CN101389214A - 具有基因修饰免疫系统的有蹄类动物 - Google Patents

具有基因修饰免疫系统的有蹄类动物 Download PDF

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Publication number
CN101389214A
CN101389214A CNA2005800441766A CN200580044176A CN101389214A CN 101389214 A CN101389214 A CN 101389214A CN A2005800441766 A CNA2005800441766 A CN A2005800441766A CN 200580044176 A CN200580044176 A CN 200580044176A CN 101389214 A CN101389214 A CN 101389214A
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ungulate
immunoglobulin
nucleotide sequence
seq
cell
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Chinese (zh)
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K·威尔斯
D·阿亚雷斯
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Revivicor Inc
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Revivicor Inc
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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CNA2005800441766A 2004-10-22 2005-10-24 具有基因修饰免疫系统的有蹄类动物 Pending CN101389214A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62143304P 2004-10-22 2004-10-22
US60/621,433 2004-10-22

Publications (1)

Publication Number Publication Date
CN101389214A true CN101389214A (zh) 2009-03-18

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US (1) US20060130157A1 (enExample)
EP (2) EP1811832A4 (enExample)
JP (5) JP2008517608A (enExample)
KR (1) KR20070072608A (enExample)
CN (1) CN101389214A (enExample)
AU (1) AU2005299413A1 (enExample)
CA (3) CA3079874C (enExample)
ES (1) ES2679282T3 (enExample)
NZ (1) NZ554824A (enExample)
WO (1) WO2006047603A2 (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
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CN104994729A (zh) * 2012-12-14 2015-10-21 Omt公司 编码具有人独特型的啮齿动物抗体的多核苷酸以及包含所述多核苷酸的动物
CN107001449A (zh) * 2014-10-15 2017-08-01 芝诺锡拉公司 具有降低的免疫原性的组合物
CN107090470A (zh) * 2011-02-25 2017-08-25 重组股份有限公司 经遗传修饰的动物及其生成方法
CN109843047A (zh) * 2016-08-11 2019-06-04 杰克逊实验室 涉及经遗传修饰的免疫缺陷型非人类动物中改善的人类红血细胞存活的方法和组合物
CN109906272A (zh) * 2016-10-31 2019-06-18 国立大学法人鸟取大学 产生人抗体的非人动物和使用该非人动物的人抗体制作方法
CN111154889A (zh) * 2020-01-16 2020-05-15 广西扬翔股份有限公司 一种与猪体重相关的snp分子标记及其应用和获取方法
CN111647627A (zh) * 2014-04-28 2020-09-11 重组股份有限公司 多重基因编辑
US10893667B2 (en) 2011-02-25 2021-01-19 Recombinetics, Inc. Non-meiotic allele introgression
CN112852826A (zh) * 2019-06-04 2021-05-28 中国农业科学院兰州兽医研究所 猪α环形转录本αCT基因及应用
CN119785879A (zh) * 2024-11-27 2025-04-08 兰州大学 基于多组学策略锁定与绵羊尾脂重相关分子标记的方法及应用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
AU2003290689A1 (en) * 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
WO2005104835A2 (en) 2004-04-22 2005-11-10 Kirin Beer Kabushiki Kaisha Transgenic animals and uses thereof
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
NZ565711A (en) 2005-08-09 2011-10-28 Revivicor Inc Transgenic ungulates expressing a porcine CTLA4 peptide fused to an immunoglobulin
EP2336329B8 (en) * 2007-06-01 2012-11-21 Omt, Inc. Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenis human idiotype antibodies
JP5511144B2 (ja) * 2008-02-12 2014-06-04 学校法人福岡大学 てんかんモデル非ヒト哺乳動物
EP2348827B1 (en) * 2008-10-27 2015-07-01 Revivicor, Inc. Immunocompromised ungulates
US9420770B2 (en) 2009-12-01 2016-08-23 Indiana University Research & Technology Corporation Methods of modulating thrombocytopenia and modified transgenic pigs
WO2020072982A1 (en) 2018-10-05 2020-04-09 Xenotherapeutics, Inc. Xenotransplantation products and methods
US10883084B2 (en) 2018-10-05 2021-01-05 Xenotherapeutics, Inc. Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
