CN101360499B - 吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途 - Google Patents
吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途 Download PDFInfo
- Publication number
- CN101360499B CN101360499B CN200680045935.5A CN200680045935A CN101360499B CN 101360499 B CN101360499 B CN 101360499B CN 200680045935 A CN200680045935 A CN 200680045935A CN 101360499 B CN101360499 B CN 101360499B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- compound
- aryl
- heteroaryl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 Cc1c(N*)[n]2ncc(*)c2nc1* Chemical compound Cc1c(N*)[n]2ncc(*)c2nc1* 0.000 description 51
- WEHXQGYRUFNZMV-UHFFFAOYSA-N C[n]1ncc(-c(cn[nH]2)c2N=C)c1 Chemical compound C[n]1ncc(-c(cn[nH]2)c2N=C)c1 WEHXQGYRUFNZMV-UHFFFAOYSA-N 0.000 description 5
- SJXYERQPUXZXSO-UHFFFAOYSA-N C=Nc([nH]nc1)c1-c(cc1)ccc1C#N Chemical compound C=Nc([nH]nc1)c1-c(cc1)ccc1C#N SJXYERQPUXZXSO-UHFFFAOYSA-N 0.000 description 2
- LWFKVGKYPDNGJJ-UHFFFAOYSA-N C=Nc([nH]nc1)c1-c1c[s]cn1 Chemical compound C=Nc([nH]nc1)c1-c1c[s]cn1 LWFKVGKYPDNGJJ-UHFFFAOYSA-N 0.000 description 2
- OUSVHNJRYHSSMU-UHFFFAOYSA-N C=Nc([nH]nc1)c1-c1cnccn1 Chemical compound C=Nc([nH]nc1)c1-c1cnccn1 OUSVHNJRYHSSMU-UHFFFAOYSA-N 0.000 description 2
- OPSFVVLOBWZVPS-UHFFFAOYSA-N C=Nc([nH]nc1)c1-c1n[o]cn1 Chemical compound C=Nc([nH]nc1)c1-c1n[o]cn1 OPSFVVLOBWZVPS-UHFFFAOYSA-N 0.000 description 1
- LRLWJVBGPZUKQQ-UHFFFAOYSA-N C=S(c(cc1)ccc1Nc([n]1nc2)cc(NCC3C(CO)CCCC3)nc1c2Br)=O Chemical compound C=S(c(cc1)ccc1Nc([n]1nc2)cc(NCC3C(CO)CCCC3)nc1c2Br)=O LRLWJVBGPZUKQQ-UHFFFAOYSA-N 0.000 description 1
- USJSFMYGTKDXFG-UHFFFAOYSA-N CC#Cc1c(N)[n]2ncc(-c3c[n](C)nc3)c2nc1C1CNCCC1 Chemical compound CC#Cc1c(N)[n]2ncc(-c3c[n](C)nc3)c2nc1C1CNCCC1 USJSFMYGTKDXFG-UHFFFAOYSA-N 0.000 description 1
- SUGPCLXPEKGGRZ-UHFFFAOYSA-N CC(C)(C)OC(C1NCCCC1C(OC)=O)=O Chemical compound CC(C)(C)OC(C1NCCCC1C(OC)=O)=O SUGPCLXPEKGGRZ-UHFFFAOYSA-N 0.000 description 1
- KZSUJXLSHQBSEB-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1)CC1c(cc(Nc1cc(C)n[s]1)[n]1nc2)nc1c2-c1c[s]cn1)=O Chemical compound CC(C)(C)OC(N(CCC1)CC1c(cc(Nc1cc(C)n[s]1)[n]1nc2)nc1c2-c1c[s]cn1)=O KZSUJXLSHQBSEB-UHFFFAOYSA-N 0.000 description 1
- SDMAONVCCZZJMZ-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1)CC1c(cc([n]1nc2)OC)nc1c2-c1c[s]cn1)=O Chemical compound CC(C)(C)OC(N(CCC1)CC1c(cc([n]1nc2)OC)nc1c2-c1c[s]cn1)=O SDMAONVCCZZJMZ-UHFFFAOYSA-N 0.000 description 1
- BEKFNIDUXLLDCE-LRDDRELGSA-N CC(C)(C)OC(N(C[C@H](CC1)c(cc(N)[n]2nc3)nc2c3-c2c[n](C)nc2)[C@@H]1C(O)=O)=O Chemical compound CC(C)(C)OC(N(C[C@H](CC1)c(cc(N)[n]2nc3)nc2c3-c2c[n](C)nc2)[C@@H]1C(O)=O)=O BEKFNIDUXLLDCE-LRDDRELGSA-N 0.000 description 1
