CN101248036B - 邻乙酰基水杨酸与碱性氨基酸的盐和甘氨酸的稳定的活性物质络合物 - Google Patents
邻乙酰基水杨酸与碱性氨基酸的盐和甘氨酸的稳定的活性物质络合物 Download PDFInfo
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- CN101248036B CN101248036B CN200680019089.XA CN200680019089A CN101248036B CN 101248036 B CN101248036 B CN 101248036B CN 200680019089 A CN200680019089 A CN 200680019089A CN 101248036 B CN101248036 B CN 101248036B
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- Prior art keywords
- active ingredient
- glycine
- acetylsalicylic acid
- ingredient complex
- salt
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000004471 Glycine Substances 0.000 title claims abstract description 30
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- 150000001413 amino acids Chemical class 0.000 title claims abstract description 27
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
- C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
- C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
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- Crystallography & Structural Chemistry (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (5)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005025283A DE102005025283A1 (de) | 2005-06-02 | 2005-06-02 | Stabiler Wirkstoffkomplex von Salzen der o-Acetylsalicylsäure mit basischen Aminosäuren und Glycin |
DE102005025283.4 | 2005-06-02 | ||
PCT/EP2006/004799 WO2006128600A2 (de) | 2005-06-02 | 2006-05-20 | Stabiler wirkstoffkomplex von salzen der o-acetylsalicylsäure mit basischen aminosäuren und glycin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101248036A CN101248036A (zh) | 2008-08-20 |
CN101248036B true CN101248036B (zh) | 2016-03-16 |
Family
ID=36649662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200680019089.XA Expired - Fee Related CN101248036B (zh) | 2005-06-02 | 2006-05-20 | 邻乙酰基水杨酸与碱性氨基酸的盐和甘氨酸的稳定的活性物质络合物 |
Country Status (32)
Country | Link |
---|---|
US (1) | US8063243B2 (zh) |
EP (1) | EP1890994B1 (zh) |
JP (1) | JP2008542316A (zh) |
KR (1) | KR101347522B1 (zh) |
CN (1) | CN101248036B (zh) |
AR (1) | AR057341A1 (zh) |
AT (1) | ATE526974T1 (zh) |
AU (1) | AU2006254429B2 (zh) |
BR (1) | BRPI0610734A2 (zh) |
CA (1) | CA2610194C (zh) |
CR (1) | CR9556A (zh) |
CY (1) | CY1112185T1 (zh) |
DE (1) | DE102005025283A1 (zh) |
DK (1) | DK1890994T3 (zh) |
ES (1) | ES2373917T3 (zh) |
HR (1) | HRP20120003T1 (zh) |
IL (1) | IL187772A (zh) |
MA (1) | MA29604B1 (zh) |
MX (1) | MX2007014988A (zh) |
NO (1) | NO20076592L (zh) |
NZ (1) | NZ563871A (zh) |
PL (1) | PL1890994T3 (zh) |
PT (1) | PT1890994E (zh) |
RS (1) | RS52111B (zh) |
RU (1) | RU2433995C2 (zh) |
SG (1) | SG162744A1 (zh) |
SI (1) | SI1890994T1 (zh) |
TN (1) | TNSN07452A1 (zh) |
TW (1) | TWI374740B (zh) |
UA (1) | UA89827C2 (zh) |
WO (1) | WO2006128600A2 (zh) |
ZA (1) | ZA200710251B (zh) |
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DE102008004386A1 (de) * | 2008-01-14 | 2009-07-23 | Activaero Gmbh | Verwendung eines Acetylsalicylsäuresalzes zur Behandlung viraler Infektionen |
BRPI1009600A2 (zh) * | 2009-06-25 | 2016-03-22 | Tetra S A | |
AU2010263409B2 (en) * | 2009-06-25 | 2013-09-05 | Tetra, Sia | Novel acetylsalicylic acid salts |
FR2950625B1 (fr) * | 2009-09-30 | 2016-12-02 | Holis Tech | Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue |
FR2965261B1 (fr) * | 2009-09-30 | 2012-10-26 | Holis Technologies | Procede de preparation d'un sel d'acide o-acetylsalicylique d'un acide amine basique et composition obtenue par ce procede |
TWI478715B (zh) * | 2010-12-03 | 2015-04-01 | Tetra Sia | 新穎乙醯柳酸鹽 |
RU2011132483A (ru) * | 2011-08-02 | 2013-02-10 | Елена Александровна Моренко | Биологически активный продукт для применения в ветеринарии и животноводстве, способ его получения и способы повышения выживаемости, стимуляции роста, иммуностимуляции и повышения общей неспецифической резистентности организма сельскохозяйственных животных |
CN102503845A (zh) * | 2011-09-28 | 2012-06-20 | 广州普星药业有限公司 | 一种dl-赖氨酸阿司匹林盐的制备方法及其应用 |
ITMI20121144A1 (it) * | 2012-06-28 | 2013-12-29 | Dipharma Francis Srl | Procedimento per la preparazione di un sale di un farmaco antinfiammatorio non steroideo |
LV14963B (lv) | 2013-06-28 | 2015-10-20 | Tetra, Sia | Endoteliālās disfunkcijas korektors |
JP7137479B2 (ja) * | 2016-02-23 | 2022-09-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | グリシン粒子 |
AU2017383071B2 (en) | 2016-12-23 | 2021-04-29 | Aspiair Gmbh | Improved synthesis of lysine acetylsalicylate · glycine particles |
CN110996965A (zh) | 2017-05-30 | 2020-04-10 | 罗山制药股份有限公司 | 稳定、无菌和结晶的邻乙酰水杨酸(阿司匹林)的小瓶内沉积物 |
CN112592286B (zh) * | 2020-11-23 | 2024-02-02 | 蚌埠丰原医药科技发展有限公司 | 一种阿司匹林与碱性氨基酸的络合物的制备方法 |
CA3239851A1 (en) | 2022-01-05 | 2023-07-13 | Karlheinz Nocker | Improved synthesis of lysine acetylsalicylate · glycine particles |
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GB2051573A (en) * | 1979-07-06 | 1981-01-21 | Green Cross Corp | Acetylsalicylate powder composition |
EP0089198A2 (en) * | 1982-03-11 | 1983-09-21 | Dynatech Laboratories, Incorporated | Nontoxic aspirin-containing composition |
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JPS5665816A (en) * | 1979-11-01 | 1981-06-03 | Green Cross Corp:The | Acetylsalicylate pharmaceutical for injection |
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2005
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