JP2009518021A - 抗原特異的エフェクターt細胞の生成法 - Google Patents

抗原特異的エフェクターt細胞の生成法 Download PDF

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JP2009518021A
JP2009518021A JP2008543852A JP2008543852A JP2009518021A JP 2009518021 A JP2009518021 A JP 2009518021A JP 2008543852 A JP2008543852 A JP 2008543852A JP 2008543852 A JP2008543852 A JP 2008543852A JP 2009518021 A JP2009518021 A JP 2009518021A
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tcr
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rna
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シャフト,ニールズ
シュラー,ゲロルト
ドリエ,ヤン
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アルゴス・セラピューティクス・インコーポレーテッド
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    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/32T-cell receptors [TCR]
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00Cellular immunotherapy
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    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
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JP2008543852A 2005-12-09 2006-12-11 抗原特異的エフェクターt細胞の生成法 Withdrawn JP2009518021A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05111928A EP1795599A1 (en) 2005-12-09 2005-12-09 Methods for generating antigen-specific effector T cells
US77958806P 2006-03-06 2006-03-06
PCT/EP2006/069549 WO2007065957A2 (en) 2005-12-09 2006-12-11 Methods for generating antigen-specific effector t cells

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JP2009518021A true JP2009518021A (ja) 2009-05-07
JP2009518021A5 JP2009518021A5 (enExample) 2010-01-28

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US (1) US20090226404A1 (enExample)
EP (2) EP1795599A1 (enExample)
JP (1) JP2009518021A (enExample)
KR (1) KR20080077272A (enExample)
CN (1) CN101415827A (enExample)
AU (1) AU2006323961A1 (enExample)
CA (1) CA2631785A1 (enExample)
WO (1) WO2007065957A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531904A (ja) * 2009-07-03 2012-12-13 イムノコア リミテッド T細胞レセプター
JP2015518816A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017169566A (ja) * 2016-03-18 2017-09-28 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP2019509753A (ja) * 2016-03-31 2019-04-11 ライオン ティーシーアール ピーティーイー.エルティーディー. 外因性ウイルス特異的t細胞受容体(tcr)を発現する非活性化t細胞

