 extract Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 17
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000741 silica gel Substances 0.000 claims description 14
- 229910002027 silica gel Inorganic materials 0.000 claims description 14
- 238000001291 vacuum drying Methods 0.000 claims description 8
- 239000000470 constituent Substances 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000013467 fragmentation Methods 0.000 claims description 3
- 238000006062 fragmentation reaction Methods 0.000 claims description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 3
- 230000008719 thickening Effects 0.000 claims description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 238000002386 leaching Methods 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 241000593508 Garcinia Species 0.000 description 3
- 235000000885 Garcinia xanthochymus Nutrition 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 241000546193 Clusiaceae Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
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Abstract
Description
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008100176408A CN101525328B (zh) | 2008-03-06 | 2008-03-06 | 从山竹果皮中提取α-倒捻子素的方法 |
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CN2008100176408A CN101525328B (zh) | 2008-03-06 | 2008-03-06 | 从山竹果皮中提取α-倒捻子素的方法 |
Publications (2)
Publication Number | Publication Date |
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CN101525328A true CN101525328A (zh) | 2009-09-09 |
CN101525328B CN101525328B (zh) | 2012-08-22 |
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CN2008100176408A Active CN101525328B (zh) | 2008-03-06 | 2008-03-06 | 从山竹果皮中提取α-倒捻子素的方法 |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103880807A (zh) * | 2014-03-18 | 2014-06-25 | 杭州博麦医药科技有限公司 | 高纯度α-倒捻子素的合成工艺 |
CN104892561A (zh) * | 2015-06-08 | 2015-09-09 | 桂林莱茵生物科技股份有限公司 | 一种从山竹皮中提取高含量α-倒捻子素的方法 |
CN105130945A (zh) * | 2015-08-30 | 2015-12-09 | 常州市鼎日环保科技有限公司 | 从山竹中分离纯化α-倒捻子素的方法 |
CN109699857A (zh) * | 2019-02-21 | 2019-05-03 | 膳立方健康产业(扬州)有限公司 | 一种抗氧化复合果蔬汁饮料及其制备方法 |
CN113717144A (zh) * | 2021-09-24 | 2021-11-30 | 浏阳朗林生物科技有限公司 | 一种提取山竹中α-倒捻子素和γ-倒捻子素的方法 |
US11517601B2 (en) | 2020-07-21 | 2022-12-06 | Junhong Biotechnology Co., Ltd. | Mangosteen pericarp extract and process for its preparation thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102004034683A1 (de) * | 2004-07-17 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Isolierung von α-Mangostin |
JP4989469B2 (ja) * | 2005-06-23 | 2012-08-01 | 国立大学法人岐阜大学 | マンゴスチンの単離方法とそれを含有する医薬品、及び健康食品 |
CN1833665A (zh) * | 2006-01-05 | 2006-09-20 | 李平亚 | 山竹果皮提取物及其提取方法及其药物用途 |
CN101028070A (zh) * | 2007-04-13 | 2007-09-05 | 桂林莱茵生物科技股份有限公司 | 一种山竹提取物及其制备方法及其应用 |
-
2008
- 2008-03-06 CN CN2008100176408A patent/CN101525328B/zh active Active
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103880807A (zh) * | 2014-03-18 | 2014-06-25 | 杭州博麦医药科技有限公司 | 高纯度α-倒捻子素的合成工艺 |
CN103880807B (zh) * | 2014-03-18 | 2016-09-28 | 杭州博麦医药科技有限公司 | 高纯度α-倒捻子素的合成工艺 |
CN104892561A (zh) * | 2015-06-08 | 2015-09-09 | 桂林莱茵生物科技股份有限公司 | 一种从山竹皮中提取高含量α-倒捻子素的方法 |
CN104892561B (zh) * | 2015-06-08 | 2017-06-16 | 桂林莱茵生物科技股份有限公司 | 一种从山竹皮中提取高含量α‑倒捻子素的方法 |
CN105130945A (zh) * | 2015-08-30 | 2015-12-09 | 常州市鼎日环保科技有限公司 | 从山竹中分离纯化α-倒捻子素的方法 |
CN109699857A (zh) * | 2019-02-21 | 2019-05-03 | 膳立方健康产业(扬州)有限公司 | 一种抗氧化复合果蔬汁饮料及其制备方法 |
US11517601B2 (en) | 2020-07-21 | 2022-12-06 | Junhong Biotechnology Co., Ltd. | Mangosteen pericarp extract and process for its preparation thereof |
TWI789606B (zh) * | 2020-07-21 | 2023-01-11 | 潤鴻生物科技股份有限公司 | 山竹果殼萃取物及其製備方法 |
CN113717144A (zh) * | 2021-09-24 | 2021-11-30 | 浏阳朗林生物科技有限公司 | 一种提取山竹中α-倒捻子素和γ-倒捻子素的方法 |
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Publication number | Publication date |
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CN101525328B (zh) | 2012-08-22 |
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Denomination of invention: Method for extracting alpha-mangostin from mangosteen fruit peel Effective date of registration: 20140822 Granted publication date: 20120822 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: Shanxi Jiahe Plant Chemical Co., Ltd. Registration number: 2014610000018 |
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Address after: 710075 Xi'an high tech Zone, Shaanxi hi tech Road, No. 25 Maple Leaf Garden District, block C, No. 157 Patentee after: SHAANXI JIAHE PHYTOCHEM CO., LTD. Address before: 710075 No. 37, science and technology road, hi tech Zone, Shaanxi, Xi'an Patentee before: Shanxi Jiahe Plant Chemical Co., Ltd. |
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Denomination of invention: Method for extracting alpha-mangostin from mangosteen fruit peel Effective date of registration: 20170110 Granted publication date: 20120822 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2017610000003 |
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Date of cancellation: 20180206 Granted publication date: 20120822 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2017610000003 |
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Denomination of invention: Method for extracting alpha-mangostin from mangosteen fruit peel Effective date of registration: 20180206 Granted publication date: 20120822 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2018990000131 |
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Denomination of invention: Method for extracting alpha-mangostin from mangosteen fruit peel Effective date of registration: 20190411 Granted publication date: 20120822 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2019610000066 |
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Denomination of invention: The method of extracting a - reversed twist element from mangosteen peel Effective date of registration: 20200910 Granted publication date: 20120822 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: Y2020610000141 |
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