CN101224186A - 双氯芬酸依泊胺凝胶剂、其制备方法及药物用途 - Google Patents
双氯芬酸依泊胺凝胶剂、其制备方法及药物用途 Download PDFInfo
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- CN101224186A CN101224186A CNA2008100329780A CN200810032978A CN101224186A CN 101224186 A CN101224186 A CN 101224186A CN A2008100329780 A CNA2008100329780 A CN A2008100329780A CN 200810032978 A CN200810032978 A CN 200810032978A CN 101224186 A CN101224186 A CN 101224186A
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
组别 | 红斑 | 水肿 | 致敏率(%) | 反应均值 | |
6h | 双氯芬酸依泊胺凝胶剂 | 0×10 | 0×10 | 0 | 0 |
赋形剂 | 0×10 | 0×10 | 0 | 0 | |
二硝基氟苯 | 1×32×7 | 0×61×4 | 1 00 | 2.3 | |
24h | 双氯芬酸依泊胺凝胶剂 | 0×10 | 0×10 | 0 | 0 |
赋形剂 | 0×10 | 0×10 | 0 | 0 | |
二硝基氟苯 | 1×52×5 | 0×61×4 | 1 00 | 1.3 | |
48h | 双氯芬酸依泊胺凝胶剂 | 0×10 | 0×10 | 0 | 0 |
赋形剂 | 0×10 | 0×10 | 0 | 0 | |
二硝基氟苯 | 0×61×4 | 0×10 | 40 | 0.4 | |
72h | 双氯芬酸依泊胺凝胶剂 | 0×10 | 0×10 | 0 | 0 |
赋形剂 | 0×10 | 0×10 | 0 | 0 | |
二硝基氟苯 | 0×10 | 0×10 | 0 | 0 |
组别 | 用量(g) | 致炎前足跖体积(ml) | 鼠左后足跖容积差(ΔV,ml) | |||
1h | 2h | 4h | 6h | |||
对照组 | 0.1g/次×3次 | 1.02±0.11 | 0.33±0.05 | 0.49±0.10 | 0.42±0.07 | 0.29±0.12 |
实施例1 | 0.1g/次×3次 | 1.08±0.08 | 0.35±0.08 | 0.52±0.14 | 0.40±0.21 | 0.25±0.11 |
实施例2 | 0.1g/次×3次 | 1.05±0.09 | 0.35±0.06 | 0.32±0.10 | 0.24±0.12 | 0.25±0.09 |
实施例3 | 0.1g/次×3次 | 1.10±0.05 | 0.30±0.10 | 0.28±0.13 | 0.25±0.08 | 0.26±0.06 |
实施例4 | 0.1g/次×3次 | 1.04±0.10 | 0.26±0.11 | 0.17±0.05* | 0.13±0.07* | 0.16±0.08* |
扶他林 | 0.1g/次×3次 | 1.09±0.05 | 0.31±0.05 | 0.28±0.09 | 0.24±0.04 | 0.22±0.10 |
Claims (19)
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CN2008100329780A CN101224186B (zh) | 2008-01-23 | 2008-01-23 | 双氯芬酸依泊胺凝胶剂、其制备方法及药物用途 |
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CN2008100329780A CN101224186B (zh) | 2008-01-23 | 2008-01-23 | 双氯芬酸依泊胺凝胶剂、其制备方法及药物用途 |
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Publication Number | Publication Date |
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CN101224186A true CN101224186A (zh) | 2008-07-23 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101991858B (zh) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | 新型外用辅料及其制备方法 |
WO2014009793A1 (en) | 2012-07-11 | 2014-01-16 | Glycores 2000 S.R.L. | Diclofenac solution for external use |
CN105395544A (zh) * | 2014-08-23 | 2016-03-16 | 南京海纳医药科技有限公司 | 双氯芬酸依泊胺凝胶制备方法及药物用途 |
CN105878214A (zh) * | 2014-08-23 | 2016-08-24 | 南京海纳医药科技有限公司 | 一种含双氯芬酸依泊胺的透皮贴剂及其制备方法 |
WO2023180792A1 (en) | 2022-03-25 | 2023-09-28 | Glycores 2000 Srl | Topical pharmaceutical composition with anti-inflammatory and analgesic activity and uses thereof |
-
2008
- 2008-01-23 CN CN2008100329780A patent/CN101224186B/zh active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101991858B (zh) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | 新型外用辅料及其制备方法 |
WO2014009793A1 (en) | 2012-07-11 | 2014-01-16 | Glycores 2000 S.R.L. | Diclofenac solution for external use |
CN105395544A (zh) * | 2014-08-23 | 2016-03-16 | 南京海纳医药科技有限公司 | 双氯芬酸依泊胺凝胶制备方法及药物用途 |
CN105878214A (zh) * | 2014-08-23 | 2016-08-24 | 南京海纳医药科技有限公司 | 一种含双氯芬酸依泊胺的透皮贴剂及其制备方法 |
WO2023180792A1 (en) | 2022-03-25 | 2023-09-28 | Glycores 2000 Srl | Topical pharmaceutical composition with anti-inflammatory and analgesic activity and uses thereof |
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