AU2006319657B2 - Process for the manufacture of epoxybutanol intermediates - Google Patents

Process for the manufacture of epoxybutanol intermediates Download PDF

Info

Publication number
AU2006319657B2
AU2006319657B2 AU2006319657A AU2006319657A AU2006319657B2 AU 2006319657 B2 AU2006319657 B2 AU 2006319657B2 AU 2006319657 A AU2006319657 A AU 2006319657A AU 2006319657 A AU2006319657 A AU 2006319657A AU 2006319657 B2 AU2006319657 B2 AU 2006319657B2
Authority
AU
Australia
Prior art keywords
formula
compound
hal
process according
same meaning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006319657A
Other languages
English (en)
Other versions
AU2006319657A1 (en
Inventor
Marc Muller
Lin Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Publication of AU2006319657A1 publication Critical patent/AU2006319657A1/en
Priority to AU2010203301A priority Critical patent/AU2010203301B2/en
Application granted granted Critical
Publication of AU2006319657B2 publication Critical patent/AU2006319657B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)
AU2006319657A 2005-12-01 2006-11-29 Process for the manufacture of epoxybutanol intermediates Ceased AU2006319657B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2010203301A AU2010203301B2 (en) 2005-12-01 2010-07-23 Process for the manufacture of epoxybutanol intermediates

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05026163 2005-12-01
EP05026163.5 2005-12-01
PCT/CH2006/000671 WO2007062542A2 (en) 2005-12-01 2006-11-29 Process for the manufacture of epoxybutanol intermediates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2010203301A Division AU2010203301B2 (en) 2005-12-01 2010-07-23 Process for the manufacture of epoxybutanol intermediates

Publications (2)

Publication Number Publication Date
AU2006319657A1 AU2006319657A1 (en) 2007-06-07
AU2006319657B2 true AU2006319657B2 (en) 2010-08-12

Family

ID=36178579

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2006319657A Ceased AU2006319657B2 (en) 2005-12-01 2006-11-29 Process for the manufacture of epoxybutanol intermediates
AU2010203301A Ceased AU2010203301B2 (en) 2005-12-01 2010-07-23 Process for the manufacture of epoxybutanol intermediates

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2010203301A Ceased AU2010203301B2 (en) 2005-12-01 2010-07-23 Process for the manufacture of epoxybutanol intermediates

Country Status (19)

Country Link
US (2) US7816537B2 (enExample)
EP (2) EP1954264B1 (enExample)
JP (1) JP5329969B2 (enExample)
KR (1) KR101191682B1 (enExample)
CN (1) CN101321522B (enExample)
AT (1) ATE444747T1 (enExample)
AU (2) AU2006319657B2 (enExample)
BR (1) BRPI0619120B1 (enExample)
CA (2) CA2711852C (enExample)
CY (1) CY1110588T1 (enExample)
DE (1) DE602006009698D1 (enExample)
DK (1) DK1954264T3 (enExample)
ES (1) ES2333258T3 (enExample)
HR (1) HRP20090675T1 (enExample)
PL (1) PL1954264T3 (enExample)
PT (1) PT1954264E (enExample)
SI (1) SI1954264T1 (enExample)
WO (1) WO2007062542A2 (enExample)
ZA (1) ZA200804218B (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ME01528B (me) 2009-09-21 2014-04-20 Gilead Sciences Inc POSTUPCI l INTERMEDIJERI ZA PROIZVODNJU 1'-CIJANOKARBANUKLEOZIDIH ANALOGA
US20120027752A1 (en) 2010-07-22 2012-02-02 Gilead Sciences, Inc. Methods and compounds for treating paramyxoviridae virus infections
MX360783B (es) 2012-08-07 2018-11-16 Basilea Pharmaceutica Ag Proceso para la manufactura de isavuconazol o ravuconazol.
WO2015150947A1 (en) 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
TWI767201B (zh) 2014-10-29 2022-06-11 美商基利科學股份有限公司 絲狀病毒科病毒感染之治療
HRP20220355T1 (hr) 2015-09-16 2022-05-13 Gilead Sciences, Inc. Postupci za liječenje infekcija coronaviridae
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种三唑类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
TW201836615A (zh) 2017-03-14 2018-10-16 美商基利科學股份有限公司 治療貓冠狀病毒感染之方法
CA3059777C (en) 2017-05-01 2023-02-21 Gilead Sciences, Inc. Crystalline forms of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate
WO2019014247A1 (en) 2017-07-11 2019-01-17 Gilead Sciences, Inc. COMPOSITIONS COMPRISING POLYMERASE RNA INHIBITOR AND CYCLODEXTRIN FOR THE TREATMENT OF VIRAL INFECTIONS
WO2019031240A1 (ja) 2017-08-10 2019-02-14 住友化学株式会社 エポキシアルコール化合物の製造方法
CN118766947A (zh) 2020-01-27 2024-10-15 吉利德科学公司 用于治疗SARS CoV-2感染的方法
TWI785528B (zh) 2020-03-12 2022-12-01 美商基利科學股份有限公司 1’-氰基核苷之製備方法
KR20220164784A (ko) 2020-04-06 2022-12-13 길리애드 사이언시즈, 인코포레이티드 1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
AU2021281351A1 (en) 2020-05-29 2023-01-19 Gilead Sciences, Inc. Remdesivir treatment methods
PH12022553530A1 (en) 2020-06-24 2024-06-24 Gilead Sciences Inc 1'-cyano nucleoside analogs and uses thereof
ES2985995T3 (es) 2020-08-27 2024-11-08 Gilead Sciences Inc Compuestos y métodos para el tratamiento de infecciones víricas
US20230295172A1 (en) 2022-03-02 2023-09-21 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
CN115536643A (zh) * 2022-12-05 2022-12-30 南京桦冠生物技术有限公司 一种艾沙康唑类药物关键中间体的制备方法
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof
CN119264078B (zh) * 2024-12-09 2025-08-01 浙江世佳科技股份有限公司 一种(5s,6r)-5,6-环氧-2-十七碳炔-1-醇的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3452213B2 (ja) * 1994-07-05 2003-09-29 エーザイ株式会社 抗真菌剤及びその製造方法
WO1999045008A1 (en) 1998-03-06 1999-09-10 F. Hoffmann-La Roche Ag 3-[4-(4-cyanophenyl)thiazol-2-y)]-1-(1h-1,2,4-triazol-1-yl)-butan-2-ol derivatives having antifungal activity
US6133485A (en) 1998-04-15 2000-10-17 Synphar Laboratories, Inc. Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
US6391903B1 (en) 1999-09-09 2002-05-21 Sankyo Company, Limited Triazole derivatives having antifungal activity
US6884892B2 (en) 2002-06-20 2005-04-26 Sumitomo Chemical Company, Limited Production methods of epoxytriazole derivative and intermediate therefor
JP4627413B2 (ja) * 2003-05-06 2011-02-09 三井化学株式会社 １−アゾール−２−フェニル−２、３−プロパンジオール誘導体の製造法

