CN101341149B - 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 - Google Patents
经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 Download PDFInfo
- Publication number
- CN101341149B CN101341149B CN2006800479255A CN200680047925A CN101341149B CN 101341149 B CN101341149 B CN 101341149B CN 2006800479255 A CN2006800479255 A CN 2006800479255A CN 200680047925 A CN200680047925 A CN 200680047925A CN 101341149 B CN101341149 B CN 101341149B
- Authority
- CN
- China
- Prior art keywords
- reaction
- group
- alkyl
- compound
- oxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *C(Nc(c(*C=C)cc(*)c1)c1[N+]([O-])=O)=O Chemical compound *C(Nc(c(*C=C)cc(*)c1)c1[N+]([O-])=O)=O 0.000 description 3
- RWQPFJHWOMLAEN-UHFFFAOYSA-N Cc1nc(c(OC2c(c(F)cc(F)c3)c3OCC2)cc(C(N(C)CCN(C)C)=O)c2)c2[nH]1 Chemical compound Cc1nc(c(OC2c(c(F)cc(F)c3)c3OCC2)cc(C(N(C)CCN(C)C)=O)c2)c2[nH]1 RWQPFJHWOMLAEN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75218105P | 2005-12-19 | 2005-12-19 | |
| US60/752,181 | 2005-12-19 | ||
| US80294406P | 2006-05-23 | 2006-05-23 | |
| US60/802,944 | 2006-05-23 | ||
| PCT/IB2006/003605 WO2007072146A1 (en) | 2005-12-19 | 2006-12-06 | Chromane substituted benzimidazoles and their use as acid pump inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101399640A Division CN102321077A (zh) | 2005-12-19 | 2006-12-06 | 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101341149A CN101341149A (zh) | 2009-01-07 |
| CN101341149B true CN101341149B (zh) | 2011-06-08 |
Family
ID=37912450
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101399640A Pending CN102321077A (zh) | 2005-12-19 | 2006-12-06 | 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 |
| CN2006800479255A Active CN101341149B (zh) | 2005-12-19 | 2006-12-06 | 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101399640A Pending CN102321077A (zh) | 2005-12-19 | 2006-12-06 | 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7723321B2 (enExample) |
| EP (1) | EP1963311B1 (enExample) |
| JP (1) | JP4481344B2 (enExample) |
| KR (1) | KR101088247B1 (enExample) |
| CN (2) | CN102321077A (enExample) |
| AR (1) | AR058120A1 (enExample) |
| AT (1) | ATE471319T1 (enExample) |
| BR (2) | BRPI0620081B8 (enExample) |
| CA (1) | CA2631880C (enExample) |
| DE (1) | DE602006014996D1 (enExample) |
| DO (1) | DOP2006000285A (enExample) |
| ES (1) | ES2345726T3 (enExample) |
| GT (1) | GT200600514A (enExample) |
| NL (1) | NL2000371C2 (enExample) |
| PE (1) | PE20071182A1 (enExample) |
| TW (1) | TW200732326A (enExample) |
| UY (1) | UY30043A1 (enExample) |
| WO (1) | WO2007072146A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109769392A (zh) * | 2016-09-21 | 2019-05-17 | Cj医药健康株式会社 | 苯并咪唑衍生物的酸加成盐 |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009000413A1 (en) * | 2007-06-26 | 2008-12-31 | Sanofi-Aventis | A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles |
| JP5802898B2 (ja) * | 2009-07-09 | 2015-11-04 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
| KR101472686B1 (ko) | 2013-07-09 | 2014-12-16 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| KR102084185B1 (ko) | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| RU2693484C1 (ru) | 2013-11-22 | 2019-07-03 | СиЭль БАЙОСАЕНСИЗ ЭлЭлСи | Антагонисты гастрина для лечения и профилактики остеопороза |
