CN101233134B - 制备泛昔洛韦和其它嘌呤衍生物 - Google Patents

制备泛昔洛韦和其它嘌呤衍生物 Download PDF

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Publication number
CN101233134B
CN101233134B CN200680017571XA CN200680017571A CN101233134B CN 101233134 B CN101233134 B CN 101233134B CN 200680017571X A CN200680017571X A CN 200680017571XA CN 200680017571 A CN200680017571 A CN 200680017571A CN 101233134 B CN101233134 B CN 101233134B
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CN
China
Prior art keywords
alkyl
formula
amino
hydroxyl
compound shown
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200680017571XA
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English (en)
Chinese (zh)
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CN101233134A (zh
Inventor
何亮
姜维平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chongqing Shenghuaxi Pharmaceutical Co Ltd
Arrow International Ltd
Original Assignee
Chongqing Shenghuaxi Pharmaceutical Co Ltd
Arrow International Ltd
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Publication of CN101233134A publication Critical patent/CN101233134A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200680017571XA 2005-05-20 2006-05-19 制备泛昔洛韦和其它嘌呤衍生物 Expired - Fee Related CN101233134B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0510345A GB2426247A (en) 2005-05-20 2005-05-20 Methods of preparing purine derivatives such as famciclovir
GB0510345.2 2005-05-20
PCT/GB2006/001877 WO2006123175A1 (en) 2005-05-20 2006-05-19 Preparation of famciclovir and other purine derivatives

Publications (2)

Publication Number Publication Date
CN101233134A CN101233134A (zh) 2008-07-30
CN101233134B true CN101233134B (zh) 2013-01-23

Family

ID=34834391

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200680017571XA Expired - Fee Related CN101233134B (zh) 2005-05-20 2006-05-19 制备泛昔洛韦和其它嘌呤衍生物

Country Status (17)

Country Link
US (1) US7601835B2 (OSRAM)
EP (1) EP1883639B1 (OSRAM)
JP (1) JP5227166B2 (OSRAM)
CN (1) CN101233134B (OSRAM)
AT (1) ATE479688T1 (OSRAM)
AU (1) AU2006248745B2 (OSRAM)
BR (1) BRPI0609632A2 (OSRAM)
CA (1) CA2608490C (OSRAM)
DE (1) DE602006016593D1 (OSRAM)
DK (1) DK1883639T3 (OSRAM)
ES (1) ES2351925T3 (OSRAM)
GB (1) GB2426247A (OSRAM)
NZ (1) NZ563636A (OSRAM)
PL (1) PL1883639T3 (OSRAM)
PT (1) PT1883639E (OSRAM)
TW (1) TW200716638A (OSRAM)
WO (1) WO2006123175A1 (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1532151A2 (en) * 2002-08-26 2005-05-25 Teva Pharmaceutical Industries Limited Crystalline solid famciclovir forms i, ii, iii and preparation thereof
EP1511750A1 (en) * 2003-04-30 2005-03-09 Teva Pharmaceutical Industries Ltd. Process for the preparation of famciclovir
US7473780B2 (en) * 2004-05-18 2009-01-06 Teva Pharmeceutical Industries Ltd. Drying process for preparing crystalline solid famciclovir
WO2008072074A1 (en) * 2006-12-11 2008-06-19 Aurobindo Pharma Limited An improved process for the preparation of purine derivative
CN101555249B (zh) * 2008-04-08 2011-05-11 浙江海正药业股份有限公司 泛昔洛韦的合成方法
CN102924455A (zh) * 2011-08-11 2013-02-13 重庆圣华曦药业股份有限公司 一种泛昔洛韦中间体的合成方法
CN104496991A (zh) * 2014-11-04 2015-04-08 常州康丽制药有限公司 高品质2-氨基-6-氯-9-(4-羟基-3–羟甲基丁基)嘌呤的制备方法
CN104744472A (zh) * 2015-03-12 2015-07-01 常州康丽制药有限公司 高品质2-氨基-6-氯-9-(4-羟基-3-羟甲基丁基)嘌呤的制备方法
CN109456329B (zh) * 2018-11-19 2021-03-09 迪嘉药业集团有限公司 一种泛昔洛韦的制备方法
EP4073035B1 (en) 2019-12-11 2025-05-07 Taro Pharmaceutical Industries Ltd. Preparation of trifarotene and intermediates and polymorphs thereof
CN112979653A (zh) * 2019-12-12 2021-06-18 上药康丽（常州）药业有限公司 一种利用微通道反应器合成泛昔洛韦的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036071A (en) * 1984-12-21 1991-07-30 Medivir Ab Derivatives of purine
WO1995028402A2 (en) * 1994-04-19 1995-10-26 Smithkline Beecham Plc Preparation of purines
JPH11180983A (ja) 1997-12-24 1999-07-06 Sumika Fine Chemicals Co Ltd ９置換２−アミノ−６−ハロゲノプリンおよびその製法
WO2004110343A2 (en) * 2003-06-13 2004-12-23 Kyungdong Pharm. Co., Ltd. 2-amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]- 2- aminopurine using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684153A (en) * 1984-08-16 1997-11-04 Beecham Group Plc Process for the preparation of purine derivatives
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
DE3582399D1 (de) * 1984-09-20 1991-05-08 Beecham Group Plc Purin-derivate und ihre pharmazeutische verwendung.
GB8817607D0 (en) * 1988-07-23 1988-09-01 Beecham Group Plc Novel process
GB8822236D0 (en) * 1988-09-21 1988-10-26 Beecham Group Plc Chemical process
GB9402161D0 (en) 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9807116D0 (en) * 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
GB9807114D0 (en) * 1998-04-02 1998-06-03 Smithkline Beecham Plc Novel process
SI20022A (sl) * 1998-07-29 2000-02-29 Kemijski inštitut Alkilno substituirani purinovi derivati in njihova priprava
JP2003146988A (ja) * 2001-08-30 2003-05-21 Ajinomoto Co Inc ファムシクロビルの製造方法、並びにその中間体の製造および晶析方法
EP1288215B8 (en) * 2001-08-30 2005-04-06 Ajinomoto Co., Inc. Production method of famciclovir and production and crystallization method of intermediate therefor
US20050215787A1 (en) * 2004-03-26 2005-09-29 Joshi Ramesh A An improved process for the preparation of purines