WO2023072081A1 (en) * 2021-10-25 2023-05-04 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric tgfbr2
CN116076438B (zh) * 2023-03-21 2024-01-30 湖南中医药大学 类风湿关节炎合并间质性肺病动物模型及其构建方法和应用

Family Cites Families (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US615374A (en) 1898-12-06 Ditch in g atxac h m e nt fo r p lows
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4994384A (en) 1986-12-31 1991-02-19 W. R. Grace & Co.-Conn. Multiplying bovine embryos
US4889806A (en) 1987-04-15 1989-12-26 Washington University Large DNA cloning system based on yeast artificial chromosomes
US5057420A (en) 1987-06-05 1991-10-15 Granada Biosciences, Inc. Bovine nuclear transplantation
US5270201A (en) 1988-03-24 1993-12-14 The General Hospital Corporation Artificial chromosome vector
HUT55052A (en) 1988-03-24 1991-04-29 Gen Hospital Corp Process for producing artificial chromosome vector
JPH04500909A (ja) 1988-09-21 1992-02-20 アニマル　バイオテクノロジー　ケンブリッジ　リミティド 家畜からの多能性胚細胞系の誘導
GB8823068D0 (en) 1988-09-30 1988-11-09 Ici Plc Recombinant dna
GB8823869D0 (en) * 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US4944384A (en) 1989-01-30 1990-07-31 Hay & Forage Industries Trash discharge apparatus for crop transferring conveyor mechanism
US4997384A (en) 1989-04-17 1991-03-05 Otis Engineering Corporation Wet connector
GB8920211D0 (en) 1989-09-07 1989-10-18 Ici Plc Diagnostic method
ES2127458T3 (es) 1989-11-06 1999-04-16 Cell Genesys Inc Produccion de proteinas utilizando recombinacion homologa.
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
ATE130049T1 (de) 1990-07-13 1995-11-15 Transkaryotic Therapies Inc Verfahren zum absuchen einer bibliothek.
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
JP2938569B2 (ja) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド 異種免疫グロブリンを作る方法及びトランスジェニックマウス
US5661016A (en) * 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) * 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
WO1993012227A1 (en) 1991-12-17 1993-06-24 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5633425A (en) * 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) * 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) * 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
AU664976B2 (en) * 1990-08-29 1995-12-14 Gene Pharming Europe Bv Homologous recombination in mammalian cells
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5382524A (en) 1990-10-24 1995-01-17 The Mount Sinai School Of Medicine Of The City University Of New York Cloning and expression of biologically active α-n-acetylgalactosaminidase
WO1992015691A1 (en) 1991-03-11 1992-09-17 Imperial Chemical Industries Plc Biocidal proteins
WO1992022670A1 (en) 1991-06-12 1992-12-23 Genpharm International, Inc. Early detection of transgenic embryos
AU2235992A (en) 1991-06-14 1993-01-12 Genpharm International, Inc. Transgenic immunodeficient non-human animals
AU2515992A (en) * 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5288625A (en) 1991-09-13 1994-02-22 Biologic Research Center Of The Hungarian Academy Of Sciences Mammalian artificial chromosomes
JPH06505400A (ja) 1991-10-15 1994-06-23 パウダージェクト　ヴァクシンズ，　インコーポレイテッド 哺乳類の非接着細胞の粒子介在形質転換
CA2135313A1 (en) 1992-06-18 1994-01-06 Theodore Choi Methods for producing transgenic non-human animals harboring a yeast artificial chromosome
SG48760A1 (en) 1992-07-24 2003-03-18 Abgenix Inc Generation of xenogenetic antibodies
US5981175A (en) 1993-01-07 1999-11-09 Genpharm Internation, Inc. Methods for producing recombinant mammalian cells harboring a yeast artificial chromosome
