CY1124340T1 - Μεθοδος για την παραγωγη συμπυκνωμενων ιμιδαζολο παραγωγων - Google Patents
Μεθοδος για την παραγωγη συμπυκνωμενων ιμιδαζολο παραγωγωνInfo
- Publication number
- CY1124340T1 CY1124340T1 CY20211100430T CY211100430T CY1124340T1 CY 1124340 T1 CY1124340 T1 CY 1124340T1 CY 20211100430 T CY20211100430 T CY 20211100430T CY 211100430 T CY211100430 T CY 211100430T CY 1124340 T1 CY1124340 T1 CY 1124340T1
- Authority
- CY
- Cyprus
- Prior art keywords
- less
- compound
- formula
- production
- imidazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε μέθοδο για παροχή της ένωσης τύπου 1, που περιλαμβάνει το στάδιο αντίδρασης ένωσης τύπου VII με βάση, παρουσία άλατος αλκαλιμετάλλου - ή αλκαλικής γαίας (MX), όπου LG είναι αποχωρούσα ομάδα. Η παρουσία άλατος αλκαλιμετάλλου- ή αλκαλικής γαίας αναπάντεχα βρέθηκε ότι καθιστά την εν λόγω αντίδραση εξαιρετικά αξιόπιστη, όσον αφορά στην απόδοση και καθαρότητα της ένωσης τύπου Ι που λαμβάνεται. Σε περαιτέρω άποψη, η παρούσα εφεύρεση αφορά στην ένωση τύπου Ι, που έχει λιγότερο από ποσότητα 1,50% ή λιγότερο από ποσότητα 1,25% ή λιγότερο από ποσότητα 1,00% ή λιγότερο από ποσότητα 0,75% ή λιγότερο από ποσότητα 0,50% ή λιγότερο από ποσότητα 0,25% ή λιγότερο από ποσότητα 0,10% της ένωσης τύπου VIII.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109307P | 2015-01-29 | 2015-01-29 | |
| PCT/IB2016/050433 WO2016120821A1 (en) | 2015-01-29 | 2016-01-28 | Process for the production of condensed imidazolo derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1124340T1 true CY1124340T1 (el) | 2022-07-22 |
Family
ID=55299696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100430T CY1124340T1 (el) | 2015-01-29 | 2021-05-18 | Μεθοδος για την παραγωγη συμπυκνωμενων ιμιδαζολο παραγωγων |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10556869B2 (el) |
| EP (1) | EP3250555B1 (el) |
| JP (1) | JP6857126B2 (el) |
| KR (1) | KR102559242B1 (el) |
| CN (1) | CN107207518B (el) |
| AU (1) | AU2016210899B2 (el) |
| BR (1) | BR112017014706A2 (el) |
| CA (1) | CA2973539A1 (el) |
| CY (1) | CY1124340T1 (el) |
| DK (1) | DK3250555T3 (el) |
| ES (1) | ES2870461T3 (el) |
| HR (1) | HRP20210654T1 (el) |
| HU (1) | HUE054248T2 (el) |
| LT (1) | LT3250555T (el) |
| MX (1) | MX2017009839A (el) |
| PL (1) | PL3250555T3 (el) |
| PT (1) | PT3250555T (el) |
| RS (1) | RS61908B1 (el) |
| RU (1) | RU2734818C2 (el) |
| SI (1) | SI3250555T1 (el) |
| WO (1) | WO2016120821A1 (el) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111592546B (zh) * | 2020-05-26 | 2023-08-25 | 上海鲲博玖瑞医药科技发展有限公司 | 奥德司他的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617307A (en) * | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| MX2012008212A (es) * | 2010-01-14 | 2012-08-03 | Novartis Ag | Uso de un agente modificador de hormonas suprarrenales. |
| SI2804863T1 (sl) | 2012-01-17 | 2016-05-31 | Novartis Ag | Nove oblike in soli zaviralca sinteze ali aromataze dihidropropirolo(1,2-c)imidazolil aldosterona |
-
2016
- 2016-01-28 CA CA2973539A patent/CA2973539A1/en active Pending
- 2016-01-28 MX MX2017009839A patent/MX2017009839A/es unknown
- 2016-01-28 PT PT167028141T patent/PT3250555T/pt unknown
- 2016-01-28 BR BR112017014706A patent/BR112017014706A2/pt not_active Application Discontinuation
- 2016-01-28 LT LTEP16702814.1T patent/LT3250555T/lt unknown
- 2016-01-28 RS RS20210655A patent/RS61908B1/sr unknown
- 2016-01-28 CN CN201680007514.7A patent/CN107207518B/zh active Active
- 2016-01-28 AU AU2016210899A patent/AU2016210899B2/en active Active
- 2016-01-28 WO PCT/IB2016/050433 patent/WO2016120821A1/en active Application Filing
- 2016-01-28 PL PL16702814T patent/PL3250555T3/pl unknown
- 2016-01-28 US US15/546,707 patent/US10556869B2/en active Active
- 2016-01-28 HU HUE16702814A patent/HUE054248T2/hu unknown
- 2016-01-28 EP EP16702814.1A patent/EP3250555B1/en active Active
- 2016-01-28 RU RU2017127127A patent/RU2734818C2/ru active
- 2016-01-28 JP JP2017540171A patent/JP6857126B2/ja active Active
- 2016-01-28 DK DK16702814.1T patent/DK3250555T3/da active
- 2016-01-28 ES ES16702814T patent/ES2870461T3/es active Active
- 2016-01-28 KR KR1020177020917A patent/KR102559242B1/ko active IP Right Grant
- 2016-01-28 SI SI201631175T patent/SI3250555T1/sl unknown
-
2021
- 2021-04-26 HR HRP20210654TT patent/HRP20210654T1/hr unknown
- 2021-05-18 CY CY20211100430T patent/CY1124340T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2870461T3 (es) | 2021-10-27 |
| AU2016210899A1 (en) | 2017-07-20 |
| PL3250555T3 (pl) | 2021-08-02 |
| EP3250555A1 (en) | 2017-12-06 |
| DK3250555T3 (da) | 2021-04-26 |
| CA2973539A1 (en) | 2016-08-04 |
| JP6857126B2 (ja) | 2021-04-14 |
| KR20170106353A (ko) | 2017-09-20 |
| WO2016120821A1 (en) | 2016-08-04 |
| EP3250555B1 (en) | 2021-03-03 |
| JP2018503659A (ja) | 2018-02-08 |
| LT3250555T (lt) | 2021-06-25 |
| HRP20210654T1 (hr) | 2021-05-28 |
| RU2017127127A3 (el) | 2019-09-23 |
| US20180002292A1 (en) | 2018-01-04 |
| AU2016210899B2 (en) | 2019-03-07 |
| SI3250555T1 (sl) | 2021-08-31 |
| CN107207518A (zh) | 2017-09-26 |
| RU2017127127A (ru) | 2019-02-28 |
| US10556869B2 (en) | 2020-02-11 |
| RS61908B1 (sr) | 2021-06-30 |
| RU2734818C2 (ru) | 2020-10-23 |
| KR102559242B1 (ko) | 2023-07-25 |
| HUE054248T2 (hu) | 2021-08-30 |
| MX2017009839A (es) | 2017-11-02 |
| PT3250555T (pt) | 2021-04-27 |
| BR112017014706A2 (pt) | 2018-02-06 |
| CN107207518B (zh) | 2021-03-30 |
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