| CN105440016B (zh) * | 2014-08-11 | 2018-08-31 | 江苏柯菲平医药股份有限公司 | 吲哚、氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
| KR101684053B1 (ko) * | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| KR101613245B1 (ko) | 2015-04-27 | 2016-04-18 | 주식회사 대웅제약 | 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물 |
| SI3305291T1 (sl) * | 2015-06-08 | 2021-08-31 | Hk Inno.N Corporation | Uporabe benzimidazolnega derivata za nočno izločanje kisline |
| KR101769204B1 (ko) * | 2015-08-04 | 2017-08-17 | 씨제이헬스케어 주식회사 | 크로마놀 유도체의 신규한 제조방법 |
| KR101777971B1 (ko) | 2016-07-05 | 2017-09-12 | 제일약품주식회사 | 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도 |
| KR101829685B1 (ko) * | 2016-07-28 | 2018-02-19 | 씨제이헬스케어 주식회사 | 안정성 및 용해도가 개선된 주사용 조성물 |
| KR101829705B1 (ko) * | 2016-09-21 | 2018-02-19 | 씨제이헬스케어 주식회사 | 안정성이 향상된 주사용 조성물 |
| US11142591B2 (en) * | 2016-12-20 | 2021-10-12 | Exxonmobil Chemical Patents Inc. | Polymerization process |
| KR101960357B1 (ko) | 2016-12-26 | 2019-03-20 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체를 포함하는 신규한 제제 |
| KR102233456B1 (ko) * | 2017-05-31 | 2021-03-29 | 주식회사 대웅제약 | 4-메톡시피롤 유도체의 중간체 제조 방법 |
| KR102262743B1 (ko) * | 2017-07-07 | 2021-06-09 | 에이치케이이노엔 주식회사 | 주사용 조성물 |
| KR20190057569A (ko) | 2017-11-20 | 2019-05-29 | 제일약품주식회사 | 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도 |
| TWI676477B (zh) * | 2017-12-05 | 2019-11-11 | 南韓商Ｃｊ醫藥健康股份有限公司 | 苯并咪唑衍生物用於夜間酸突破的用途 |
| JOP20190198A1 (ar) * | 2018-08-28 | 2020-02-28 | Hk Inno N Corp | تركيبة صيدلانية تشتمل على عامل مضاد للصفيحات ومثبط إفراز حمض معدي |
| JOP20190201A1 (ar) * | 2018-08-29 | 2020-02-29 | Hk Inno N Corp | تركيبة لاستئصال الملوية البوابية |
| CN109320485B (zh) * | 2018-12-02 | 2021-06-18 | 江苏慧聚药业有限公司 | 合成特戈拉赞手性醇的方法 |
| JP2022520276A (ja) | 2019-02-18 | 2022-03-29 | エイチケー イノ．エヌ コーポレーション | ベンズイミダゾール誘導体化合物を含む医薬組成物 |
| CN112851646B (zh) * | 2019-11-12 | 2023-06-13 | 中国医学科学院药物研究所 | 特戈拉赞的制备方法 |
| UY39094A (es) * | 2020-02-27 | 2021-07-30 | Hk Inno N Corp | Composición farmacéutica que comprende compuesto derivado de bencimidazol |
| CN111303131B (zh) * | 2020-03-19 | 2021-06-04 | 江苏慧聚药业有限公司 | 特戈拉赞(Tegoprazan)类似物及其合成方法 |
| AU2021256161A1 (en) * | 2020-04-13 | 2022-12-15 | Hk Inno.N Corporation | Pharmaceutical composition comprising benzimidazole derivative compound |
| CN114249694B (zh) * | 2020-09-22 | 2025-06-17 | 浙江四维医药科技有限公司 | 一种特格拉赞中间体的制备方法 |
| CN116507318A (zh) * | 2020-10-23 | 2023-07-28 | 怡诺安有限公司 | 包含苯并咪唑衍生物化合物的口服崩解片剂及其制备方法 |
| CN112358450A (zh) * | 2020-11-19 | 2021-02-12 | 南京艾康生物科技有限公司 | 一种4-(苄氧基)-2-甲基-1H-苯并[d]咪唑-6-羧酸的合成方法 |
| KR20220141700A (ko) | 2021-04-13 | 2022-10-20 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체 화합물을 포함하는 약학적 조성물 |
| CN113527272B (zh) * | 2021-08-06 | 2023-07-21 | 西安淳甄新材料有限公司 | 一种特戈拉赞的合成方法 |
| CN118355013A (zh) * | 2021-12-08 | 2024-07-16 | 制药基因科学株式会社 | 苯并咪唑衍生物化合物及其用途 |
| KR102708701B1 (ko) * | 2021-12-27 | 2024-09-24 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| CN114805317A (zh) * | 2022-05-20 | 2022-07-29 | 江苏威奇达药业有限公司 | 一种特戈拉赞的制备方法 |
| US12060148B2 (en) | 2022-08-16 | 2024-08-13 | Honeywell International Inc. | Ground resonance detection and warning system and method |
| KR20240028127A (ko) | 2022-08-24 | 2024-03-05 | 위더스제약주식회사 | 테고프라잔 고체분산체 조성물 |
| WO2024045255A1 (zh) * | 2022-08-30 | 2024-03-07 | 上海皓元医药股份有限公司 | 一种特戈拉赞晶型b及其制备方法 |
| WO2024087155A1 (zh) * | 2022-10-28 | 2024-05-02 | 深圳市华先医药科技有限公司 | 一种合成4-羟基-n,n,2-三甲基苯并咪唑-6-甲酰胺的方法 |
| WO2024087156A1 (zh) * | 2022-10-28 | 2024-05-02 | 深圳市华先医药科技有限公司 | 4-羟基-n,n,2-三甲基苯并咪唑-6-甲酰胺的可放大生产方法 |
| CN116253685B (zh) * | 2022-12-30 | 2024-12-10 | 成都安满生物医药科技有限公司 | 一种特戈拉赞中间体的制备方法 |
| KR20240109898A (ko) | 2023-01-05 | 2024-07-12 | 위더스제약주식회사 | 무정형 테고프라잔 고체분산체 |
| KR20240118377A (ko) | 2023-01-27 | 2024-08-05 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
| KR102638900B1 (ko) | 2023-01-27 | 2024-02-21 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
| WO2024171128A1 (en) * | 2023-02-18 | 2024-08-22 | Lee Pharma Limited | Stable amorphous form of potassium-competitive acid blocker and process for the preparation thereof |
| KR20240131641A (ko) | 2023-02-24 | 2024-09-02 | 엠에프씨 주식회사 | 신규 테고프라잔의 염 결정형 및 이의 용매화물 결정형, 및 이들의 제조방법 |
| KR102715562B1 (ko) * | 2023-03-16 | 2024-10-11 | (주) 에프엔지리서치 | 테고프라잔의 신규 염 및 이의 제조 방법 |
| CN118724858B (zh) * | 2023-03-31 | 2025-09-19 | 上海医药工业研究院有限公司 | 一种(r)-苯并吡喃-4-醇类化合物的制备方法 |
| KR20250164238A (ko) * | 2023-04-07 | 2025-11-24 | 제이더블유중외제약 주식회사 | 벤즈이미다졸 유도체의 염 |
| CN116621821A (zh) * | 2023-05-29 | 2023-08-22 | 宙晟智维生命科学(上海)有限公司 | 一种无定形的苯并咪唑基化合物及固体分散体 |
| KR20240171624A (ko) | 2023-05-31 | 2024-12-09 | 권대길 | 치환된 벤즈이미다졸의 결정형 및 이의 제조방법 |
| CN116715660A (zh) * | 2023-06-14 | 2023-09-08 | 上海柏狮生物科技有限公司 | 一种特格拉赞的无定型物及其制备方法 |
| CN117024417A (zh) * | 2023-06-27 | 2023-11-10 | 上海柏狮生物科技有限公司 | 一种特格拉赞的制备方法 |
| CN116789654A (zh) * | 2023-07-10 | 2023-09-22 | 杭州小蓓医药科技有限公司 | 一种特戈拉赞的制备方法 |
| WO2025037242A1 (en) * | 2023-08-14 | 2025-02-20 | Ami Lifesciences Private Limited | Solid forms of tegoprazan and process thereof |
| KR102689851B1 (ko) | 2023-09-26 | 2024-07-30 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
| TW202535866A (zh) * | 2023-11-01 | 2025-09-16 | 日商拉夸里亞創藥股份有限公司 | 苯并咪唑化合物的製造製程 |
| KR20250066641A (ko) | 2023-11-07 | 2025-05-14 | 엠에프씨 주식회사 | 테고프라잔 말리에이트염 1수화물 결정형 및 이의 제조방법 |
| CN117903097A (zh) * | 2024-01-04 | 2024-04-19 | 浙江永太科技股份有限公司 | 一种特戈拉赞关键中间体母液料的回收方法 |
| KR20250118583A (ko) | 2024-01-30 | 2025-08-06 | 진양제약주식회사 | 테고프라잔을 포함하는 제약 조성물 |
| KR102825970B1 (ko) | 2024-02-16 | 2025-06-26 | 스마트바이오팜 주식회사 | 테고프라잔 중간체를 제조하는 방법 및 이에 사용되는 신규 중간체 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004054984A1 (en) * | 2002-12-13 | 2004-07-01 | Altana Pharma Ag | 4-substituted benzimidazoles and their use as inhibitors of gastric secretion |
| WO2005111000A1 (en) * | 2004-05-18 | 2005-11-24 | Altana Pharma Ag | 7-substituted benzimidazoles and their use as inhibitors of gastric acid secretion |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| US5444775A (en) | 1993-11-09 | 1995-08-22 | Tobish; John J. | Telephone key selection aid |
| SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| GB9914022D0 (en) | 1999-06-17 | 1999-08-18 | Zeneca Ltd | Chemical compounds |
| EP1893197B1 (en) * | 2005-06-14 | 2009-09-09 | RaQualia Pharma Inc | Chromane substituted benzimidazole derivatives as acid pump antagonists |
