PL1883639T3 - Otrzymywanie famcyklowiru i innych pochodnych purynowych - Google Patents
Otrzymywanie famcyklowiru i innych pochodnych purynowychInfo
- Publication number
- PL1883639T3 PL1883639T3 PL06743955T PL06743955T PL1883639T3 PL 1883639 T3 PL1883639 T3 PL 1883639T3 PL 06743955 T PL06743955 T PL 06743955T PL 06743955 T PL06743955 T PL 06743955T PL 1883639 T3 PL1883639 T3 PL 1883639T3
- Authority
- PL
- Poland
- Prior art keywords
- purine derivatives
- famciclovir
- preparation
- purine
- substituted
- Prior art date
Links
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title abstract 2
- 229960004396 famciclovir Drugs 0.000 title 1
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 title 1
- 150000003212 purines Chemical class 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 abstract 2
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0510345A GB2426247A (en) | 2005-05-20 | 2005-05-20 | Methods of preparing purine derivatives such as famciclovir |
| EP06743955A EP1883639B1 (en) | 2005-05-20 | 2006-05-19 | Preparation of famciclovir and other purine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1883639T3 true PL1883639T3 (pl) | 2011-04-29 |
Family
ID=34834391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06743955T PL1883639T3 (pl) | 2005-05-20 | 2006-05-19 | Otrzymywanie famcyklowiru i innych pochodnych purynowych |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7601835B2 (OSRAM) |
| EP (1) | EP1883639B1 (OSRAM) |
| JP (1) | JP5227166B2 (OSRAM) |
| CN (1) | CN101233134B (OSRAM) |
| AT (1) | ATE479688T1 (OSRAM) |
| AU (1) | AU2006248745B2 (OSRAM) |
| BR (1) | BRPI0609632A2 (OSRAM) |
| CA (1) | CA2608490C (OSRAM) |
| DE (1) | DE602006016593D1 (OSRAM) |
| DK (1) | DK1883639T3 (OSRAM) |
| ES (1) | ES2351925T3 (OSRAM) |
| GB (1) | GB2426247A (OSRAM) |
| NZ (1) | NZ563636A (OSRAM) |
| PL (1) | PL1883639T3 (OSRAM) |
| PT (1) | PT1883639E (OSRAM) |
| TW (1) | TW200716638A (OSRAM) |
| WO (1) | WO2006123175A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2496684A1 (en) * | 2002-08-26 | 2004-03-04 | Teva Pharmaceutical Industries Ltd | Crystalline solid famciclovir forms i, ii, iii and preparation thereof |
| WO2004099208A1 (en) * | 2003-04-30 | 2004-11-18 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of famciclovir |
| TW200613304A (en) * | 2004-05-18 | 2006-05-01 | Teva Pharma | Drying process for preparing crystalline solid famciclovir |
| WO2008072074A1 (en) * | 2006-12-11 | 2008-06-19 | Aurobindo Pharma Limited | An improved process for the preparation of purine derivative |
| CN101555249B (zh) * | 2008-04-08 | 2011-05-11 | 浙江海正药业股份有限公司 | 泛昔洛韦的合成方法 |
| CN102924455A (zh) * | 2011-08-11 | 2013-02-13 | 重庆圣华曦药业股份有限公司 | 一种泛昔洛韦中间体的合成方法 |
| CN104496991A (zh) * | 2014-11-04 | 2015-04-08 | 常州康丽制药有限公司 | 高品质2-氨基-6-氯-9-(4-羟基-3–羟甲基丁基)嘌呤的制备方法 |
| CN104744472A (zh) * | 2015-03-12 | 2015-07-01 | 常州康丽制药有限公司 | 高品质2-氨基-6-氯-9-(4-羟基-3-羟甲基丁基)嘌呤的制备方法 |
| CN109456329B (zh) * | 2018-11-19 | 2021-03-09 | 迪嘉药业集团有限公司 | 一种泛昔洛韦的制备方法 |
| ES3037292T3 (en) | 2019-12-11 | 2025-09-30 | Taro Pharma Ind | Preparation of trifarotene and intermediates and polymorphs thereof |
| CN112979653A (zh) * | 2019-12-12 | 2021-06-18 | 上药康丽（常州）药业有限公司 | 一种利用微通道反应器合成泛昔洛韦的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0141927B1 (en) * | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Antiviral guanine derivatives |
| US5684153A (en) | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
| EP0182024B1 (en) * | 1984-09-20 | 1991-04-03 | Beecham Group Plc | Purine derivatives and their pharmaceutical use |