US5496720A (en) 1993-02-10 1996-03-05 Susko-Parrish; Joan L. Parthenogenic oocyte activation
WO1994023049A2 (en) 1993-04-02 1994-10-13 The Johns Hopkins University The introduction and expression of large genomic sequences in transgenic animals
GB9308271D0 (en) 1993-04-21 1993-06-02 Univ Edinburgh Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
CA2161351C (en) 1993-04-26 2010-12-21 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US6096878A (en) 1993-05-10 2000-08-01 Japan Tobacco Inc. Human immunoglobulin VH gene segments and DNA fragments containing the same
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5851760A (en) 1993-06-15 1998-12-22 The Salk Institute For Biological Studies Method for generation of sequence sampled maps of complex genomes
WO1995003400A1 (en) 1993-07-23 1995-02-02 Johns Hopkins University School Of Medicine Recombinationally targeted cloning in yeast artificial chromosomes
WO1995005847A1 (en) 1993-08-20 1995-03-02 University Of Medicine & Dentistry Of New Jersey Accessory factor function for interferon gamma and its receptor
US5597694A (en) 1993-10-07 1997-01-28 Massachusetts Institute Of Technology Interspersed repetitive element-bubble amplification of nucleic acids
US5625825A (en) 1993-10-21 1997-04-29 Lsi Logic Corporation Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
JPH09509046A (ja) 1993-11-29 1997-09-16 ユニヴァーシティ オブ サウス フロリダ トランスジェニックマウス
WO1996001276A1 (en) 1994-07-06 1996-01-18 University Of Medicine & Dentistry Of New Jersey Expression of a functional human type i interferon receptor
US5643763A (en) 1994-11-04 1997-07-01 Genpharm International, Inc. Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating
US5733744A (en) 1995-01-13 1998-03-31 Cornell Research Foundation, Inc. Binary BAC vector
EP0823941A4 (en) 1995-04-28 2001-09-19 Abgenix Inc HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
US6150170A (en) 1998-05-03 2000-11-21 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
US6682729B1 (en) 1995-05-03 2004-01-27 University Of Maryland, Baltimore Method for introducing and expressing genes in animal cells, and live invasive bacterial vectors for use in the same
US5877159A (en) 1995-05-03 1999-03-02 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same
US6348353B1 (en) 1995-06-07 2002-02-19 Case Western Reserve University Artificial mammalian chromosome
US5985846A (en) 1995-06-07 1999-11-16 Baylor College Of Medicine Gene therapy for muscular dystrophy
US6455254B1 (en) 1995-07-18 2002-09-24 Diversa Corporation Sequence based screening
JP2000513923A (ja) 1995-07-18 2000-10-24 ワシントン・ユニバーシティ 変異ｓ１８２遺伝子
KR19990035820A (ko) 1995-07-21 1999-05-25 잭 스피겔 리콤비나아제 에이를 이용한 유전자 클로닝 방법
AU718138B2 (en) 1995-08-29 2000-04-06 Kyowa Hakko Kirin Co., Ltd. Chimeric animal and method for constructing the same
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
US6133503A (en) 1995-10-31 2000-10-17 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
WO1997016533A1 (en) 1995-10-31 1997-05-09 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US6150160A (en) 1995-11-16 2000-11-21 The John Hopkins University Compositions and methods of use of mammalian retrotransposons
US5997881A (en) 1995-11-22 1999-12-07 University Of Maryland, Baltimore Method of making non-pyrogenic lipopolysaccharide or A
US5866404A (en) 1995-12-06 1999-02-02 Yale University Yeast-bacteria shuttle vector
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US20020132295A1 (en) 1996-02-09 2002-09-19 Short Jay M. Enzymes having transaminase and aminotransferase activity and methods of use thereof