-
2006
- 2006-12-06 BR BRPI0620081A patent/BRPI0620081B8/pt active IP Right Grant
- 2006-12-06 KR KR1020087017466A patent/KR101088247B1/ko active Active
- 2006-12-06 EP EP06831708A patent/EP1963311B1/en active Active
- 2006-12-06 CN CN2011101399640A patent/CN102321077A/zh active Pending
- 2006-12-06 CA CA2631880A patent/CA2631880C/en active Active
- 2006-12-06 AT AT06831708T patent/ATE471319T1/de not_active IP Right Cessation
- 2006-12-06 DE DE602006014996T patent/DE602006014996D1/de active Active
- 2006-12-06 ES ES06831708T patent/ES2345726T3/es active Active
- 2006-12-06 CN CN2006800479255A patent/CN101341149B/zh active Active
- 2006-12-06 BR BR122020004679-1A patent/BR122020004679B1/pt not_active IP Right Cessation
- 2006-12-06 JP JP2008546663A patent/JP4481344B2/ja active Active
- 2006-12-06 WO PCT/IB2006/003605 patent/WO2007072146A1/en not_active Ceased
- 2006-12-13 NL NL2000371A patent/NL2000371C2/nl not_active IP Right Cessation
- 2006-12-18 GT GT200600514A patent/GT200600514A/es unknown
- 2006-12-18 PE PE2006001625A patent/PE20071182A1/es not_active Application Discontinuation
- 2006-12-18 TW TW095147456A patent/TW200732326A/zh unknown
- 2006-12-18 DO DO2006000285A patent/DOP2006000285A/es unknown
- 2006-12-19 US US11/612,583 patent/US7723321B2/en active Active
- 2006-12-19 UY UY30043A patent/UY30043A1/es not_active Application Discontinuation
- 2006-12-19 AR ARP060105611A patent/AR058120A1/es unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004054984A1 (en) * | 2002-12-13 | 2004-07-01 | Altana Pharma Ag | 4-substituted benzimidazoles and their use as inhibitors of gastric secretion |
| WO2005111000A1 (en) * | 2004-05-18 | 2005-11-24 | Altana Pharma Ag | 7-substituted benzimidazoles and their use as inhibitors of gastric acid secretion |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109769392A (zh) * | 2016-09-21 | 2019-05-17 | Cj医药健康株式会社 | 苯并咪唑衍生物的酸加成盐 |
| CN109769392B (zh) * | 2016-09-21 | 2022-06-24 | 怡诺安有限公司 | 苯并咪唑衍生物的酸加成盐 |
| US11535610B2 (en) | 2016-09-21 | 2022-12-27 | Hk Inno.N Corporation | Acid addition salts of benzimidazole derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101088247B1 (ko) | 2011-11-30 |
| WO2007072146A1 (en) | 2007-06-28 |
| US20070142448A1 (en) | 2007-06-21 |
| US7723321B2 (en) | 2010-05-25 |
| ES2345726T3 (es) | 2010-09-30 |
| BRPI0620081B1 (pt) | 2020-10-20 |
| DOP2006000285A (es) | 2007-07-31 |
| UY30043A1 (es) | 2007-07-31 |
| NL2000371C2 (nl) | 2007-09-06 |
| TW200732326A (en) | 2007-09-01 |
| PE20071182A1 (es) | 2008-02-07 |
| BRPI0620081B8 (pt) | 2021-05-25 |
| JP4481344B2 (ja) | 2010-06-16 |
| NL2000371A1 (nl) | 2007-06-20 |
| AR058120A1 (es) | 2008-01-23 |
| BRPI0620081A2 (pt) | 2011-11-01 |
| CN101341149A (zh) | 2009-01-07 |
| CA2631880A1 (en) | 2007-06-28 |
| DE602006014996D1 (de) | 2010-07-29 |
| CA2631880C (en) | 2011-03-29 |
| CN102321077A (zh) | 2012-01-18 |
| ATE471319T1 (de) | 2010-07-15 |
| JP2009520017A (ja) | 2009-05-21 |
| EP1963311B1 (en) | 2010-06-16 |
| EP1963311A1 (en) | 2008-09-03 |
| HK1125368A1 (en) | 2009-08-07 |
| BR122020004679B1 (pt) | 2021-09-21 |
| GT200600514A (es) | 2007-07-17 |
