CN101282960A - Raf抑制剂化合物和方法 - Google Patents

Raf抑制剂化合物和方法 Download PDF

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Publication number
CN101282960A
CN101282960A CNA2006800109351A CN200680010935A CN101282960A CN 101282960 A CN101282960 A CN 101282960A CN A2006800109351 A CNA2006800109351 A CN A2006800109351A CN 200680010935 A CN200680010935 A CN 200680010935A CN 101282960 A CN101282960 A CN 101282960A
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China
Prior art keywords
compound
pyridin
pyrazol
alkyl
cancer
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Pending
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CNA2006800109351A
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Chinese (zh)
Inventor
埃伦·莱尔德
约瑟夫·P·利西卡托斯
迈克·韦尔奇
乔纳斯·格林纳
乔希·汉森
布雷德·纽豪斯
艾伦·奥利弗罗
乔治·托波拉夫
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Genentech Inc
Array Biopharma Inc
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Genentech Inc
Array Biopharma Inc
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Publication of CN101282960A publication Critical patent/CN101282960A/zh
Pending legal-status Critical Current

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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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CNA2006800109351A 2005-02-04 2006-02-02 Raf抑制剂化合物和方法 Pending CN101282960A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65005005P 2005-02-04 2005-02-04
US60/650,050 2005-02-04

Publications (1)

Publication Number Publication Date
CN101282960A true CN101282960A (zh) 2008-10-08

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US (2) US7491829B2 (cg-RX-API-DMAC10.html)
EP (1) EP1846391A2 (cg-RX-API-DMAC10.html)
JP (1) JP2008530011A (cg-RX-API-DMAC10.html)
KR (1) KR20070107104A (cg-RX-API-DMAC10.html)
CN (1) CN101282960A (cg-RX-API-DMAC10.html)
AR (1) AR053014A1 (cg-RX-API-DMAC10.html)
AU (1) AU2006210626A1 (cg-RX-API-DMAC10.html)
BR (1) BRPI0607346A2 (cg-RX-API-DMAC10.html)
CA (1) CA2596973A1 (cg-RX-API-DMAC10.html)
CR (1) CR9365A (cg-RX-API-DMAC10.html)
IL (1) IL185024A0 (cg-RX-API-DMAC10.html)
MA (1) MA29310B1 (cg-RX-API-DMAC10.html)
MX (1) MX2007009405A (cg-RX-API-DMAC10.html)
NO (1) NO20074473L (cg-RX-API-DMAC10.html)
RU (1) RU2007133111A (cg-RX-API-DMAC10.html)
TW (1) TW200639163A (cg-RX-API-DMAC10.html)
WO (1) WO2006084015A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200707289B (cg-RX-API-DMAC10.html)

Cited By (4)

* Cited by examiner, † Cited by third party
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CN102666498A (zh) * 2009-08-28 2012-09-12 健泰科生物技术公司 Raf抑制剂化合物及其使用方法
WO2023098439A1 (zh) * 2021-11-30 2023-06-08 上海和誉生物医药科技有限公司 一种吡唑衍生物，其制备方法和在药学上的应用
WO2024022186A1 (zh) * 2022-07-29 2024-02-01 四川科伦博泰生物医药股份有限公司 甲基吡唑化合物、包含其的药物组合物及其制备方法和用途
CN117510491A (zh) * 2016-12-23 2024-02-06 阿尔维纳斯运营股份有限公司 用于迅速加速性纤维肉瘤多肽的靶向降解的化合物和方法

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