CY1110588T1 - Μεθοδος για την παραγωγη παραγωγων εποξυβουτανολης - Google Patents
Μεθοδος για την παραγωγη παραγωγων εποξυβουτανοληςInfo
- Publication number
- CY1110588T1 CY1110588T1 CY20091101343T CY091101343T CY1110588T1 CY 1110588 T1 CY1110588 T1 CY 1110588T1 CY 20091101343 T CY20091101343 T CY 20091101343T CY 091101343 T CY091101343 T CY 091101343T CY 1110588 T1 CY1110588 T1 CY 1110588T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compound
- formula
- epoxybutanol
- products
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal nitrite Chemical class 0.000 abstract 1
- 150000008052 alkyl sulfonates Chemical class 0.000 abstract 1
- 150000007860 aryl ester derivatives Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05026163 | 2005-12-01 | ||
| EP06804890A EP1954264B1 (en) | 2005-12-01 | 2006-11-29 | Process for the manufacture of epoxybutanol intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110588T1 true CY1110588T1 (el) | 2015-04-29 |
Family
ID=36178579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091101343T CY1110588T1 (el) | 2005-12-01 | 2009-12-29 | Μεθοδος για την παραγωγη παραγωγων εποξυβουτανολης |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7816537B2 (enExample) |
| EP (2) | EP1954264B1 (enExample) |
| JP (1) | JP5329969B2 (enExample) |
| KR (1) | KR101191682B1 (enExample) |
| CN (1) | CN101321522B (enExample) |
| AT (1) | ATE444747T1 (enExample) |
| AU (2) | AU2006319657B2 (enExample) |
| BR (1) | BRPI0619120B1 (enExample) |
| CA (2) | CA2711852C (enExample) |
| CY (1) | CY1110588T1 (enExample) |
| DE (1) | DE602006009698D1 (enExample) |
| DK (1) | DK1954264T3 (enExample) |
| ES (1) | ES2333258T3 (enExample) |
| HR (1) | HRP20090675T1 (enExample) |
| PL (1) | PL1954264T3 (enExample) |
| PT (1) | PT1954264E (enExample) |
| SI (1) | SI1954264T1 (enExample) |
| WO (1) | WO2007062542A2 (enExample) |
| ZA (1) | ZA200804218B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME01528B (me) | 2009-09-21 | 2014-04-20 | Gilead Sciences Inc | POSTUPCI l INTERMEDIJERI ZA PROIZVODNJU 1'-CIJANOKARBANUKLEOZIDIH ANALOGA |
| US20120027752A1 (en) | 2010-07-22 | 2012-02-02 | Gilead Sciences, Inc. | Methods and compounds for treating paramyxoviridae virus infections |
| MX360783B (es) | 2012-08-07 | 2018-11-16 | Basilea Pharmaceutica Ag | Proceso para la manufactura de isavuconazol o ravuconazol. |
| WO2015150947A1 (en) | 2014-03-29 | 2015-10-08 | Wockhardt Limited | A process for the preparation of isavuconazole and its intermediates |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| HRP20220355T1 (hr) | 2015-09-16 | 2022-05-13 | Gilead Sciences, Inc. | Postupci za liječenje infekcija coronaviridae |
| CN105367528A (zh) * | 2015-11-10 | 2016-03-02 | 南通诺泰生物医药技术有限公司 | 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法 |
| TW201836615A (zh) | 2017-03-14 | 2018-10-16 | 美商基利科學股份有限公司 | 治療貓冠狀病毒感染之方法 |
| CA3059777C (en) | 2017-05-01 | 2023-02-21 | Gilead Sciences, Inc. | Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| WO2019014247A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS |
| WO2019031240A1 (ja) | 2017-08-10 | 2019-02-14 | 住友化学株式会社 | エポキシアルコール化合物の製造方法 |
| CN118766947A (zh) | 2020-01-27 | 2024-10-15 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
| KR20220164784A (ko) | 2020-04-06 | 2022-12-13 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형 |
| AU2021281351A1 (en) | 2020-05-29 | 2023-01-19 | Gilead Sciences, Inc. | Remdesivir treatment methods |
| PH12022553530A1 (en) | 2020-06-24 | 2024-06-24 | Gilead Sciences Inc | 1'-cyano nucleoside analogs and uses thereof |
| ES2985995T3 (es) | 2020-08-27 | 2024-11-08 | Gilead Sciences Inc | Compuestos y métodos para el tratamiento de infecciones víricas |
| US20230295172A1 (en) | 2022-03-02 | 2023-09-21 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| CN115536643A (zh) * | 2022-12-05 | 2022-12-30 | 南京桦冠生物技术有限公司 | 一种艾沙康唑类药物关键中间体的制备方法 |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| CN119264078B (zh) * | 2024-12-09 | 2025-08-01 | 浙江世佳科技股份有限公司 | 一种(5s,6r)-5,6-环氧-2-十七碳炔-1-醇的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3452213B2 (ja) * | 1994-07-05 | 2003-09-29 | エーザイ株式会社 | 抗真菌剤及びその製造方法 |
| WO1999045008A1 (en) | 1998-03-06 | 1999-09-10 | F. Hoffmann-La Roche Ag | 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity |
| US6133485A (en) | 1998-04-15 | 2000-10-17 | Synphar Laboratories, Inc. | Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols |
| US6391903B1 (en) | 1999-09-09 | 2002-05-21 | Sankyo Company, Limited | Triazole derivatives having antifungal activity |
