CN112469733A - Mart-1(27-35)表位特异性t细胞受体 - Google Patents
Mart-1(27-35)表位特异性t细胞受体 Download PDFInfo
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- CN112469733A CN112469733A CN201880095200.6A CN201880095200A CN112469733A CN 112469733 A CN112469733 A CN 112469733A CN 201880095200 A CN201880095200 A CN 201880095200A CN 112469733 A CN112469733 A CN 112469733A
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Abstract
提供一种MART‑1(27‑35)表位特异性T细胞受体，该T细胞受体包含α链和β链；所述α链包含三个互补决定区，序列分别为SEQ ID No.3的第61‑66位、第84‑89位以及第124‑136位；所述β链包含三个互补决定区，氨基酸序列分别为SEQ ID No.4的第46‑50位、第68‑73位以及第112‑125位。提供表达TCR的T细胞可以有效的识别T2细胞负载的MART‑1(27‑35)表位多肽，并分泌IFN‑γ，证明其具有功能。该TCR与相关药物靶标联用，可以有效的进行药物开发。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2018/095395 WO2020010565A1 (zh) | 2018-07-12 | 2018-07-12 | Mart-1(27-35)表位特异性t细胞受体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112469733A true CN112469733A (zh) | 2021-03-09 |
| CN112469733B CN112469733B (zh) | 2022-04-19 |
Family
ID=69142897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880095200.6A Active CN112469733B (zh) | 2018-07-12 | 2018-07-12 | Mart-1(27-35)表位特异性t细胞受体 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20220340638A1 (zh) |
| CN (1) | CN112469733B (zh) |
| WO (1) | WO2020010565A1 (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008039818A2 (en) * | 2006-09-26 | 2008-04-03 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified t cell receptors and related materials and methods |
| WO2008042814A2 (en) * | 2006-09-29 | 2008-04-10 | California Institute Of Technology | Mart-1 t cell receptors |
| CN101415827A (zh) * | 2005-12-09 | 2009-04-22 | 阿哥斯医疗公司 | 产生抗原特异性效应t细胞的方法 |
| CN105821080A (zh) * | 2016-05-06 | 2016-08-03 | 深圳精准医疗科技有限公司 | 一种提升安全性、用于表达密码子优化的Anti-MART-1 TCR基因的慢病毒载体的制备及其应用 |
| CN106478809A (zh) * | 2015-11-06 | 2017-03-08 | 广州市香雪制药股份有限公司 | 识别prame抗原短肽的tcr |
| WO2017193104A1 (en) * | 2016-05-06 | 2017-11-09 | Fred Hutchinson Cancer Research Center | T-cell immunotherapy specific for mart-1 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5808079B2 (ja) * | 2007-03-05 | 2015-11-10 | 株式会社癌免疫研究所 | 癌抗原特異的ｔ細胞のレセプター遺伝子およびそれによりコードされるペプチドならびにそれらの使用 |
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- 2018-07-12 WO PCT/CN2018/095395 patent/WO2020010565A1/zh active Application Filing
- 2018-07-12 CN CN201880095200.6A patent/CN112469733B/zh active Active
- 2018-07-12 US US17/259,584 patent/US20220340638A1/en active Pending
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| US20220340638A1 (en) | 2022-10-27 |
| CN112469733B (zh) | 2022-04-19 |
| WO2020010565A1 (zh) | 2020-01-16 |
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