CN101490253A - 用于抑制蛋白激酶3表达的方法 - Google Patents

用于抑制蛋白激酶3表达的方法 Download PDF

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CN101490253A
CN101490253A CNA200780026982XA CN200780026982A CN101490253A CN 101490253 A CN101490253 A CN 101490253A CN A200780026982X A CNA200780026982X A CN A200780026982XA CN 200780026982 A CN200780026982 A CN 200780026982A CN 101490253 A CN101490253 A CN 101490253A
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seq
nucleotide
sequence
pkn3
nucleic acid
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Chinese (zh)
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约尔格·考夫曼
奥利弗·凯尔
安斯加尔·桑特尔
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Silence Therapeutics GmbH
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Silence Therapeutics GmbH
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CNA200780026982XA 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法 Pending CN101490253A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06015262.6 2006-07-21
EP06015262 2006-07-21

Related Child Applications (2)

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CN201110188043.3A Division CN102321626B (zh) 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法
CN201410643357.1A Division CN104531701A (zh) 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法

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CNA200780026982XA Pending CN101490253A (zh) 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法
CN201110188043.3A Expired - Fee Related CN102321626B (zh) 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法
CN201410643357.1A Pending CN104531701A (zh) 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法

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CN201410643357.1A Pending CN104531701A (zh) 2006-07-21 2007-07-20 用于抑制蛋白激酶3表达的方法

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US (1) US8232256B2 (enExample)
EP (2) EP2546337A1 (enExample)
JP (3) JP2009544281A (enExample)
KR (1) KR101670085B1 (enExample)
CN (3) CN101490253A (enExample)
AU (1) AU2007276388A1 (enExample)
BR (1) BRPI0714875A2 (enExample)
CA (1) CA2658550C (enExample)
HK (1) HK1208701A1 (enExample)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1295611T3 (da) * 2000-06-20 2010-10-04 Dainippon Sumitomo Pharma Co Oligonukleotid-transformerende forbindelser
CN1313158C (zh) * 2001-06-20 2007-05-02 大日本住友制药株式会社 促进核酸转移的方法
EP2055310B1 (en) 2002-08-14 2015-12-16 Silence Therapeutics GmbH Protein kinase N beta for the diagnosis and the treatment of late stage tumor
DK1830888T3 (en) 2004-12-27 2015-10-19 Silence Therapeutics Gmbh LIPID COMPLEX COATED WITH PEG AND APPLICATION THEREOF
WO2008009477A2 (en) 2006-07-21 2008-01-24 Silence Therapeutics Ag Means for inhibiting the expression of protein kinase 3
JPWO2010110314A1 (ja) * 2009-03-27 2012-10-04 協和発酵キリン株式会社 核酸を含有する肺高血圧症治療剤
EP2382994A1 (en) * 2010-04-26 2011-11-02 Maurizio Victor Cattaneo Ligand targeted nanocapsules for the delivery of RNAi and other agents
US9133515B2 (en) 2012-05-16 2015-09-15 Silence Therapeutics Gmbh Use of VEGFR1 as a biomarker
WO2016083623A1 (en) * 2014-11-28 2016-06-02 Silence Therapeutics Gmbh Means for the treatment of pre-eclampsia
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
RU2698199C1 (ru) * 2018-05-18 2019-08-23 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт общей патологии и патофизиологии" Средство для подавления экспрессии генов, связанных с накоплением холестерина макрофагами человека
CN120682233B (zh) * 2025-08-25 2025-12-12 浙江大学 Pkn3激酶抑制剂、药物组合物及pkn3激酶抑制剂的制备方法和应用

