CN101296702B - 用于诊断或治疗bcl2相关癌症的组合物和方法 - Google Patents
用于诊断或治疗bcl2相关癌症的组合物和方法 Download PDFInfo
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- CN101296702B CN101296702B CN2006800397768A CN200680039776A CN101296702B CN 101296702 B CN101296702 B CN 101296702B CN 2006800397768 A CN2006800397768 A CN 2006800397768A CN 200680039776 A CN200680039776 A CN 200680039776A CN 101296702 B CN101296702 B CN 101296702B
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210380806.9A CN103028120B (zh) | 2005-09-12 | 2006-09-11 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71613405P | 2005-09-12 | 2005-09-12 | |
| US60/716,134 | 2005-09-12 | ||
| PCT/US2006/035100 WO2007033023A2 (en) | 2005-09-12 | 2006-09-11 | Compositions and methods for the diagnosis and therapy of bcl2-associated cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210380806.9A Division CN103028120B (zh) | 2005-09-12 | 2006-09-11 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101296702A CN101296702A (zh) | 2008-10-29 |
| CN101296702B true CN101296702B (zh) | 2012-11-28 |
Family
ID=37865464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800397768A Expired - Fee Related CN101296702B (zh) | 2005-09-12 | 2006-09-11 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
| CN201210380806.9A Expired - Fee Related CN103028120B (zh) | 2005-09-12 | 2006-09-11 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210380806.9A Expired - Fee Related CN103028120B (zh) | 2005-09-12 | 2006-09-11 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US8481505B2 (https=) |
| EP (2) | EP2796554A3 (https=) |
| JP (2) | JP2009507918A (https=) |
| CN (2) | CN101296702B (https=) |
| AU (1) | AU2006291165B2 (https=) |
| CA (2) | CA2845251A1 (https=) |
| ES (1) | ES2523989T3 (https=) |
| WO (1) | WO2007033023A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111349704A (zh) * | 2020-03-17 | 2020-06-30 | 河北医科大学第三医院 | 肝癌的诊断产品和治疗组合物 |
Families Citing this family (82)
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| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| CA2857881A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| WO2006107826A2 (en) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| JP5489459B2 (ja) | 2005-08-01 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物 |
| CA2845251A1 (en) | 2005-09-12 | 2007-03-22 | The Ohio State University Research Foundation | Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof |
| US20090270484A1 (en) * | 2005-10-05 | 2009-10-29 | The Ohio State University Research Foundation | WWOX Vectors and Uses in Treatment of Cancer |
| EP2487258B1 (en) * | 2006-01-05 | 2014-10-01 | The Ohio State University Research Foundation | MicroRNA-based methods for the diagnosis of colon, pancreas and stomach cancer |
| JP5490413B2 (ja) | 2006-01-05 | 2014-05-14 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常 |
| CN102943108B (zh) | 2006-01-05 | 2014-05-21 | 俄亥俄州立大学研究基金会 | 用于肺癌的诊断、预后和治疗的基于微小rna的方法和组合物 |
| ES2446362T3 (es) | 2006-03-20 | 2014-03-07 | The Ohio State University Research Foundation | Huellas de microARN durante megacariocipoyesis humana |
| CA2657030A1 (en) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| CN101535505A (zh) | 2006-09-19 | 2009-09-16 | 俄亥俄州立大学研究基金会 | 慢性淋巴细胞性白血病(CLL)中受miR-29和miR-181调控的TCL1的表达 |
| EP2087135B8 (en) | 2006-11-01 | 2013-07-24 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| CA2671302A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mirna regulated genes and pathways as targets for therapeutic intervention |
| CN105256004A (zh) * | 2007-01-31 | 2016-01-20 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| ES2527648T3 (es) | 2007-06-08 | 2015-01-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Métodos para determinar el subtipo de carcinoma hepatocelular |
| JP2010529966A (ja) * | 2007-06-08 | 2010-09-02 | アシュラジェン インコーポレイテッド | 治療的介入の標的としてmiR−34によって調節される遺伝子および経路 |
| EP2719773A3 (en) | 2007-06-15 | 2014-07-30 | The Ohio State University Research Foundation | miRNA as marker for acute lamphomic leucemia |
| ES2496172T3 (es) | 2007-07-31 | 2014-09-18 | The Ohio State University Research Foundation | Métodos para invertir la metilación por selección dirigida de DNMT3A y DNMT3B |
| AU2008283795B2 (en) | 2007-07-31 | 2013-11-21 | Board Of Regents, The University Of Texas System | A micro-RNA family that modulates fibrosis and uses thereof |
| JP2010535473A (ja) | 2007-08-03 | 2010-11-25 | ズィ、オハイオウ、ステイト、ユーニヴァーサティ、リサーチ、ファウンデイシャン | ncRNAをコードする超保存領域 |
