BRPI0616985B1 - Composto de pirazolo[1,5-a]pirimidina, e, uso de um composto - Google Patents
Composto de pirazolo[1,5-a]pirimidina, e, uso de um composto Download PDFInfo
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- BRPI0616985B1 BRPI0616985B1 BRPI0616985-6A BRPI0616985A BRPI0616985B1 BR PI0616985 B1 BRPI0616985 B1 BR PI0616985B1 BR PI0616985 A BRPI0616985 A BR PI0616985A BR PI0616985 B1 BRPI0616985 B1 BR PI0616985B1
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- compound
- alkyl
- nr5r6
- aryl
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 469
- -1 PYRIMIDINE COMPOUND Chemical class 0.000 title claims description 136
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- 230000002401 inhibitory effect Effects 0.000 claims abstract description 20
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- 125000000217 alkyl group Chemical group 0.000 claims description 261
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 175
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| US72415805P | 2005-10-06 | 2005-10-06 | |
| US60/724,158 | 2005-10-06 | ||
| PCT/US2006/038917 WO2007044441A2 (en) | 2005-10-06 | 2006-10-04 | Use of pyrazolo [1 , 5 -a] pyrimidine derivatives for inhibiting protein kinases methods for inhibiting protein kinases |
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| WO (1) | WO2007044441A2 (enExample) |
| ZA (1) | ZA200802998B (enExample) |
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| US7196092B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
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| US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7605155B2 (en) * | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7563798B2 (en) * | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| TW200803863A (en) * | 2005-11-10 | 2008-01-16 | Schering Corp | Method for inhibiting protein kinases |
| US20090069315A1 (en) * | 2006-03-08 | 2009-03-12 | Rajeev Sivasankaran | Use of Pyrazolo(1,5A)Pyrimidin-7-YL Amine Derivatives in the Treatment of Neurological Disorders |
| JP2009538304A (ja) * | 2006-05-22 | 2009-11-05 | シェーリング コーポレイション | ＣＤＫ阻害剤としてのピラゾロ［１，５−ａ］ピリミジン |
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| JP5608097B2 (ja) | 2008-01-08 | 2014-10-15 | アレイ バイオファーマ、インコーポレイテッド | キナーゼ阻害薬としてのピロロピリジン |
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| AU2011204405B2 (en) * | 2010-01-05 | 2015-06-18 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
| EP2525659B1 (en) * | 2010-01-19 | 2019-02-27 | Merck Sharp & Dohme Corp. | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS |
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| ES2620521T3 (es) | 2011-03-23 | 2017-06-28 | Amgen Inc. | Inhibidores duales tricíclicos condensados de CDK 4/6 y FLT3 |
| EP2723746A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
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| AU2013344716B2 (en) * | 2012-11-16 | 2018-03-01 | University Health Network | Pyrazolopyrimidine compounds |
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| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
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| JP6095857B2 (ja) * | 2013-11-15 | 2017-03-15 | ユニバーシティ・ヘルス・ネットワーク | ピラゾロピリミジン化合物 |
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| WO2015097121A1 (en) | 2013-12-23 | 2015-07-02 | Norgine B.V. | Compounds useful as ccr9 modulators |
| GB201403093D0 (en) * | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| AU2015271030B2 (en) | 2014-06-05 | 2019-05-16 | Vertex Pharmaceuticals Incorporated | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo [1,5-a] pyrimidin-3-carboxamide compound useful as ATR kinase inhibitor, the preparation of said compound and different solid forms thereof |
| LT3157566T (lt) | 2014-06-17 | 2019-08-12 | Vertex Pharmaceuticals Incorporated | Vėžio gydymo būdas, panaudojant chk1 ir atr inhibitorių derinį |
| CA2967951C (en) | 2014-11-16 | 2023-11-07 | Array Biopharma, Inc. | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
| TW201702218A (zh) | 2014-12-12 | 2017-01-16 | 美國杰克森實驗室 | 關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法 |