| KR20080080195A (ko) | 2008-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101341149B (zh) | 经色原烷取代的苯并咪唑类和它们作为酸泵抑制剂的用途 | |
| TWI469979B (zh) | 脂肪酸醯胺水解酶(faah)抑制劑、以及其藥學組成物與用途 | |
| CN101193869B (zh) | 糖皮质激素模拟物、其制备方法、药物组合物及其用途 | |
| AU2005244736B2 (en) | Raf modulators and methods of use | |
| AU2009247262B2 (en) | Amide compound | |
| CN101918376B (zh) | 用作硬脂酰-辅酶a去饱和酶抑制剂的1，2，3-三唑衍生物 | |
| JP5140080B2 (ja) | 選択的アシッドポンプ阻害剤としてのベンゾイミダゾール誘導体 | |
| CN101547909A (zh) | 糖皮质激素模拟物、其制备方法、药物组合物及其用途 | |
| CN110546140A (zh) | 选择性hdac6抑制剂 | |
| EP3027602A1 (fr) | Nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| CA2984971A1 (en) | Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity | |
| CN107849049A (zh) | 脲衍生物或其药用盐 | |
| JP2008543824A (ja) | アシッドポンプアンタゴニストとしてのクロマン置換ベンゾイミダゾール誘導体 | |
| CN101677548A (zh) | 硬骨鱼紧张肽ⅱ受体拮抗剂 | |
| JP2009530262A (ja) | クロマン誘導体 | |
| CN106496132B (zh) | N-(4-取代苯基)-2-取代乙酰胺类化合物及其作为sirt2蛋白抑制剂的用途 | |
| HK1163065A (en) | Chromane substituted benzimidazoles and their use as acid pump inhibitors | |
| HK1125368B (en) | Chromane substituted benzimidazoles and their use as acid pump inhibitors | |
| WO2007072142A2 (en) | Benzimidazole-5-carboxamide derivatives | |
| CN101528750B (zh) | 作为选择性酸泵抑制剂的苯并咪唑衍生物 | |
| WO2007031860A1 (en) | Indane substituted benzimidazoles and their use as acid pump inhibitors | |
| MX2008007030A (en) | Chromane substituted benzimidazoles and their use as acid pump inhibitors | |
| HK1132993A (en) | Benzimidazole derivatives and selective acid pump inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20090206 Address after: Aichi Applicant after: Raqualia Pharma Inc. Address before: American New York Applicant before: Smithkline Beecham PLC |
|
| ASS | Succession or assignment of patent right |
Owner name: GLIARELLA MEDICINE CO., LTD. Free format text: FORMER OWNER: AGOURON PHARMA Effective date: 20090206 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1125368 Country of ref document: HK |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: CJ Corp. Assignor: Raqualia Pharma Inc. Contract record no.: 2011990000915 Denomination of invention: Chromane substituted benzimidazoles and their use as acid pump inhibitors Granted publication date: 20110608 License type: Exclusive License Open date: 20090107 Record date: 20110921 |
|
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1125368 Country of ref document: HK |
|
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: CJ Corp. Assignor: Raqualia Pharma Inc. Contract record no.: 2011990000915 Date of cancellation: 20150410 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20090107 Assignee: Shandong Luo Xin Pharmaceutical Group Plc Assignor: CJ CHEILJEDANG CORPORATION Contract record no.: 2016990000057 Denomination of invention: Chromane substituted benzimidazoles and their use as acid pump inhibitors Granted publication date: 20110608 License type: Exclusive License Record date: 20160302 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| EM01 | Change of recordation of patent licensing contract | ||
| EM01 | Change of recordation of patent licensing contract |
Change date: 20220221 Contract record no.: 2016990000057 Assignor after: Inoon Ltd. Assignor before: CJ HEALTHCARE Corp. |