- DXNUWSBXATWONU-GUYCJALGSA-N CC(C)(C)OC(N(C[C@H](CC1)c(cc(N)[n]2nc3)nc2c3-c2c[n](C)nc2)[C@@H]1C(OC)=O)=O Chemical compound CC(C)(C)OC(N(C[C@H](CC1)c(cc(N)[n]2nc3)nc2c3-c2c[n](C)nc2)[C@@H]1C(OC)=O)=O DXNUWSBXATWONU-GUYCJALGSA-N 0.000 description 1
- VLAQTXAAMGVABL-AWEZNQCLSA-N CC(C)(C)OC(N[C@@H](CC1)CN1c(c(-c1ccccc1)c(N)[n]1nc2)nc1c2Br)=O Chemical compound CC(C)(C)OC(N[C@@H](CC1)CN1c(c(-c1ccccc1)c(N)[n]1nc2)nc1c2Br)=O VLAQTXAAMGVABL-AWEZNQCLSA-N 0.000 description 1
- NTHXWOFGAQYAKM-UWJYYQICSA-N CC(C)(C)OC(Nc([n]1nc2)cc([C@@H](CC[C@H]3C(C)=O)CN3C(OC(C)(C)C)=O)nc1c2-c1c[n](C)nc1)=O Chemical compound CC(C)(C)OC(Nc([n]1nc2)cc([C@@H](CC[C@H]3C(C)=O)CN3C(OC(C)(C)C)=O)nc1c2-c1c[n](C)nc1)=O NTHXWOFGAQYAKM-UWJYYQICSA-N 0.000 description 1
- GDZAEXWWECSROO-UHFFFAOYSA-N CC(C)(C)OC(c1ncccc1C(OC)=N)=O Chemical compound CC(C)(C)OC(c1ncccc1C(OC)=N)=O GDZAEXWWECSROO-UHFFFAOYSA-N 0.000 description 1
- JEFNYYAMKRRXMK-UHFFFAOYSA-N CC(C)(C)OC(c1ncccc1C(OC)=O)=O Chemical compound CC(C)(C)OC(c1ncccc1C(OC)=O)=O JEFNYYAMKRRXMK-UHFFFAOYSA-N 0.000 description 1
- IVBKFHRDXZDBMN-HEHNFIMWSA-N CC(C)(CN/C=C(\C)/c(cc1)ccc1C(c([n]1nc2)cc(C3C=CC=CC3)nc1c2Br)=C)CN(C)C Chemical compound CC(C)(CN/C=C(\C)/c(cc1)ccc1C(c([n]1nc2)cc(C3C=CC=CC3)nc1c2Br)=C)CN(C)C IVBKFHRDXZDBMN-HEHNFIMWSA-N 0.000 description 1
- FPYXKQPWZHOUBC-UHFFFAOYSA-N CC(C)NC(Nc([n]1nc2)cc(-c(cccc3)c3Cl)nc1c2Br)=O Chemical compound CC(C)NC(Nc([n]1nc2)cc(-c(cccc3)c3Cl)nc1c2Br)=O FPYXKQPWZHOUBC-UHFFFAOYSA-N 0.000 description 1
- CHOSBRWVSVDTRI-KXBFYZLASA-N CC(C)NC([C@H](CC[C@@H](C1)c(cc(N)[n]2nc3)nc2c3-c2c[n](C)nc2)N1C(OC(C)(C)C)=O)=O Chemical compound CC(C)NC([C@H](CC[C@@H](C1)c(cc(N)[n]2nc3)nc2c3-c2c[n](C)nc2)N1C(OC(C)(C)C)=O)=O CHOSBRWVSVDTRI-KXBFYZLASA-N 0.000 description 1
- HGZUUMWQBPLRLA-UHFFFAOYSA-N CC(C)c([n]1nc2)cc(C3CNCCC3)nc1c2-c1c[n](C)nc1 Chemical compound CC(C)c([n]1nc2)cc(C3CNCCC3)nc1c2-c1c[n](C)nc1 HGZUUMWQBPLRLA-UHFFFAOYSA-N 0.000 description 1
- OERXSGSZMTVWTO-KDBUZZBASA-N CC([C@H](CC1)N(C)C[C@H]1c(cc(NC(OC(C)(C)C)=O)[n]1nc2)nc1c2-c1c[n](C)nc1)O Chemical compound CC([C@H](CC1)N(C)C[C@H]1c(cc(NC(OC(C)(C)C)=O)[n]1nc2)nc1c2-c1c[n](C)nc1)O OERXSGSZMTVWTO-KDBUZZBASA-N 0.000 description 1
- NAKWVURGJNPGMF-UHFFFAOYSA-N CC(c1c(N)[n]2ncc(-c3c[n](C)nc3)c2nc1C1CNCCC1)=O Chemical compound CC(c1c(N)[n]2ncc(-c3c[n](C)nc3)c2nc1C1CNCCC1)=O NAKWVURGJNPGMF-UHFFFAOYSA-N 0.000 description 1
- YHEMDDZDHYKQGZ-UHFFFAOYSA-N CC1(C)OB(c2c[o]c(C=O)c2)OC1(C)C Chemical compound CC1(C)OB(c2c[o]c(C=O)c2)OC1(C)C YHEMDDZDHYKQGZ-UHFFFAOYSA-N 0.000 description 1
- XBCVOQREXSPJOQ-UHFFFAOYSA-N CC1C(C)(CCN[N](c(cc2)ccc2NC2=CC(c3ccccc3)=NC3N2N=CC3(C)Br)(O)O)C1 Chemical compound CC1C(C)(CCN[N](c(cc2)ccc2NC2=CC(c3ccccc3)=NC3N2N=CC3(C)Br)(O)O)C1 XBCVOQREXSPJOQ-UHFFFAOYSA-N 0.000 description 1
