CN101321522B - 环氧丁醇中间体的制备方法 - Google Patents

环氧丁醇中间体的制备方法 Download PDF

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Publication number
CN101321522B
CN101321522B CN2006800449743A CN200680044974A CN101321522B CN 101321522 B CN101321522 B CN 101321522B CN 2006800449743 A CN2006800449743 A CN 2006800449743A CN 200680044974 A CN200680044974 A CN 200680044974A CN 101321522 B CN101321522 B CN 101321522B
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formula
compound
hal
reacted
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Chinese (zh)
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CN101321522A (zh
Inventor
M·莫勒尔
徐林
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Basilea Pharmaceutica AG
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Basilea Pharmaceutica AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
CN2006800449743A 2005-12-01 2006-11-29 环氧丁醇中间体的制备方法 Active CN101321522B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05026163.5 2005-12-01
EP05026163 2005-12-01
PCT/CH2006/000671 WO2007062542A2 (en) 2005-12-01 2006-11-29 Process for the manufacture of epoxybutanol intermediates

Publications (2)

Publication Number Publication Date
CN101321522A CN101321522A (zh) 2008-12-10
CN101321522B true CN101321522B (zh) 2012-05-30

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Family Applications (1)

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CN2006800449743A Active CN101321522B (zh) 2005-12-01 2006-11-29 环氧丁醇中间体的制备方法

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US (2) US7816537B2 (enExample)
EP (2) EP1954264B1 (enExample)
JP (1) JP5329969B2 (enExample)
KR (1) KR101191682B1 (enExample)
CN (1) CN101321522B (enExample)
AT (1) ATE444747T1 (enExample)
AU (2) AU2006319657B2 (enExample)
BR (1) BRPI0619120B1 (enExample)
CA (2) CA2711852C (enExample)
CY (1) CY1110588T1 (enExample)
DE (1) DE602006009698D1 (enExample)
DK (1) DK1954264T3 (enExample)
ES (1) ES2333258T3 (enExample)
HR (1) HRP20090675T1 (enExample)
PL (1) PL1954264T3 (enExample)
PT (1) PT1954264E (enExample)
SI (1) SI1954264T1 (enExample)
WO (1) WO2007062542A2 (enExample)
ZA (1) ZA200804218B (enExample)