Also Published As

Publication number Publication date
PL1954264T3 (pl) 2010-02-26
BRPI0619120B1 (pt) 2023-10-10
CN101321522B (zh) 2012-05-30
JP5329969B2 (ja) 2013-10-30
US8076494B2 (en) 2011-12-13
PT1954264E (pt) 2009-12-23
CN101321522A (zh) 2008-12-10
EP2133345A1 (en) 2009-12-16
AU2010203301A1 (en) 2010-08-12
US20110021794A1 (en) 2011-01-27
KR20080075014A (ko) 2008-08-13
BRPI0619120A2 (pt) 2011-09-13
US7816537B2 (en) 2010-10-19
DE602006009698D1 (de) 2009-11-19
EP1954264A2 (en) 2008-08-13
ES2333258T3 (es) 2010-02-18
CA2711852A1 (en) 2007-06-07
CY1110588T1 (el) 2015-04-29
KR101191682B1 (ko) 2012-10-16
CA2629092A1 (en) 2007-06-07
WO2007062542A2 (en) 2007-06-07
ATE444747T1 (de) 2009-10-15
ZA200804218B (en) 2009-01-28
US20090299073A1 (en) 2009-12-03
CA2711852C (en) 2011-10-04
SI1954264T1 (sl) 2010-01-29
EP1954264B1 (en) 2009-10-07
CA2629092C (en) 2012-01-03
DK1954264T3 (da) 2010-01-11
AU2010203301B2 (en) 2012-06-21
HRP20090675T1 (hr) 2010-01-31
JP2009517413A (ja) 2009-04-30
AU2006319657A1 (en) 2007-06-07
WO2007062542A3 (en) 2007-11-01

Similar Documents

Publication Publication Date Title
AU2010203301B2 (en) Process for the manufacture of epoxybutanol intermediates
JP2009517413A5 (enExample)
EP1127886B1 (en) Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-2H-pyran-2one
HU208808B (en) Process for producing new acetidine derivatives
JP5148482B2 (ja) テトラヒドロピラン−３−オン類からテトラヒドロピラン類を調製する方法
US6133485A (en) Asymmetric synthesis of 2-(2,4-difluorophenyl)-1-heterocycl-1-yl butan-2,3-diols
JP2002511434A5 (enExample)
EP1693358B1 (en) Process for producing epoxytriazole compound and intermediate therefor
KR0125155B1 (ko) 프탈이미드 화합물 및 그 제조방법
EP2947077A1 (en) Stereoselective synthesis of intermediates in the preparation of ß-C-arylglucosides
JP3008029B2 (ja) メルカプト化合物の製造法
JPH1017561A (ja) アリルアルコール類およびその製造方法
KR20160126700A (ko) 스타틴의 중간체, 이의 제조방법 및 이를 이용한 로수바스타틴의 제조방법
JP2710837B2 (ja) 光学活性β―ヒドロキシチオエステルの製造方法
US6127579A (en) Method of manufacturing 1-indanone
HU189674B (en) Improved process for preparing hydroxyethyl-tetrazole-thiol
JPH0651694B2 (ja) 光学活性化合物
HU180573B (hu) Új eljárás 2-ciklopentenon-származékok előállítására
HK1060882B (en) Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues
HK1060882A1 (en) Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired