CN101374519A - 毒蕈碱性受体调节剂 - Google Patents

毒蕈碱性受体调节剂 Download PDF

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Publication number
CN101374519A
CN101374519A CNA2006800529466A CN200680052946A CN101374519A CN 101374519 A CN101374519 A CN 101374519A CN A2006800529466 A CNA2006800529466 A CN A2006800529466A CN 200680052946 A CN200680052946 A CN 200680052946A CN 101374519 A CN101374519 A CN 101374519A
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China
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alkyl
carbonyl
aryl
group
chemical compound
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CNA2006800529466A
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Chinese (zh)
Inventor
L·R·马金斯
M·加西亚-古斯曼布兰科
D·J·哈尔利
I·德鲁图
G·拉菲
D·M·伯格伦
A·纳卡塔尼
A·P·特尔明
A·西利纳
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CN101374519A publication Critical patent/CN101374519A/zh
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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    • C07D491/10—Spiro-condensed systems

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  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNA2006800529466A 2005-12-22 2006-12-22 毒蕈碱性受体调节剂 Pending CN101374519A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75318705P 2005-12-22 2005-12-22
US60/753,187 2005-12-22

Publications (1)

Publication Number Publication Date
CN101374519A true CN101374519A (zh) 2009-02-25

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CNA2006800529466A Pending CN101374519A (zh) 2005-12-22 2006-12-22 毒蕈碱性受体调节剂

Country Status (12)

Country Link
US (1) US7858635B2 (https=)
EP (1) EP1973543A2 (https=)
JP (1) JP2009521483A (https=)
KR (1) KR20080087841A (https=)
CN (1) CN101374519A (https=)
AU (1) AU2006330866A1 (https=)
CA (1) CA2634456A1 (https=)
IL (1) IL192327A0 (https=)
NO (1) NO20083011L (https=)
RU (1) RU2008130094A (https=)
WO (1) WO2007076070A2 (https=)
ZA (1) ZA200806028B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104039321A (zh) * 2011-11-18 2014-09-10 赫普泰雅治疗有限公司 药物化合物
CN104640851A (zh) * 2012-09-18 2015-05-20 赫普泰雅治疗有限公司 作为毒蕈碱的m1受体激动剂的二环氮杂化合物
CN106659719A (zh) * 2014-03-19 2017-05-10 赫普泰雅治疗有限公司 毒蕈碱受体激动剂
CN115667273A (zh) * 2020-05-22 2023-01-31 范德堡大学 毒蕈碱型乙酰胆碱受体m5的竞争性和非竞争性抑制剂

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JP2003294742A (ja) 2002-03-29 2003-10-15 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板及びその使用方法
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
NZ570497A (en) * 2006-02-22 2011-09-30 Vertex Pharma Spiro condensed 4,4'-quinilino-piperidines derivatives as modulators of muscarinic receptors
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
TW201322983A (zh) * 2007-08-31 2013-06-16 Purdue Pharma Lp 經取代之喹□啉型哌啶化合物及其用途
HRP20120968T1 (hr) * 2008-02-06 2013-01-31 Astrazeneca Ab Spojevi
CA2794153C (en) 2010-03-25 2018-01-02 Glaxosmithkline Llc Substituted indoline derivatives as perk inhibitors
TW201643169A (zh) * 2010-07-09 2016-12-16 艾伯維股份有限公司 作為s1p調節劑的螺-哌啶衍生物
GB2519470A (en) * 2013-09-18 2015-04-22 Heptares Therapeutics Ltd Bicyclic aza compounds as muscarinic M1 receptor agonists
KR102352388B1 (ko) 2014-02-06 2022-01-17 헵테얼즈 테라퓨틱스 리미티드 무스카린성 m1 수용체 및/또는 m4 수용체 작용제로서 바이사이클릭 아자 화합물
US10118890B2 (en) 2014-10-10 2018-11-06 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
GB201504675D0 (en) * 2015-03-19 2015-05-06 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
AR105911A1 (es) 2015-09-03 2017-11-22 Forma Therapeutics Inc Inhibidores de hdac8 bicíclicos fusionados [6,6]
GB201519352D0 (en) 2015-11-02 2015-12-16 Heptares Therapeutics Ltd Pharmaceutical compounds
WO2017107089A1 (en) 2015-12-23 2017-06-29 Merck Sharp & Dohme Corp. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor
US10329289B2 (en) 2015-12-23 2019-06-25 Merck Sharp & Dohme Corp. 6,7-dihydro-5H-pyrrolo[3,4-B]pyridin-5-one allosteric modulators of the M4 muscarinic acetylcholine receptor
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
WO2018112842A1 (en) 2016-12-22 2018-06-28 Merck Sharp & Dohme Corp. 6,6-fused heteroaryl piperidine ether allosteric modulators of m4 muscarinic acetylcholine receptor
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