CN101415827A - 产生抗原特异性效应t细胞的方法 - Google Patents

产生抗原特异性效应t细胞的方法 Download PDF

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CN101415827A
CN101415827A CNA2006800510949A CN200680051094A CN101415827A CN 101415827 A CN101415827 A CN 101415827A CN A2006800510949 A CNA2006800510949 A CN A2006800510949A CN 200680051094 A CN200680051094 A CN 200680051094A CN 101415827 A CN101415827 A CN 101415827A
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cells
cell
tcr
rna
antigen
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G·舒勒
J·德里
尼尔斯·沙夫特
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Novo Nordisk AS
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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CNA2006800510949A 2005-12-09 2006-12-11 产生抗原特异性效应t细胞的方法 Pending CN101415827A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05111928.7 2005-12-09
EP05111928A EP1795599A1 (en) 2005-12-09 2005-12-09 Methods for generating antigen-specific effector T cells
US60/779,588 2006-03-06

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CN101415827A true CN101415827A (zh) 2009-04-22

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US (1) US20090226404A1 (enExample)
EP (2) EP1795599A1 (enExample)
JP (1) JP2009518021A (enExample)
KR (1) KR20080077272A (enExample)
CN (1) CN101415827A (enExample)
AU (1) AU2006323961A1 (enExample)
CA (1) CA2631785A1 (enExample)
WO (1) WO2007065957A2 (enExample)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102574906A (zh) * 2009-07-03 2012-07-11 英美偌科有限公司 T细胞受体
CN102911267A (zh) * 2012-09-19 2013-02-06 南方医科大学 一种结核/hiv抗原肽双特异性tcr、其重组逆转录病毒载体与应用
CN107557339A (zh) * 2017-09-19 2018-01-09 深圳市北科生物科技有限公司 特异性识别plac1的t细胞及其与细胞因子的联合的应用
CN107630005A (zh) * 2017-09-19 2018-01-26 深圳市北科生物科技有限公司 表达plac1特异性tcr的t细胞及其应用
CN108778291A (zh) * 2016-01-06 2018-11-09 健康研究公司 包含重组t细胞受体的组合物和文库以及使用重组t细胞受体的方法
CN108949694A (zh) * 2012-09-11 2018-12-07 康宁有限公司 瞬时过表达编码药物转运蛋白和/或药物代谢酶的基因的可消耗的低温保存的细胞
CN109477073A (zh) * 2016-03-31 2019-03-15 来恩生物医药私人有限公司 表达外源病毒特异性t细胞受体(tcr)的非活化t细胞
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
CN110627895A (zh) * 2018-06-25 2019-12-31 北京大学 肺癌特异性tcr及其分析技术和应用
WO2020010565A1 (zh) * 2018-07-12 2020-01-16 深圳华大生命科学研究院 Mart-1(27-35)表位特异性t细胞受体
CN110913892A (zh) * 2017-05-02 2020-03-24 免疫治疗有限公司 包含癌抗原的lamp(溶酶体相关膜蛋白)构建物
CN110951690A (zh) * 2010-09-20 2020-04-03 生物技术细胞和基因治疗公司 抗原特异性t细胞受体和t细胞表位
CN112941030A (zh) * 2021-01-25 2021-06-11 吉林大学 一种抗原特异性Treg及其制备方法和应用
CN113185602A (zh) * 2018-04-13 2021-07-30 深圳源正细胞医疗技术有限公司 获得肿瘤特异性t细胞受体的方法
CN117797253A (zh) * 2024-02-29 2024-04-02 诺未科技（北京）有限公司 一种能扩展t细胞抗原表位的肿瘤疫苗及其制备方法