- YJFXTICLBSAZTC-UHFFFAOYSA-N CC1C=NN2C(NC(Nc3ccncc3)=O)=CC(c(cccc3)c3F)=NC12C Chemical compound CC1C=NN2C(NC(Nc3ccncc3)=O)=CC(c(cccc3)c3F)=NC12C YJFXTICLBSAZTC-UHFFFAOYSA-N 0.000 description 1
- VPZFGLVHLUJRBD-UHFFFAOYSA-N CCOC(Cc1c(N)[n]2ncc(Br)c2nc1C)=O Chemical compound CCOC(Cc1c(N)[n]2ncc(Br)c2nc1C)=O VPZFGLVHLUJRBD-UHFFFAOYSA-N 0.000 description 1
- YFDRYBUJCGOYCQ-UHFFFAOYSA-N CN1C(C2)CNC2C1 Chemical compound CN1C(C2)CNC2C1 YFDRYBUJCGOYCQ-UHFFFAOYSA-N 0.000 description 1
- WRXUWVBJBUWDKY-PKPIPKONSA-N CN1N=CC[C@@H]2NN=CCC12 Chemical compound CN1N=CC[C@@H]2NN=CCC12 WRXUWVBJBUWDKY-PKPIPKONSA-N 0.000 description 1
- WANKZKMZZQHOET-UHFFFAOYSA-N CNc([n]1nc2)cc(C3CN(CCOC)CCC3)nc1c2-c1c[n](C)nc1 Chemical compound CNc([n]1nc2)cc(C3CN(CCOC)CCC3)nc1c2-c1c[n](C)nc1 WANKZKMZZQHOET-UHFFFAOYSA-N 0.000 description 1
- AFBPFSWMIHJQDM-UHFFFAOYSA-N CNc1ccccc1 Chemical compound CNc1ccccc1 AFBPFSWMIHJQDM-UHFFFAOYSA-N 0.000 description 1
- TUGJJKKQXXMMGU-UHFFFAOYSA-N CS(c(cc1)ccc1Nc([n]1nc2)cc(-c(cccc3)c3Cl)nc1c2Br)(=O)=O Chemical compound CS(c(cc1)ccc1Nc([n]1nc2)cc(-c(cccc3)c3Cl)nc1c2Br)(=O)=O TUGJJKKQXXMMGU-UHFFFAOYSA-N 0.000 description 1
- OXVWAHKCCDIWQP-UHFFFAOYSA-N C[n]1ncc(-c(cn[n]2c(O)c3)c2nc3O)c1 Chemical compound C[n]1ncc(-c(cn[n]2c(O)c3)c2nc3O)c1 OXVWAHKCCDIWQP-UHFFFAOYSA-N 0.000 description 1
- VPJIDHLGGJAEOZ-UHFFFAOYSA-N C[n]1ncc(-c2c(N)[nH]nc2)c1 Chemical compound C[n]1ncc(-c2c(N)[nH]nc2)c1 VPJIDHLGGJAEOZ-UHFFFAOYSA-N 0.000 description 1
- CFRVIQGIHQAFCH-UHFFFAOYSA-N C[n]1ncc(-c2c3nc(C4CNCCC4)c(C(F)(F)F)c(N)[n]3nc2)c1 Chemical compound C[n]1ncc(-c2c3nc(C4CNCCC4)c(C(F)(F)F)c(N)[n]3nc2)c1 CFRVIQGIHQAFCH-UHFFFAOYSA-N 0.000 description 1
- XSORFODKYDJTGR-UHFFFAOYSA-N C[n]1ncc(-c2c3nc(C4CNCCC4)cc(N)[n]3nc2)c1 Chemical compound C[n]1ncc(-c2c3nc(C4CNCCC4)cc(N)[n]3nc2)c1 XSORFODKYDJTGR-UHFFFAOYSA-N 0.000 description 1
- JEODZOXXDIVJCS-GWCFXTLKSA-N C[n]1ncc(-c2c3nc([C@@H](CC4)CN[C@@H]4C(OC)=O)cc(N)[n]3nc2)c1 Chemical compound C[n]1ncc(-c2c3nc([C@@H](CC4)CN[C@@H]4C(OC)=O)cc(N)[n]3nc2)c1 JEODZOXXDIVJCS-GWCFXTLKSA-N 0.000 description 1
- COERXJUGIGLDSN-GXTWGEPZSA-N C[n]1ncc(-c2c3nc([C@@H](CCC4)C[C@@H]4NCCO)cc(N)[n]3nc2)c1 Chemical compound C[n]1ncc(-c2c3nc([C@@H](CCC4)C[C@@H]4NCCO)cc(N)[n]3nc2)c1 COERXJUGIGLDSN-GXTWGEPZSA-N 0.000 description 1
- PVNCDORSSRVOJP-UHFFFAOYSA-N Cc(c(CC(N1CCN(C)CC1)=O)c(N)[n]1nc2)nc1c2Br Chemical compound Cc(c(CC(N1CCN(C)CC1)=O)c(N)[n]1nc2)nc1c2Br PVNCDORSSRVOJP-UHFFFAOYSA-N 0.000 description 1
- FNRSJVQILSSLND-UHFFFAOYSA-N Cc(cc([n]1nc2)O)nc1c2-c1ccncc1 Chemical compound Cc(cc([n]1nc2)O)nc1c2-c1ccncc1 FNRSJVQILSSLND-UHFFFAOYSA-N 0.000 description 1
- PYJYJNWZBWPBDP-UHFFFAOYSA-N Cc1c[s]c(NC)c1 Chemical compound Cc1c[s]c(NC)c1 PYJYJNWZBWPBDP-UHFFFAOYSA-N 0.000 description 1
