CA2658550C - Means for inhibiting the expression of protein kinase 3 - Google Patents

Means for inhibiting the expression of protein kinase 3 Download PDF

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Publication number
CA2658550C
CA2658550C CA2658550A CA2658550A CA2658550C CA 2658550 C CA2658550 C CA 2658550C CA 2658550 A CA2658550 A CA 2658550A CA 2658550 A CA2658550 A CA 2658550A CA 2658550 C CA2658550 C CA 2658550C
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Prior art keywords
cancer
seq
nucleic acid
stretch
nucleotides
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Expired - Fee Related
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CA2658550A
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English (en)
French (fr)
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CA2658550A1 (en
Inventor
Joerg Kaufmann
Oliver Keil
Ansgar Santel
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Silence Therapeutics GmbH
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Silence Therapeutics GmbH
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification

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  • Communicable Diseases (AREA)
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  • Physics & Mathematics (AREA)
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  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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CA2658550A 2006-07-21 2007-07-20 Means for inhibiting the expression of protein kinase 3 Expired - Fee Related CA2658550C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06015262.6 2006-07-21
EP06015262 2006-07-21
PCT/EP2007/006492 WO2008009477A2 (en) 2006-07-21 2007-07-20 Means for inhibiting the expression of protein kinase 3

Publications (2)

Publication Number Publication Date
CA2658550A1 CA2658550A1 (en) 2008-01-24
CA2658550C true CA2658550C (en) 2018-06-19

Family

ID=38663298

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2658550A Expired - Fee Related CA2658550C (en) 2006-07-21 2007-07-20 Means for inhibiting the expression of protein kinase 3

Country Status (12)

Country Link
US (1) US8232256B2 (enExample)
EP (2) EP2049658A2 (enExample)
JP (3) JP2009544281A (enExample)
KR (1) KR101670085B1 (enExample)
CN (3) CN101490253A (enExample)
AU (1) AU2007276388A1 (enExample)
BR (1) BRPI0714875A2 (enExample)
CA (1) CA2658550C (enExample)
HK (1) HK1208701A1 (enExample)
MX (1) MX2009000654A (enExample)
RU (1) RU2553561C2 (enExample)
WO (1) WO2008009477A2 (enExample)

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JPWO2010110314A1 (ja) * 2009-03-27 2012-10-04 協和発酵キリン株式会社 核酸を含有する肺高血圧症治療剤
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JP2015521041A (ja) 2012-05-16 2015-07-27 サイレンス・セラピューティクス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Ｐｋｎ３阻害剤投与のためのバイオマーカーとしてのｖｅｇｆｒ１の使用
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RU2698199C1 (ru) * 2018-05-18 2019-08-23 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт общей патологии и патофизиологии" Средство для подавления экспрессии генов, связанных с накоплением холестерина макрофагами человека
CN120682233B (zh) * 2025-08-25 2025-12-12 浙江大学 Pkn3激酶抑制剂、药物组合物及pkn3激酶抑制剂的制备方法和应用

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CN102321626B (zh) 2014-12-10
RU2553561C2 (ru) 2015-06-20
HK1208701A1 (en) 2016-03-11
JP2015128433A (ja) 2015-07-16
CN101490253A (zh) 2009-07-22
CA2658550A1 (en) 2008-01-24
EP2546337A1 (en) 2013-01-16
MX2009000654A (es) 2009-07-22
WO2008009477A3 (en) 2008-05-29
US8232256B2 (en) 2012-07-31
KR101670085B1 (ko) 2016-10-28
CN104531701A (zh) 2015-04-22
JP2009544281A (ja) 2009-12-17
US20090304678A1 (en) 2009-12-10
JP2013172714A (ja) 2013-09-05
AU2007276388A1 (en) 2008-01-24
CN102321626A (zh) 2012-01-18
BRPI0714875A2 (pt) 2013-05-28
KR20090039715A (ko) 2009-04-22
WO2008009477A2 (en) 2008-01-24
RU2009106071A (ru) 2010-08-27

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