US7288400B2 (en) 1996-02-16 2007-10-30 Verenium Corporation Nucleic acids encoding esterases and methods of making and using them
US6987016B2 (en) 1996-03-08 2006-01-17 Diversa Corporation α-galactosidases and methods for making and using them
WO1997037020A1 (en) 1996-04-01 1997-10-09 Genentech, Inc. Apo-2li and apo-3 apoptosis polypeptides
US6025155A (en) 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6077697A (en) 1996-04-10 2000-06-20 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US6495318B2 (en) 1996-06-17 2002-12-17 Vectorobjects, Llc Method and kits for preparing multicomponent nucleic acid constructs
US20020137185A1 (en) 1996-06-17 2002-09-26 Jay Short Enzymes having amidase activity and methods of use thereof
EP0814156B1 (en) 1996-06-18 2003-03-05 The Institute Of Physical & Chemical Research Method for the purification of DNA
US20020102680A1 (en) 1996-07-03 2002-08-01 Robertson Dan E. Catalases
CA2259158A1 (en) 1996-07-09 1998-01-15 The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services Transformation-associated recombination cloning
EP0934403A4 (en) 1996-08-19 2001-03-14 Univ Massachusetts ROWS OF EMBRYONIC OR STRAIN-LIKE CELLS PRODUCED BY CROSS NUCLEAR TRANSPLANTATION OF SPECIES
US6017755A (en) 1996-08-22 2000-01-25 Hsc Research & Development Limited MADR2 tumour suppressor gene
ATE403733T1 (de) 1996-08-26 2008-08-15 Chromo Res Inc Künstliche säuger chromosome
US6187533B1 (en) 1996-09-10 2001-02-13 Arch Development Corporation Mutations in the diabetes susceptibility genes hepatocyte nuclear factor (HNF) 1 alpha (α), HNF1β and HNF4α
CZ88199A3 (cs) 1996-09-18 1999-08-11 Christian Jung Gen indukující odolnost proti nematodům (hlísticím)
WO1998012336A1 (en) 1996-09-18 1998-03-26 Dnavec Research Inc. Artificial chromosome
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
US6020142A (en) 1996-10-04 2000-02-01 Millennium Pharmaceuticals, Inc. Rath genes and polypeptides and methods for the treatment and diagnosis of immune disorders
US6136566A (en) 1996-10-04 2000-10-24 Lexicon Graphics Incorporated Indexed library of cells containing genomic modifications and methods of making and utilizing the same
US6287854B1 (en) 1996-10-22 2001-09-11 Imperial Cancer Research Technology Limited Diagnosis of susceptibility to cancer and treatment thereof
ES2301183T3 (es) 1996-12-03 2008-06-16 Amgen Fremont Inc. Anticuerpo completamente humano que se une al receptor del egfr.
US6358523B1 (en) 1996-12-06 2002-03-19 The Regents Of The University Of California Macromolecule-lipid complexes and methods for making and regulating
US7279316B2 (en) 1996-12-06 2007-10-09 Verenium Corporation Enzymes having glycosidase activity and methods of use thereof
WO1998027200A2 (en) 1996-12-16 1998-06-25 Mcgill University Human and mammalian dna replication origin consensus sequences
GB9702802D0 (en) 1997-02-12 1997-04-02 Babraham The Inst Yeast artificial chromosomes
US6489458B2 (en) 1997-03-11 2002-12-03 Regents Of The University Of Minnesota DNA-based transposon system for the introduction of nucleic acid into DNA of a cell
JP3151657B2 (ja) 1997-03-26 2001-04-03 農林水産省農業生物資源研究所長 遺伝子導入法
EP1000161B1 (en) 1997-03-26 2006-02-22 Imperial College Innovations Limited Anticoagulant fusion protein anchored to cell membrane
US5843671A (en) 1997-04-01 1998-12-01 Princeton University Methods for measuring trinucleotide repeat expansion in Saccharomyces cerevisiae
ATE302851T1 (de) 1997-05-07 2005-09-15 Genomics One Corp Verbesserter klonierungsvektor mit markerinaktivierungssystem