- MJRDYLXYCDPCQI-UHFFFAOYSA-N Clc(cccc1)c1-c(cc(Nc1ccccc1)[n]1nc2)nc1c2Br Chemical compound Clc(cccc1)c1-c(cc(Nc1ccccc1)[n]1nc2)nc1c2Br MJRDYLXYCDPCQI-UHFFFAOYSA-N 0.000 description 1
- PEWIHHKGXFKVTP-UHFFFAOYSA-N Nc([n]1nc2)c(-c3ccccc3)c(Cl)nc1c2Br Chemical compound Nc([n]1nc2)c(-c3ccccc3)c(Cl)nc1c2Br PEWIHHKGXFKVTP-UHFFFAOYSA-N 0.000 description 1
- VCSFKWDNZJFNPZ-SCDVKCJHSA-N Nc([n]1nc2)cc(C3CNCCC3)nc1c2-c1c[o]c(/C=N\O)c1 Chemical compound Nc([n]1nc2)cc(C3CNCCC3)nc1c2-c1c[o]c(/C=N\O)c1 VCSFKWDNZJFNPZ-SCDVKCJHSA-N 0.000 description 1
- NUKYPUAOHBNCPY-UHFFFAOYSA-N Nc1cc[n]cc1 Chemical compound Nc1cc[n]cc1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 description 1
- JVVRJMXHNUAPHW-UHFFFAOYSA-N Nc1ccn[nH]1 Chemical compound Nc1ccn[nH]1 JVVRJMXHNUAPHW-UHFFFAOYSA-N 0.000 description 1
- MDKZAJFENNTSET-UHFFFAOYSA-N Nc1n[nH]cc1-c1ccncc1 Chemical compound Nc1n[nH]cc1-c1ccncc1 MDKZAJFENNTSET-UHFFFAOYSA-N 0.000 description 1
- MCQOWYALZVKMAR-UHFFFAOYSA-N O=C(c1cccnc11)OC1=O Chemical compound O=C(c1cccnc11)OC1=O MCQOWYALZVKMAR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72415805P | 2005-10-06 | 2005-10-06 | |
| US60/724,158 | 2005-10-06 | ||
| PCT/US2006/038917 WO2007044441A2 (en) | 2005-10-06 | 2006-10-04 | Use of pyrazolo [1 , 5 -a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101360499A CN101360499A (zh) | 2009-02-04 |
| CN101360499B true CN101360499B (zh) | 2015-10-07 |
Family
ID=37943366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200680045935.5A Active CN101360499B (zh) | 2005-10-06 | 2006-10-04 | 吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20070082900A1 (enExample) |
| EP (1) | EP1942900B1 (enExample) |
| JP (3) | JP5152922B2 (enExample) |
| CN (1) | CN101360499B (enExample) |
| BR (1) | BRPI0616985B1 (enExample) |
| CA (1) | CA2627623C (enExample) |
| NO (1) | NO20082093L (enExample) |
| NZ (1) | NZ567151A (enExample) |
| TW (1) | TWI421078B (enExample) |
| WO (1) | WO2007044441A2 (enExample) |
| ZA (1) | ZA200802998B (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8580782B2 (en) * | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7563798B2 (en) * | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7605155B2 (en) * | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7196092B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| EP1945216A1 (en) * | 2005-11-10 | 2008-07-23 | Schering Corporation | Methods for inhibiting protein kinases |
| BRPI0708693A2 (pt) * | 2006-03-08 | 2011-06-14 | Novartis Ag | uso de derivados de pirazol[1,5,a]pirimidin-7-il amina no tratamento de distérbios neurolàgicos |
| AU2007268083A1 (en) * | 2006-05-22 | 2007-12-06 | Schering Corporation | Pyrazolo [1, 5-A] pyrimidines as CDK inhibitors |
