CN101245050A - 4-苯胺喹唑啉衍生物的盐 - Google Patents
4-苯胺喹唑啉衍生物的盐 Download PDFInfo
- Publication number
- CN101245050A CN101245050A CNA2007100375572A CN200710037557A CN101245050A CN 101245050 A CN101245050 A CN 101245050A CN A2007100375572 A CNA2007100375572 A CN A2007100375572A CN 200710037557 A CN200710037557 A CN 200710037557A CN 101245050 A CN101245050 A CN 101245050A
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- Prior art keywords
- salt
- acid
- quinazoline
- triethylamine
- benzyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 1
- 229960000201 isosorbide dinitrate Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
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- 229940099584 lactobionate Drugs 0.000 description 1
- JYTUSYBCFIZPBE-AMTLMPIISA-N lactobionic acid Chemical compound OC(=O)[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O JYTUSYBCFIZPBE-AMTLMPIISA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000012204 lemonade/lime carbonate Nutrition 0.000 description 1
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- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
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- ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical compound CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- 230000026731 phosphorylation Effects 0.000 description 1
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- 102000020233 phosphotransferase Human genes 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- NPSSWQJHYLDCNV-UHFFFAOYSA-N prop-2-enoic acid;hydrochloride Chemical compound Cl.OC(=O)C=C NPSSWQJHYLDCNV-UHFFFAOYSA-N 0.000 description 1
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- 238000004885 tandem mass spectrometry Methods 0.000 description 1
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100375572A CN101245050A (zh) | 2007-02-14 | 2007-02-14 | 4-苯胺喹唑啉衍生物的盐 |
| US12/527,345 US8349854B2 (en) | 2007-02-14 | 2008-02-04 | Salts of 4-aniline quinazoline derivative |
| PCT/CN2008/000318 WO2008098485A1 (en) | 2007-02-14 | 2008-02-04 | The salts of 4-aniline quinazoline derivative |
| CA2677978A CA2677978C (en) | 2007-02-14 | 2008-02-04 | Salts forms of 4-phenylamino quinazoline derivative |
| AU2008215053A AU2008215053B2 (en) | 2007-02-14 | 2008-02-04 | The salts of 4-aniline quinazoline derivative |
| JP2009549760A JP5504460B2 (ja) | 2007-02-14 | 2008-02-04 | ４−フェニルアミノキナゾリン誘導体の塩形態 |
| KR1020097018740A KR20100014947A (ko) | 2007-02-14 | 2008-02-04 | 4-아닐린 퀴나졸린 유도체의 염 |
| EP08706496.0A EP2116540B1 (en) | 2007-02-14 | 2008-02-04 | P-toluenesulfonate salt of a 4-aniline quinazoline derivative |
| CN200880005090A CN101668750A (zh) | 2007-02-14 | 2008-02-04 | 4-苯胺喹唑啉衍生物的盐 |
| CN201510098689.0A CN104628658B (zh) | 2007-02-14 | 2008-02-04 | 4-苯胺喹唑啉衍生物的盐 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100375572A CN101245050A (zh) | 2007-02-14 | 2007-02-14 | 4-苯胺喹唑啉衍生物的盐 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101245050A true CN101245050A (zh) | 2008-08-20 |
Family
ID=39689656
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100375572A Pending CN101245050A (zh) | 2007-02-14 | 2007-02-14 | 4-苯胺喹唑啉衍生物的盐 |
| CN201510098689.0A Active CN104628658B (zh) | 2007-02-14 | 2008-02-04 | 4-苯胺喹唑啉衍生物的盐 |
| CN200880005090A Pending CN101668750A (zh) | 2007-02-14 | 2008-02-04 | 4-苯胺喹唑啉衍生物的盐 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510098689.0A Active CN104628658B (zh) | 2007-02-14 | 2008-02-04 | 4-苯胺喹唑啉衍生物的盐 |
| CN200880005090A Pending CN101668750A (zh) | 2007-02-14 | 2008-02-04 | 4-苯胺喹唑啉衍生物的盐 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8349854B2 (enExample) |