EP0996719A4 (en) 1997-05-13 2002-05-08 Amrad Operations Pty Ltd A novel nucleic acid molecule
US5972649A (en) 1997-05-29 1999-10-26 Incyte Pharmaceuticals, Inc. Polynucleotide sequence encoding human multiple endocrine neoplasia type 1 protein
EP0986648A1 (en) 1997-06-03 2000-03-22 Arch Development Corporation Plant artificial chromosome (plac) compositions and methods
US6156574A (en) 1997-06-23 2000-12-05 The Rockefeller University Methods of performing gene trapping in bacterial and bacteriophage-derived artificial chromosomes and use thereof
US6143566A (en) 1997-06-23 2000-11-07 The Rockfeller University Methods of performing homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof
US6136952A (en) 1997-06-25 2000-10-24 University Of Washington Human jagged polypeptide, encoding nucleic acids and methods of use
US6207648B1 (en) 1997-07-24 2001-03-27 Trustees Of Boston University Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy
US7056703B2 (en) 1997-08-06 2006-06-06 Diversa Corporation Polypeptides having polymerase activity and methods of use thereof
US6855365B2 (en) 1997-08-13 2005-02-15 Diversa Corporation Recombinant bacterial phytases and uses thereof
US6090584A (en) 1997-08-21 2000-07-18 University Technologies International Inc. Baculovirus artificial chromosomes and methods of use
CA2304642C (en) 1997-09-26 2014-11-18 Athersys, Inc. Expression of endogenous genes by non-homologous recombination of a vector construct with cellular dna
US5874259A (en) 1997-11-21 1999-02-23 Wisconsin Alumni Research Foundation Conditionally amplifiable BAC vector
US6485910B1 (en) 1998-02-09 2002-11-26 Incyte Genomics, Inc. Ras association domain containing protein
US6277621B1 (en) 1998-02-26 2001-08-21 Medigene, Inc. Artificial chromosome constructs containing foreign nucleic acid sequences
US6080576A (en) 1998-03-27 2000-06-27 Lexicon Genetics Incorporated Vectors for gene trapping and gene activation
GB9807520D0 (en) 1998-04-09 1998-06-10 Univ Wales Medicine Modified biological material
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
GB9809280D0 (en) 1998-04-30 1998-07-01 Rpms Technology Ltd Immunosupression
US6383756B1 (en) 1998-05-06 2002-05-07 Genprofile Ag Method for non-radioactive detection of membrane-bonded nucleic acids and test kit
US6723564B2 (en) 1998-05-07 2004-04-20 Sequenom, Inc. IR MALDI mass spectrometry of nucleic acids using liquid matrices
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6534262B1 (en) 1998-05-14 2003-03-18 Whitehead Institute For Biomedical Research Solid phase technique for selectively isolating nucleic acids
AUPP388298A0 (en) 1998-06-03 1998-06-25 Polychip Pharmaceuticals Pty Ltd Precursers of pharmaceutical compounds
US6413776B1 (en) 1998-06-12 2002-07-02 Galapagos Geonomics N.V. High throughput screening of gene function using adenoviral libraries for functional genomics applications
WO2000000609A2 (en) 1998-06-29 2000-01-06 Incyte Pharmaceuticals, Inc. Molecules associated with apoptosis
US6689606B2 (en) 1998-07-21 2004-02-10 M.L. Laboratories Plc Polynucleotide
US6670154B1 (en) 1998-07-27 2003-12-30 Ronald A. Hitzeman Automatic eukaryotic artificial chromosome vector
WO2000009674A1 (en) 1998-08-11 2000-02-24 University Of Hawaii Mammalian transgenesis by intracytoplasmic sperm injection
US6673909B1 (en) 1998-08-25 2004-01-06 The General Hospital Corporation Oligonucleotides for dysferlin, a gene mutated in distal myopathy and limb girdle muscular dystrophy