| US20100143332A1 (en) * | 2006-11-17 | 2010-06-10 | Schering Corporation | Combination therapy for proliferative disorders |
| WO2008140724A1 (en) | 2007-05-08 | 2008-11-20 | Schering Corporation | Methods of treatment using intravenous formulations comprising temozolomide |
| WO2008153870A1 (en) * | 2007-06-07 | 2008-12-18 | Schering Corporation | Synthesis of substituted-3-aminopyrazoles |
| JP2011503084A (ja) * | 2007-11-07 | 2011-01-27 | シェーリング コーポレイション | 新規の細胞周期チェックポイント調節剤およびこれらの調節剤とチェックポイント阻害剤との併用 |
| CA2709202C (en) * | 2007-12-19 | 2013-04-23 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| WO2009089352A1 (en) | 2008-01-08 | 2009-07-16 | Array Biopharma Inc. | Pyrrolopyridines as kinase inhibitors |
| JP5608098B2 (ja) * | 2008-01-09 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピラゾロピリジン |
| WO2009126584A1 (en) * | 2008-04-07 | 2009-10-15 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
| ES2464461T3 (es) | 2008-09-22 | 2014-06-02 | Array Biopharma, Inc. | Compuestos de imidazo[1,2B]piridazina sustituidos como inhibidores de la TRK cinasa |
| SG196855A1 (en) * | 2008-10-22 | 2014-02-13 | Array Biopharma Inc | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| JP5769199B2 (ja) * | 2008-10-31 | 2015-08-26 | ジェネンテック, インコーポレイテッド | ピラゾロピリミジンjak阻害剤化合物と方法 |
| MA33032B1 (fr) * | 2009-02-13 | 2012-02-01 | Bayer Schering Pharma Ag | Pyrimidines condensees |
| EP2417138B1 (en) | 2009-04-09 | 2019-11-27 | Merck Sharp & Dohme Corp. | Pyrazolo[1, 5-a]pyrimidine derivatives as mtor inhibitors |
| AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
| EP2475652A1 (en) * | 2009-09-11 | 2012-07-18 | Cylene Pharmaceuticals, Inc. | Pharmaceutically useful heterocycle-substituted lactams |
| SG10201500048SA (en) | 2010-01-05 | 2015-03-30 | Vascular Biogenics Ltd | Compositions and methods for treating glioblastoma gbm |
| SG182367A1 (en) * | 2010-01-05 | 2012-08-30 | Vascular Biogenics Ltd | Methods for use of a specific anti-angiogenic adenoviral agent |
| WO2011090935A1 (en) * | 2010-01-19 | 2011-07-28 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
| AU2011256380C1 (en) | 2010-05-20 | 2016-09-08 | Array Biopharma Inc. | Macrocyclic compounds as Trk kinase inhibitors |
| KR20160035613A (ko) | 2011-03-23 | 2016-03-31 | 암젠 인크 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| AU2012284088B2 (en) | 2011-07-19 | 2015-10-08 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| US9345705B2 (en) | 2011-09-15 | 2016-05-24 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
| US9573954B2 (en) * | 2012-11-16 | 2017-02-21 | University Health Network | Pyrazolopyrimidine compounds |
| PL3808749T3 (pl) | 2012-12-07 | 2023-07-10 | Vertex Pharmaceuticals Incorporated | Pirazolo[1,5-a]pirymidyny użyteczne jako inhibitory kinazy atr do leczenia chorób nowotworowych |