| WO2017059357A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
| GB201517263D0 (en) * | 2015-09-30 | 2015-11-11 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| PT3439662T (pt) | 2016-04-04 | 2024-09-30 | Loxo Oncology Inc | Formulações líquidas de (s)-n-(5-((r)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| PT3458456T (pt) | 2016-05-18 | 2020-12-07 | Array Biopharma Inc | Preparação de (s)-n-(5-((r)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidino-1-carboxamida |
| JOP20190092A1 (ar) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها |
| AR110252A1 (es) * | 2016-11-30 | 2019-03-13 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como inhibidores de la quinasa cam |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| DK3658557T3 (da) | 2017-07-28 | 2024-07-29 | Takeda Pharmaceuticals Co | Tyk2-inhibitorer og anvendelser deraf |
| EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
| JP7619951B2 (ja) * | 2018-10-15 | 2025-01-22 | 武田薬品工業株式会社 | Ｔｙｋ２阻害剤およびその使用 |
| CR20210202A (es) | 2018-10-30 | 2022-02-08 | Kronos Bio Inc | Compuestos, composiciones y métodos para modular la actividad cdk9 |
| BR112021010930A2 (pt) * | 2018-12-07 | 2021-08-24 | Betta Pharmaceuticals Co., Ltd | Inibidores da tirosina quinase, composições e seus procedimentos |
| EA202192625A1 (ru) | 2019-03-26 | 2022-03-21 | Вентикс Байосайенсес, Инк. | Лиганды псевдокиназы tyk2 |
| MX2022005563A (es) * | 2019-11-08 | 2022-08-19 | Ventyx Biosciences Inc | Ligandos de la pseudoquinasa tyk2. |
| JP7254246B2 (ja) | 2019-11-25 | 2023-04-07 | アムジエン・インコーポレーテツド | デルタ－５デサチュラーゼ阻害剤としての複素環式化合物及び使用方法 |
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| JPH0438730Y2 (enExample) * | 1986-03-26 | 1992-09-10 | ||
| JP3039751U (ja) * | 1996-12-09 | 1997-07-31 | 尚子 小園 | 鞄類用補助具 |
| JP2002295682A (ja) * | 2001-03-28 | 2002-10-09 | Yazaki Corp | 防水構造およびこの防水構造に用いられる座金部材 |
| ATE389656T1 (de) * | 2002-06-04 | 2008-04-15 | Neogenesis Pharmaceuticals Inc | Pyrazolo(1,5-a)pyrimidin-verbindungen als antivirale agentien |
| CA2497440C (en) * | 2002-09-04 | 2011-03-22 | Schering Corporation | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
| ATE364608T1 (de) * | 2002-09-04 | 2007-07-15 | Schering Corp | Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen |
| US7196092B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7605155B2 (en) * | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| KR20050115252A (ko) * | 2003-02-28 | 2005-12-07 | 데이진 화-마 가부시키가이샤 | 피라졸로[1,5-ａ]피리미딘 유도체 |
| EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JP3940700B2 (ja) * | 2003-05-22 | 2007-07-04 | 茂 相馬 | 楽器用ケース |
| PE20051089A1 (es) * | 2004-01-22 | 2006-01-25 | Novartis Ag | Derivados de pirazolo [1,5-a] pirimidin-7-il-amina como inhibidores de quinasa de proteina |
| JP3104094U (ja) * | 2004-03-18 | 2004-09-02 | チャン ホアン−リン | 両用スーツケース |
| CN101321759A (zh) * | 2005-10-06 | 2008-12-10 | 先灵公司 | 作为蛋白激酶抑制剂的吡唑并嘧啶化合物 |
| RU2008117298A (ru) * | 2005-10-06 | 2009-11-20 | Шеринг Корпорейшн (US) | Пиразолопиримидины как ингибиторы протеинкиназ |
| JP3174645U (ja) * | 2012-01-19 | 2012-03-29 | 株式会社セイバン | ランドセル |
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- 2006-10-04 EP EP06836185.6A patent/EP1942900B1/en active Active
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| TW200800218A (en) | 2008-01-01 |
| CA2627623C (en) | 2014-04-22 |
| JP5520325B2 (ja) | 2014-06-11 |
| CN101360499A (zh) | 2009-02-04 |
| NZ567151A (en) | 2012-03-30 |
| CA2627623A1 (en) | 2007-04-19 |
| WO2007044441A2 (en) | 2007-04-19 |
| TWI421078B (zh) | 2014-01-01 |
| EP1942900A2 (en) | 2008-07-16 |
| JP2014062129A (ja) | 2014-04-10 |
| US20070082900A1 (en) | 2007-04-12 |
| JP2009511486A (ja) | 2009-03-19 |
| US20100125068A1 (en) | 2010-05-20 |
| BRPI0616985A2 (pt) | 2009-08-04 |
| EP1942900B1 (en) | 2015-06-03 |
| JP5152922B2 (ja) | 2013-02-27 |
| ZA200802998B (en) | 2009-10-28 |
| US8211854B2 (en) | 2012-07-03 |
| NO20082093L (no) | 2008-07-03 |
| WO2007044441A3 (en) | 2007-07-26 |
| JP2012082234A (ja) | 2012-04-26 |
| CN101360499B (zh) | 2015-10-07 |
| AU2006302435A1 (en) | 2007-04-19 |
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