CN101346395A - 阻止复合有IL-6Rα的IL-6与GP130结合的抗IL-6抗体 - Google Patents

阻止复合有IL-6Rα的IL-6与GP130结合的抗IL-6抗体 Download PDF

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CN101346395A
CN101346395A CNA2006800491952A CN200680049195A CN101346395A CN 101346395 A CN101346395 A CN 101346395A CN A2006800491952 A CNA2006800491952 A CN A2006800491952A CN 200680049195 A CN200680049195 A CN 200680049195A CN 101346395 A CN101346395 A CN 101346395A
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seq
antibody
aminoacid sequence
light chain
heavy chain
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J·C·韦
S·D·吉利斯
劳健明
刘媛
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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CNA2006800491952A 2005-12-30 2006-12-19 阻止复合有IL-6Rα的IL-6与GP130结合的抗IL-6抗体 Pending CN101346395A (zh)

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US75538305P 2005-12-30 2005-12-30
US60/755,383 2005-12-30

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US (2) US7820155B2 (enExample)
EP (1) EP1966244B1 (enExample)
JP (1) JP2009521909A (enExample)
KR (1) KR20080090484A (enExample)
CN (1) CN101346395A (enExample)
AT (1) ATE550353T1 (enExample)
AU (1) AU2006332216A1 (enExample)
BR (1) BRPI0620797A2 (enExample)
CA (1) CA2635615A1 (enExample)
DK (1) DK1966244T3 (enExample)
EA (1) EA200870130A1 (enExample)
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CN103897061A (zh) * 2014-03-25 2014-07-02 宝船生物医药科技(上海)有限公司 阻断西妥昔单抗和egfr结合的抗体、其试剂盒及杂交瘤细胞
CN104903349A (zh) * 2012-11-08 2015-09-09 十一生物治疗股份有限公司 Il-6拮抗剂及其应用
CN107223132A (zh) * 2014-12-01 2017-09-29 辉凌有限公司 选择性il‑6‑跨信号转导抑制剂的给予
CN107249631A (zh) * 2014-11-07 2017-10-13 十生物治疗股份有限公司 改进的il‑6抗体
CN107406491A (zh) * 2014-12-01 2017-11-28 辉凌有限公司 选择性il‑6‑跨信号转导抑制剂组合物
US12048746B2 (en) 2016-02-23 2024-07-30 Hoffmann-La Roche Inc. IL-6 antagonist formulations and uses thereof

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US20070178098A1 (en) 2007-08-02
BRPI0620797A2 (pt) 2011-11-22
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AU2006332216A1 (en) 2007-07-12
EA200870130A1 (ru) 2009-02-27

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