| JP2016512239A (ja) | 2013-03-15 | 2016-04-25 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な化合物 |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| JP6095857B2 (ja) * | 2013-11-15 | 2017-03-15 | ユニバーシティ・ヘルス・ネットワーク | ピラゾロピリミジン化合物 |
| PL3077397T3 (pl) | 2013-12-06 | 2020-04-30 | Vertex Pharmaceuticals Inc. | Związek 2-amino-6-fluoro-n-[5-fluoro-pirydyn-3-ylo]pyrazolo [1,5-a]pirymidino-3-karboksamidu przydatny jako inhibitor kinazy atr, jego wytwarzanie, różne postacie stałe i ich radioznakowane pochodne |
| EP3087069B1 (en) | 2013-12-23 | 2019-01-30 | Norgine B.V. | Compounds useful as ccr9 modulators |
| GB201403093D0 (en) * | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| SG10201902206QA (en) | 2014-06-05 | 2019-04-29 | Vertex Pharma | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof |
| PT3157566T (pt) | 2014-06-17 | 2019-07-11 | Vertex Pharma | Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr |
| EP3699181B1 (en) | 2014-11-16 | 2023-03-01 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| RU2768621C1 (ru) | 2015-09-30 | 2022-03-24 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr |
| GB201517263D0 (en) * | 2015-09-30 | 2015-11-11 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
| US10724102B2 (en) | 2015-10-26 | 2020-07-28 | Loxo Oncology, Inc. | Point mutations in TRK inhibitor-resistant cancer and methods relating to the same |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| SG11201808559PA (en) | 2016-04-04 | 2018-10-30 | Loxo Oncology Inc | Liquid formulations of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
| FI3800189T3 (fi) | 2016-05-18 | 2023-07-31 | Loxo Oncology Inc | (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin valmistaminen |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| AR110252A1 (es) * | 2016-11-30 | 2019-03-13 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| MY205416A (en) * | 2017-07-28 | 2024-10-21 | Takeda Pharmaceuticals Co | Tyk2 inhibitors and uses thereof |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| CN113271940A (zh) * | 2018-10-15 | 2021-08-17 | 林伯士拉克许米公司 | Tyk2抑制剂和其用途 |
| SG11202104229WA (en) | 2018-10-30 | 2021-05-28 | Kronos Bio Inc | Compounds, compositions, and methods for modulating cdk9 activity |
| US20210395256A1 (en) * | 2018-12-07 | 2021-12-23 | Betta Pharmaceuticals Co., Ltd. | Tyrosine kinase inhibitors, compositions and methods there of |
| SG11202110523XA (en) | 2019-03-26 | 2021-10-28 | Ventyx Biosciences Inc | Tyk2 pseudokinase ligands |
| TWI882032B (zh) | 2019-11-08 | 2025-05-01 | 美商凡帝克斯生物科學公司 | Tyk2假激酶配位體 |
