DE602006010219D1 - Kombination aus einem hypnotischen mittel und einer substituierten bis-aryl- und heteroaryl-verbindung und ihre therapeutische anwendung - Google Patents

Kombination aus einem hypnotischen mittel und einer substituierten bis-aryl- und heteroaryl-verbindung und ihre therapeutische anwendung

Info

Publication number
DE602006010219D1
DE602006010219D1 DE602006010219T DE602006010219T DE602006010219D1 DE 602006010219 D1 DE602006010219 D1 DE 602006010219D1 DE 602006010219 T DE602006010219 T DE 602006010219T DE 602006010219 T DE602006010219 T DE 602006010219T DE 602006010219 D1 DE602006010219 D1 DE 602006010219D1
Authority
DE
Germany
Prior art keywords
aryl
combination
therapeutic application
heteroaryl compound
substituted bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006010219T
Other languages
English (en)
Inventor
Gary T Emmons
Sathapana Kongsamut
Craig N Karson
Corrine M Legoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Aventis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc filed Critical Aventis Pharmaceuticals Inc
Publication of DE602006010219D1 publication Critical patent/DE602006010219D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE602006010219T 2005-08-19 2006-08-16 Kombination aus einem hypnotischen mittel und einer substituierten bis-aryl- und heteroaryl-verbindung und ihre therapeutische anwendung Active DE602006010219D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70965505P 2005-08-19 2005-08-19
PCT/US2006/032027 WO2007024600A2 (en) 2005-08-19 2006-08-16 Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof

Publications (1)

Publication Number Publication Date
DE602006010219D1 true DE602006010219D1 (de) 2009-12-17

Family

ID=37772166

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006010219T Active DE602006010219D1 (de) 2005-08-19 2006-08-16 Kombination aus einem hypnotischen mittel und einer substituierten bis-aryl- und heteroaryl-verbindung und ihre therapeutische anwendung

Country Status (17)

Country Link
US (1) US7618650B2 (de)
EP (1) EP1928442B1 (de)
JP (1) JP2009504761A (de)
KR (1) KR20080038416A (de)
CN (1) CN101242819A (de)
AR (1) AR055609A1 (de)
AT (1) ATE447400T1 (de)
AU (1) AU2006283703A1 (de)
BR (1) BRPI0614943A2 (de)
CA (1) CA2617980A1 (de)
DE (1) DE602006010219D1 (de)
ES (1) ES2336142T3 (de)
MX (1) MX2008001778A (de)
RU (1) RU2008110498A (de)
SG (1) SG140147A1 (de)
TW (1) TW200815009A (de)
WO (1) WO2007024600A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2889811B1 (fr) * 2005-08-19 2009-10-09 Sanofi Aventis Sa Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique.
BRPI0520797B8 (pt) * 2005-11-18 2021-05-25 Accu Break Tech Inc forma de dosagem farmacêutica comprimida em bicamadas
JP2012505892A (ja) 2008-10-15 2012-03-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｍｍｐ−１３阻害剤として有用な縮合ヘテロアリールジアミド化合物
CA2738929A1 (en) 2008-10-17 2010-04-22 Boehringer Ingelheim International Gmbh Heteroaryl substituted indole compounds useful as mmp-13 inhibitors
CN102018681A (zh) * 2010-12-10 2011-04-20 荣港生技医药科技（北京）有限公司 一种美乐托宁缓释剂、其制备方法及其应用
US20130060052A1 (en) * 2011-01-17 2013-03-07 Takeda Pharmaceutical Company Limited Orally dispersible tablet
US9120757B2 (en) 2013-03-14 2015-09-01 Epizyme, Inc. Arginine methyltransferase inhibitors and uses thereof
BR112015022785A2 (pt) 2013-03-14 2017-07-18 Epizyme Inc composto; composição farmacêutica; kit ou artigo farmacêutico embalado; método de inibição de uma arginina metil transferase (rmt); método de modulação da expressão genética; método de modulação da transcrição; e método de tratamento de um distúrbio mediado por rmt

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ334868A (en) * 1996-10-21 2001-02-23 Neurosearch As 1-Phenyl-benzimidazole compounds and their use as BAGA-a receptor modulators
US20040258750A1 (en) * 1999-06-28 2004-12-23 Gerard Alaux Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
AU5721301A (en) * 2000-04-24 2001-11-07 Teva Pharma Zolpidem hemitartrate
GT200600042A (es) * 2005-02-10 2006-09-27 Aventis Pharma Inc Compuestos de bis arilo y heteroarilo sustituido como antagonistas selectivos de 5ht2a

Also Published As

Publication number Publication date
CA2617980A1 (en) 2007-03-01
TW200815009A (en) 2008-04-01
US20080138413A1 (en) 2008-06-12
ES2336142T3 (es) 2010-04-08
KR20080038416A (ko) 2008-05-06
ATE447400T1 (de) 2009-11-15
WO2007024600A3 (en) 2007-05-24
CN101242819A (zh) 2008-08-13
MX2008001778A (es) 2008-04-07
EP1928442A2 (de) 2008-06-11
RU2008110498A (ru) 2009-09-27
AU2006283703A1 (en) 2007-03-01
AR055609A1 (es) 2007-08-29
JP2009504761A (ja) 2009-02-05
SG140147A1 (en) 2008-03-28
WO2007024600A2 (en) 2007-03-01
US7618650B2 (en) 2009-11-17
EP1928442B1 (de) 2009-11-04
BRPI0614943A2 (pt) 2011-04-26

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Legal Events

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