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036071A (en) * 1984-12-21 1991-07-30 Medivir Ab Derivatives of purine
WO1995028402A2 (en) * 1994-04-19 1995-10-26 Smithkline Beecham Plc Preparation of purines
JPH11180983A (ja) 1997-12-24 1999-07-06 Sumika Fine Chemicals Co Ltd ９置換２−アミノ−６−ハロゲノプリンおよびその製法
WO2004110343A2 (en) * 2003-06-13 2004-12-23 Kyungdong Pharm. Co., Ltd. 2-amino-9-(2-substituted ethyl)purines and preparing methods for 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]- 2- aminopurine using the same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Briony Brand,et.al..Convenient Syntheses of 9-[4-Hydroxy-3-(hydroxymethyl)butyl]-guanine (Penciclovir) and 9-[4-Acetoxy-3-(acetoxymethyl)butyl]-2-amino-9H-purine (Famciclovir).《Tetrahedron》.1999,555239-5252. *
Michael R. Harnden,et.al..Prodrugs of the Selective Antiherpesvirus Agent 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL39123) with Improved Gastrointestinal Absorption Properties.《Journal of MedicinalChemistry》.1989,32(8),1738-1743. *
Paola Ciapetti,et.al..A Simple Preparation of N-Vinyl Derivatives of DNA Nucleobases.《Tetrahedron》.1998,5411305-11310. *

Also Published As

Publication number Publication date
CA2608490A1 (en) 2006-11-23
EP1883639A1 (en) 2008-02-06
ATE479688T1 (de) 2010-09-15
JP5227166B2 (ja) 2013-07-03
WO2006123175A1 (en) 2006-11-23
CN101233134A (zh) 2008-07-30
GB2426247A (en) 2006-11-22
PL1883639T3 (pl) 2011-04-29
JP2008540628A (ja) 2008-11-20
DE602006016593D1 (de) 2010-10-14
US7601835B2 (en) 2009-10-13
DK1883639T3 (da) 2010-11-15
ES2351925T3 (es) 2011-02-14
CA2608490C (en) 2013-09-10
EP1883639B1 (en) 2010-09-01
AU2006248745A1 (en) 2006-11-23
AU2006248745B2 (en) 2011-06-23
BRPI0609632A2 (pt) 2011-10-18
GB0510345D0 (en) 2005-06-29
TW200716638A (en) 2007-05-01
NZ563636A (en) 2010-10-29
PT1883639E (pt) 2010-12-07
US20060264629A1 (en) 2006-11-23

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