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JP5767643B2 (ja) 2009-09-21 2015-08-19 ギリード・サイエンシズ・インコーポレーテッド １’−置換カルバヌクレオシド類似体の調製のためのプロセスおよび中間体
PE20130400A1 (es) 2010-07-22 2013-04-10 Gilead Sciences Inc Metodos y compuestos para tratar infecciones virales por paramyxoviridae
JP6334529B2 (ja) 2012-08-07 2018-05-30 バジリア ファルマスーチカ アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ ＡＧ イサブコナゾールまたはラブコナゾールの製造方法
WO2015150947A1 (en) 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
TWI698444B (zh) 2014-10-29 2020-07-11 美商基利科學股份有限公司 製備核糖苷的方法
PT3349758T (pt) 2015-09-16 2022-07-13 Gilead Sciences Inc Métodos para o tratamento de infeções pelo vírus arenaviridae
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
CN110869028B (zh) 2017-03-14 2023-01-20 吉利德科学公司 治疗猫冠状病毒感染的方法
KR20190141747A (ko) 2017-05-01 2019-12-24 길리애드 사이언시즈, 인코포레이티드 (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
SG11201911637QA (en) 2017-08-10 2020-01-30 Sumitomo Chemical Co Process for producing epoxy alcohol compound
CN118766947A (zh) 2020-01-27 2024-10-15 吉利德科学公司 用于治疗SARS CoV-2感染的方法
CA3169340A1 (en) 2020-03-12 2021-09-16 Pavel R. Badalov Methods of preparing 1'-cyano nucleosides
JP7482250B2 (ja) 2020-04-06 2024-05-13 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノ置換カルバヌクレオシド類似体の吸入製剤
PL4157272T3 (pl) 2020-05-29 2025-10-20 Gilead Sciences, Inc. Remdesiwir do leczenia zakażeń wirusowych
JP2023531524A (ja) 2020-06-24 2023-07-24 ギリアード サイエンシーズ， インコーポレイテッド １’－シアノヌクレオシド類似体及びその使用
LT4204421T (lt) 2020-08-27 2024-06-25 Gilead Sciences, Inc. Virusinių infekcijų gydymui skirti junginiai ir būdai
US20230295172A1 (en) 2022-03-02 2023-09-21 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
CN115536643A (zh) * 2022-12-05 2022-12-30 南京桦冠生物技术有限公司 一种艾沙康唑类药物关键中间体的制备方法
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof
CN119264078B (zh) * 2024-12-09 2025-08-01 浙江世佳科技股份有限公司 一种(5s,6r)-5,6-环氧-2-十七碳炔-1-醇的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045008A1 (en) * 1998-03-06 1999-09-10 F. Hoffmann-La Roche Ag 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
WO1999052840A1 (en) * 1998-04-15 1999-10-21 Naeja Pharmaceutical Inc. Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols
EP1083175A2 (en) * 1999-09-09 2001-03-14 Sankyo Company Limited Triazole derivatives having antifungal activity
EP1535914A1 (en) * 2002-06-20 2005-06-01 Sumitomo Chemical Company, Limited Processes for producing epoxytriazole derivative and intermediate therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
JP4627413B2 (ja) * 2003-05-06 2011-02-09 三井化学株式会社 １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045008A1 (en) * 1998-03-06 1999-09-10 F. Hoffmann-La Roche Ag 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
WO1999052840A1 (en) * 1998-04-15 1999-10-21 Naeja Pharmaceutical Inc. Asymmetric synthesis of 2-aryl-1-substituted butan-2,3-diols
EP1083175A2 (en) * 1999-09-09 2001-03-14 Sankyo Company Limited Triazole derivatives having antifungal activity
EP1535914A1 (en) * 2002-06-20 2005-06-01 Sumitomo Chemical Company, Limited Processes for producing epoxytriazole derivative and intermediate therefor

Also Published As

Publication number Publication date
PL1954264T3 (pl) 2010-02-26
CA2711852A1 (en) 2007-06-07
WO2007062542A3 (en) 2007-11-01
WO2007062542A2 (en) 2007-06-07
CA2629092A1 (en) 2007-06-07
ATE444747T1 (de) 2009-10-15
HRP20090675T1 (hr) 2010-01-31
US20110021794A1 (en) 2011-01-27
JP5329969B2 (ja) 2013-10-30
US7816537B2 (en) 2010-10-19
BRPI0619120B1 (pt) 2023-10-10
DE602006009698D1 (de) 2009-11-19
PT1954264E (pt) 2009-12-23
KR20080075014A (ko) 2008-08-13
CA2711852C (en) 2011-10-04
EP2133345A1 (en) 2009-12-16
AU2010203301B2 (en) 2012-06-21
EP1954264A2 (en) 2008-08-13
ES2333258T3 (es) 2010-02-18
AU2006319657B2 (en) 2010-08-12
KR101191682B1 (ko) 2012-10-16
BRPI0619120A2 (pt) 2011-09-13
AU2006319657A1 (en) 2007-06-07
CN101321522A (zh) 2008-12-10
AU2010203301A1 (en) 2010-08-12
EP1954264B1 (en) 2009-10-07
SI1954264T1 (sl) 2010-01-29
CY1110588T1 (el) 2015-04-29
ZA200804218B (en) 2009-01-28
US8076494B2 (en) 2011-12-13
JP2009517413A (ja) 2009-04-30
DK1954264T3 (da) 2010-01-11
US20090299073A1 (en) 2009-12-03
CA2629092C (en) 2012-01-03

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