| US6884892B2 (en) | 2002-06-20 | 2005-04-26 | Sumitomo Chemical Company, Limited | Production methods of epoxytriazole derivative and intermediate therefor |
| JP4627413B2 (ja) * | 2003-05-06 | 2011-02-09 | 三井化学株式会社 | １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法 |
-
2006
- 2006-11-29 WO PCT/CH2006/000671 patent/WO2007062542A2/en not_active Ceased
- 2006-11-29 EP EP06804890A patent/EP1954264B1/en active Active
- 2006-11-29 CN CN2006800449743A patent/CN101321522B/zh active Active
- 2006-11-29 PL PL06804890T patent/PL1954264T3/pl unknown
- 2006-11-29 CA CA2711852A patent/CA2711852C/en active Active
- 2006-11-29 PT PT06804890T patent/PT1954264E/pt unknown
- 2006-11-29 JP JP2008542575A patent/JP5329969B2/ja active Active
- 2006-11-29 AT AT06804890T patent/ATE444747T1/de active
- 2006-11-29 DK DK06804890T patent/DK1954264T3/da active
- 2006-11-29 DE DE602006009698T patent/DE602006009698D1/de active Active
- 2006-11-29 US US12/085,617 patent/US7816537B2/en active Active
- 2006-11-29 EP EP09168177A patent/EP2133345A1/en not_active Withdrawn
- 2006-11-29 SI SI200630502T patent/SI1954264T1/sl unknown
- 2006-11-29 CA CA2629092A patent/CA2629092C/en active Active
- 2006-11-29 ES ES06804890T patent/ES2333258T3/es active Active
- 2006-11-29 BR BRPI0619120-7A patent/BRPI0619120B1/pt not_active IP Right Cessation
- 2006-11-29 HR HR20090675T patent/HRP20090675T1/hr unknown
- 2006-11-29 AU AU2006319657A patent/AU2006319657B2/en not_active Ceased
- 2006-11-29 KR KR1020087015976A patent/KR101191682B1/ko active Active
-
2008
- 2008-05-15 ZA ZA200804218A patent/ZA200804218B/xx unknown
-
2009
- 2009-12-29 CY CY20091101343T patent/CY1110588T1/el unknown
-
2010
- 2010-07-23 AU AU2010203301A patent/AU2010203301B2/en not_active Ceased
- 2010-08-31 US US12/872,599 patent/US8076494B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110588T1 (el) | Μεθοδος για την παραγωγη παραγωγων εποξυβουτανολης | |
| MX2009008858A (es) | Derivado de pirazolcarbonitrilo que contiene fluor y el metodo para producirlo y derivado del acido pirazolcarboxilico que contiene fluor obtenido utilizando el derivado de pirazolcarbonitrilo que contiene fluor y el método para producirlo. | |
| CY1111428T1 (el) | Μεθοδος για τη συνθεση της 5-(μεθυλ-1η-ιμιδαζολ-1-υλο)-3-(τριφθορομεθυλο)-βενζολαμινης | |
| CY1116540T1 (el) | Μεθοδος παραγωγης 2'-δεοξυ-5-αζακυτιδινης (δεσιταβινη) | |
| CY1118475T1 (el) | Αντιοξειδωτικοι ρυθμιστες φλεγμονης: c-17 ομολογοποιημενα παραγωγα ολεανολικου οξεος | |
| CY1109809T1 (el) | Διαδικασια για την παρασκευη παραγωγων τετραζολης απο οργανο βοριο και οργανο αργιλιο αζιδια | |
| EA200900817A1 (ru) | Способ получения фторметилзамещённых гетероциклических соединений | |
| CR11270A (es) | Pirimidinas biciclicas fusionadas | |
| WO2010147965A3 (en) | Process for production of heterodimers of glutamic acid | |
| CY1112520T1 (el) | Βενζυλαμινες, μια διαδικασια για την παραγωγη τους και η χρηση τους ως αντι-φλεγμονωδεις παραγοντες | |
| PE20100051A1 (es) | Nuevo procedimiento de sintesis de 7,8-dimetoxi-1,3-dihidro-2h-3-benzazepin-2-oa y aplicacion en la sintesis de ivabradina y de sus sales de adicion a un acido farmaceuticamente aceptable | |
| DK2076123T3 (da) | Fremgangsmåde til fremstilling af substituerede brom-benzener | |
| EA200701470A1 (ru) | Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений | |
| ATE402185T1 (de) | Verfahren für fluorcytidinderivate | |
| CY1107101T1 (el) | Μεθοδος συνθεσης παραγωγων της 1,3-διϋδρο-2h-3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης με φαρμακευτικως αποδεκτο οξυ | |
| ECSP077244A (es) | Proceso para la síntesis de indoles n-alquilatados c-2, c-3 sustituidos útiles como inhibidores cpla2 | |
| EA201000819A1 (ru) | Способ получения фармацевтических промежуточных соединений | |
| ES2597853T3 (es) | Procedimiento para la preparación de ésteres alquílicos de ácido dihaloacetoacético | |
| CY1110066T1 (el) | Διαδικασια για την παρασκευη ντουλοξετινης | |
| CY1114798T1 (el) | Ενωσεις σουλφοναμιδιου για τη θεραπευτικη αντιμετωπιση αναπνευστικων διαταραχων | |
| DK1877370T3 (da) | Fremgangsmåde til fremstilling af hydrazon-derivater | |
| MX2009007029A (es) | Derivado de acil-3-aminoacrilonitrilo 2-fluorado y metodo para producir el mismo. | |
| ATE353868T1 (de) | Herstellungsverfahren für optisch reine 2-(4- hydroxyphenoxy)-propionsäureverbindungen | |
| CY1124340T1 (el) | Μεθοδος για την παραγωγη συμπυκνωμενων ιμιδαζολο παραγωγων | |
| DE60330171D1 (de) | Verfahren zur herstellung wasserlöslicher fluorhaltiger vinylether |