CN101242819A - 催眠药以及取代的双芳基和杂芳基化合物的组合产品及其治疗应用 - Google Patents

催眠药以及取代的双芳基和杂芳基化合物的组合产品及其治疗应用 Download PDF

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Publication number
CN101242819A
CN101242819A CNA2006800296536A CN200680029653A CN101242819A CN 101242819 A CN101242819 A CN 101242819A CN A2006800296536 A CNA2006800296536 A CN A2006800296536A CN 200680029653 A CN200680029653 A CN 200680029653A CN 101242819 A CN101242819 A CN 101242819A
Authority
CN
China
Prior art keywords
alkyl
formula
compound
heteroaryl
short
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800296536A
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English (en)
Chinese (zh)
Inventor
G·T·埃蒙斯
S·孔沙穆特
C·N·卡尔森
C·M·莱戈夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of CN101242819A publication Critical patent/CN101242819A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2006800296536A 2005-08-19 2006-08-16 催眠药以及取代的双芳基和杂芳基化合物的组合产品及其治疗应用 Pending CN101242819A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70965505P 2005-08-19 2005-08-19
US60/709,655 2005-08-19

Publications (1)

Publication Number Publication Date
CN101242819A true CN101242819A (zh) 2008-08-13

Family

ID=37772166

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800296536A Pending CN101242819A (zh) 2005-08-19 2006-08-16 催眠药以及取代的双芳基和杂芳基化合物的组合产品及其治疗应用

Country Status (17)

Country Link
US (1) US7618650B2 (https=)
EP (1) EP1928442B1 (https=)
JP (1) JP2009504761A (https=)
KR (1) KR20080038416A (https=)
CN (1) CN101242819A (https=)
AR (1) AR055609A1 (https=)
AT (1) ATE447400T1 (https=)
AU (1) AU2006283703A1 (https=)
BR (1) BRPI0614943A2 (https=)
CA (1) CA2617980A1 (https=)
DE (1) DE602006010219D1 (https=)
ES (1) ES2336142T3 (https=)
MX (1) MX2008001778A (https=)
RU (1) RU2008110498A (https=)
SG (1) SG140147A1 (https=)
TW (1) TW200815009A (https=)
WO (1) WO2007024600A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102018681A (zh) * 2010-12-10 2011-04-20 荣港生技医药科技（北京）有限公司 一种美乐托宁缓释剂、其制备方法及其应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889811B1 (fr) * 2005-08-19 2009-10-09 Sanofi Aventis Sa Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique.
US8231902B2 (en) * 2005-11-18 2012-07-31 Accu-Break Technologies, Inc. Segmented pharmaceutical dosage forms
US8338367B2 (en) 2008-10-15 2012-12-25 Boehringer Ingelheim International Gmbh Fused heteroaryl diamide compounds useful as MMP-13 inhibitors
US8785489B2 (en) 2008-10-17 2014-07-22 Boehringer Ingelheim International Gmbh Heteroaryl substituted indole compounds useful as MMP-13 inhibitors
US20130060052A1 (en) * 2011-01-17 2013-03-07 Takeda Pharmaceutical Company Limited Orally dispersible tablet
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
PL2970132T3 (pl) 2013-03-14 2021-04-06 Epizyme, Inc. Inhibitory metylotransferazy argininy i ich zastosowania
CN116715633B (zh) * 2022-04-27 2025-08-12 杭州新元素药业股份有限公司 可用于降尿酸的化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502675A (ja) * 1996-10-21 2001-02-27 ニューロサーチ・アクティーゼルスカブ １―フエニル―ベンズイミダゾール化合物及びこれをｂａｇａ▲下ａ▼―レセプターモデュレーターとして使用する方法
US20040258750A1 (en) * 1999-06-28 2004-12-23 Gerard Alaux Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
CZ20023775A3 (cs) * 2000-04-24 2003-10-15 Teva Pharmaceutical Industries Ltd. Zolpidem hemitartrát
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102018681A (zh) * 2010-12-10 2011-04-20 荣港生技医药科技（北京）有限公司 一种美乐托宁缓释剂、其制备方法及其应用

Also Published As

Publication number Publication date
ES2336142T3 (es) 2010-04-08
EP1928442A2 (en) 2008-06-11
KR20080038416A (ko) 2008-05-06
DE602006010219D1 (de) 2009-12-17
ATE447400T1 (de) 2009-11-15
RU2008110498A (ru) 2009-09-27
BRPI0614943A2 (pt) 2011-04-26
AR055609A1 (es) 2007-08-29
WO2007024600A2 (en) 2007-03-01
SG140147A1 (en) 2008-03-28
US7618650B2 (en) 2009-11-17
MX2008001778A (es) 2008-04-07
WO2007024600A3 (en) 2007-05-24
US20080138413A1 (en) 2008-06-12
AU2006283703A1 (en) 2007-03-01
TW200815009A (en) 2008-04-01
JP2009504761A (ja) 2009-02-05
CA2617980A1 (en) 2007-03-01
EP1928442B1 (en) 2009-11-04

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