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE318832T1 (de) 1990-06-11 2006-03-15 Gilead Sciences Inc Verfahren zur vervendung von nukleinsäureliganden
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
KR940703846A (ko) 1991-12-24 1994-12-12 비. 린네 파샬 갭(gap)이 형성된 2′ 변성된 올리고뉴클레오티드(gapped 2′ modifed oligonucleotides)
JPH07509133A (ja) 1992-07-17 1995-10-12 リボザイム・ファーマシューティカルズ・インコーポレイテッド 動物疾患の処置のための方法および剤
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
US5777153A (en) 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
EP0869937A4 (en) 1995-07-21 2004-07-21 Promega Biosciences Inc AMID BASED CATIONIC LIPIDS
US6605713B1 (en) 1996-08-30 2003-08-12 Jens Peter Furste Mirror-symmetrical selection and evolution of nucleic acids
US5989912A (en) 1996-11-21 1999-11-23 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
US5849902A (en) 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
CA2217550A1 (en) 1996-10-22 1998-04-22 F. Hoffmann-La Roche Ag Cationic lipids for gene therapy
US6358523B1 (en) 1996-12-06 2002-03-19 The Regents Of The University Of California Macromolecule-lipid complexes and methods for making and regulating
US6001311A (en) 1997-02-05 1999-12-14 Protogene Laboratories, Inc. Apparatus for diverse chemical synthesis using two-dimensional array
CA2286739A1 (en) 1997-04-04 1998-10-15 Jinkang Wang Improved methods of delivery using cationic lipids and helper lipids
WO1998051285A2 (en) 1997-05-15 1998-11-19 Genzyme Corporation Cationic amphiphile formulations
US6395713B1 (en) 1997-07-23 2002-05-28 Ribozyme Pharmaceuticals, Inc. Compositions for the delivery of negatively charged molecules
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
JP2001510808A (ja) 1997-07-24 2001-08-07 イネックス ファーマシューティカルズ コーポレイション 核酸触媒の供給のためのリポソーム組成物
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
JP2003528024A (ja) 1997-12-16 2003-09-24 バレンティス・インコーポレーテッド 製剤化された核酸分子の無針注入
AU3751299A (en) 1998-04-20 1999-11-08 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
US6150345A (en) 1998-08-10 2000-11-21 Regents Of The University Of California Methods for promoting survival of myelin producing cells
FR2788275B1 (fr) 1999-01-11 2002-06-14 Lipha ((aminoiminomethyl)amino) alcane carboxamides et leurs applications en therapeutique
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US7015040B2 (en) 1999-02-26 2006-03-21 Mirus Bio Corporation Intravascular delivery of nucleic acid
AU767195B2 (en) 1999-03-10 2003-11-06 Phogen Limited Delivery of substances to cells
CA2383244A1 (en) 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases
EP1064944A1 (en) 1999-06-25 2001-01-03 Schering Aktiengesellschaft Protein kinase N inhibitor comprising Fasudil
WO2001005374A1 (en) 1999-07-15 2001-01-25 Inex Pharmaceuticals Corp. Methods for preparation of lipid-encapsulated therapeutic agents
US6133032A (en) 1999-09-09 2000-10-17 Isis Pharmaceutical Inc. Antisense modulation of PI3 kinase p110 beta expression
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
AU2001240375A1 (en) 2000-03-17 2001-10-03 Benitec Australia Limited Genetic silencing
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Rna 간섭의 rna 서열 특이적인 매개체
WO2001080900A2 (en) 2000-04-20 2001-11-01 The University Of British Columbia Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane
WO2002034236A2 (en) 2000-10-25 2002-05-02 The University Of British Columbia Lipid formulations for target delivery
KR100909681B1 (ko) 2000-12-01 2009-07-29 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. Rna 간섭을 매개하는 작은 rna 분자
US6394713B1 (en) * 2001-03-05 2002-05-28 Phillip E. Yates, Sr. Drill guide apparatus
WO2003070910A2 (en) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US20030135033A1 (en) 2002-01-04 2003-07-17 Anke Klippel-Giese Compounds and methods for the identification and/ or validation of a target
JP2005517427A (ja) 2002-02-20 2005-06-16 サーナ・セラピューティクス・インコーポレイテッド 短干渉核酸(siNA)を用いるC型肝炎ウイルス(HCV)遺伝子発現のRNA干渉媒介性阻害
HUE032289T2 (en) * 2002-08-05 2017-09-28 Silence Therapeutics Gmbh Other new forms of interfering RNA molecules
US7452987B2 (en) 2002-08-05 2008-11-18 Silence Therapeutics Aktiengesellschaft (Ag) Interfering RNA molecules
AU2003258075A1 (en) 2002-08-06 2004-02-23 Lyotropic Therapeutics, Inc. Lipid-drug complexes in reversed liquid and liquid crystalline phases
EP1393742A1 (en) * 2002-08-14 2004-03-03 atugen AG Use of protein kinase N beta
EP2055310B1 (en) * 2002-08-14 2015-12-16 Silence Therapeutics GmbH Protein kinase N beta for the diagnosis and the treatment of late stage tumor
US7635770B2 (en) 2002-11-14 2009-12-22 Dharmacon, Inc. siRNA targeting protein kinase N-3 (PKN-3)
JP2007503514A (ja) 2003-08-26 2007-02-22 スミスクライン・ビーチャム・コーポレイション グリセロールおよびポリエチレングリコールのヘテロ官能性コポリマー、そのコンジュゲートおよび組成物
US8017804B2 (en) 2004-05-05 2011-09-13 Silence Therapeutics Ag Lipids, lipid complexes and use thereof
US20060159737A1 (en) 2004-11-19 2006-07-20 Steffen Panzner Pharmaceutical compositions for local administration
DK1830888T3 (en) 2004-12-27 2015-10-19 Silence Therapeutics Gmbh LIPID COMPLEX COATED WITH PEG AND APPLICATION THEREOF
WO2006074546A1 (en) 2005-01-13 2006-07-20 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
WO2008009477A2 (en) 2006-07-21 2008-01-24 Silence Therapeutics Ag Means for inhibiting the expression of protein kinase 3
RU2360967C1 (ru) * 2007-10-01 2009-07-10 Химический факультет Московского государственного университета имени М.В.Ломоносова Биокатализатор на основе иммобилизованных клеток бактерий для разложения метилфосфоновой кислоты и ее эфиров

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JP2013172714A (ja) 2013-09-05
KR101670085B1 (ko) 2016-10-28
HK1208701A1 (en) 2016-03-11
WO2008009477A2 (en) 2008-01-24
AU2007276388A1 (en) 2008-01-24
CN102321626A (zh) 2012-01-18
US20090304678A1 (en) 2009-12-10
US8232256B2 (en) 2012-07-31
WO2008009477A3 (en) 2008-05-29
BRPI0714875A2 (pt) 2013-05-28
KR20090039715A (ko) 2009-04-22
CA2658550A1 (en) 2008-01-24
CN102321626B (zh) 2014-12-10
JP2015128433A (ja) 2015-07-16
EP2546337A1 (en) 2013-01-16
RU2553561C2 (ru) 2015-06-20
EP2049658A2 (en) 2009-04-22
RU2009106071A (ru) 2010-08-27
JP2009544281A (ja) 2009-12-17
CA2658550C (en) 2018-06-19
CN104531701A (zh) 2015-04-22
MX2009000654A (es) 2009-07-22

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