US6632934B1 (en) 1998-09-30 2003-10-14 Board Of Regents, The University Of Texas System MORC gene compositions and methods of use
GB9821193D0 (en) 1998-09-30 1998-11-25 Medical Res Council Mammalian artificial chromosomes and uses thereof
US6743906B1 (en) 1998-10-02 2004-06-01 Board Of Regents, The University Of Texas PPP2R1B is a tumor suppressor
GB9825555D0 (en) 1998-11-20 1999-01-13 Imp College Innovations Ltd Suppression of xenotransplant rejection
WO2000034497A2 (en) 1998-12-09 2000-06-15 The General Hospital Corporation Enhanced packaging of herpes virus amplicons and generation of recombinant virus vectors
CA2357677A1 (en) 1999-01-07 2000-07-13 Incyte Pharmaceuticals, Inc. Insulin-synthesis genes
US20020015950A1 (en) 1999-07-07 2002-02-07 Karen Anne Jones Atherosclerosis-associated genes
DE60043578D1 (de) 1999-03-04 2010-02-04 Revivicor Inc Genetische veränderung von somatischen zellen und deren verwendungen
GB9909446D0 (en) 1999-04-23 1999-06-23 Medical Res Council Vector
US6544768B1 (en) 1999-05-11 2003-04-08 Cornell Research Foundation, Inc. Mammalian soluble adenylyl cyclase
US6284882B1 (en) 1999-06-10 2001-09-04 Abbott Laboratories Myostatin gene promoter and inhibition of activation thereof
FR2795093B1 (fr) 1999-06-21 2003-08-22 Inst Rech Developpement Ird Moyens pour l'identification du locus d'un gene majeur de la resistance au virus de la panachure jaune du riz et leurs applications
JP2003180356A (ja) 1999-07-09 2003-07-02 Mitsubishi Chemicals Corp アトピー遺伝子
AU6229800A (en) 1999-07-20 2001-02-05 Rockefeller University, The Conditional homologous recombination of large genomic vector inserts
US6475752B1 (en) 1999-07-30 2002-11-05 Incyte Genomics, Inc. Mammalian imidazoline receptor
US7074983B2 (en) * 1999-11-19 2006-07-11 Kirin Beer Kabushiki Kaisha Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
US7414170B2 (en) * 1999-11-19 2008-08-19 Kirin Beer Kabushiki Kaisha Transgenic bovines capable of human antibody production
WO2001035735A1 (en) * 1999-11-19 2001-05-25 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
ES2170622B1 (es) 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
AUPQ462599A0 (en) 1999-12-13 2000-01-13 Polychip Pharmaceuticals Pty Ltd Yeast-based process for production of l-pac
EP1241935A2 (en) 1999-12-17 2002-09-25 Gerald Schatten Methods for producing transgenic animals
US6458561B1 (en) 2000-03-13 2002-10-01 Incyte Genomics, Inc. Human NIM1 kinase
US6492577B1 (en) 2000-03-16 2002-12-10 The Regents Of The University Of California Leafy cotyledon2 genes and their uses
AU2001267342A1 (en) 2000-04-07 2001-10-23 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Novel chromosomal vectors and uses thereof
CA2412609C (en) 2000-06-23 2010-09-07 The University Of Chicago Methods for isolating centromere dna
WO2002000916A2 (en) 2000-06-28 2002-01-03 California Institute Of Technology Methods for identifying an essential gene in a prokaryotic microorganism
US6548256B2 (en) 2000-07-14 2003-04-15 Eppendorf 5 Prime, Inc. DNA isolation method and kit
US6610006B1 (en) 2000-07-25 2003-08-26 C. R. Bard, Inc. Implantable prosthesis
US6730500B1 (en) 2000-08-30 2004-05-04 Zymogenetics, Inc. Methods for generating a continuous nucleotide sequence from noncontiguous nucleotide sequences
US20020049986A1 (en) 2000-10-10 2002-04-25 Steven Farber High throughput genetic screening of lipid and cholesterol processing using fluorescent compounds
US6692954B1 (en) 2000-11-03 2004-02-17 The Scripps Research Institute Generation of human cytomegalovirus yeast artificial chromosome recombinants