| JOP20220125A1 (ar) | 2019-11-25 | 2023-01-30 | Amgen Inc | مركبات حلقية غير متجانسة على هيئة مثبطات دلتا-5 ديساتوراز وطرق لاستخدامها |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005070431A1 (en) * | 2004-01-22 | 2005-08-04 | Novartis Ag | Pyrazolo[1,5-a]pyrimidin-7-yl-amine derivatives for use in the treatment of protein kinase dependent diseases |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0438730Y2 (enExample) * | 1986-03-26 | 1992-09-10 | ||
| JP3039751U (ja) * | 1996-12-09 | 1997-07-31 | 尚子 小園 | 鞄類用補助具 |
| JP2002295682A (ja) * | 2001-03-28 | 2002-10-09 | Yazaki Corp | 防水構造およびこの防水構造に用いられる座金部材 |
| EP1511751B1 (en) * | 2002-06-04 | 2008-03-19 | Neogenesis Pharmaceuticals, Inc. | Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents |
| US7078525B2 (en) * | 2002-09-04 | 2006-07-18 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7196092B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7605155B2 (en) * | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| CA2497440C (en) * | 2002-09-04 | 2011-03-22 | Schering Corporation | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
| US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| BRPI0407834A (pt) * | 2003-02-28 | 2006-02-14 | Teijin Pharma Ltd | composto, processo para a manufatura do mesmo, composição, processo para a manufatura da mesma, método de tratamento ou prevenção de um distúrbio mediado por proteìna quinase em um indivìduo, uso de um composto, ensaio para determinar a atividade dos compostos, e, método de inibição da atividade ou função de uma proteìna quinase |
| WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JP3940700B2 (ja) * | 2003-05-22 | 2007-07-04 | 茂 相馬 | 楽器用ケース |
| JP3104094U (ja) * | 2004-03-18 | 2004-09-02 | チャン ホアン−リン | 両用スーツケース |
| TWI333953B (en) * | 2005-10-06 | 2010-12-01 | Schering Corp | Pyrazolopyrimidines as protein kinase inhibitors |
| US7776865B2 (en) * | 2005-10-06 | 2010-08-17 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| JP3174645U (ja) * | 2012-01-19 | 2012-03-29 | 株式会社セイバン | ランドセル |
-
2006
- 2006-10-04 BR BRPI0616985-6A patent/BRPI0616985B1/pt active IP Right Grant
- 2006-10-04 NZ NZ567151A patent/NZ567151A/en not_active IP Right Cessation
- 2006-10-04 CN CN200680045935.5A patent/CN101360499B/zh active Active
- 2006-10-04 WO PCT/US2006/038917 patent/WO2007044441A2/en not_active Ceased
- 2006-10-04 CA CA2627623A patent/CA2627623C/en active Active
- 2006-10-04 EP EP06836185.6A patent/EP1942900B1/en active Active
- 2006-10-04 TW TW095136818A patent/TWI421078B/zh not_active IP Right Cessation
- 2006-10-04 US US11/542,801 patent/US20070082900A1/en not_active Abandoned
- 2006-10-04 JP JP2008534673A patent/JP5152922B2/ja active Active
-
2008
- 2008-04-04 ZA ZA200802998A patent/ZA200802998B/xx unknown