| SE8406538D0 (sv) | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | Novel derivatives of purine |
| GB8817607D0 (en) * | 1988-07-23 | 1988-09-01 | Beecham Group Plc | Novel process |
| GB8822236D0 (en) | 1988-09-21 | 1988-10-26 | Beecham Group Plc | Chemical process |
| GB9402161D0 (en) | 1994-02-04 | 1994-03-30 | Wellcome Found | Chloropyrimidine intermediates |
| GB9407698D0 (en) | 1994-04-19 | 1994-06-15 | Smithkline Beecham Plc | Pharmaceuticals |
| JPH11180983A (ja) | 1997-12-24 | 1999-07-06 | Sumika Fine Chemicals Co Ltd | ９置換２−アミノ−６−ハロゲノプリンおよびその製法 |
| GB9807116D0 (en) * | 1998-04-02 | 1998-06-03 | Smithkline Beecham Plc | Novel process |
| GB9807114D0 (en) * | 1998-04-02 | 1998-06-03 | Smithkline Beecham Plc | Novel process |
| SI20022A (sl) * | 1998-07-29 | 2000-02-29 | Kemijski inštitut | Alkilno substituirani purinovi derivati in njihova priprava |
| DE60202245T2 (de) | 2001-08-30 | 2005-09-01 | Ajinomoto Co., Inc. | Herstellungsmethode von Famciclovir und Herstellungs- bzw. Kristallisationsmethode eines entsprechenden Intermediates |
| JP2003146988A (ja) * | 2001-08-30 | 2003-05-21 | Ajinomoto Co Inc | ファムシクロビルの製造方法、並びにその中間体の製造および晶析方法 |
| KR100573860B1 (ko) | 2003-06-13 | 2006-04-25 | 경동제약 주식회사 | 2-아미노-9-(2-치환에틸)푸린을 이용한 9-[4-아세톡시-3-(아세톡시메틸)부트-1-일]-2-아미노푸린의 제조방법 |
| US20050215787A1 (en) * | 2004-03-26 | 2005-09-29 | Joshi Ramesh A | An improved process for the preparation of purines |
-
2005
- 2005-05-20 GB GB0510345A patent/GB2426247A/en not_active Withdrawn
- 2005-11-10 US US11/270,777 patent/US7601835B2/en not_active Expired - Fee Related
-
2006
- 2006-05-19 EP EP06743955A patent/EP1883639B1/en not_active Not-in-force
- 2006-05-19 WO PCT/GB2006/001877 patent/WO2006123175A1/en not_active Ceased
- 2006-05-19 DE DE602006016593T patent/DE602006016593D1/de active Active
- 2006-05-19 PT PT06743955T patent/PT1883639E/pt unknown
- 2006-05-19 BR BRPI0609632-8A patent/BRPI0609632A2/pt not_active IP Right Cessation
- 2006-05-19 ES ES06743955T patent/ES2351925T3/es active Active
- 2006-05-19 AT AT06743955T patent/ATE479688T1/de active
- 2006-05-19 CA CA2608490A patent/CA2608490C/en not_active Expired - Fee Related
- 2006-05-19 CN CN200680017571XA patent/CN101233134B/zh not_active Expired - Fee Related
- 2006-05-19 PL PL06743955T patent/PL1883639T3/pl unknown
- 2006-05-19 NZ NZ563636A patent/NZ563636A/en not_active IP Right Cessation
- 2006-05-19 TW TW095117840A patent/TW200716638A/zh unknown
- 2006-05-19 DK DK06743955.4T patent/DK1883639T3/da active
- 2006-05-19 JP JP2008511798A patent/JP5227166B2/ja not_active Expired - Fee Related
- 2006-05-19 AU AU2006248745A patent/AU2006248745B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540628A (ja) | 2008-11-20 |
| CA2608490C (en) | 2013-09-10 |
| DE602006016593D1 (de) | 2010-10-14 |
| US20060264629A1 (en) | 2006-11-23 |
| GB0510345D0 (en) | 2005-06-29 |
| TW200716638A (en) | 2007-05-01 |
| US7601835B2 (en) | 2009-10-13 |
| CN101233134B (zh) | 2013-01-23 |
| GB2426247A (en) | 2006-11-22 |
| AU2006248745A1 (en) | 2006-11-23 |
| PT1883639E (pt) | 2010-12-07 |
| ES2351925T3 (es) | 2011-02-14 |
| CN101233134A (zh) | 2008-07-30 |
| AU2006248745B2 (en) | 2011-06-23 |
| BRPI0609632A2 (pt) | 2011-10-18 |
| JP5227166B2 (ja) | 2013-07-03 |
| EP1883639A1 (en) | 2008-02-06 |
| DK1883639T3 (da) | 2010-11-15 |
| ATE479688T1 (de) | 2010-09-15 |
| EP1883639B1 (en) | 2010-09-01 |
| CA2608490A1 (en) | 2006-11-23 |
| NZ563636A (en) | 2010-10-29 |
| WO2006123175A1 (en) | 2006-11-23 |
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