AU2008215053B2 - The salts of 4-aniline quinazoline derivative - Google Patents

The salts of 4-aniline quinazoline derivative Download PDF

Info

Publication number
AU2008215053B2
AU2008215053B2 AU2008215053A AU2008215053A AU2008215053B2 AU 2008215053 B2 AU2008215053 B2 AU 2008215053B2 AU 2008215053 A AU2008215053 A AU 2008215053A AU 2008215053 A AU2008215053 A AU 2008215053A AU 2008215053 B2 AU2008215053 B2 AU 2008215053B2
Authority
AU
Australia
Prior art keywords
salt
cancer
acid
compound
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2008215053A
Other languages
English (en)
Other versions
AU2008215053A1 (en
Inventor
Jianhui Guo
Yong Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Allist Pharmaceuticals Inc
Original Assignee
Shanghai Allist Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Allist Pharmaceuticals Inc filed Critical Shanghai Allist Pharmaceuticals Inc
Publication of AU2008215053A1 publication Critical patent/AU2008215053A1/en
Application granted granted Critical
Publication of AU2008215053B2 publication Critical patent/AU2008215053B2/en
Assigned to SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. reassignment SHANGHAI ALLIST PHARMACEUTICALS CO., LTD. Request to Amend Deed and Register Assignors: SHANGHAI ALLIST PHARMACEUTICALS, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2008215053A 2007-02-14 2008-02-04 The salts of 4-aniline quinazoline derivative Active AU2008215053B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200710037557.2 2007-02-14
CNA2007100375572A CN101245050A (zh) 2007-02-14 2007-02-14 4-苯胺喹唑啉衍生物的盐
PCT/CN2008/000318 WO2008098485A1 (en) 2007-02-14 2008-02-04 The salts of 4-aniline quinazoline derivative

Publications (2)

Publication Number Publication Date
AU2008215053A1 AU2008215053A1 (en) 2008-08-21
AU2008215053B2 true AU2008215053B2 (en) 2013-10-24

Family

ID=39689656

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008215053A Active AU2008215053B2 (en) 2007-02-14 2008-02-04 The salts of 4-aniline quinazoline derivative

Country Status (8)

Country Link
US (1) US8349854B2 (enExample)
EP (1) EP2116540B1 (enExample)
JP (1) JP5504460B2 (enExample)
KR (1) KR20100014947A (enExample)
CN (3) CN101245050A (enExample)
AU (1) AU2008215053B2 (enExample)
CA (1) CA2677978C (enExample)
WO (1) WO2008098485A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101347433B (zh) * 2007-07-20 2012-05-02 江苏艾力斯生物医药有限公司 4-苯胺喹唑啉衍生物的制药用途
CN101544609A (zh) * 2008-03-25 2009-09-30 上海艾力斯医药科技有限公司 4-苯胺喹唑啉衍生物的结晶形式
CN101584696A (zh) * 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
WO2017111076A1 (ja) * 2015-12-24 2017-06-29 協和発酵キリン株式会社 α、β不飽和アミド化合物
CN106117182B (zh) * 2016-06-20 2019-08-30 中国药科大学 喹唑啉-n-苯乙基四氢异喹啉类化合物及其制备方法和应用
CN112225679A (zh) * 2020-10-13 2021-01-15 苏州亚科科技股份有限公司 一种3-(环己胺)-2-羟基-1-丙磺酸的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007082434A1 (en) * 2006-01-20 2007-07-26 Shanghai Allist Pharmaceutical., Inc. Quinazoline derivatives,preparation methods and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
GB9300059D0 (en) 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
GB9510757D0 (en) * 1994-09-19 1995-07-19 Wellcome Found Therapeuticaly active compounds
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
SK284073B6 (sk) 1996-04-12 2004-09-08 Warner-Lambert Company Polycyklické zlúčeniny, ich použitie a farmaceutické kompozície na ich báze
GB9800569D0 (en) * 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800575D0 (en) * 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
AR020114A1 (es) 1998-07-30 2002-04-10 America Home Products Corp Proceso para la preparacion de derivados de quinazolina sustituida y compuestos para su exclusivo uso en dicho proceso
AU7307101A (en) * 2000-06-30 2002-01-14 Glaxo Group Ltd Quinazoline ditosylate salt compounds
KR100735639B1 (ko) 2004-12-29 2007-07-04 한미약품 주식회사 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007082434A1 (en) * 2006-01-20 2007-07-26 Shanghai Allist Pharmaceutical., Inc. Quinazoline derivatives,preparation methods and uses thereof

Also Published As

Publication number Publication date
JP5504460B2 (ja) 2014-05-28
CN104628658A (zh) 2015-05-20
US20100168142A1 (en) 2010-07-01
EP2116540A1 (en) 2009-11-11
CN101245050A (zh) 2008-08-20
AU2008215053A1 (en) 2008-08-21
CN101668750A (zh) 2010-03-10
KR20100014947A (ko) 2010-02-11
EP2116540B1 (en) 2014-08-13
JP2010518173A (ja) 2010-05-27
CA2677978A1 (en) 2008-08-21
EP2116540A4 (en) 2010-04-28
CA2677978C (en) 2015-04-07
CN104628658B (zh) 2015-10-21
US8349854B2 (en) 2013-01-08
WO2008098485A1 (en) 2008-08-21

Similar Documents

Publication Publication Date Title
CN102898386B (zh) 喹唑啉衍生物、其制备方法、中间体、组合物及其应用
EP2248806B1 (en) Quinazoline derivatives as tyrosine kinase inhibitors
US9102629B2 (en) Polymorphic forms of 4-phenylamine quinazoline derivative, the preparation method and uses thereof
EP3181560A1 (en) Pyridine amidopyrimidine derivative, preparation method and use thereof
NO319357B1 (no) N-(4-(3-klor-4-fluor-fenylamino)-7-(3-morfolin-4-yl-propoksy)-kinazolin-6-yl)-akrylamid, en irreversibel inhibitor av tyrosin-kinaser
AU2008215053B2 (en) The salts of 4-aniline quinazoline derivative
KR20150005698A (ko) 키나제 저해제로서 유용한 치환된 아미노퀴나졸린
JP7036798B2 (ja) キナゾリン誘導体の塩の結晶
CN107827877B (zh) 二烷基氨基喹唑啉类化合物及其在制备抗肿瘤药物中的应用
CN101932326A (zh) 4-苯胺喹唑啉衍生物的制药用途
AU2013231084B2 (en) The polymorphs of 4-anilinoquinazoline derivatives, the preparation methods and uses thereof
CN110078712A (zh) 一类含有氨基咪唑基化合物、其药物组合物和用途

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
HB Alteration of name in register

Owner name: SHANGHAI ALLIST PHARMACEUTICALS CO., LTD.

Free format text: FORMER NAME(S): SHANGHAI ALLIST PHARMACEUTICALS, INC.