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112851C1 (de) 2001-03-16 2002-10-10 Gsf Forschungszentrum Umwelt Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
JP2008521406A (ja) 2004-11-24 2008-06-26 フレッド ハッチンソン キャンサー リサーチ センター 養子免疫療法のためのil−21の使用法および腫瘍抗原の同定法
ATE461215T1 (de) * 2005-09-05 2010-04-15 Immatics Biotechnologies Gmbh Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden
HRP20161191T1 (hr) 2007-01-31 2016-11-18 Yeda Research And Development Company Limited Preusmjerene, genetski projektirane t regulacijske stanice i njihova uporaba u suspenziji autoimunih i upalnih bolesti
US8859229B2 (en) * 2007-02-02 2014-10-14 Yale University Transient transfection with RNA
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
GB0718160D0 (en) 2007-09-18 2007-10-24 Medical Res Council Methods
WO2009045308A2 (en) 2007-10-03 2009-04-09 Fred Hutchinson Cancer Research Center Enhanced generation of cytotoxic t-lymphocytes by il-21 mediated foxp3 suppression
KR100900837B1 (ko) 2007-12-07 2009-06-04 (주)두비엘 리포펩타이드와 폴리(i:c)를 아쥬반트로 포함하는 강력한백신 조성물
EP2090659A1 (en) * 2008-02-14 2009-08-19 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Infectious particle, process for its preparation and use thereof
WO2009108341A1 (en) 2008-02-28 2009-09-03 Argos Therapeutics, Inc. Transient expression of immunomodulatory polypeptides for the prevention and treatment of autoimmune disease, allergy and transplant rejection
DK2279253T3 (en) * 2008-04-09 2017-02-13 Maxcyte Inc Construction and application of therapeutic compositions of freshly isolated cells
US20140161782A1 (en) * 2008-06-09 2014-06-12 Targazyme, Inc. Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase
EP2352756B1 (en) 2008-11-24 2012-09-19 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH High affinity t cell receptor and use thereof
US9409969B2 (en) 2009-02-09 2016-08-09 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Repertoire of allo-restricted peptide-specific T cell receptor sequences and use thereof
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
BR112013006718B1 (pt) * 2010-09-20 2021-12-07 Tron - Translationale Onkologie An Der Universitätsmedizin Der Johannes Gutenberguniversität Mainz Gemeinnutzige Gmbh Receptor de células t com especificidade para ny-eso-1, composição farmacêutica compreendendo o mesmo e uso do mesmo
CN110200997A (zh) * 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US10501513B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
JP6389166B2 (ja) 2012-05-07 2018-09-12 トラスティーズ・オブ・ダートマス・カレッジ 抗b7−h6抗体、融合タンパク質、及びこれらを使用する方法
WO2014043170A1 (en) * 2012-09-11 2014-03-20 Corning Incorporated Consumable cryopreserved cells transiently overexpressing gene(s) encoding drug transporter proteins(s) and/or drug metabolizing enzyme(s)
CN102911267B (zh) * 2012-09-19 2014-04-02 南方医科大学 一种结核/hiv抗原肽双特异性tcr、其重组逆转录病毒载体与应用
CA2934729C (en) * 2014-01-29 2021-08-17 University Health Network Methods and compositions for producing a cell expressing a t cell receptor
WO2016095934A2 (en) * 2014-12-14 2016-06-23 El Abd Hisham Mohamed Magdy A novel genetic device to engineer cell behavior
WO2016127257A1 (en) 2015-02-12 2016-08-18 University Health Network Chimeric antigen receptors
CN108778291B (zh) * 2016-01-06 2020-11-10 健康研究公司 包含重组t细胞受体的组合物和文库以及使用重组t细胞受体的方法
ES3008636T3 (en) 2016-06-02 2025-03-24 Immunocore Ltd Dosing regimen for gp100-specific tcr - anti-cd3 scfv fusion protein
KR20200016224A (ko) 2017-05-02 2020-02-14 이뮤노믹 쎄라퓨틱스, 인크. 암 항원을 포함하는 lamp (리소솜 연관 막 단백질) 구축물
CN107630005A (zh) * 2017-09-19 2018-01-26 深圳市北科生物科技有限公司 表达plac1特异性tcr的t细胞及其应用
EP3684821A4 (en) 2017-09-19 2021-06-16 The University Of British Columbia ANTI-HLA-A2 ANTIBODIES AND METHOD OF USING THEREOF
CN107557339A (zh) * 2017-09-19 2018-01-09 深圳市北科生物科技有限公司 特异性识别plac1的t细胞及其与细胞因子的联合的应用
KR102740924B1 (ko) 2017-09-20 2024-12-13 더 유니버시티 오브 브리티쉬 콜롬비아 신규한 항-hla-a2 항체 및 이의 용도
WO2019196088A1 (en) * 2018-04-13 2019-10-17 Syz Cell Therapy Co. Methods of obtaining tumor-specific t cell receptors
WO2019241549A1 (en) 2018-06-15 2019-12-19 A2 Biotherapeutics, Inc. Foxp3-expressing car-t regulatory cells
CN110627895B (zh) * 2018-06-25 2021-03-23 北京大学 肺癌特异性tcr及其分析技术和应用
US12134637B2 (en) 2018-07-12 2024-11-05 Bgi Shenzhen MART-1(27-35) epitope-specific T cell receptor
WO2021026522A2 (en) * 2019-08-08 2021-02-11 Cedars-Sinai Medical Center Method of generating activated t cells for cancer therapy
US12378521B2 (en) 2020-04-15 2025-08-05 Amgen Inc. Method for enhancing production of genetically engineered autologous T cells
US12241086B2 (en) 2020-04-15 2025-03-04 Amgen Inc. Process for generating genetically engineered autologous T cells
CN112941030B (zh) * 2021-01-25 2023-08-08 吉林大学 一种抗原特异性Treg及其制备方法和应用
AU2022288058A1 (en) 2021-06-07 2023-11-16 Agonox, Inc. Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use
WO2024008274A1 (en) * 2022-07-04 2024-01-11 Universiteit Antwerpen T regulatory cell modification
CN117797253A (zh) * 2024-02-29 2024-04-02 诺未科技(北京)有限公司 一种能扩展t细胞抗原表位的肿瘤疫苗及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211422B2 (en) * 1992-03-18 2012-07-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric receptor genes and cells transformed therewith
EP1188825A1 (en) * 2000-09-18 2002-03-20 Universiteit Leiden T cell receptor transfer into a candidate effector cell or a precursor thereof
US7723111B2 (en) * 2001-03-09 2010-05-25 The United States Of America As Represented By The Department Of Health And Human Services Activated dual specificity lymphocytes and their methods of use
GB0111015D0 (en) * 2001-05-04 2001-06-27 Norsk Hydro As Genetic material
JP2007512030A (ja) * 2003-11-25 2007-05-17 アルゴス・セラピューティクス・インコーポレーテッド mRNAをトランスフェクションした抗原提示細胞

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012531904A (ja) * 2009-07-03 2012-12-13 イムノコア リミテッド T細胞レセプター
JP2016039812A (ja) * 2009-07-03 2016-03-24 イムノコア リミテッド T細胞レセプター
JP2015518816A (ja) * 2012-04-02 2015-07-06 モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. 腫瘍学関連タンパク質およびペプチドの産生のための修飾ポリヌクレオチド
JP2017169566A (ja) * 2016-03-18 2017-09-28 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP2021184738A (ja) * 2016-03-18 2021-12-09 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP7138881B2 (ja) 2016-03-18 2022-09-20 北海道公立大学法人 札幌医科大学 T細胞レセプターとその利用
JP2019509753A (ja) * 2016-03-31 2019-04-11 ライオン ティーシーアール ピーティーイー.エルティーディー. 外因性ウイルス特異的t細胞受容体(tcr)を発現する非活性化t細胞

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US20090226404A1 (en) 2009-09-10
AU2006323961A1 (en) 2007-06-14
WO2007065957A2 (en) 2007-06-14
KR20080077272A (ko) 2008-08-21
EP1960527A2 (en) 2008-08-27
WO2007065957A3 (en) 2007-07-26
CN101415827A (zh) 2009-04-22
EP1795599A1 (en) 2007-06-13
CA2631785A1 (en) 2007-06-14

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