CN101273024A - 新颖苯并[d][1,3]-二氧杂环戊烯衍生物 - Google Patents

新颖苯并[d][1,3]-二氧杂环戊烯衍生物 Download PDF

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Publication number
CN101273024A
CN101273024A CNA2006800351923A CN200680035192A CN101273024A CN 101273024 A CN101273024 A CN 101273024A CN A2006800351923 A CNA2006800351923 A CN A2006800351923A CN 200680035192 A CN200680035192 A CN 200680035192A CN 101273024 A CN101273024 A CN 101273024A
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compound
deuterium
prodrug
disorder
salt
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Chinese (zh)
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R·通
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Concert Pharmaceuticals Inc
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Concert Pharmaceuticals Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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CNA2006800351923A 2005-07-29 2006-07-28 新颖苯并[d][1,3]-二氧杂环戊烯衍生物 Pending CN101273024A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70407305P 2005-07-29 2005-07-29
US60/704,073 2005-07-29

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CN101273024A true CN101273024A (zh) 2008-09-24

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US (5) US20080287495A1 (https=)
EP (1) EP1910322B1 (https=)
JP (1) JP5301991B2 (https=)
KR (1) KR101380190B1 (https=)
CN (1) CN101273024A (https=)
AU (1) AU2006275595B2 (https=)
BR (1) BRPI0615973A2 (https=)
CA (1) CA2616383C (https=)
EA (1) EA014432B1 (https=)
ES (1) ES2396365T3 (https=)
WO (1) WO2007016431A2 (https=)
ZA (1) ZA200800785B (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102245613A (zh) * 2008-10-13 2011-11-16 詹森药业有限公司 苯基和杂芳基取代的噻吩并[2，3-d]嘧啶及它们作为腺苷A2a受体拮抗剂的用途
CN104039777A (zh) * 2012-01-31 2014-09-10 卫材R&D管理有限公司 帕罗西汀衍生物
CN105324376A (zh) * 2013-06-27 2016-02-10 辉瑞大药厂 杂芳族化合物及其作为多巴胺d1配体的用途
US9896423B2 (en) 2014-05-30 2018-02-20 Jiangsu Jibeier Pharmaceutical Co., Ltd. Deuterium substituted 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine compound or derivatives thereof, and pharmaceutical composition and use thereof
CN107970243A (zh) * 2017-10-30 2018-05-01 江苏理工学院 一种去甲氯氮平的新用途
CN109134432A (zh) * 2017-06-15 2019-01-04 泰州华元医药科技有限公司 氘代抗抑郁药物
CN110283156A (zh) * 2019-07-29 2019-09-27 河北省农林科学院经济作物研究所 从刺五加中提取的新型降血脂化合物

