AU2006330866A1 - Modulators of muscarinic receptors - Google Patents

Modulators of muscarinic receptors Download PDF

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Publication number
AU2006330866A1
AU2006330866A1 AU2006330866A AU2006330866A AU2006330866A1 AU 2006330866 A1 AU2006330866 A1 AU 2006330866A1 AU 2006330866 A AU2006330866 A AU 2006330866A AU 2006330866 A AU2006330866 A AU 2006330866A AU 2006330866 A1 AU2006330866 A1 AU 2006330866A1
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Australia
Prior art keywords
pct
compound
optionally substituted
alkyl
halo
Prior art date
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Abandoned
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AU2006330866A
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English (en)
Inventor
Daniele M. Bergeron
Ioana Drutu
Miguel Garcia-Guzman Blanco
Dennis J. Hurley
Lewis R. Makings
Akiko Nakatani
Gabriel Raffai
Alina Silina
Andreas P. Termin
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2006330866A1 publication Critical patent/AU2006330866A1/en
Abandoned legal-status Critical Current

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2006330866A 2005-12-22 2006-12-22 Modulators of muscarinic receptors Abandoned AU2006330866A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75318705P 2005-12-22 2005-12-22
US60/753,187 2005-12-22
PCT/US2006/049141 WO2007076070A2 (en) 2005-12-22 2006-12-22 Modulators of muscarinic receptors

Publications (1)

Publication Number Publication Date
AU2006330866A1 true AU2006330866A1 (en) 2007-07-05

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ID=38138812

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006330866A Abandoned AU2006330866A1 (en) 2005-12-22 2006-12-22 Modulators of muscarinic receptors

Country Status (12)

Country Link
US (1) US7858635B2 (https=)
EP (1) EP1973543A2 (https=)
JP (1) JP2009521483A (https=)
KR (1) KR20080087841A (https=)
CN (1) CN101374519A (https=)
AU (1) AU2006330866A1 (https=)
CA (1) CA2634456A1 (https=)
IL (1) IL192327A0 (https=)
NO (1) NO20083011L (https=)
RU (1) RU2008130094A (https=)
WO (1) WO2007076070A2 (https=)
ZA (1) ZA200806028B (https=)

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US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
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TW201322983A (zh) * 2007-08-31 2013-06-16 Purdue Pharma Lp 經取代之喹□啉型哌啶化合物及其用途
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GB2519470A (en) * 2013-09-18 2015-04-22 Heptares Therapeutics Ltd Bicyclic aza compounds as muscarinic M1 receptor agonists
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CA2634456A1 (en) 2007-07-05
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WO2007076070A3 (en) 2007-10-25
WO2007076070A2 (en) 2007-07-05
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US7858635B2 (en) 2010-12-28
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NO20083011L (no) 2008-09-19

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