| CA2696887C (en) | 2007-08-22 | 2016-06-28 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| CN102137927B (zh) | 2007-10-26 | 2014-03-12 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
| JP5654352B2 (ja) | 2007-11-09 | 2015-01-14 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | miR−15ファミリーのマイクロRNAによる心筋細胞生存及び心臓修復の調節 |
| JP2011505143A (ja) * | 2007-11-30 | 2011-02-24 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | マイクロrna発現プロファイリング及び肺癌における末梢血ターゲティング |
| EP2235213A2 (en) | 2007-12-20 | 2010-10-06 | Celgene Corporation | Use of micro-rna as a biomarker of immunomodulatory drug activity |
| AU2009219193A1 (en) * | 2008-02-28 | 2009-09-03 | The Ohio State University Research Foundation | MicroRNA signatures associated with human chronic lymphocytic leukemia (CCL) and uses thereof |
| US20110054009A1 (en) * | 2008-02-28 | 2011-03-03 | The Ohio State University Research Foundation | MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders |
| CA2718520C (en) | 2008-03-17 | 2020-01-07 | The Board Of Regents Of The University Of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| EP2271757A2 (en) * | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Compositions and methods related to mir-16 and therapy of prostate cancer |
| US9261508B2 (en) | 2008-04-25 | 2016-02-16 | Istituto Superiore Di Sanita | Antisense RNA for treating cancer and inhibition of metastasis and vectors for antisense sequestration |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| ES2433940T3 (es) | 2008-06-11 | 2013-12-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Uso de la familia miR-26 como marcador predictivo del carcinoma hepatocelular y sensibilidad a la terapia |
| WO2010017510A1 (en) * | 2008-08-07 | 2010-02-11 | University Of Southern California | A system for synergistic expression of multiple small functional rna elements |
| WO2010036939A2 (en) * | 2008-09-26 | 2010-04-01 | University Of Southern California | A system for synergistic expression of multiple small functional rna elements |
| WO2010020787A1 (en) * | 2008-08-22 | 2010-02-25 | Oncomethylome Sciences Sa | Diagnosis and treatment of tumours |
| ES2610622T3 (es) * | 2009-03-31 | 2017-04-28 | The General Hospital Corporation | Regulación de microARN miR-33 en el tratamiento de trastornos relacionados con colesterol |
| CN101988060A (zh) * | 2009-07-30 | 2011-03-23 | 江苏命码生物科技有限公司 | 结直肠癌检测标记物及其检测方法、试剂盒和生物芯片 |
| US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
| NZ704322A (en) * | 2010-07-06 | 2016-07-29 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
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| US8933051B2 (en) | 2010-09-30 | 2015-01-13 | University Of Zurich | Treatment of B-cell lymphoma with microRNA |
| SG180031A1 (en) * | 2010-10-15 | 2012-05-30 | Agency Science Tech & Res | Combination treatment of cancer |
| JP5931897B2 (ja) | 2010-11-12 | 2016-06-08 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | マイクロrna−21、ミスマッチ修復および結腸直腸癌に関連する物質および方法 |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| WO2012122239A1 (en) | 2011-03-07 | 2012-09-13 | The Ohio State University | MUTATOR ACTIVITY INDUCED BY MICRORNA-155 (miR-155) LINKS INFLAMMATION AND CANCER |
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| CN105039537B (zh) * | 2014-07-10 | 2018-07-06 | 上海益诺思生物技术股份有限公司 | mo-miR-211在制备肾毒性生物标志物中的用途 |
| CN105363042B (zh) * | 2015-10-21 | 2022-05-06 | 圣诺生物医药技术(苏州)有限公司 | 一种药物组合物及其应用 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111349704A (zh) * | 2020-03-17 | 2020-06-30 | 河北医科大学第三医院 | 肝癌的诊断产品和治疗组合物 |
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| EP1937280A4 (en) | 2009-11-11 |
| US20130267580A1 (en) | 2013-10-10 |
| EP1937280B1 (en) | 2014-08-27 |
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| AU2006291165A1 (en) | 2007-03-22 |
| US9480699B2 (en) | 2016-11-01 |
| CN103028120B (zh) | 2015-08-12 |
| ES2523989T3 (es) | 2014-12-03 |
| EP1937280A2 (en) | 2008-07-02 |
| US20100184830A1 (en) | 2010-07-22 |
| CA2621441A1 (en) | 2007-03-22 |
| CA2621441C (en) | 2014-05-20 |
| CN101296702A (zh) | 2008-10-29 |
| US8481505B2 (en) | 2013-07-09 |
| EP2796554A3 (en) | 2014-12-10 |
| US20140335161A1 (en) | 2014-11-13 |
| JP2009507918A (ja) | 2009-02-26 |
| AU2006291165B2 (en) | 2013-03-14 |
| EP2796554A2 (en) | 2014-10-29 |
| WO2007033023A2 (en) | 2007-03-22 |
| JP2013166766A (ja) | 2013-08-29 |
| CA2845251A1 (en) | 2007-03-22 |
| CN103028120A (zh) | 2013-04-10 |
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