AU2001297523B2 (en) * 2000-11-17 2007-01-18 Sab, Llc Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
US6448041B1 (en) 2000-12-18 2002-09-10 Incyte Genomics, Inc. Colon cancer marker
WO2002059330A2 (en) 2001-01-25 2002-08-01 Evolva Biotech A/S Artificial chromosomes comprising concatemers of expressible nucleotide sequences
CA2474161C (en) 2001-01-25 2012-03-27 Evolva Ltd. Concatemers of differentially expressed multiple genes
WO2002061073A2 (en) 2001-01-30 2002-08-08 Thomas Jefferson University Mutwnt fish for genetic screebibg of lipid and cholesterol metabolism
US20020108132A1 (en) 2001-02-02 2002-08-08 Avigenics Inc. Production of a monoclonal antibody by a transgenic chicken
US7323336B2 (en) 2001-02-21 2008-01-29 Verenium Corporation Enzymes having alpha amylase activity and methods of use thereof
US7700316B2 (en) 2001-03-07 2010-04-20 Andre Schuh CD109 nucleic acid molecules, polypeptides and methods of use
US6936469B2 (en) 2001-03-22 2005-08-30 Chromos Molecular Systems Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
US20030186390A1 (en) 2001-03-22 2003-10-02 De Jong Gary Methods for delivering nucleic acid molecules into cells and assessment thereof
NZ527972A (en) 2001-03-22 2006-04-28 Chromos Molecular Systems Inc Methods for delivering nucleic acid molecules into cells and assessment thereof
US6455026B1 (en) 2001-03-23 2002-09-24 Agy Therapeutics, Inc. Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
US20040245317A1 (en) 2001-04-06 2004-12-09 Vladimir Larionov Artificial chromosomes that can shuttle between bacteria yeast and mammalian cells
US6472177B1 (en) 2001-04-23 2002-10-29 Wisconsin Alumni Research Foundation Expression vector with dual control of replication and transcription
CA2446050A1 (en) 2001-05-10 2002-11-21 Baylor College Of Medicine Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
WO2002092812A1 (fr) 2001-05-11 2002-11-21 Kirin Beer Kabushiki Kaisha CHROMOSOME HUMAIN ARTIFICIEL CONTENANT LE GENE A CHAINE LEGERE DE L'ANTICORPS HUMAIN $g(l)
BR0209989A (pt) 2001-05-30 2005-04-12 Chromos Molecular Systems Inc Plataformas baseadas em cromossomas
US20050287647A9 (en) 2001-05-30 2005-12-29 Carl Perez Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes
JP2004534540A (ja) 2001-06-11 2004-11-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 双極性障害に関連する脳で発現する遺伝子およびタンパク質
US6638722B2 (en) 2001-06-13 2003-10-28 Invitrogen Corporation Method for rapid amplification of DNA
WO2003006610A2 (en) 2001-07-09 2003-01-23 Diversa Corporation Thermostable phosphatases and methods of making and using them
AU2002365070A1 (en) 2001-08-03 2003-06-30 Diversa Corporation P450 enzymes, nucleic acids encoding them and methods of making and using them
US6979733B2 (en) 2001-08-03 2005-12-27 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods of making and using them
WO2003020898A2 (en) 2001-08-30 2003-03-13 Spectral Genomics, Inc. Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
JP2005505272A (ja) 2001-09-17 2005-02-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 双極性障害と関連する脳で発現されるｃａｐ−２遺伝子およびタンパク質
AU2002330141B2 (en) 2001-09-27 2007-11-22 Perkinelmer Las, Inc. Methods for detecting genetic mosaicisms using arrays
AU2002367886B8 (en) 2001-10-12 2008-08-14 Perkinelmer Las, Inc. Compilations of nucleic acids and arrays and methods of using them
EP3269235B1 (en) * 2001-11-30 2022-01-26 Amgen Fremont Inc. Transgenic mice bearing human ig lambda light chain genes
US20030124542A1 (en) 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
AU2002217606A1 (en) * 2001-12-29 2003-11-03 Woo Suk Hwang Gfp-transfected clon pig, gt knock-out clon pig and methods for production thereof
US7482332B2 (en) 2002-01-04 2009-01-27 The Board Of Trustees Of The Leland Stanford Junior University Telomere-encoding synthetic DNA nanocircles, and their use for the elongation of telomere repeats
US20040023257A1 (en) 2002-01-28 2004-02-05 Diversa Corporation Enzymes having secondary amidases activity and methods of use thereof
NZ535140A (en) 2002-03-04 2008-08-29 Texas A & M Univ Sys Genetic markers linked to the bovine somatostatin (SST) locus, single nucleotide polymorphisms (SNPs) in the bovine SST locus, all of which are predictive of a particular trait of interest, such as marbling, meat quality grade, and yield grade
EP1495125B1 (en) 2002-04-10 2010-06-16 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Vac-bac shuttle vector system
AU2003221584A1 (en) 2002-05-01 2003-11-17 Chromos Molecular Systems, Inc. Methods for delivering nucleic acid molecules into cells and assessment thereof
KR20050000558A (ko) 2002-05-17 2005-01-05 헤마테크, 엘엘씨 인간 항체를 제조할 수 있는 트랜스제닉 유제동물
EP1532254A4 (en) 2002-05-31 2006-05-10 Univ Rochester VIRUS-FREE HELPER HERPESVIRUS AMPLICON PARTICLES AND ITS USES
WO2004007750A2 (en) 2002-07-11 2004-01-22 Diversa Corporation Monooxygenases, nucleic acids encoding them and methods for making and using them
US20040180378A1 (en) 2002-07-19 2004-09-16 Eileen Tozer Fluorescent proteins, nucleic acids encoding them and methods for making and using them
US20060252156A1 (en) 2002-08-01 2006-11-09 Evolva Ltd. C/O Dr. Iur. Martin Eisenring Methods of mixing large numbers of heterologous genes
US7518033B2 (en) 2002-08-02 2009-04-14 The General Hospital Corporation Methods for the production of cells and mammals with desired genetic modifications
NZ562736A (en) * 2002-08-21 2009-07-31 Revivicor Inc Porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
JP2006512086A (ja) 2002-09-20 2006-04-13 ダイヴァーサ コーポレイション スタチンおよびスタチン中間体の合成のための酵素化学的方法
WO2004031385A1 (ja) 2002-10-04 2004-04-15 Kirin Beer Kabushiki Kaisha ヒト人工染色体（ｈａｃ）ベクター
KR20050052666A (ko) 2002-10-10 2005-06-03 다이버사 코포레이션 프로테아제, 이를 암호화하는 핵산, 및 이를 제조하고사용하는 방법
AU2003284983A1 (en) 2002-11-06 2004-06-03 Diversa Corporation Xylose isomerases, nucleic acids encoding them and methods for making and using them
AU2003290689A1 (en) 2002-11-08 2004-06-03 Kyowa Hakko Kirin Co., Ltd. Transgenic ungulates having reduced prion protein activity and uses thereof
AU2002952993A0 (en) 2002-11-29 2002-12-12 The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland Therapeutic and diagnostic agents
WO2004066945A2 (en) 2003-01-24 2004-08-12 Diversa Corporation Enzymes and the nucleic acids encoding them and methods for making and using them
JP2007525955A (ja) * 2003-06-06 2007-09-13 ユニバーシティー オブ ピッツバーグ ブタｃｍｐ−ｎ−アセチルノイラミン酸ヒドロキシラーゼ遺伝子
US7560538B2 (en) * 2003-11-05 2009-07-14 University Of Pittsburgh Porcine isogloboside 3 synthase protein, cDNA, genomic organization, and regulatory region
AU2005243169A1 (en) * 2004-05-07 2005-11-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region
EP2348827B1 (en) * 2008-10-27 2015-07-01 Revivicor, Inc. Immunocompromised ungulates

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US10893667B2 (en) 2011-02-25 2021-01-19 Recombinetics, Inc. Non-meiotic allele introgression
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CN119785879A (zh) * 2024-11-27 2025-04-08 兰州大学 基于多组学策略锁定与绵羊尾脂重相关分子标记的方法及应用

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