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112851C1 (de) 2001-03-16 2002-10-10 Gsf Forschungszentrum Umwelt Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
JP2008521406A (ja) 2004-11-24 2008-06-26 フレッド ハッチンソン キャンサー リサーチ センター 養子免疫療法のためのｉｌ−２１の使用法および腫瘍抗原の同定法
ATE461215T1 (de) * 2005-09-05 2010-04-15 Immatics Biotechnologies Gmbh Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden
HRP20161191T1 (hr) 2007-01-31 2016-11-18 Yeda Research And Development Company Limited Preusmjerene, genetski projektirane t regulacijske stanice i njihova uporaba u suspenziji autoimunih i upalnih bolesti
US8859229B2 (en) * 2007-02-02 2014-10-14 Yale University Transient transfection with RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
GB0718160D0 (en) 2007-09-18 2007-10-24 Medical Res Council Methods
WO2009045308A2 (en) 2007-10-03 2009-04-09 Fred Hutchinson Cancer Research Center Enhanced generation of cytotoxic t-lymphocytes by il-21 mediated foxp3 suppression
KR100900837B1 (ko) 2007-12-07 2009-06-04 (주)두비엘 리포펩타이드와 폴리(ｉ:ｃ)를 아쥬반트로 포함하는 강력한백신 조성물
EP2090659A1 (en) * 2008-02-14 2009-08-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Infectious particle, process for its preparation and use thereof
WO2009108341A1 (en) 2008-02-28 2009-09-03 Argos Therapeutics, Inc. Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection
DK2279253T3 (en) * 2008-04-09 2017-02-13 Maxcyte Inc Construction and application of therapeutic compositions of freshly isolated cells
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase
EP2352756B1 (en) 2008-11-24 2012-09-19 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH High affinity t cell receptor and use thereof
US9409969B2 (en) 2009-02-09 2016-08-09 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Repertoire of allo-restricted peptide-specific T cell receptor sequences and use thereof
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
AU2013243952A1 (en) 2012-04-02 2014-10-30 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US10501513B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
JP6389166B2 (ja) 2012-05-07 2018-09-12 トラスティーズ・オブ・ダートマス・カレッジ 抗ｂ７−ｈ６抗体、融合タンパク質、及びこれらを使用する方法
CA2934729C (en) * 2014-01-29 2021-08-17 University Health Network Methods and compositions for producing a cell expressing a t cell receptor
WO2016095934A2 (en) * 2014-12-14 2016-06-23 El Abd Hisham Mohamed Magdy A novel genetic device to engineer cell behavior
WO2016127257A1 (en) 2015-02-12 2016-08-18 University Health Network Chimeric antigen receptors
JP6952225B2 (ja) * 2016-03-18 2021-10-20 北海道公立大学法人 札幌医科大学 Ｔ細胞レセプターとその利用
ES3008636T3 (en) 2016-06-02 2025-03-24 Immunocore Ltd Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein
EP3684821A4 (en) 2017-09-19 2021-06-16 The University Of British Columbia ANTI-HLA-A2 ANTIBODIES AND METHOD OF USING THEREOF
KR102740924B1 (ko) 2017-09-20 2024-12-13 더 유니버시티 오브 브리티쉬 콜롬비아 신규한 항-ｈｌａ-ａ2 항체 및 이의 용도
WO2019241549A1 (en) 2018-06-15 2019-12-19 A2 Biotherapeutics, Inc. Foxp3-expressing car-t regulatory cells
WO2021026522A2 (en) * 2019-08-08 2021-02-11 Cedars-Sinai Medical Center Method of generating activated t cells for cancer therapy
US12378521B2 (en) 2020-04-15 2025-08-05 Amgen Inc. Method for enhancing production of genetically engineered autologous T cells
US12241086B2 (en) 2020-04-15 2025-03-04 Amgen Inc. Process for generating genetically engineered autologous T cells
AU2022288058A1 (en) 2021-06-07 2023-11-16 Agonox, Inc. Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
WO2024008274A1 (en) * 2022-07-04 2024-01-11 Universiteit Antwerpen T regulatory cell modification

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211422B2 (en) * 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
EP1188825A1 (en) * 2000-09-18 2002-03-20 Universiteit Leiden T cell receptor transfer into a candidate effector cell or a precursor thereof
US7723111B2 (en) * 2001-03-09 2010-05-25 The United States Of America As Represented By The Department Of Health And Human Services Activated dual specificity lymphocytes and their methods of use
GB0111015D0 (en) * 2001-05-04 2001-06-27 Norsk Hydro As Genetic material
JP2007512030A (ja) * 2003-11-25 2007-05-17 アルゴス・セラピューティクス・インコーポレーテッド ｍＲＮＡをトランスフェクションした抗原提示細胞

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102574906A (zh) * 2009-07-03 2012-07-11 英美偌科有限公司 T细胞受体
CN104017067A (zh) * 2009-07-03 2014-09-03 英美偌科有限公司 T细胞受体
CN110951690A (zh) * 2010-09-20 2020-04-03 生物技术细胞和基因治疗公司 抗原特异性t细胞受体和t细胞表位
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
CN108949694A (zh) * 2012-09-11 2018-12-07 康宁有限公司 瞬时过表达编码药物转运蛋白和/或药物代谢酶的基因的可消耗的低温保存的细胞
CN108949694B (zh) * 2012-09-11 2022-06-17 康宁有限公司 瞬时过表达编码药物转运蛋白和/或药物代谢酶的基因的可消耗的低温保存的细胞
CN102911267A (zh) * 2012-09-19 2013-02-06 南方医科大学 一种结核/hiv抗原肽双特异性tcr、其重组逆转录病毒载体与应用
CN108778291B (zh) * 2016-01-06 2020-11-10 健康研究公司 包含重组t细胞受体的组合物和文库以及使用重组t细胞受体的方法
CN108778291A (zh) * 2016-01-06 2018-11-09 健康研究公司 包含重组t细胞受体的组合物和文库以及使用重组t细胞受体的方法
US11020431B2 (en) 2016-01-06 2021-06-01 Health Research, Inc. Compositions and libraries comprising recombinant T-cell receptors and methods of using recombinant T-cell receptors
CN109477073A (zh) * 2016-03-31 2019-03-15 来恩生物医药私人有限公司 表达外源病毒特异性t细胞受体(tcr)的非活化t细胞
CN109477073B (zh) * 2016-03-31 2024-04-12 来恩生物医药私人有限公司 表达外源病毒特异性t细胞受体(tcr)的非活化t细胞
CN110913892A (zh) * 2017-05-02 2020-03-24 免疫治疗有限公司 包含癌抗原的lamp(溶酶体相关膜蛋白)构建物
CN107630005A (zh) * 2017-09-19 2018-01-26 深圳市北科生物科技有限公司 表达plac1特异性tcr的t细胞及其应用
CN107557339A (zh) * 2017-09-19 2018-01-09 深圳市北科生物科技有限公司 特异性识别plac1的t细胞及其与细胞因子的联合的应用
CN113185602A (zh) * 2018-04-13 2021-07-30 深圳源正细胞医疗技术有限公司 获得肿瘤特异性t细胞受体的方法
CN113185602B (zh) * 2018-04-13 2023-03-10 深圳源正细胞医疗技术有限公司 获得肿瘤特异性t细胞受体的方法
CN110627895B (zh) * 2018-06-25 2021-03-23 北京大学 肺癌特异性tcr及其分析技术和应用
CN110627895A (zh) * 2018-06-25 2019-12-31 北京大学 肺癌特异性tcr及其分析技术和应用
CN112469733B (zh) * 2018-07-12 2022-04-19 深圳华大生命科学研究院 Mart-1(27-35)表位特异性t细胞受体
CN112469733A (zh) * 2018-07-12 2021-03-09 深圳华大生命科学研究院 Mart-1(27-35)表位特异性t细胞受体
WO2020010565A1 (zh) * 2018-07-12 2020-01-16 深圳华大生命科学研究院 Mart-1(27-35)表位特异性t细胞受体
US12134637B2 (en) 2018-07-12 2024-11-05 Bgi Shenzhen MART-1(27-35) epitope-specific T cell receptor
CN112941030A (zh) * 2021-01-25 2021-06-11 吉林大学 一种抗原特异性Treg及其制备方法和应用
CN112941030B (zh) * 2021-01-25 2023-08-08 吉林大学 一种抗原特异性Treg及其制备方法和应用
CN117797253A (zh) * 2024-02-29 2024-04-02 诺未科技（北京）有限公司 一种能扩展t细胞抗原表位的肿瘤疫苗及其制备方法

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