- 2008-05-05 NO NO20082093A patent/NO20082093L/no not_active Application Discontinuation
-
2010
- 2010-01-15 US US12/688,664 patent/US8211854B2/en active Active
-
2012
- 2012-01-27 JP JP2012015831A patent/JP5520325B2/ja active Active
-
2014
- 2014-01-09 JP JP2014002164A patent/JP2014062129A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005070431A1 (en) * | 2004-01-22 | 2005-08-04 | Novartis Ag | Pyrazolo[1,5-a]pyrimidin-7-yl-amine derivatives for use in the treatment of protein kinase dependent diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5520325B2 (ja) | 2014-06-11 |
| EP1942900A2 (en) | 2008-07-16 |
| NO20082093L (no) | 2008-07-03 |
| TW200800218A (en) | 2008-01-01 |
| CN101360499A (zh) | 2009-02-04 |
| JP2012082234A (ja) | 2012-04-26 |
| JP5152922B2 (ja) | 2013-02-27 |
| WO2007044441A2 (en) | 2007-04-19 |
| ZA200802998B (en) | 2009-10-28 |
| JP2009511486A (ja) | 2009-03-19 |
| BRPI0616985B1 (pt) | 2021-10-26 |
| CA2627623C (en) | 2014-04-22 |
| JP2014062129A (ja) | 2014-04-10 |
| CA2627623A1 (en) | 2007-04-19 |
| US8211854B2 (en) | 2012-07-03 |
| TWI421078B (zh) | 2014-01-01 |
| US20100125068A1 (en) | 2010-05-20 |
| EP1942900B1 (en) | 2015-06-03 |
| NZ567151A (en) | 2012-03-30 |
| BRPI0616985A2 (pt) | 2009-08-04 |
| US20070082900A1 (en) | 2007-04-12 |
| WO2007044441A3 (en) | 2007-07-26 |
| AU2006302435A1 (en) | 2007-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101360499B (zh) | 吡唑并[1,5-a]嘧啶衍生物在制备抑制蛋白激酶的药物中的用途 | |
| CN101801958B (zh) | 作为蛋白质激酶抑制剂的杂环酰胺化合物 | |
| CN101573363B (zh) | 作为细胞周期蛋白依赖性激酶抑制剂的新颖的吡唑并嘧啶 | |
| KR101661405B1 (ko) | 사이클린 의존성 키나제 억제제로서의 신규 피라졸로피리미딘 유도체 | |
| JP5031760B2 (ja) | プロテインキナーゼインヒビターとしてのイミダゾピラジン | |
| US20070105864A1 (en) | Methods for inhibiting protein kinases | |
| CN101772500A (zh) | 作为蛋白质激酶抑制剂的咪唑并吡嗪 | |
| CN101316847A (zh) | 用作蛋白激酶抑制剂的吡唑并(1,5a)嘧啶化合物 | |
| CN101321760A (zh) | 作为蛋白激酶抑制剂的吡唑并嘧啶 | |
| CN101516883A (zh) | 作为蛋白激酶抑制剂的咪唑并吡嗪化合物 | |
| CN101589045A (zh) | 作为蛋白质激酶抑制剂的咪唑并吡嗪 | |
| CN101321759A (zh) | 作为蛋白激酶抑制剂的吡唑并嘧啶化合物 | |
| CN101331135A (zh) | 作为细胞周期蛋白依赖激酶抑制剂的新型咪唑并吡嗪 | |
| AU2006302435B2 (en) | Use of pyrazolo [1 , 5 -a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases | |
| MX2008004668A (en) | Use of pyrazolo [1 , 5 -a]pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: New jersey, USA Applicant after: MERCK SHARP & DOHME Corp. Address before: New jersey, USA Applicant before: SCHERING Corp. |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: SCHERING CORP (US) TO: MSD CORP. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220825 Address after: new jersey Patentee after: MERCK SHARP & DOHME B.V. Address before: new jersey Patentee before: MERCK SHARP & DOHME Corp. |