CN101371139B - 用于检测分析物的支持物以及制造和利用该支持物的方法 - Google Patents

用于检测分析物的支持物以及制造和利用该支持物的方法 Download PDF

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CN101371139B
CN101371139B CN2006800495277A CN200680049527A CN101371139B CN 101371139 B CN101371139 B CN 101371139B CN 2006800495277 A CN2006800495277 A CN 2006800495277A CN 200680049527 A CN200680049527 A CN 200680049527A CN 101371139 B CN101371139 B CN 101371139B
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maleic anhydride
substrate
blocking
binding
groups
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CN101371139A (zh
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A·G·弗鲁托斯
D·享利
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Corning Inc
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/30Introducing nitrogen atoms or nitrogen-containing groups
    • C08F8/32Introducing nitrogen atoms or nitrogen-containing groups by reaction with amines
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    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
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    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/00626Covalent
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    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/0063Other, e.g. van der Waals forces, hydrogen bonding
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
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    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00639Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00641Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being continuous, e.g. porous oxide substrates
    • BPERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00725Peptides
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    • B01J2219/00736Non-biologic macromolecules, e.g. polymeric compounds
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]

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CN2006800495277A 2005-12-29 2006-12-15 用于检测分析物的支持物以及制造和利用该支持物的方法 Expired - Fee Related CN101371139B (zh)

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Application Number Priority Date Filing Date Title
US75474705P 2005-12-29 2005-12-29
US60/754,747 2005-12-29
US11/448,486 2006-06-07
US11/448,486 US7781203B2 (en) 2005-12-29 2006-06-07 Supports for assaying analytes and methods of making and using thereof
PCT/US2006/047885 WO2007078873A1 (en) 2005-12-29 2006-12-15 Supports for assaying analytes and methods of making and using thereof

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CN101371139A CN101371139A (zh) 2009-02-18
CN101371139B true CN101371139B (zh) 2013-05-22

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US (3) US7781203B2 (https=)
EP (1) EP1974214B1 (https=)
JP (1) JP4903224B2 (https=)
CN (1) CN101371139B (https=)
DK (1) DK1974214T3 (https=)
WO (1) WO2007078873A1 (https=)

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US8168399B2 (en) 2012-05-01
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