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2616383C (en) * 2005-07-29 2015-06-09 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
CA2629514A1 (en) * 2005-11-14 2007-05-24 Auspex Pharmaceuticals, Inc. Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
MX2008012566A (es) * 2006-04-03 2008-10-10 Hoffmann La Roche Proceso para preparar acidos beta-aril o heteroaril-carboxilicos ciclicos enantiomericamente enriquecidos.
JP5302200B2 (ja) * 2006-10-23 2013-10-02 コンサート ファーマシューティカルズ インコーポレイテッド オキサゾリジノン誘導体および使用方法
JP2010520291A (ja) * 2007-03-07 2010-06-10 コンサート ファーマシューティカルズ インコーポレイテッド 抗狭心症化合物としての重水素化ピペラジン誘導体
FI3825306T3 (fi) 2007-05-01 2023-08-23 Concert Pharmaceuticals Inc Morfinaaniyhdisteitä
WO2008137461A1 (en) * 2007-05-01 2008-11-13 Concert Pharmaceuticals Inc. Naphthyl(ethyl) acetamides
US7973049B2 (en) * 2007-05-01 2011-07-05 Concert Pharmaceuticals Inc. Morphinan compounds
JP2010529994A (ja) * 2007-06-13 2010-09-02 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換ピペラジン
CA2698808A1 (en) 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
AU2009270936B2 (en) * 2008-07-15 2014-12-18 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use
WO2010010141A1 (en) * 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Pramipexole for treating cardiomyopathy
EA201391720A1 (ru) * 2008-11-14 2014-04-30 Консерт Фармасьютикалс Инк. Замещенные диоксопиперидинилфталимидные производные
US9045453B2 (en) 2008-11-14 2015-06-02 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
US20100143505A1 (en) * 2008-12-09 2010-06-10 Auspex Pharmaceuticals, Inc. Indanone inhibitors of acetylcholinesterase
WO2010075086A2 (en) * 2008-12-15 2010-07-01 Auspex Pharmaceuticals, Inc. Pyrrolidinone inhibitors of pde-4
PH12012500762A1 (en) 2009-10-26 2012-11-26 Otsuka Pharma Co Ltd Benzazepine compound
WO2011159920A1 (en) * 2010-06-17 2011-12-22 Concert Pharmaceuticals, Inc. [5,6]-dihydro-2h-pyran-2-one derivatives
PL3135656T3 (pl) 2011-06-20 2019-07-31 H. Lundbeck A/S Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii
US8586552B2 (en) 2012-02-03 2013-11-19 Selectx Pharmaceuticals, Inc. 4,6-substituted 2,5-dideoxystreptamine aminoglycoside antibiotics
EP2687854A1 (en) * 2012-07-19 2014-01-22 Chiron AS Test kit for the quantitative determination of narcotic drugs
US9643950B2 (en) 2012-10-22 2017-05-09 Concert Pharmaceuticals, Inc. Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidine-3,4,4,5,5-d5)-2,6-dione}
AR094054A1 (es) * 2012-12-19 2015-07-08 H Lundbeck As 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma
HK1220184A1 (zh) 2013-03-13 2017-04-28 Boston Biomedical, Inc. 用於治疗癌症的作为癌症干细胞途径激酶抑制剂的3-(芳基或杂芳基)甲基吲哚-2-酮衍生物
CA2945609C (en) 2014-07-29 2023-05-23 Shenzhen Hightide Biopharmaceutical, Ltd. Berberine-ursodeoxycholic salt, method of preparation and application therof
US10089505B1 (en) 2015-09-29 2018-10-02 Amazon Technologies, Inc. Inventory tracking using RFID
US10037449B1 (en) 2015-09-29 2018-07-31 Amazon Technologies, Inc. Inventory tracking using RFID
JP6969800B2 (ja) 2016-05-04 2021-11-24 ジェノシアンス ファルマ 増殖性疾患の治療に使用される置換２，４−ジアミノ−キノリン誘導体
AU2016406709C1 (en) 2016-05-10 2023-04-27 Shenzhen Hightide Biopharmaceutical., Ltd. Composition, and application and pharmaceutical preparation thereof
US11758928B2 (en) 2016-12-15 2023-09-19 Société des Produits Nestlé S.A. Compositions and methods that modulate phosphorus or enzymes in a companion animal
CN108864077B (zh) 2017-05-12 2020-05-22 深圳君圣泰生物技术有限公司 小檗碱有机酸盐的固体形式及其制备方法
EP3675860B1 (en) 2017-08-28 2023-03-08 Zhihong, Chen Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof
TWI851577B (zh) 2018-06-07 2024-08-11 美商思進公司 喜樹鹼結合物
EP3856742B1 (en) 2018-11-01 2024-10-02 Lynk Pharmaceuticals Co. Ltd. Tricyclic janus kinase 1 inhibitors, and compositions and methods thereof
EP3891134A1 (en) 2018-12-03 2021-10-13 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine
WO2020118683A1 (en) 2018-12-14 2020-06-18 Lynk Pharmaceuticals Co. Ltd. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
WO2020146845A1 (en) 2019-01-11 2020-07-16 University Of Rochester Compositions and methods for treating prostate cancer with enzalutamide and an inhibitor of monoamin oxidase a
WO2020160054A1 (en) 2019-02-01 2020-08-06 Canwell Biotech Limited Imidazoquinoline amine derivatives, pharmaceutical composition, use thereof
CN114616234B (zh) 2019-02-07 2024-04-12 康威(广州)生物科技有限公司 磷咪唑并喹啉胺衍生物、及其药物组合物和应用
AU2020356955A1 (en) 2019-10-04 2022-04-14 Seagen Inc. Camptothecin peptide conjugates
WO2021216325A1 (en) 2020-04-22 2021-10-28 University Of Rochester Compositions and methods for treating metabolic and cardiovascular diseases
JP2022100060A (ja) * 2020-12-23 2022-07-05 大陽日酸株式会社 モノ重水素化ジハロゲン化メタン、重水素化シクロプロパン化合物及びそれらの製造方法
JP2024506999A (ja) 2021-02-02 2024-02-15 コン，ヤンピン がんを処置するための組成物および方法
WO2022271861A1 (en) 2021-06-22 2022-12-29 Dana-Farber Cancer Institute, Inc. (1h-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl-amino-phenyl--acrylamide inhibitors of egfr for use in the treatment of brain tumors
WO2025126109A1 (en) 2023-12-15 2025-06-19 Ensem Therapeutics, Inc. Anilino-pyrazole derivatives, compositions and methods thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
GB8430581D0 (en) * 1984-12-04 1985-01-09 Ferrosan As Treatment
WO1989001342A2 (en) * 1987-08-07 1989-02-23 Mallinckrodt, Inc. Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound
US6221335B1 (en) * 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CN1087725C (zh) * 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
US5597826A (en) * 1994-09-14 1997-01-28 Pfizer Inc. Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist
AU3108097A (en) * 1997-06-10 1998-12-30 Synthon B.V. 4-phenylpiperidine compounds
US6440710B1 (en) * 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
PT1104760E (pt) * 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
EP1134290A3 (en) * 2000-03-14 2004-01-02 Pfizer Products Inc. Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors
US6436938B1 (en) * 2001-01-22 2002-08-20 Pfizer Inc. Combination treatment for depression
US6720003B2 (en) * 2001-02-16 2004-04-13 Andrx Corporation Serotonin reuptake inhibitor formulations
TW200413273A (en) * 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
US20080033011A1 (en) * 2005-07-29 2008-02-07 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
CA2616383C (en) * 2005-07-29 2015-06-09 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
CN101309917B (zh) * 2005-10-06 2013-09-11 奥斯拜客斯制药有限公司 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂
CA2629514A1 (en) * 2005-11-14 2007-05-24 Auspex Pharmaceuticals, Inc. Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
US7750168B2 (en) * 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
JO2630B1 (en) 2006-04-13 2012-06-17 نوفارتيس ايه جي Organic compounds
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
CA2698808A1 (en) * 2007-09-13 2009-03-19 Concert Pharmaceuticals, Inc. Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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US9896423B2 (en) 2014-05-30 2018-02-20 Jiangsu Jibeier Pharmaceutical Co., Ltd. Deuterium substituted 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine compound or derivatives thereof, and pharmaceutical composition and use thereof
CN109134432A (zh) * 2017-06-15 2019-01-04 泰州华元医药科技有限公司 氘代抗抑郁药物
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WO2019085827A1 (zh) * 2017-10-30 2019-05-09 江苏理工学院 一种去甲氯氮平的新用途
KR20200059209A (ko) * 2017-10-30 2020-05-28 지앙수 유니버시티 오브 테크놀로지 데스메틸클로자핀의 새로운 용도
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KR102401604B1 (ko) 2017-10-30 2022-05-24 지앙수 유니버시티 오브 테크놀로지 데스메틸클로자핀의 새로운 용도
CN110283156A (zh) * 2019-07-29 2019-09-27 河北省农林科学院经济作物研究所 从刺五加中提取的新型降血脂化合物
CN110283156B (zh) * 2019-07-29 2020-06-30 河北省农林科学院经济作物研究所 从刺五加中提取的新型降血脂化合物

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