CN101331112A - 一种联苯乙酸盐及其制备方法与应用 - Google Patents

一种联苯乙酸盐及其制备方法与应用 Download PDF

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Publication number
CN101331112A
CN101331112A CNA2007800006970A CN200780000697A CN101331112A CN 101331112 A CN101331112 A CN 101331112A CN A2007800006970 A CNA2007800006970 A CN A2007800006970A CN 200780000697 A CN200780000697 A CN 200780000697A CN 101331112 A CN101331112 A CN 101331112A
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CN
China
Prior art keywords
ammonia acetate
biphenyl ammonia
acetate butantriol
butantriol salt
biphenyl
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CNA2007800006970A
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English (en)
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CN101331112B (zh
Inventor
陈文展
王伟
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Shijiazhuang Yiling Pharmaceutical Co Ltd
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Priority to CN2007800006970A priority Critical patent/CN101331112B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

本发明公开了一种联苯乙酸盐及其制备方法与应用。本发明所公开的联苯乙酸盐是联苯乙酸氨丁三醇盐。该联苯乙酸氨丁三醇盐，可通过将联苯乙酸和氨丁三醇在有机溶剂中进行反应得到。该联苯乙酸氨丁三醇盐的制备工艺简单可行，原料易得，反应条件稳定，反应产率高，产品纯度好。该联苯乙酸氨丁三醇盐可用于制备镇痛和/或抗炎和/或解热药物。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN2007800006970A 2006-10-23 2007-09-27 一种联苯乙酸盐及其制备方法与应用 Active CN101331112B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN2007800006970A CN101331112B (zh) 2006-10-23 2007-09-27 一种联苯乙酸盐及其制备方法与应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200610122917.4 2006-10-23
CNA2006101229174A CN1944378A (zh) 2006-10-23 2006-10-23 一种联苯乙酸氨丁三醇盐及其制备方法
PCT/CN2007/002830 WO2008049317A1 (en) 2006-10-23 2007-09-27 Biphenyl acetate, preparation and uses thereof
CN2007800006970A CN101331112B (zh) 2006-10-23 2007-09-27 一种联苯乙酸盐及其制备方法与应用

Publications (2)

Publication Number Publication Date
CN101331112A true CN101331112A (zh) 2008-12-24
CN101331112B CN101331112B (zh) 2012-03-21

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Family Applications (2)

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CNA2006101229174A Pending CN1944378A (zh) 2006-10-23 2006-10-23 一种联苯乙酸氨丁三醇盐及其制备方法
CN2007800006970A Active CN101331112B (zh) 2006-10-23 2007-09-27 一种联苯乙酸盐及其制备方法与应用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2006101229174A Pending CN1944378A (zh) 2006-10-23 2006-10-23 一种联苯乙酸氨丁三醇盐及其制备方法

Country Status (3)

Country Link
US (3) US8653298B2 (zh)
CN (2) CN1944378A (zh)
WO (1) WO2008049317A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093234B (zh) * 2009-11-26 2014-06-18 福州乾正药业有限公司 一种二元酯酸的氨丁三醇盐化合物及其制备方法和药物应用
CN102885803A (zh) * 2011-12-29 2013-01-23 广东中科药物研究有限公司 联苯乙酸氨丁三醇盐在制备治疗眼部炎症反应药物中的应用
CN103169653A (zh) * 2013-03-13 2013-06-26 广东中科药物研究有限公司 一种联苯乙酸及其盐的新用途
WO2017156648A1 (zh) * 2016-03-18 2017-09-21 广州诺威生物技术有限公司 一种用于抗炎的化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2194144B (en) * 1986-08-22 1990-04-25 American Cyanamid Co Stable pharmaceutical gel preparation
US3624142A (en) * 1964-09-10 1971-11-30 Merck & Co Inc Substituted biphenyl acetic acid derivatives
US3784704A (en) * 1972-10-13 1974-01-08 American Cyanamid Co Compositions of 4-biphenyl acetic acid and method of use
GB2214809A (en) * 1988-02-16 1989-09-13 American Cyanamid Co Non-steroidal anti-inflammatory suppositories
GB2260079B (en) * 1991-10-01 1995-08-09 American Cyanamid Co Pharmaceutical composition containing felbinac
US6139946A (en) * 1997-05-30 2000-10-31 Imation Corp. Magnetic recording media incorporating a quaternary ammonium functional binder and magnetic pigment surface treated with compound having acidic and electron withdrawing functionalities
EP1444231A4 (en) * 2001-11-06 2005-11-09 Merck & Co Inc AMINO SALTS OF AN INTEGRIN RECEPTOR ANTAGONIST
WO2003048140A1 (fr) * 2001-12-03 2003-06-12 Japan Tobacco Inc. Compose azole et utilisation medicinale de celui-ci
US20050119314A1 (en) * 2002-04-05 2005-06-02 Sankyo Company, Limited Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent
EP1697505A1 (en) * 2003-12-23 2006-09-06 Schering Corporation Methods for producing a549 cell lines stable in serum-free medium suspension culture

Also Published As

Publication number Publication date
US20130035505A1 (en) 2013-02-07
CN1944378A (zh) 2007-04-11
US20100016632A1 (en) 2010-01-21
WO2008049317A1 (en) 2008-05-02
US20140179949A1 (en) 2014-06-26
CN101331112B (zh) 2012-03-21
US8653298B2 (en) 2014-02-18

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Owner name: YILING PHARMACEUTICAL CO. LTD., SHIJIAZHUANG

Free format text: FORMER OWNER: GUANGDONG ZONK DRUG R+D LIMITED

Effective date: 20121023

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Address after: 050035 Shijiazhuang high tech Development Zone, Hebei Province, Tianshan Road, No. 238

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Address before: 510630, Guangdong, Zhongshan, Guangzhou Avenue, Tangxia, B Road, building on the four floor

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Address after: No.23, Keji Road, economic development zone, Miyun District, Beijing 101500

Patentee after: Beijing Yiling Bioengineering Co.,Ltd.

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TR01 Transfer of patent right