| EP (1) | EP2116540B1 (enExample) |
| JP (1) | JP5504460B2 (enExample) |
| KR (1) | KR20100014947A (enExample) |
| CN (3) | CN101245050A (enExample) |
| AU (1) | AU2008215053B2 (enExample) |
| CA (1) | CA2677978C (enExample) |
| WO (1) | WO2008098485A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009012702A1 (fr) * | 2007-07-20 | 2009-01-29 | Shanghai Allist Pharmaceutical., Inc. | Utilisation d'un dérivé de 4-aniline quinazoline pour la préparation de médicaments |
| CN106117182A (zh) * | 2016-06-20 | 2016-11-16 | 中国药科大学 | 喹唑啉‑n‑苯乙基四氢异喹啉类化合物及其制备方法和应用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101544609A (zh) * | 2008-03-25 | 2009-09-30 | 上海艾力斯医药科技有限公司 | 4-苯胺喹唑啉衍生物的结晶形式 |
| CN101584696A (zh) | 2008-05-21 | 2009-11-25 | 上海艾力斯医药科技有限公司 | 包含喹唑啉衍生物的组合物及制备方法、用途 |
| CN108430972B (zh) | 2015-12-24 | 2022-12-27 | 协和麒麟株式会社 | α,β不饱和酰胺化合物 |
| CN112225679A (zh) * | 2020-10-13 | 2021-01-15 | 苏州亚科科技股份有限公司 | 一种3-(环己胺)-2-羟基-1-丙磺酸的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| GB9510757D0 (en) * | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
| EP1110953B1 (en) | 1995-03-30 | 2009-10-28 | Pfizer Products Inc. | Quinazoline derivatives |
| RO121900B1 (ro) | 1996-04-12 | 2008-07-30 | Warner-Lambert Company | Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora |
| GB9800575D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| TW533204B (en) | 1998-07-30 | 2003-05-21 | Wyeth Corp | A process for preparing substituted quinazoline derivatives |
| CZ300945B6 (cs) * | 2000-06-30 | 2009-09-23 | Glaxo Group Limited | Zpusob prípravy 5-(6-chinazolinyl)-furan-2-karbaldehydu |
| KR100735639B1 (ko) * | 2004-12-29 | 2007-07-04 | 한미약품 주식회사 | 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법 |
| CN101003514A (zh) * | 2006-01-20 | 2007-07-25 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、其制备方法及用途 |
-
2007
- 2007-02-14 CN CNA2007100375572A patent/CN101245050A/zh active Pending
-
2008
- 2008-02-04 CN CN201510098689.0A patent/CN104628658B/zh active Active
- 2008-02-04 AU AU2008215053A patent/AU2008215053B2/en active Active
- 2008-02-04 WO PCT/CN2008/000318 patent/WO2008098485A1/zh not_active Ceased
- 2008-02-04 EP EP08706496.0A patent/EP2116540B1/en active Active
- 2008-02-04 CN CN200880005090A patent/CN101668750A/zh active Pending
- 2008-02-04 JP JP2009549760A patent/JP5504460B2/ja active Active
- 2008-02-04 KR KR1020097018740A patent/KR20100014947A/ko not_active Ceased
- 2008-02-04 US US12/527,345 patent/US8349854B2/en active Active
- 2008-02-04 CA CA2677978A patent/CA2677978C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009012702A1 (fr) * | 2007-07-20 | 2009-01-29 | Shanghai Allist Pharmaceutical., Inc. | Utilisation d'un dérivé de 4-aniline quinazoline pour la préparation de médicaments |
| CN106117182A (zh) * | 2016-06-20 | 2016-11-16 | 中国药科大学 | 喹唑啉‑n‑苯乙基四氢异喹啉类化合物及其制备方法和应用 |
| CN106117182B (zh) * | 2016-06-20 | 2019-08-30 | 中国药科大学 | 喹唑啉-n-苯乙基四氢异喹啉类化合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010518173A (ja) | 2010-05-27 |
| CN104628658B (zh) | 2015-10-21 |
| AU2008215053A1 (en) | 2008-08-21 |
| EP2116540A4 (en) | 2010-04-28 |
| KR20100014947A (ko) | 2010-02-11 |
| JP5504460B2 (ja) | 2014-05-28 |
| US20100168142A1 (en) | 2010-07-01 |
| AU2008215053B2 (en) | 2013-10-24 |
| US8349854B2 (en) | 2013-01-08 |
| EP2116540A1 (en) | 2009-11-11 |
| CA2677978C (en) | 2015-04-07 |
| CA2677978A1 (en) | 2008-08-21 |
| CN104628658A (zh) | 2015-05-20 |
| EP2116540B1 (en) | 2014-08-13 |
| WO2008098485A1 (en) | 2008-08-21 |
| CN101668750A (zh) | 2010-03-10 |
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