CN101370479A - 用于递送治疗剂的纳米团簇 - Google Patents

用于递送治疗剂的纳米团簇 Download PDF

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Publication number
CN101370479A
CN101370479A CN200680051564.1A CN200680051564A CN101370479A CN 101370479 A CN101370479 A CN 101370479A CN 200680051564 A CN200680051564 A CN 200680051564A CN 101370479 A CN101370479 A CN 101370479A
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Prior art keywords
nanoparticles
nanocluster
nanoclusters
composition
active ingredient
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Pending
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CN200680051564.1A
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English (en)
Chinese (zh)
Inventor
C·J·伯克兰德
史联军
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University of Kansas
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University of Kansas
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN200680051564.1A 2005-12-16 2006-12-14 用于递送治疗剂的纳米团簇 Pending CN101370479A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75117205P 2005-12-16 2005-12-16
US60/751,172 2005-12-16

Publications (1)

Publication Number Publication Date
CN101370479A true CN101370479A (zh) 2009-02-18

Family

ID=37808148

Family Applications (1)

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CN200680051564.1A Pending CN101370479A (zh) 2005-12-16 2006-12-14 用于递送治疗剂的纳米团簇

Country Status (11)

Country Link
US (3) US7651770B2 (https=)
EP (1) EP1968550A2 (https=)
JP (1) JP2009519975A (https=)
CN (1) CN101370479A (https=)
AU (1) AU2006330627A1 (https=)
BR (1) BRPI0619938A2 (https=)
CA (1) CA2633380A1 (https=)
IL (1) IL192159A0 (https=)
MX (1) MX2008007697A (https=)
WO (1) WO2007076295A2 (https=)
ZA (1) ZA200805918B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
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CN103221070A (zh) * 2010-08-30 2013-07-24 哈佛大学校长及研究员协会 用于狭窄病变和溶解血栓疗法的切变控制释放
CN104550936A (zh) * 2014-12-31 2015-04-29 中国科学院合肥物质科学研究院 纳米颗粒组装的胶状体材料及其制备方法
CN105899197A (zh) * 2013-11-13 2016-08-24 蒂洛特斯制药股份有限公司 多颗粒药物递送系统
CN114901261A (zh) * 2019-04-02 2022-08-12 淅川海灵生物科技有限公司 细胞外液中激活的原子粒子的动态团簇

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221070A (zh) * 2010-08-30 2013-07-24 哈佛大学校长及研究员协会 用于狭窄病变和溶解血栓疗法的切变控制释放
CN103221070B (zh) * 2010-08-30 2019-07-12 哈佛大学校长及研究员协会 用于狭窄病变和溶解血栓疗法的切变控制释放
CN105899197A (zh) * 2013-11-13 2016-08-24 蒂洛特斯制药股份有限公司 多颗粒药物递送系统
CN104550936A (zh) * 2014-12-31 2015-04-29 中国科学院合肥物质科学研究院 纳米颗粒组装的胶状体材料及其制备方法
CN104550936B (zh) * 2014-12-31 2017-05-31 中国科学院合肥物质科学研究院 纳米颗粒组装的胶状体材料及其制备方法
CN114901261A (zh) * 2019-04-02 2022-08-12 淅川海灵生物科技有限公司 细胞外液中激活的原子粒子的动态团簇

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AU2006330627A1 (en) 2007-07-05
JP2009519975A (ja) 2009-05-21
EP1968550A2 (en) 2008-09-17
ZA200805918B (en) 2009-05-27
US7651770B2 (en) 2010-01-26
US20070172653A1 (en) 2007-07-26
US20090081295A1 (en) 2009-03-26
MX2008007697A (es) 2008-09-26
BRPI0619938A2 (pt) 2011-10-25
IL192159A0 (en) 2008-12-29
US20090053316A1 (en) 2009-02-26
WO2007076295A2 (en) 2007-07-05
WO2007076295A3 (en) 2007-11-29
CA2633380A1 (en) 2007-07-05

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Application publication date: 20090218